In the winter of 2021, the Swedish Nobel Foundation organized a Nobel symposium 'One Hundred Years of Game Theory' to commemorate the publication of famous mathematician Emile Borel's 'La théorie du jeu et les équations intégrales à noyau symétrique'. The symposium gathered roughly forty of the world's most prominent scholars ranging from mathematical foundations to applications in economics, political science, computer science, biology, sociology, and other fields. One Hundred Years of Game Theory brings together their writings to summarize and put in perspective the main achievements of game theory in the last one hundred years. They address past achievements, taking stock of what has been accomplished and contemplating potential future developments and challenges. Offering cross-disciplinary discussions between eminent researchers including five Nobel laureates, one Fields medalist and two Gödel prize winners, the contributors provide a fascinating landscape of game theory and its wide range of applications.