Arabinoxylans (AX), the primary hemicellulose found in cereals and grasses, play a crucial role in regulating immunity, metabolism and various physiological processes, underscoring their value as essential components in dietary nutrition. Considering the extensive research on AX in piglet nutrition, this paper systematically reviews their impacts on gut health and microbiota in piglets, as well as the underlying mechanisms of action. AX have been shown to mediate gut barrier fortification through tight junction protein upregulation and orchestrate mucosal immunity homeostasis, consequently ameliorating early-weaning-associated diarrheal pathogenesis in piglets. Additionally, AX function as microbial ecological modulators through selective enrichment of beneficial commensal microbiota (e.g. Bifidobacterium spp. and Lactobacillus spp.), while simultaneously stimulating microbial biosynthesis of SCFA and ferulic acid exhibiting potent antioxidant and anti-inflammatory activity, thereby maintaining the intestinal health of piglets. This review offers valuable insights into their potential as a dietary intervention to support gut health and immune function in early-weaned piglets. However, most studies focus on single-source AX such as wheat or maize, with limited exploration of novel sources or comparative effects of source combinations. Future research should systematically investigate the molecular mechanisms of AX action, provide data-driven guidance for selecting AX sources in feed formulations and establish optimal inclusion levels in practical feeding regimens. Such efforts will further solidify the precision nutrition potential of AX in promoting sustainable and healthy growth in piglets.

In this study, we present a low-numerical-aperture (NA) confined-doped fiber architecture that synergistically mitigates transverse mode instability (TMI) through combined optical waveguide engineering and spatially tailored gain distribution. The individual and combined benefits of low-NA fiber design and the confined-doped fiber design strategy on TMI mitigation are numerically investigated. Building upon these theoretical analyses, a self-developed fiber, featuring a core/cladding diameter of approximately 26/400 μm, a core NA of approximately 0.045 and a core doping ratio of approximately 75%, is fabricated. Further experimental validation in a master oscillator power amplifier demonstrates 6.74 kW output power with near-single-mode (M${}^2\sim$1.49) beam quality, validating the design’s efficacy. This study establishes a novel fiber design paradigm that concurrently addresses TMI mitigation, beam quality maintenance and power scalability, offering a viable pathway toward robust high-power fiber laser sources with near-diffraction-limited beam quality.

The effects of the external intermittent behaviour on the Kolmogorov constants $C_{k1}$ and $C_2$ in spectral and the physical spaces are investigated using high-resolution direct numerical simulations of a turbulent plane jet. Well-defined $- 5/3$ energy spectrum and $2/3$ structure function can be found in the intermittent flows without large-scale vortex shedding. For different cross-wise positions, the profiles of conditional energy spectra and conditional structure functions exhibit self-similarity at small and intermediate scales when normalised by the conditional Kolmogorov scale of the turbulent region. The conditional Kolmogorov constants are close to those of the fully turbulent flow. The constants $C_{k1}$ and $C_2$ are found to have a power-law dependence on the intermittency factor $\gamma$, that is, $C_{k1}\sim \gamma ^{1/3}$ and $C_{2}\sim \gamma ^{1/3}$, except for the scaling of the structure function in the highly intermittent region with $\gamma =0.25$. In the highly intermittent region, e.g. $\gamma =0.25$, the scaling in the conditional structure function can be considerably influenced by the blocking/sheltering mechanisms of the turbulent/non-turbulent interface (TNTI), leading to slight deviations from self-similarity. We further confirm that the conditional structure function recovers self-similarity after excluding a turbulent region at an average distance of approximately $20$ Kolmogorov length scales from the outer edge of the TNTI, which is comparable to the mean thickness of the TNTI. These findings contribute to the modelling of the edge of a turbulent region.

In compressible turbulent boundary layers (CTBLs), the strong Reynolds analogy (SRA) refers to a set of quantitative relationships between temperature and velocity fluctuations. The essence of the SRA is the linear relationship between these fluctuations in large-scale motions. We investigate the transport processes of the second-order statistical moments associated with temperature and velocity fluctuations to reveal the physical mechanisms underlying this linear correlation. An important finding is that there exists a strong linear mechanism between the turbulent production of velocity and temperature fluctuations. Nonlinear mechanisms, such as the viscous-thermal dissipation, the work contribution, and particularly the pressure term, lead to the failure of the existing SRAs in the outer layer. Based on the above findings, a refined SRA (RSRA) is proposed, which better describes the quantitative relation between the temperature and velocity fluctuation intensities. An approximate expression for the turbulent Prandtl number under different Mach numbers and wall-cooling conditions is derived with the newly proposed RSRA. The relations proposed in this paper are validated through the direct numerical simulation data of flat-plate zero-pressure-gradient CTBLs at different Mach numbers and wall temperatures.

Coarctation of the aorta is characterised by narrowing of the descending aorta and is a rare cause of secondary hypertension in children and young adults. The aortic stenosis lesion is in a special location with severe consequences, and long-term survival is very low, with high rates of disability and mortality, and can be challenging to detect due to its few clinical manifestations. We report a case of a young patient with atrial fibrillation, renal infarction, and acute cerebral infarction, which are consequences of untreated hypertension due to coarctation of the aorta. The purpose of this report is to emphasize the importance of early diagnosis and management of coarctation of the aorta as a cause of secondary hypertension in children and young adults.

The aerodynamic sound generated by the oblique collision of two vortex rings is featured by the asymmetric emission associated with the octupole mode, which differs from the symmetric emission associated with the quadrupole mode observed in the coaxial collision of two vortex rings. This distinctive feature of aerodynamic sound is closely related to the tilting and reconnecting of the vortex rings. While previous studies have explored the effects of reconnecting on aerodynamic sound, this study specifically addresses the impact of vortex ring tilting. We propose a novel vortex sound formula to quantitatively assess the role of tilting in aerodynamic sound generation. The proposed formula relates the far-field sound pressure to equivalent circulations and vorticity centroids by referring to Truesdell’s consistency conditions for vorticity moments. The variations of the equivalent circulations and vorticity centroids in the oblique collision of two vortex rings under different configurations are analysed based on the numerical solution of the Navier–Stokes equations in the source region. It is found that the tilting of vortex rings results in a rapid change of the equivalent circulation associated with the vorticity in the collision direction. However, the change caused by titling is almost out of phase with that caused by reconnecting and deforming. The vortex tilting significantly reduces the aerodynamic sound associated with the longitudinal quadrupole and octupole modes, which is opposite to the role of vortex reconnecting that was reported in the oblique collision of vortex rings.

In prognosis studies with time-to-event outcomes, the survivals of groups with high/low biomarker expression are often estimated by the Kaplan–Meier method, and the difference between groups is measured by the hazard ratios (HRs). Since the high/low expressions are usually determined by study-specific cutoff values, synthesizing only HRs for summarizing the prognostic capacity of a biomarker brings heterogeneity in the meta-analysis. The time-dependent summary receiver operating characteristics (SROC) curve was proposed as a cutoff-free summary of the prognostic capacity, extended from the SROC curve in meta-analysis of diagnostic studies. However, estimates of the time-dependent SROC curve may be threatened by reporting bias in that studies with significant outcomes, such as HRs, are more likely to be published and selected in meta-analyses. Under this conjecture, this paper proposes a sensitivity analysis method for quantifying and adjusting reporting bias on the time-dependent SROC curve. We model the publication process determined by the significance of the HRs and introduce a sensitivity analysis method based on the conditional likelihood constrained by some expected proportions of published studies. Simulation studies showed that the proposed method could reduce reporting bias given the correctly-specified marginal selection probability. The proposed method is illustrated on the real-world meta-analysis of Ki67 for breast cancer.

The betatron radiation source features a micrometer-scale source size, a femtosecond-scale pulse duration, milliradian-level divergence angles and a broad spectrum exceeding tens of keV. It is conducive to the high-contrast imaging of minute structures and for investigating interdisciplinary ultrafast processes. In this study, we present a betatron X-ray source derived from a high-charge, high-energy electron beam through a laser wakefield accelerator driven by the 1 PW/0.1 Hz laser system at the Shanghai Superintense Ultrafast Laser Facility (SULF). The critical energy of the betatron X-ray source is 22 ± 5 keV. The maximum X-ray flux reaches up to 4 × 109 photons for each shot in the spectral range of 5–30 keV. Correspondingly, the experiment demonstrates a peak brightness of 1.0 × 1023 photons·s−1·mm−2·mrad−2·0.1%BW−1, comparable to those demonstrated by third-generation synchrotron light sources. In addition, the imaging capability of the betatron X-ray source is validated. This study lays the foundation for future imaging applications.

Urban air mobility (UAM) utilising novel transportation tools is gradually being recognised as a significant means to alleviate ground transportation pressures, vertiports which serve as pivotal nodes in UAM require efficient methods for assessing its operational capacity to develop an appropriate operational strategy and help to design vertiport ground infrastructure scientifically. This study proposes a multi-dimensional assessment method for the capacity of vertiports considering throughput and quality of service based on genetic algorithm (CEGA). The method comprehensively considers constraints such as unmanned aerial vehicle (UAV) safety separation, battery endurance, number of landing vertipads and UAV speed. The experimental results indicate that the vertiport with the scheduling algorithm proposed by this study has a larger capacity and experiences fewer delay than the vertiport with first-come-first-served (FCFS) algorithm when the vertiport has the same limited number of vertipads. Different proportions of UAVs significantly affect the quality of service and the degree of operation delays. The weights of vertiport throughput and customer satisfaction are the parameters that represent the importance of throughput and customer satisfaction in the objective function of the capacity assessment model. When the weights of throughput and customer satisfaction are set to 0.8 and 0.2 respectively, the performance of this optimisation model is optimal. This study provides a novel solution for capacity assessment and operation scheduling of vertiports, laying the foundation for improving the efficiency of UAM operations.

Direct numerical simulations are performed to explore the evolution behaviour of the turbulent/non-turbulent interface (TNTI) in a temporally evolving turbulent plane jet, using the evolution equation for the TNTI surface area. A novel algorithm is used to calculate the surface area of the TNTI and entrainment flux. It is shown that the surface area remains relatively constant, which leads to the mean entrainment velocity being inversely proportional to the square root of time. On average, the effects of the stretching and curvature/viscous terms on the TNTI area roughly counterbalance each other, while the curvature/inviscid term associated with vortex stretching is virtually zero. More specifically, the stretching term contributes to the production of the surface area, while the curvature/viscous term is associated with a destruction in the surface area. The local effect of the curvature/viscous term exhibits high spatial intermittency with small-scale extreme/intense events, whereas the effect of the large-scale stretching term is more continuous. To shed light on the contribution of curvature/viscous term to the evolution of the surface area, we decompose it into three components. The effect of the curvature/normal diffusion term (the curvature/viscous dissipation term) in the bulging regions (the valley regions) mainly contributes to the production of the area. The continuous decrease of the average mean curvature is associated with the production of the bulging regions and the destruction of the valley regions. Finally, although the entrainment velocity is mainly dominated by the normal diffusion effect, all three components related to the viscous effect are indispensable to the production and destruction of the TNTI area. This numerical study contributes to a better understanding of the evolution of the TNTI area.

Timing of food intake is an emerging aspect of nutrition; however, there is a lack of research accurately assessing food timing in the context of the circadian system. The study aimed to investigate the relation between food timing relative to clock time and endogenous circadian timing with adiposity and further explore sex differences in these associations among 151 young adults aged 18–25 years. Participants wore wrist actigraphy and documented sleep and food schedules in real time for 7 consecutive days. Circadian timing was determined by dim-light melatonin onset (DLMO). The duration between last eating occasion and DLMO (last EO-DLMO) was used to calculate the circadian timing of food intake. Adiposity was assessed using bioelectrical impedance analysis. Of the 151 participants, 133 were included in the statistical analysis finally. The results demonstrated that associations of adiposity with food timing relative to circadian timing rather than clock time among young adults living in real-world settings. Sex-stratified analyses revealed that associations between last EO-DLMO and adiposity were significant in females but not males. For females, each hour increase in last EO-DLMO was associated with higher BMI by 0·51 kg/m2 (P = 0·01), higher percent body fat by 1·05 % (P = 0·007), higher fat mass by 0·99 kg (P = 0·01) and higher visceral fat area by 4·75 cm2 (P = 0·02), whereas non-significant associations were present among males. The findings highlight the importance of considering the timing of food intake relative to endogenous circadian timing instead of only as clock time.

Perinatal malnutrition is a critical cause of diseases in offspring. Based on the different rates of organ development, we hypothesised that malnutrition at varying early life stages would have a differential impact on cardiovascular disease in middle-aged and older adults. This study sought to assess the long-term impact of exposure to the 1959–1961 Great Chinese Famine (GCF) during early developmental periods on risks of cardiovascular diseases in the late middle-aged offspring. A total 6, 662 individuals, born between 1958 and 1964, were divided into six groups according to the birth date. The generalised line model was used to control age and estimate differences with 95% confidence interval (CI) in blood pressure. Binary logistic regression was applied to evaluate the association between famine exposure and cardiovascular diseases. Compared to the unexposed late middle-aged persons, blood pressure was elevated in the entire gestation exposure group, regardless of postnatal exposure to GCF. Increased blood pressure was also found in the female offspring exposed to GCF during early and middle gestation. The early-childhood exposure was associated with the risk of bradycardia in the offspring. The risks of vertebral artery atherosclerosis were elevated in GCF famine-exposed groups except first trimester exposed group. The chronic influence of GCF in early life periods was specific to the developmental timing window, sexesand organs, suggesting an essential role of interactions among multiple factors and prenatal malnutrition in developmentally “programming” cardiovascular diseases.

MicroRNAs (miRNAs) play important roles in regulating salt tolerance in Dongxiang wild rice (DXWR, Oryza rufipogon Griff.). The development of salt-responsive miRNA-simple sequence repeat (SSR) markers will significantly bolster research on DXWR, providing novel tools for exploring salt-tolerant genetic resources and advancing the development of salt-tolerant rice varieties. In the present study, a total of 137 miRNA-SSR markers were successfully developed, specifically derived from miRNAs responsive to salt stress in DXWR. Subsequently, a subset of 20 markers was randomly selected for validation across three distinct DXWR populations, along with 35 modern rice varieties. Notably, 13 of these markers exhibited remarkable polymorphism. The polymorphic markers collectively amplified 52 SSR loci, averaging four alleles per locus. The polymorphism information content values associated with these loci spanned from 0.23 to 0.70, with a mean value of 0.49. Particularly noteworthy is the miR162a-SSR marker, which demonstrated distinct allelic patterns and holds potential as a diagnostic marker for discriminating the salt-tolerant rice varieties from the non-tolerant varieties. This study provides a valuable tool for genetic analysis and precision breeding, facilitating the identification and utilization of valuable salt-tolerant genetic resources.

Aphis spiraecola Patch is one of the most economically important tree fruit pests worldwide. The pyrethroid insecticide lambda-cyhalothrin is commonly used to control A. spiraecola. In this 2-year study, we quantified the resistance level of A. spiraecola to lambda-cyhalothrin in different regions of the Shaanxi province, China. The results showed that A. spiraecola had reached extremely high resistance levels with a 174-fold resistance ratio (RR) found in the Xunyi region. In addition, we compared the enzymatic activity and expression level of P450 genes among eight A. spiraecola populations. The P450 activity of A. spiraecola was significantly increased in five regions (Xunyi, Liquan, Fengxiang, Luochuan, and Xinping) compared to susceptible strain (SS). The expression levels of CYP6CY7, CYP6CY14, CYP6CY22, P4504C1-like, P4506a13, CYP4CZ1, CYP380C47, and CYP4CJ2 genes were significantly increased under lambda-cyhalothrin treatment and in the resistant field populations. A L1014F mutation in the sodium channel gene was found and the mutation rate was positively correlated with the LC50 of lambda-cyhalothrin. In conclusion, the levels of lambda-cyhalothrin resistance of A. spiraecola field populations were associated with P450s and L1014F mutations. Our combined findings provide evidence on the resistance mechanism of A. spiraecola to lambda-cyhalothrin and give a theoretical basis for rational and effective control of this pest species.