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We show that for any integer $k\ge 1$ there exists an integer $t_0(k)$ such that, for integers $t, k_1, \ldots , k_{t+1}, n$ with $t\gt t_0(k)$, $\max \{k_1, \ldots , k_{t+1}\}\le k$, and $n \gt 2k(t+1)$, the following holds: If $F_i$ is a $k_i$-uniform hypergraph with vertex set $[n]$ and more than $ \binom{n}{k_i}-\binom{n-t}{k_i} - \binom{n-t-k}{k_i-1} + 1$ edges for all $i \in [t+1]$, then either $\{F_1,\ldots , F_{t+1}\}$ admits a rainbow matching of size $t+1$ or there exists $W\in \binom{[n]}{t}$ such that $W$ intersects $F_i$ for all $i\in [t+1]$. This may be viewed as a rainbow non-uniform extension of the classical Hilton-Milner theorem. We also show that the same holds for every $t$ and $n \gt 2k^3t$, generalizing a recent stability result of Frankl and Kupavskii on matchings to rainbow matchings.
This study uses a coupled lattice Boltzmann and discrete element method to perform interface-resolved simulations of turbulent channel flow laden with finite-size cylindrical particles. The aim is to investigate interactions between wall-bounded turbulence and non-spherical particles with sharp edges. The particle-to-fluid density ratio is unity and gravity is neglected. Comparative analyses are conducted among long (length-to-diameter aspect ratio 2), unit (1) and short ($ 1/2 $) cylinders, along with spheres and literature data for spheroids. Results reveal both shared and distinct dynamic behaviours of cylinders and their effects on turbulence modulation. Notably, disk-like short cylinders can remain trapped near the wall due to their flat faces aligning closely with it – a behaviour unique to particles with sharp edges. Long and unit cylinders, as well as spheres, preferentially accumulate in high-speed streaks, while short cylinders cluster in low-speed streaks, demonstrating a strong aspect-ratio effect. Near the wall, long cylinders align their axis with the streamwise direction, while short cylinders orient perpendicular to the wall. Rotationally, long cylinders primarily spin, whereas short ones predominantly tumble. These trends arise from orientation preferences and differences in axial and spanwise moments of inertia. Cylindrical particles increase wall drag compared with the single-phase case, with short cylinders causing the greatest enhancement due to strong near-wall accumulation. Overall, the influence of aspect ratio on particle dynamics and turbulence modulation is more pronounced for cylindrical particles than for spheroidal ones.
Previous research has mainly explored the relationship between bilingual language control and domain-general cognitive control through behavioral correlations, often revealing epiphenomenal links rather than causality. This study utilizes transcranial magnetic stimulation (TMS) to investigate the causal roles of the left inferior frontal gyrus (LIFG) and left middle temporal gyrus (LMTG) in 33 unbalanced Chinese-English bilinguals. Continuous theta burst stimulation was applied in separate sessions to decrease cortical excitability, with vertex stimulation as a control. LIFG stimulation significantly increased switching costs in nonverbal switching tasks, highlighting its role in domain-general cognitive control. LMTG stimulation did not affect switching or mixing costs in language or nonverbal switching tasks, suggesting no causal involvement, but it reduced reaction times (RTs) during language switching tasks, underscoring its specialization in language processing. These findings highlight distinctions between the neural mechanisms of bilingual language control and domain-general cognitive control, particularly in the LIFG.
Aerothermal issues in hypersonic transitional swept shock wave/boundary-layer interactions (SBLIs) are critical for the structural safety of high-speed vehicles but remain poorly understood. In this work, previously scarce, high-resolution heat transfer distributions of the hypersonic transitional swept SBLIs, are obtained from fast-responding temperature-sensitive paint (fast TSP) measurements. A series of $34^\circ$ compression ramps with sweep angles ranging from $0^\circ$ to $45^\circ$ are tested in a Mach 12.1 shock tunnel, with a unit Reynolds number of 3.0 $\times$ 10$^{6}$ m$^{-1}$. The fast TSP provides a global view of the three-dimensional aerothermal effects on the ramps, allowing in-depth analysis on the sweep effects and the symmetry of heat transfer. The time-averaged results reveal that the heat flux peak near reattachment shifts upstream with decreasing amplitude as the sweep angle increases, and a second peak emerges in the $45^\circ$ swept ramp due to a type V shock–shock interaction. Downstream of reattachment, the heat flux streaks induced by Görtler-like vortices weaken with increasing sweep angle, whereas their dominant projected wavelengths show little dependence on sweep angle or spanwise location. Away from the ramp’s leading side, the transition onset of the reattached boundary layer gradually approaches the reattachment point. Finally, a general quasi-conical aerothermal symmetry is identified upstream of reattachment, although spanwise variations in transition onset, shock–shock interaction and heat flux streaks are found to disrupt this symmetry downstream of reattachment with varying degrees.
Computer vision-based precision weed control has proven effective in reducing herbicide usage, lowering weed management costs, and enhancing sustainability in modern agriculture. However, developing deep learning models remains challenging due to the effort required for weed dataset annotation and the difficulty of identifying weeds at different stages and densities in complex field conditions. To address these challenges, this study introduces an indirect weed detection method that combines deep learning and image processing techniques. The proposed approach first employs an object detection network to identify and label crops within the images. Subsequently, image processing techniques are applied to segment the remaining green pixels, thereby enabling indirect detection of weeds. Furthermore, a novel detection network–CD-YOLOv10n (You Only Look Once version 10 nano)–was developed based on the YOLOv10 framework to optimize computational efficiency. By redesigning the backbone (C2f-DBB) and integrating an optimized upsampling module (DySample), the network achieved higher detection accuracy while maintaining a lightweight structure. Specifically, the model achieved a mean average precision (mAP50) of 98.1%, which is a 1.4% percentage-point increase compared with the YOLOv10n baseline, a relevant improvement given the already strong baseline performance. At the same time, compared to YOLOv10n, its GFLOPs were reduced by 22.62%, and the number of parameters decreased by 15.87%. These innovations make CD-YOLOv10n highly suitable for deployment on resource-constrained platforms.
The Body Mass Index-Based Figure Rating Scale for Chinese Adolescents (C-BMI-FRS; Yu et al., 2022) provides a brief way to assess the body dissatisfaction of Chinese adolescents via calculating the discrepancy between their chosen actual and ideal body silhouettes. Height, weight, sex, and age data was calculated from a large sample of Chinese adolescents and a professional artist drew four equal height silhouettes for each sex (girls, boys) based on these data. The four silhouettes, which represented BMI values at the 20th, 40th, 60th, and 80th percentiles, were placed above a horizontal bar with 25 grids. Respondents choose the number (1-25) that represents the figure that they actually have and the figure they ideally would like to have. Their chosen ideal figure is then subtracted from their chosen actual figure. The figures and logistics of use, such as permissions, copyright, and contact information, are provided for readers.
How psychotic symptoms, depressive symptoms, cognitive deficits, and functional impairment may interact with one another in schizophrenia or bipolar disorder is unclear.
Methods
This study explored these interactions in a discovery sample of 339 Chinese, of whom 146 had first-episode schizophrenia and 193 had bipolar disorder. Psychotic symptoms were assessed using the Positive and Negative Symptom Scale; depressive symptoms, using the Hamilton Depression Rating Scale; cognitive deficits, using tests of processing speed, executive function, and logical memory; and functional impairment, using clinical assessments. Network models connecting the four types of variables were developed and compared between men and women and between disorders. Potential causal relationships among the variables were explored through directed acyclic graphing. The results in the discovery sample were compared to those obtained for a validation sample of 235 Chinese, of whom 138 had chronic schizophrenia and 97 had bipolar disorder.
Results
In the discovery and validation cohorts, schizophrenia and bipolar disorder showed similar networks of associations, in which the central hubs included ‘disorganized’ symptoms, depressive symptoms, and deficits in processing speed during the digital symbol substitution test. Directed acyclic graphing suggested that disorganized symptoms were upstream drivers of cognitive impairment and functional decline, while core depressive symptoms (e.g. low mood) drove somatic and anxiety symptoms.
Conclusions
Our study advocates for transdiagnostic, network-informed strategies prioritizing the mitigation of disorganization and depressive symptoms to disrupt symptom cascades and improve functional outcomes in schizophrenia and bipolar disorder.
We give criteria for the Turán inequality of any order, the double Turán inequality, and the Laguerre inequality of any order of $c(n)$ for sufficiently large n. We also give the companion inequalities for the Turán inequality and the Laguerre inequality of any order for $c(n)$. As applications, we will show that the numbers of commuting $\ell $-tuples in $S_n$, the partition without sequence, the plane partition, the partition into k-gonal numbers, the finite-dimensional representations of groups $\mathfrak {su}(3)$ and $\mathfrak {so}(5),$ and the coefficients of infinite product generating functions asymptotically satisfy these inequalities. Some of them settle open problems proposed by Bringmann, Franke, and Heim.
To address the complexity and excessive reliance on expert experience in tuning fuzzy Proportional-Integral-Derivative (PID) controller parameters, this study proposes a variable-rate spraying control system that integrates an improved Beetle Antennae Search (IBAS) algorithm with fuzzy PID control. To evaluate the feasibility of the system, a mathematical transfer function of the variable-rate spraying system was constructed, and a flow control simulation platform was established for simulation analysis. To overcome the limitations of conventional BAS, which is prone to premature convergence and limited search precision, the IBAS algorithm was developed. The improvements include a hybrid disturbance strategy to enhance individual search capability and a simulated annealing mechanism to prevent the algorithm from being trapped in local optima. Using the IBAS algorithm, the proportional and quantization factors of the fuzzy PID controller were optimized offline to obtain the optimal parameters. The IBAS-fuzzy PID controller was then compared in simulation with conventional PID, fuzzy PID, and BAS-optimized fuzzy PID controllers. The simulation results demonstrated that the IBAS-fuzzy PID algorithm achieved higher flow control accuracy than existing methods. To further validate the effectiveness of the improved algorithm under practical conditions, field experiments were conducted. The results indicated that the IBAS-optimized fuzzy PID controller outperformed the three other control methods in terms of flow control accuracy. Overall, both simulation and field results confirm that the proposed IBAS algorithm for fuzzy PID parameter optimization significantly enhances response speed, control precision, and overshoot reduction, providing a novel approach and potential application for variable-rate spraying technology.
Linear Temporal Logic (LTL) offers a formal way of specifying complex objectives for Cyber-Physical Systems (CPS). In the presence of uncertain dynamics, the planning for an LTL objective can be solved by model-free reinforcement learning (RL). Surrogate rewards for LTL objectives are commonly utilized in model-free RL for LTL objectives. In a widely adopted surrogate reward approach, two discount factors are used to ensure that the expected return (i.e., the cumulative reward) approximates the satisfaction probability of the LTL objective. The expected return then can be estimated by methods using the Bellman updates such as RL. However, the uniqueness of the solution to the Bellman equation with two discount factors has not been explicitly discussed. We demonstrate, through an example, that when one of the discount factors is set to one, as allowed in many previous works, the Bellman equation may have multiple solutions, leading to an inaccurate evaluation of the expected return. To address this issue, we propose a condition that ensures the Bellman equation has the expected return as its unique solution. Specifically, we require that the solutions for states within rejecting bottom strongly connected components (BSCCs) be zero. We prove that this condition guarantees the uniqueness of the solution, first for recurrent states (i.e., states within a BSCC) and then for transient states. Finally, we numerically validate our results through case studies.
The treatment response for the negative symptoms of schizophrenia is not ideal, and the efficacy of antidepressant treatment remains a matter of considerable controversy. This systematic review and meta-analysis aimed to assess the efficacy of adjunctive antidepressant treatment for negative symptoms of schizophrenia under strict inclusion criteria.
Methods
A systematic literature search (PubMed/Web of Science) was conducted to identify randomized, double-blind, effect-focused trials comparing adjuvant antidepressants with placebo for the treatment of negative symptoms of schizophrenia from database establishment to April 16, 2025. Negative symptoms were examined as the primary outcome. Data were extracted from published research reports, and the overall effect size was calculated using standardized mean differences (SMD).
Results
A total of 15 articles, involving 655 patients, were included in this review. Mirtazapine (N = 2, n = 48, SMD −1.73, CI −2.60, −0.87) and duloxetine (N = 1, n = 64, SMD −1.19, CI −2.17, −0.21) showed significantly better efficacy for negative symptoms compared to placebo. In direct comparisons between antidepressants, mirtazapine showed significant differences compared to reboxetine, escitalopram, and bupropion, but there were no significant differences between other antidepressants or between antidepressants and placebo. No publication bias for the prevalence of this condition was observed.
Conclusions
These findings suggest that adjunctive use of mirtazapine and duloxetine can effectively improve the negative symptoms of schizophrenia in patients who are stably receiving antipsychotic treatment. Therefore, incorporating antidepressants into future treatment plans for negative symptoms of schizophrenia is a promising strategy that warrants further exploration.
The hospitality industry’s commercial activities contribute to many negative environmental impacts; hence, promoting green restaurants is necessary. Considering the prevalent dining-out culture, green restaurants also bear the responsibility of changing people’s dietary habits to reduce greenhouse gas (GHG) emissions. This study examines how to increase people’s demand for green restaurants while changing their dietary habits to include more GHG-mitigating ingredients. Using the Attention, Interest, and Desire (AID) model and questionnaire survey, this study found that individuals exhibit a negative correlation between label attention and desire when interest is not considered. This may be attributed to the absence of sustainable social norms and values. In light of this, this study suggests that relevant government authorities could enhance subsidies for green restaurants, enabling them to compete with regular restaurants in terms of pricing, thereby accelerating the integration of green restaurants and GHG-mitigating ingredients into people’s daily lives.
Significant changes in Taiwan’s psychiatric services over recent decades include expansion of community-based clinics and implementation of the Schizophrenia Pay-for-Performance programme.
Aims
This study aimed to assess the trend of the quality of healthcare for individuals with schizophrenia, using various indicators of the treatment process and outcomes between 2010 and 2019.
Method
Individuals with schizophrenia were identified using Taiwan’s National Health Insurance claims database. The quality of healthcare for individuals with schizophrenia was assessed using treatment process and outcome indicators, including antipsychotic types, medication adherence, daily dose for antipsychotics and concurrent use of other psychotropic agents. Outcome indicators included all-cause mortality, suicide deaths, psychiatric hospitalisation, emergency department visits and employment status.
Results
Antipsychotic medication usage has shifted towards second-generation antipsychotics (SGAs) and long-acting injectable antipsychotics (LAIs), with declines in first-generation antipsychotics. The percentage of medication adherence declined, while that of individuals with an adequate daily dose increased. Concurrently, anticholinergic and benzodiazepine use decreased while antidepressant and mood stabiliser use increased. Outcome indicators showed no significant change in all-cause mortality or suicide rates over time, but there were reductions in psychiatric hospitalisations and emergency department visits. Employment rates increased overall, particularly in urban areas.
Conclusions
The quality of healthcare for individuals with schizophrenia, as measured by treatment process and outcome indicators, improved alongside changes in Taiwan’s psychiatric services; however, causality cannot be inferred from our findings. Future research should evaluate the effectiveness of psychiatric service policies and continuously monitor healthcare quality to further enhance the lives of individuals with schizophrenia.
Magnetic massive stars are stars of spectral types O, B, and A that harbour $\sim$ kG strength (mostly dipolar) surface magnetic fields. Their non-thermal radio emission has been demonstrated to be an important magnetospheric probe, provided the emission is fully characterised. A necessary step for that is to build a statistically significant sample of radio-bright magnetic massive stars. In this paper, we present the ‘VAST project to study Magnetic Massive Stars’ or VAST-MeMeS that aims to achieve that by taking advantage of survey data acquired with the Australian SKA Pathfinder telescope. VAST-MeMeS is defined under the ‘Variables and Slow Transients’ survey, although it also uses data from other ASKAP surveys. We found radio detections from 48 magnetic massive stars, out of which, 14 do not have any prior radio detections. We also identified 9 ‘Main-sequence Radio Pulse Emitter’ candidates based on variability and circular polarisation of flux densities. The expanded sample suggests a slightly lower efficiency in the radio production than that reported in earlier work. In addition to significantly expanding the sample of radio-bright magnetic massive stars, the addition of flux density measurements at ${\lesssim} 1$ GHz revealed that the spectra of incoherent radio emission can extend to much lower frequencies than that assumed in the past. In the future, radio observations spanning wide frequency and rotational phase ranges should be conducted so as to reduce the uncertainties in the incoherent radio luminosities. The results from these campaigns, supplemented with precise estimations of stellar parameters, will allow us to fully understand particle acceleration and non-thermal radio production in large-scale stellar magnetospheres.
Rice water weevils (RWWs) (Lissorhoptrus oryzophilus) and rice weevils (RW) (Echinocnemus squameus) (both Coleoptera: Curculionidae) are major rice pests that cause significant economic losses in China. Understanding their potential distribution areas is crucial for effective management. This study used the Biomod2 package in R to simulate and predict the current and future potential distributions, changes in suitable areas, shifts in distribution centres, and overlaps under climate change for both pests under three greenhouse gas emission scenarios. By 2023, the suitable areas for RWWs and RWs were 538.52 × 104 km2 and 376.05 × 104 km2, respectively. The suitable area for the former pest expanded southwestward and northeastward across China, whereas the latter spread mainly into Northeast China. The suitable area for RWWs is projected to remain stable, whereas that for RWs is expected to decline. The distribution centroid of RWWs is anticipated to shift toward southeastern or southwestern Shaanxi, whereas RWs are likely to migrate toward central-eastern or northeastern Shaanxi. The niche overlap between the two pests is high (Schoener’s D = 0.658, I = 0.816), with overlap concentrated in central, eastern, and southern China. The key factors influencing their distributions include precipitation of the wettest month (Bio13), mean temperature of the warmest quarter (Bio10), and precipitation of the driest month (Bio14). This study provides a theoretical basis for the prediction of the potential distribution of both pests, which offers valuable insights for the development of effective pest control strategies in China.
Although guidelines recommend targeted vitamin D testing for high-risk populations, testing has increased globally. Limited studies have examined real-world testing patterns and their relationship with deficiency outcomes. This study investigates trends, demographic determinants and deficiency outcomes associated with voluntary vitamin D testing among Taiwanese adults.
Design:
A retrospective cohort study analysing electronic medical records to assess vitamin D testing trends, demographic predictors of deficiency and status changes following consecutive tests within 2 years. Vitamin D status was classified based on serum 25-hydroxyvitamin D levels as deficient (< 20 ng/ml), insufficient (20–29·9 ng/ml) or sufficient (≥ 30 ng/ml).
Setting:
A tertiary medical centre in Taiwan.
Participants:
Between 2013 and 2022, 13 381 outpatients underwent voluntary vitamin D testing. After excluding those aged < 18 years, with advanced renal disease, osteomalacia, rickets or hyperparathyroidism, 8383 were included in the final analysis.
Results:
Testing increased sharply after 2019. Although women underwent twice as many tests, men had a higher deficiency prevalence (56·94 % v. 53·01 %). Adults aged 18–34 years had the highest prevalence (67·81 %). Obstetrics and Gynecology specialists ordered the most tests, particularly for female infertility, with 65·73 % of patients deficient. Among those with repeat tests, deficiency prevalence decreased from 59.32 % to 43·25 %.
Conclusions:
The increase in voluntary vitamin D testing with demographic disparities highlights the importance of understanding testing behaviours and public health implications. Improved vitamin D status at follow-up suggests potential benefits in identifying high-risk individuals and emphasises the need for further research to evaluate outcomes and guide prevention strategies.
Fiber-coupled laser pumps with low size, weight and power consumption (SWaP) have become more and more compelling for applications in both industrial and defense applications. This study presents an innovative approach employing the spectral beam combining technique and double-junction laser diode chips to create efficient, high-power, high-brightness fiber-coupled packages. We successfully demonstrated a wavelength-stabilized pump module capable of delivering over 560 W of ex-fiber power with an electro-optical conversion efficiency of 55% from a 135 μm diameter, 0.22 numerical aperture fiber. The specific mass and volume metrics achieved are 0.34 $\mathrm{kg}/\mathrm{kW}$ and 0.23 ${\mathrm{cm}}^3/\mathrm{W}$, respectively. The module exhibits a stabilized spectrum with a 3.6 nm consistent interval of two spectral peaks and a 4.2 nm full width at half maximum across a wide range of operating currents.
Previous studies highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the ‘relative association’ to ascertain the optimal consumption strategy (including total intake and optimal allocation strategy) for coffee, tea and plain water associated with decreased mortality. Self-reported coffee, tea and plain water intake were used from the UK Biobank. Within a compositional data analysis framework, a multivariate Cox model was used to assess the relative associations after adjusting for a range of potential confounders. The lower mortality risk was observed with at least approximately 7–8 drinks/d of total consumption. When the total intake > 4 drinks/d, substituting plain water with coffee or tea was linked to reduced mortality; nevertheless, the benefit was not seen for ≤ 4 drinks/d. Besides, a balanced consumption of coffee and tea (roughly a ratio of 2:3) associated with the lowest hazard ratios of 0·55 (95 % CI 0·47, 0·64) for all-cause mortality, 0·59 (95 % CI 0·48, 0·72) for cancer mortality, 0·69 (95 % CI 0·49, 0·99) for CVD mortality, 0·28 (95 % CI 0·15, 0·52) for respiratory disease mortality and 0·35 (95 % CI 0·15, 0·82) for digestive disease mortality than other combinations. These results highlight the importance of the rational combination of coffee, tea and plain water, with particular emphasis on ensuring adequate total intake, offering more comprehensive and explicit guidance for individuals.
Magnetohydrodynamic turbulence with Hall effects is ubiquitous in heliophysics and plasma physics. Direct numerical simulations reveal that, when the forcing scale is comparable to the ion inertial scale, the Hall effects induce remarkable cross-helicity. It then suppresses the cascade efficiency, leading to the accumulation of large-scale magnetic energy and helicity. The process is accompanied by the disruption of current sheets through the entrainment by vortex tubes or the excitation of whistler waves. Using the solar wind data from the Parker Solar Probe, the numerical findings are separately confirmed. These findings provide new insights into the emergence of large-scale solar wind turbulence driven by helical fields and Hall effects.
A novel particle-resolved direct numerical simulations (PR-DNS) method for non-spherical particles is developed and validated in the open-source MFiX (Multi-phase Flow with Interphase eXchanges) code for simulating the suspension of non-spherical particles and fluidisation. The model is implemented by coupling superquadric Discrete Element Method-Computational Fluid Dynamics (DEM-CFD) with the immersed boundary method. The model was first validated by applying it to analyse fluid dynamic coefficients ($C_{\!D} , C_{\!L} , C_{\!T}$) of superellipsoids and cylinders at different Reynolds numbers, and the PR-DNS results closely matched those of previous methods, demonstrating the reliability of the current PR-DNS approach. Then, the model was applied to the simulation of the fluidisation of spheres and cylinders. The PR-DNS results were compared with both particle-unresolved superquadric DEM-CFD simulation and experimental data. The pressure drop, height distribution and orientation distribution of particles were analysed. The results show that the PR-DNS method provides a reliable method for reproducing fluidisation experimental results of non-spherical particles. In addition, the comparison of the drag correction coefficients predicted by existing models with that obtained from PR-DNS results indicates the need for a new drag model for particle-unresolved simulation of non-spherical particles.