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Transient thermocapillary convection flows near a suddenly heated vertical wire are widely present in nature and industrial systems. The current study investigates the dynamical evolution and heat transfer for these transient flows near a suddenly heated vertical wire, employing scaling analysis and axisymmetric numerical simulation methodologies. Scaling analysis indicates that there exist four possible scenarios of the dynamical evolution and heat transfer for these transient flows, dependent on the wire curvature, Marangoni number and Prandtl number. In a typical scenario of the dynamical evolution and heat transfer, heat is first conducted into the fluid after sudden heating, resulting in an annular vertical thermal boundary layer around the wire. The radial temperature gradient may generate a thermocapillary force on the liquid surface, dragging the liquid away from the wire. The pressure gradient also drives a vertical flow along the wire. Further, the current study analyses and derives the scaling laws of the velocity, thickness and Nusselt number for the surface and vertical flows in different scenarios. Additionally, a number of two-dimensional axisymmetric numerical simulations are performed. The flow structure around the suddenly heated vertical wire is characterised under different regimes and the validation for the proposed scaling laws in comparison with numerical results is presented.
To investigate the association of midlife and late-life undiagnosed mood symptoms, especially their comorbidity, with long-term dementia risk among multi-regional and ethnic adults.
Methods
The prospective study used data from the UK Biobank (N = 142,670; mean follow-up 11.0 years) and three Asian studies (N = 1,610; mean follow-up 4.4 years). Undiagnosed mood symptoms (manic symptoms, depressive symptoms and comorbidity of depressive and manic symptoms) and diagnosed mood disorders (depression, mania and bipolar disorders) were classified. Plasma levels of 168 metabolites were measured. The association between undiagnosed mood symptoms and 12-year dementia (including subtypes) risk and domain-specific cognitive function was examined. The contribution of metabolites in explaining the association between symptom comorbidity and dementia risk was estimated.
Results
Undiagnosed mood symptoms were prevalent (11.4% in the UK cohort and 31.2% in Asian cohorts) among 1,462 (1.0%) and 74 (19.4%) participants who developed dementia. Comorbidity of undiagnosed mood symptoms was associated with higher dementia risk (sub-distribution hazard ratios = 9.46; 95% confidence interval = 4.07–21.97), especially Alzheimer’s disease, and with worse reasoning ability, poorer numeric memory and metabolic dysfunction. Glucose and total Esterified Cholesterol explained 9.1% of the association between symptom comorbidity and dementia, with most of the contribution being from glucose (6.8%).
Conclusions
Comorbidity of undiagnosed mood symptoms was associated with a higher cumulative risk of dementia in the long term. Glucose metabolism could be implicated in the development of mood disorders and dementia. The distinctive pathophysiological mechanism between psychiatric and neurodegenerative disorders warrants further exploration.
We study the temperature–velocity (TV) relation for laminar adiabatic and diabatic hypersonic boundary layers. By applying an asymptotic expansion to the compressible boundary-layer temperature equation, we derive a first-order equation for the TV relation, where the zeroth-order solution is found to be the classical Crocco–Busemann quadratic relation. The ensuing relation predicts accurately the temperature profile by using the velocity for hypersonic boundary layers with Chapman, power and Sutherland viscosity laws, arbitrary heat capacity ratios, variable Prandtl numbers close to unity and Mach number of up to 10. The Mach-number- and wall-temperature-independent quantities in our relation are also investigated. The present relation has the potential to function as a temperature wall model for laminar hypersonic boundary layers, especially for cold-wall cases.
Magnetite-enriched mining tailings are a cost-effective and abundant catalytic material with inherent magnetic recyclability. Yet their practical application in catalysis is often constrained by their limited surface area and sluggish reaction kinetics. To address these issues, we developed a facile one-step co-precipitation method to synthesize a magnetic nano-Fe3O4 (MNP) catalyst that exhibits enhanced surface reactivity for efficient activation of H2O2 towards tetracycline (TC) degradation. The system achieved complete (100%) removal of TC at an initial concentration of 20 mg L–1 within 90 min and demonstrated robust catalytic performance across weakly acidic to neutral pH conditions. Mechanistic investigations confirmed that ⋅OH is the primary reactive oxygen species involved, with ⋅O2⁻ and 1O2 providing supplementary contributions to the degradation. Remarkably, the intrinsic magnetic properties ensured efficient MNP catalyst recovery. This work provides a sustainable and scalable wastewater treatment strategy, leveraging mining tailings as a cost-effective resource to treat wastewater while also providing economic and environmental benefits.
Grasp detection is a significant research direction in the field of robotics. Traditional analysis methods typically require prior knowledge of the object parameters, limiting grasp detection to structured environments and resulting in suboptimal performance. In recent years, the generative convolutional neural network (GCNN) has gained increasing attention, but they suffer from issues such as insufficient feature extraction capabilities and redundant noise. Therefore, we proposed an improved method for the GCNN, aimed at enabling fast and accurate grasp detection. First, a two-dimensional (2D) Gaussian kernel was introduced to re-encode grasp quality to address the issue of false positives in grasp rectangular metrics, emphasizing high-quality grasp poses near the central point. Additionally, to address the insufficient feature extraction capabilities of the shallow network, a receptive field module was added at the neck to enhance the network’s ability to extract distinctive features. Furthermore, the rich feature information in the decoding phase often contains redundant noise. To address this, we introduced a global-local feature fusion module to suppress noise and enhance features, enabling the model to focus more on target information. Finally, relevant evaluation experiments were conducted on public grasping datasets, including Cornell, Jacquard, and GraspNet-1 Billion, as well as in real-world robotic grasping scenarios. All results showed that the proposed method performs excellently in both prediction accuracy and inference speed and is practically feasible for robotic grasping.
Drawing on semi-structured interviews with 36 policymakers, experts and scholars, this paper employs a principal-agent framework to analyse China’s carbon market governance. The findings reveal that institutional misalignment between central and local priorities undermines market efficacy. While mechanisms like the Target Responsibility System (TRS) and environmental inspections aim to enforce compliance, fragmented incentives and passive central supervision exacerbate policy incoherence. Owing to competing mandates, local governments prioritize short-term GDP growth over the development of the carbon market, thereby relegating emissions trading to a peripheral status. State-owned enterprises (SOEs) dominate market participation, fulfilling compliance through political alignment but distorting price signals and marginalizing private actors. China’s hybrid governance model, which combines top-down controls with decentralized experimentation, generates systemic contradictions where weak enforcement, ritualistic compliance and data opacity persist as the dominance of SOEs colludes with local developmentalism to weaken carbon pricing. Overall, carbon market governance mechanisms have paradoxically incentivized regulated entities to prioritize developmental goals over improving carbon market infrastructure.
Late-onset depression (LOD) is featured by disrupted cognitive performance, which is refractory to conventional treatments and increases the risk of dementia. Aberrant functional connectivity among various brain regions has been reported in LOD, but their abnormal patterns of functional network connectivity remain unclear in LOD.
Methods
A total of 82 LOD and 101 healthy older adults (HOA) accepted functional magnetic resonance imaging scanning and a battery of neuropsychological tests. Static functional network connectivity (sFNC) and dynamic functional network connectivity (dFNC) were analyzed using independent component analysis, with dFNC assessed via a sliding window approach. Both sFNC and dFNC contributions were classified using a support vector machine.
Results
LOD exhibited decreased sFNC among the default mode network (DMN), salience network (SN), sensorimotor network (SMN), and language network (LAN), along with reduced dFNC of DMN-SN and SN-SMN. The sFNC of SMN-LAN and dFNC of DMN-SN contributed the most in differentiating LOD and HOA by support vector machine. Additionally, abnormal sFNC of DMN-SN and DMN-SMN both correlated with working memory, with DMN-SMN mediating the relationship between depression and working memory. The dFNC of SN-SMN was associated with depressive severity and multiple domains of cognition, and mediated the impact of depression on memory and semantic function.
Conclusions
This study displayed the abnormal connectivity among DMN, SN, and SMN that involved the relationship between depression and cognition in LOD, which might reveal mutual biomarkers between depression and cognitive decline in LOD.
Antimicrobial resistance (AMR) is a global health crisis exacerbated by policies like China’s Volume-Based Procurement (VBP), which may inadvertently increase antimicrobial overuse. This study evaluates a clinical pharmacist-led Antimicrobial Stewardship (AMS) program with prospective audit for special-restricted antimicrobials under VBP.
Methods:
A retrospective quasi-experimental interrupted time-series analysis compared pre-intervention (2022) and post-intervention (2023–2024) data at Tongji Hospital, a tertiary hospital in Wuhan, China. Key metrics included Antimicrobial Use Density (AUD), prescription rationality, antimicrobial costs, and multidrug-resistant infection rates.
Results:
The intervention significantly improved prescription appropriateness for special-restricted antimicrobials (80.24% vs. 93.83%, P < 0.005) and reduced AUD (47.87 vs. 34.25, P < 0.001). Total antimicrobial costs decreased by 41.26%, with a reduction in the incidence of multidrug-resistant infections from 0.084% to 0.062% (P < 0.05). Carbapenem use correlated with CRKP isolation rates (R = 0.62, P < 0.05). Clinical pharmacists rejected 10.24% of prescriptions, all accepted by physicians.
Conclusion:
Pharmacist-led prospective audits optimize antimicrobial use under VBP, mitigate resistance risks, and reduce costs, while acknowledging that concurrent infection control measures may have contributed to these trends. This model may inform similar interventions in other institutions, particularly those in resource-limited settings.
With the eastward expansion of the Western Zhou c. 1050 BC, the Jiaodong Peninsula on the north-east coast of modern-day China became part of a large polity. Excavations at Qianzhongzitou, located on this peninsula, are revealing how political control over local populations took place. Here, the authors focus on a sequence of Zhou-period, non-residential platforms, the construction of which signifies new forms of ritual spaces. These types of spaces, also found elsewhere in the region, arguably aided in the state assimilation of local deities, illustrating the critical role that ritual played in political unification of early Chinese states and dynasties.
Psychomotor disturbance (PmD) is prevalent in major depressive disorder (MDD), with neural substrates implicated in disrupted motor circuits and the interaction to non-motor cortex. Our objective is to explore the functional connectivity pattern underlying PmD using functional magnetic resonance imaging (fMRI).
Methods
A total of 150 patients with MDD and 91 healthy controls (HCs) were included in this study. The patients were categorized into psychomotor (pMDD, n = 107) and non-psychomotor (npMDD, n = 43) groups based on the Hamilton Depression Rating Scale. Seed-based connectivity (SBC) analysis was conducted using predefined somatomotor and cerebellar network (SMN and CN) coordinates as seeds, to assess group differences and symptom correlations. Subsequently, we correlated the group-contrast SBC map with existing neurotransmitter maps to explore the neurochemical basis.
Results
In pMDD patients compared to HC, we observed decreased connectivity, especially between the SMN and frontal cortex, within the bilateral SMN, and between the CN and right precentral cortex. Meanwhile, connectivity increased between the SMN and the middle cingulate cortex and between the CN and left precentral cortex in pMDD relative to npMDD and HC. Connectivity between the SMN and angular gyrus was positively correlated with the severity of PmD. Additionally, the aberrant SBC patterns in pMDD were linked to the distribution of dopamine D1 and D2 receptors.
Conclusions
This study provides insights into the aberrant connectivity within the motor circuits and its interactions with non-motor regions in PmD. It also suggests a potential role for dopaminergic dysregulation in the connectivity abnormalities associated with PmD.
Synthetic Aperture Radar Interferometry (InSAR) is an active remote sensing method that uses repeated radar scans of the Earth's solid surface to measure relative deformation at centimeter precision over a wide swath. It has revolutionized our understanding of the earthquake cycle, volcanic eruptions, landslides, glacier flow, ice grounding lines, ground fluid injection/withdrawal, underground nuclear tests, and other applications requiring high spatial resolution measurements of ground deformation. This book examines the theory behind and the applications of InSAR for measuring surface deformation. The most recent generation of InSAR satellites have transformed the method from investigating 10's to 100's of SAR images to processing 1000's and 10,000's of images using a wide range of computer facilities. This book is intended for students and researchers in the physical sciences, particularly for those working in geophysics, natural hazards, space geodesy, and remote sensing. This title is also available as Open Access on Cambridge Core.
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
Chapter 3 details the kinematics of satellite orbits and their use in InSAR processing and its automation. It covers the six parameters needed to describe an orbit (Kepler elements or Cartesian state vector), transforming coordinates from an Earth-fixed frame to the satellite frame, and methods to calculate a centimeter-accuracy satellite trajectory from a sequence of state vectors.
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
Chapter 8 explores a wide range of SAR operational modes, including polarization and wide swath modes. It reviews the fundamental limitation of the standard swath-mode acquisition and discusses three methods for increasing swath width: ScanSAR, Terrain Observation by Progressive Scans (TOPS), and SweepSAR for the upcoming NISAR mission.
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
Chapter 5 explains the process of forming an interferogram from two geometrically aligned SLC images and methods for extracting deformation and topography from the interferometric phase. It also covers critical baseline, geocoding, and geocoded SLCs.
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
Chapter 9 examines the three factors that affect radar range measurement: spatial and temporal variations of the dry and wet components of the troposphere, phase advance of radar waves through the ionosphere, and the solid Earth tides. It also discusses practical corrections and mitigation approaches.
David T. Sandwell, Scripps Institution of Oceanography, University of California, San Diego,Xiaohua Xu, University of Science and Technology of China,Jingyi Chen, University of Texas at Austin,Robert J. Mellors, Scripps Institution of Oceanography, University of California, San Diego,Meng Wei, University of Rhode Island,Xiaopeng Tong, Institute of Geophysics, China Earthquake Administration,John B. DeSanto, University of Washington,Qi Ou, University of Edinburgh
Chapter 4 provides a comprehensive presentation of the commonly used range-Doppler algorithm for focusing complex backscatter data into a single-look complex (SLC) image.