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This article examines the evolution of breastfeeding practices in twentieth-century China, focusing on the complex interplay between medical knowledge, state policies and social transformation. This study demonstrates how medical recommendations concerning lactation timing, intervals and weaning were shaped by factors beyond purely scientific developments. Mid-twentieth-century biochemical studies validated traditional practices while revolutionising attitudes towards colostrum, marking a critical juncture in Chinese infant nutrition science. Following the establishment of the People’s Republic in 1949, maternal and child health initiatives underwent fundamental changes. Drawing on new understanding of breast milk’s nutritional value, health benefits, and economic advantages, healthcare professionals and state authorities actively promoted scientific breastfeeding methods. Their multifaceted approach reflected both the dissemination of medical knowledge and the state’s strategic consideration of female labour force participation. This study analyses how women’s liberation from feudal constraints, changing employment patterns, Soviet medical influence, and advances in artificial feeding technologies shaped breastfeeding practices. Through examining the intersection of medical advice, health policies, and women’s labour liberation, it provides fresh insights into the evolution of breastfeeding discourse within Chinese medical circles. Situating these developments within broader medical, social and cultural contexts, this research not only illuminates the multiple factors that shaped modern Chinese infant feeding practices but also contributes to our understanding of the complex relationships between medical practice, state policy, and social change in twentieth-century China.
Schizophrenia progresses through high-risk, first-episode, and chronic stages, each associated with altered spontaneous brain activity. Resting state functional MRI studies highlight these changes, but inconsistencies persist, and the genetic basis remains unclear.
Methods
A neuroimaging meta-analysis was conducted to assess spontaneous brain activity alterations in each schizophrenia stage. The largest available genome-wide association study (GWAS) summary statistics for schizophrenia (N = 53,386 cases, 77,258 controls) were used, followed by Hi-C-coupled multimarker analysis of genomic annotation (H-MAGMA) to identify schizophrenia-associated genes. Transcriptome-neuroimaging association and gene prioritization analyses were performed to identify genes consistently linked to brain activity alterations. Biological relevance was explored by functional enrichment.
Results
Fifty-two studies met the inclusion criteria, covering the high-risk (Nhigh-risk = 409, Ncontrol = 475), first-episode (Ncase = 1842, Ncontrol = 1735), and chronic (Ncase = 1242, Ncontrol = 1300) stages. High-risk stage showed reduced brain activity in the right median cingulate and paracingulate gyri. First-episode stage revealed increased activity in the right putamen and decreased activity in the left gyrus rectus and right postcentral gyrus. Chronic stage showed heightened activity in the right inferior frontal gyrus and reduced activity in the superior occipital gyrus and right postcentral gyrus. Across all stages, 199 genes were consistently linked to brain activity changes, involved in biological processes such as nervous system development, synaptic transmission, and synaptic plasticity.
Conclusions
Brain activity alterations across schizophrenia stages and genes consistently associated with these changes highlight their potential as universal biomarkers and therapeutic targets for schizophrenia.
In this paper, we first describe the cohomology theory of Lie supertriple systems by using the cohomology theory of the associated Leibniz superalgebras. Then we focus on Lie supertriple systems with superderivations, called LSTSDer pairs. We introduce the notion of representations of LSTSDer pairs and investigate their corresponding cohomology theory. We also construct a differential graded Lie algebra whose Maurer–Cartan elements are LSTSDer pairs. Moreover, we consider the relationship between a LSTSDer pair and the associated LeibSDer pair. Furthermore, we develop the 1-parameter formal deformation theory of LSTSDer pairs and prove that it is governed by the cohomology groups. At last, we study abelian extensions of LSTSDer pairs and show that equivalent abelian extensions of LSTSDer pairs are classified by the third cohomology groups.
High-order harmonic generation (HHG) in noble gases driven by femtosecond lasers is currently a feasible solution to obtain ultrafast pulses in the extreme ultraviolet (EUV) wavelength range. Implementation of high-flux EUV sources requires driving HHG using an ultrafast laser source in the visible wavelength range with MHz repetition rate. In this paper, we employ a multi-pass cell followed by chirped mirrors to compress 1-MHz, 200-W, 300-fs pulses at 1.03 μm to a duration of 35 fs. The resulting 186-W compressed pulses are focused onto 0.5-mm thick beta barium borate crystal to drive second-harmonic generation and produce positively chirped pulses at 520 nm. These green pulses are de-chirped to 26 fs in duration with an average power of 64 W, which, to the best of our knowledge, represents the highest average power of green pulses with a duration below 100 fs.
The incorporation of trace metals into land snail shells may record the ambient environmental conditions, yet this potential remains largely unexplored. In this study, we analyzed modern snail shells (Cathaica sp.) collected from 16 sites across the Chinese Loess Plateau to investigate their trace metal compositions. Our results show that both the Sr/Ca and Ba/Ca ratios exhibit minimal intra-shell variability and small inter-shell variability at individual sites. A significant positive correlation is observed between the shell Sr/Ca and Ba/Ca ratios across the plateau, with higher values being recorded in the northwestern sites where less monsoonal rainfall is received. We propose that shell Sr/Ca and Ba/Ca ratios, which record the composition of soil solution, may be controlled by the Rayleigh distillation in response to prior calcite precipitation. Higher rainfall amounts may lead to a lower degree of Rayleigh distillation and thus lower shell Sr/Ca and Ba/Ca ratios. This is supported by the distinct negative correlation between summer precipitation and shell Sr/Ca and Ba/Ca ratios, enabling us to reconstruct summer precipitation amounts using the Sr/Ca and Ba/Ca ratios of Cathaica sp. shells. The potential application of these novel proxies may also be promising for other terrestrial mollusks living in the loess deposits globally.
An actively controllable cascaded proton acceleration driven by a separate 0.8 picosecond (ps) laser is demonstrated in proof-of-principle experiments. MeV protons, initially driven by a femtosecond laser, are further accelerated and focused into a dot structure by an electromagnetic pulse (EMP) on the solenoid, which can be tuned into a ring structure by increasing the ps laser energy. An electrodynamics model is carried out to explain the experimental results and show that the dot-structured proton beam is formed when the outer part of the incident proton beam is optimally focused by the EMP force on the solenoid; otherwise, it is overfocused into a ring structure by a larger EMP. Such a separately controlled mechanism allows precise tuning of the proton beam structures for various applications, such as edge-enhanced proton radiography, proton therapy and pre-injection in traditional accelerators.
Porcine small intestinal epithelial cell line (IPEC-J2) is a good research model exploring the impact of feed additives on intestinal epithelial cells. Monobutyrin (MB), as a derivative of butyric acid (BA), overcomes the shortcomings of BA. MB can maintain intestinal barrier function in animals, but its underlying regulatory mechanism is unknown. Thus, we used IPEC-J2 cells as the research object. We were using real-time fluorescence quantitative PCR, western blot, immunofluorescence, and transcriptomics technology to explore the effect of MB on the barrier function of IPEC-J2 cells and its regulatory mechanism. The results found that MB treatment could cause IPEC-J2 cells to occur a response to hypoxia at the transcriptional level, thereby increasing the expression of hypoxia-inducible factor 1 and phospho-extracellular signal-regulated kinase 1/2 protein and improving the expression of tight junction proteins. Therefore, MB can alleviate the activation of the NF-κB signaling pathway. In addition, MB mitigates the damage to cell transmembrane glycoproteins, microvilli, and tight junctions caused by lipopolysaccharides (LPS) stimulation, thus resisting the effects of LPS. As a dietary supplement, MB has good application prospects in maintaining the intestinal epithelial barrier function of animals.
We demonstrate a high-peak-power master oscillator power amplifier burst-mode laser system that generates microsecond burst duration pulses at 355 nm with a GHz-adjustable intra-burst pulse frequency. In the fiber seed, a high-bandwidth electro-optic modulator is employed to modulate a continuous-wave (CW) laser into a pulse train at GHz frequency. To acquire a microsecond rectangular burst pulse envelope, two acousto-optic modulators are used to chop the CW pulse train and generate a pre-compensation burst envelope. A three-stage neodymium-doped yttrium aluminum garnet amplifier boosts the burst-mode fiber seed’s burst energy of 1.65 J at 1064 nm. To achieve a high-power ultraviolet (UV) burst-mode laser, sum frequency generation in a LiB3O5 crystal is employed to convert the wavelength, achieving over 300 kW of peak power at 1.15 μs/10 Hz. The intra-burst pulse frequency of the UV burst laser can be adjustable from 1 to 10 GHz with a sinusoidal waveform. To the best of our knowledge, this paper represents the highest reported microsecond UV burst-mode laser in terms of output energy and peak power with the GHz-adjustable intra-burst frequency. The high-power microsecond UV burst-mode pulse laser can be directly used as a light-driven source in large-bandwidth/high-power microwave photonic systems, providing a long pulse width and high peak power laser while significantly improving the system’s multi-parameter adjustment capability and adaptability.
A conceptual framework, called Innovation of Health Technology Assessment Methods (IHTAM), has been developed to facilitate the understanding of how to innovate methods of health technology assessment (HTA). However, the framework applicability has not been evaluated in practice. Hence, we aimed to explore framework applicability in three cases of method innovation that are part of the HTx project and to develop a roadmap to improve framework applicability.
Methods
The IHTAM framework was applied to three cases of innovating HTA methods. We collected feedback from case study leaders and consortium members after a training session, an approximately 1-year follow-up of periodic case study meetings, and a general assembly meeting where innovation progresses of the three cases were reported through surveys and interviews. Feedback was then summarized using an open-coding technique.
Results
According to feedback, the framework provided a structured way of deliberation and helped to improve collaboration among HTA stakeholders. However, framework applicability could be improved if it was complemented by a roadmap with a loop structure to provide tailored guidance for different cases, and with items to elaborate actions to be taken by stakeholders. Accordingly, a 48-item roadmap was developed.
Conclusions
The IHTAM framework was generally applicable to the three case studies. A roadmap, with loop structure and actionable items, could complement the framework, and may provide HTA stakeholders with tailored guidance on developing new methods. To further examine the framework applicability, we recommend stakeholders to apply the IHTAM framework and its roadmap in future practice.
Unraveling the neurobiological foundations of childhood maltreatment is important due to the persistent associations with adverse mental health outcomes. However, the mechanisms through which abuse and neglect disturb resting-state network connectivity remain elusive. Moreover, it remains unclear if positive parenting can mitigate the negative impact of childhood maltreatment on network connectivity. We analyzed a cohort of 194 adolescents and young adults (aged 14–25, 47.42% female) from the Neuroscience in Psychiatry Network (NSPN) to investigate the impact of childhood abuse and neglect on resting-state network connectivity. Specifically, we examined the SAN, DMN, FPN, DAN, and VAN over time. We also explored the moderating role of positive parenting. The results showed that childhood abuse was linked to stronger connectivity within the SAN and VAN, as well as between the DMN-DAN, DMN-VAN, DMN-SAN, SAN-DAN, FPN-DAN, SAN-VAN, and VAN-DAN networks about 18 months later. Positive parenting during childhood buffered the negative impact of childhood abuse on network connectivity. To our knowledge, this is the first study to demonstrate the protective effect of positive parenting on network connectivity following childhood abuse. These findings not only highlight the importance of positive parenting but also lead to a better understanding of the neurobiology and resilience mechanisms of childhood maltreatment.
Previous studies have revealed an association between dietary factors and atopic dermatitis (AD). To explore whether there was a causal relationship between diet and AD, we performed Mendelian randomisation (MR) analysis. The dataset of twenty-one dietary factors was obtained from UK Biobank. The dataset for AD was obtained from the publicly available FinnGen consortium. The main research method was the inverse-variance weighting method, which was supplemented by MR‒Egger, weighted median and weighted mode. In addition, sensitivity analysis was performed to ensure the accuracy of the results. The study revealed that beef intake (OR = 0·351; 95 % CI 0·145, 0·847; P = 0·020) and white bread intake (OR = 0·141; 95 % CI 0·030, 0·656; P = 0·012) may be protective factors against AD. There were no causal relationships between AD and any other dietary intake factors. Sensitivity analysis showed that our results were reliable, and no heterogeneity or pleiotropy was found. Therefore, we believe that beef intake may be associated with a reduced risk of AD. Although white bread was significant in the IVW analysis, there was large uncertainty in the results given the wide 95 % CI. Other factors were not associated with AD in this study.
This study compared the concentrations, types and distributions of sialic acid (SA) in human milk at different stages of the postnatal period with those in a range of infant formulas. Breast milk from mothers of healthy, full-term and exclusively breastfed infants was collected on the 2nd (n 246), 7th (n 135), 30th (n 85) and 90th (n 48) day after birth. The SA profiles of human milk, including their distribution, were analysed and compared with twenty-four different infant formulas. Outcome of this observational study was the result of natural exposure. Only SA of type Neu5Ac was detected in human milk. Total SA concentrations were highest in colostrum and reduced significantly over the next 3 months. Approximately 68·7–76·1 % of all SA in human milk were bound to oligosaccharides. Two types of SA, Neu5Ac and Neu5Gc, have been detected in infant formulas. Most SA was present in infant formulas combined with protein. Breastfed infants could receive more SA than formula-fed infants with the same energy intake. Overall, human milk is a preferable source of SA than infant formulas in terms of total SA content, dynamics, distribution and type. These SA profiles in the natural state are worth to be considered by the production of formulas because they may have a great effect on infant nutrition and development.
The type species of Squamarina has two varieties, S. gypsacea var. gypsacea and S. gypsacea var. subcetrarioides. In this study, a phylogenetic and taxonomic analysis of these two varieties shows that S. var. subcetrarioides merits treatment as a species separate from S. gypsacea. Therefore, we raise this variety to species level as S. subcetrarioides (Zahlbr.) Y. Y. Zhang. Squamarina subcetrarioides is phylogenetically not closely related to S. gypsacea and differs from that species in the thallus forming rosettes when young, later becoming cracked and irregular in outline, and consisting of numerous small squamules.
Childhood adversity is associated with abnormalities in brain structure, but this association has not been tested for childhood unpredictability, one form of adversity. We studied whether abnormalities in gray matter volume (GMV) could be a mechanism linking childhood unpredictability and psychopathology, over and above the effect of childhood trauma.
Methods
Participants were 158 right-handed healthy young adults (aged 17–28 years, M = 22.07, s.d. = 2.08; 66.46% female) who underwent structural magnetic resonance imaging measurements and provided retrospective reports of childhood unpredictability. The anxiety and depression subscales of the self-report Brief Symptom Inventory-53 were used to index psychopathology.
Results
Whole-brain voxel-based morphometric analyses showed that after controlling for the effect of childhood trauma, childhood unpredictability was correlated with greater GMV in bilateral frontal pole, bilateral precuneus, bilateral postcentral gyrus, right hemisphere of fusiform, and lingual gyrus, and left hemisphere of ventrolateral prefrontal cortex as well as occipital gyrus. Greater GMV in bilateral frontal pole, bilateral precuneus, and bilateral postcentral gyrus mediated associations between unpredictability and symptoms of depression and anxiety.
Conclusions
The findings suggest that childhood unpredictability could exact unique effects on neural development, over and above the effect of childhood trauma. These findings are relevant for understanding the occurrence of psychopathology following childhood unpredictability and have implications for intervention.
The strongly nonlinear Miyata–Choi–Camassa model under the rigid lid approximation (MCC-RL model) can describe accurately the dynamics of large-amplitude internal waves in a two-layer fluid system for shallow configurations. In this paper, we apply the MCC-RL model to study the internal waves generated by a moving body on the bottom. For the case of the moving body speed $U=1.1c_{0}$, where ${c_0}$ is the linear long-wave speed, the accuracy of the MCC-RL results is assessed by comparing with Euler's solutions, and very good agreement is observed. It is found that when the moving body speed increases from $U=0.8c_{0}$ to $U=1.241c_{0}$, the amplitudes of the generated internal solitary waves in front of the moving body become larger. However, a critical moving body speed is found between $U=1.241c_{0}$ and $U=1.242c_{0}$. After exceeding this critical speed, only one internal wave right above the body is generated. When the moving body speed increases from $U=1.242c_{0}$ to $U=1.5c_{0}$, the amplitudes of the internal waves become smaller.
Yarlung Zangbo is a multimedia symphony combining orchestra, visual images and electroacoustic music by one of China’s most internationally influential electroacoustic music composers, Zhang Xiaofu. This article focuses on the spatial aspects of Yarlung Zangbo. First, we discuss two different spatial composition preferences in electroacoustic music: image delivery and creation. We then divide the development of electroacoustic orchestral music into three different periods and examine the general spatial intention of the works in these periods. Finally, we analyse and identify four spatial composition strategies of Yarlung Zangbo: equity, virtuosity, diversity and unity. The successful utilisation of these strategies has not only made the piece a milestone in Chinese electroacoustic music, but also a unique and meaningful contribution to the electroacoustic music repertoire worldwide. We believe this article will provide valuable knowledge and insight for future research and practice of spatial composition.
Recently, deep learning methods have achieved considerable performance in gesture recognition using surface electromyography signals. However, improving the recognition accuracy in multi-subject gesture recognition remains a challenging problem. In this study, we aimed to improve recognition performance by adding subject-specific prior knowledge to provide guidance for multi-subject gesture recognition. We proposed a time–frequency feature transform suite (TFFT) that takes the maps generated by continuous wavelet transform (CWT) as input. The TFFT can be connected to a neural network to obtain an end-to-end architecture. Thus, we integrated the suite into traditional neural networks, such as convolutional neural networks and long short-term memory, to adjust the intermediate features. The results of comparative experiments showed that the deep learning models with the TFFT suite based on CWT improved the recognition performance of the original architectures without the TFFT suite in gesture recognition tasks. Our proposed TFFT suite has promising applications in multi-subject gesture recognition and prosthetic control.
This chapter explores the complexity of migrant communities in Japan through the lens of digital media. It aims to illustrate how migrants’ everyday diasporic experiences and their digital media usage are manifested in the Japanese context, so as to explore the intersection of digital connectivity and human mobility. The first section dissects the concept of “migrants in Japan,” followed by an introduction to transnationalism as a theoretical toolkit for digital migration studies. This chapter is then concluded by a case study focusing on digital media appropriation among Chinese migrants in Japan, demonstrating migrants’ indigenized application of digital media and transnational social engagement.
Introduction
With the rise of digital technologies, the time we are living in is marked by two interlocked phenomena, namely globalization and digitization. Globalization brings an easier means of transport together with evolving and transgressing technologies, leading to the increasing interaction, interpenetration and interdependence of economic, social and political activities across national boundaries. Meanwhile, digitization facilitates these transnational activities. Digital media, such as the internet and internet-based hardware (i.e., computers and smartphones) and software (i.e., social networking services, digital communication technologies and online streaming), have expedited the global process of interconnectivity and digitalized exchange, where flows of ideas and ideologies, languages and cultures contribute to the construction of a borderless world.
The increasingly interconnected and transnational media may also transform the meanings of being mobile and the logic of migration. Although transnational connections have always constituted an intrinsic element of human mobility, the instant communication and constant contact contemporary migrants enjoy differentiate them from their counterparts in other periods of history. Using digital media to mediate texts, images, sounds, discourses and ideologies, migrants today are able to engage in continuous contact with the homeland and at the same time negotiate the local reality in their host society as well as while on the move. In the context where digital media turn mobile individuals into connected dots (Diminescu 2008) that together compose a transnational social formation (Vertovec 1999), digitally connected migrants are no longer just a group of displaced people. Instead, through their development of new modes of social organizations, group actions, as well as collectively interpreted diasporic experiences (Guarnizo and Smith 1998; Wang 2020a), they are now designated as “transnational communities” (Anderson 1983; Retis and Tsagarousianou 2019; Ponzanesi 2020).
Do US Circuit Courts' decisions on criminal appeals influence sentence lengths imposed by US District Courts? This Element explores the use of high-dimensional instrumental variables to estimate this causal relationship. Using judge characteristics as instruments, this Element implements two-stage models on court sentencing data for the years 1991 through 2013. This Element finds that Democratic, Jewish judges tend to favor criminal defendants, while Catholic judges tend to rule against them. This Element also finds from experiments that prosecutors backlash to Circuit Court rulings while District Court judges comply. Methodologically, this Element demonstrates the applicability of deep instrumental variables to legal data.
In this paper, we focus on the formation behaviour of the kinetic Cucker–Smale model for initial datum without compact support for the position variable. Comparing with the case of compact support, the attractive force between particles is weak. First, we obtain the existence and uniqueness of the classical solution to the kinetic Cucker–Smale model by standard approximation method. Second, by using the characteristic flow, we overcome the difficulty brought by the weak attractive force between particles through some estimates and establish the formation behaviour, i.e., consensus of velocity, of the classical solution to the kinetic Cucker–Smale model. Finally, for the measure-valued solution to the kinetic Cucker–Smale model, the formation behaviour is also established.