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1 results

  • Grey matter and social functioning correlates of glutamatergicmetabolite loss in schizophrenia

  • Naoko Aoyama, Jean Théberge, Dick J. Drost, Rahul Manchanda, Sandra Northcott, Richard W. J. Neufeld, Ravi S. Menon, Nagalingam Rajakumar, William F. Pavlosky, Maria Densmore, Betsy Schaefer, Peter C. Williamson
  • Journal:
    The British Journal of Psychiatry / Volume 198 / Issue 6 / June 2011
    Published online by Cambridge University Press:
    02 January 2018, pp. 448-456
    Print publication:
    June 2011
    • Article
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  • Background

    Thalamic glutamine loss and grey matter reduction suggest neurodegeneration in first-episode schizophrenia, but the duration is unknown.

    Aims

    To observe glutamine and glutamate levels, grey matter volumes and social functioning in patients with schizophrenia followed to 80 months after diagnosis.

    Method

    Grey matter volumes and proton magnetic resonance spectroscopy metabolites in left anterior cingulate and left thalamus were measured in 17 patients with schizophrenia before medication and 10 and 80 months after diagnosis. Social functioning was assessed with the Life Skills Profile Rating Scale (LSPRS) at 80 months.

    Results

    The sum of thalamic glutamate and glutamine levels decreased over 80 months, and correlated inversely with the LSPRS. Thalamic glutamine and grey matter loss were significantly correlated in frontal, parietal, temporal and limbic regions.

    Conclusions

    Brain metabolite loss is correlated with deteriorated social functioning and grey matter losses in schizophrenia, consistent with neurodegeneration.