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In ‘Aristotle on the Stages of Cognitive Development’, Thomas Kjeller Johansen examines Aristotle’s contributions to our thinking about concepts from a different perspective, namely in connection to Aristotle’s psychology. He revisits Aristotle’s account of how we acquire universal concepts mainly on the basis of Metaphysics A.1, Posterior Analytics 1.31 and 2.19, and the De Anima. The chapter begins by articulating the following puzzle. On the one hand, Aristotle points out (An. Post. 1.31, 2.19) that we perceive the universal in the particular. On the other, he suggests (Metaph. A.1) that it is only when we have craft and science that we grasp the universal, while perception, memory, and experience all are concerned with the particular. Building on the widespread view that, according to Aristotle, the universal grasped in craft and science is the universal cause, Johansen argues that we should understand perception, memory, and experience teleologically, as stages in the ordering of perceptual information that allows this causal concept to emerge.
The Introduction sets the scene by addressing first the problems involved with translating the term technê and related issues with circumscribing the Greek concept. The social context of craft and craftsmen is briefly discussed. Criteria for technê are outlined, with the importance of the Hippocratic writings for Plato and Aristotle highlighted. The central role of technê as a model of knowledge is introduced, and its applications to a range of disciplines, including ethics, politics and cosmology.
This chapter discusses the use of technê to characterize the creator god in Plato’s Timaeus. Timaeus explains how a divine craftsman, the Demiurge, made the whole cosmos as a living being. He created the heavenly bodies, but left the creation of human and other mortal beings to these ‘lesser’ gods. But if the Demiurge was the best of all craftsmen, seeking to make the finest cosmos possible, why did he not make the mortal beings too? Having outlined Plato’s conception of craft, Johansen explains how this problem, which he calls the ‘technodicy’, arises for Timaeus, contrasting it with the classical theodicy. The Demiurge’s creation is limited by his craft. Timaeus therefore assigns another craft to the lesser gods to produce mortal beings. However, even this craft prevents the lesser gods from directly producing non-human animals, and so the problem is reiterated. The issue is sought to be resolved by making humans themselves responsible for their own reincarnation as lower animals. Timaeus’ position is comparable to the view in Laws X: the lesser gods, consistent with their role as craftsmen, have overall responsibility for the organization of lower kinds of living being, without causing any particular beings to belong to particular kinds.
This work investigates how ancient philosophers understood productive knowledge or technê and used it to explain ethics, rhetoric, politics and cosmology. In eleven chapters leading scholars set out the ancient debates about technê from the Presocratic and Hippocratic writers, through Plato and Aristotle and the Hellenistic age (Stoics, Epicureans and Sceptics), ending in the Neoplatonism of Plotinus and Proclus. Amongst the many themes that come into focus are: the model status of ancient medicine in defining the political art, the similarities between the Platonic and Aristotelian conceptions of technê, the use of technê as a paradigm for virtue and practical rationality, technê´s determining role in Platonic conceptions of cosmology, technê´s relationship to experience and theoretical knowledge, virtue as an 'art of living', the adaptability of the criteria of technê to suit different skills, including philosophy itself, the use in productive knowledge of models, deliberation, conjecture and imagination.
Johansen examines the role of internal heat in the theories of nutrition and animal generation in Plato’s Timaeus. There, Plato does not ascribe the status of being besouled to all beings which engage in nutrition, but to beings with perceptive faculties. This raises questions as to the status of nutrition in the explanation of life and besouled beings.
A teleological explanation is an explanation in terms of an end or a purpose. So saying that ‘X came about for the sake of Y’ is a teleological account of X. It is a striking feature of ancient Greek philosophy that many thinkers accepted that the world should be explained in this way. However, before Aristotle, teleological explanations of the cosmos were generally based on the idea that it had been created by a divine intelligence. If an intelligent power made the world, then it makes sense that it did so with a purpose in mind, so grasping this purpose will help us understand the world. This is the pattern of teleological explanation that we find in the Presocratics and in Plato. However, with Aristotle teleology underwent a change: instead of thinking that the ends were explanatory because a mind had sought to bring them about, Aristotle took the ends to operate in natural beings independently of the efforts of any creative intelligence. Indeed, he thought that his predecessors had failed to understand what was distinctive of nature, namely, that its ends work from the inside of natural beings themselves.
Enteral sildenafil may be used in the intensive care unit for treatment of pulmonary arterial hypertension. We aimed to determine if initial enteral sildenafil dosing is safe in children receiving concurrent vasoactive infusions.
Methods:
We performed a single-centre retrospective chart review that included patients less than 2 years of age in paediatric and cardiovascular intensive care units at an academic medical centre from 1 January, 2010 to 30 November, 2016. Included patients received concomitant enteral sildenafil and a continuously infused vasoactive agent. Exclusion criteria consisted of mechanical circulatory support, any form of dialysis, or a suspicion of septic shock at the time of sildenafil initiation. We sought to identify patients who developed worsening hemodynamic instability after initiation of enteral sildenafil defined as one or more of the following observations within 24 hours of sildenafil initiation: sildenafil discontinuation, total fluid bolus receipt >10 ml/kg, increased vasoactive support, epinephrine intravenous push administration, and/or the initiation of mechanical circulatory support.
Results:
Worsening hemodynamic instability was identified in 35% of the 130-patient cohort. Patients younger than 4 months were at increased risk of further hemodynamic instability compared with older patients (56% versus 44%, p = 0.0003) despite receiving lower median doses (1.28 mg/kg/day versus 1.78 mg/kg/day, p = 0.01).
Conclusions:
Critically ill children receiving vasoactive infusions may be at increased risk for further hemodynamic instability after initiation of enteral sildenafil, particularly in younger patients. This population may benefit from lower starting enteral sildenafil doses of 0.25 mg/kg/dose or less every 8 hours to avoid further hemodynamic compromise.
In studies of genocide and other mass atrocities, the importance of hatred for our understanding of the causes and dynamics of such violence is an issue of continued contestation. In the context of transitional justice and reconciliation, notions of hatred as a lingering remainder to be appeased by justice or overcome through forgiveness abound. However, in spite of the many references to hatred, and in spite of the intensity with which the significance of hatred is affirmed or denied, focused and explorative investigations of hatred are few and far-between. This chapter embarks on such an investigation, not just to qualify the conceptual basis for discussion of hatred’s causal role, but more importantly to invite reflection on the very nature and possible forms of hatred at stake in mass atrocities. Drawing on insights from philosophical and sociological understandings of the nature, meaning, and location of the emotions, Thomas Brudholm and Birgitte S. Johansen aim to bring a more nuanced understanding of hatred to the field of genocide studies, not least by probing the premises of conventional Western notions of hatred and passions more generally as irrational, unmanageable, unpredictable, and interiorized.
In this paper, the small- and large-signal modeling of InP heterojunction bipolar transistors (HBTs) in transferred substrate (TS) technology is investigated. The small-signal equivalent circuit parameters for TS-HBTs in two-terminal and three-terminal configurations are determined by employing a direct parameter extraction methodology dedicated to III–V based HBTs. It is shown that the modeling of measured S-parameters can be improved in the millimeter-wave frequency range by augmenting the small-signal model with a description of AC current crowding. The extracted elements of the small-signal model structure are employed as a starting point for the extraction of a large-signal model. The developed large-signal model for the TS-HBTs accurately predicts the DC over temperature and small-signal performance over bias as well as the large-signal performance at millimeter-wave frequencies.