The mechanical feedback from the central active galactic nuclei (AGNs) can be crucial for balancing the radiative cooling of the intracluster medium (ICM) at the cluster centre. We aim to understand the relationship between the power of AGN feedback and the cooling of gas in the centres of galaxy clusters by correlating the radio properties of the brightest cluster galaxies (BCGs) with the X-ray properties of their host clusters. We used the catalogues from the first SRG/eROSITA All-Sky Survey (eRASS1) along with radio observations from the Australian SKA Pathfinder (ASKAP). In total, we identified 134 radio sources associated with BCGs of the 151 eRASS1 clusters located in the PS1, PS2, and SWAG-X ASKAP fields. Non-detections were treated as upper limits. We correlated the radio properties of the BCGs (radio luminosity, largest linear size/LLS, and BCG offset from the cluster centre) with the integrated X-ray luminosity of the host clusters. We utilised the concentration parameter, $c_{R_{500}}$, to categorise the clusters into cool cores (CCs) and non-cool cores (NCCs). By combining $c_{R_{500}}$ with the BCG offset, we assessed the dynamical states of the clusters in our sample. Furthermore, we analysed the correlation between radio mechanical power and X-ray luminosity within the CC subsample. We observe a potential positive trend between LLS and BCG offset, which may hint at an environmental influence on the morphology of central radio sources. We find a weak trend suggesting that more luminous central radio galaxies are found in clusters with higher X-ray luminosity. Additionally, there is a positive but highly scattered relationship between the mechanical luminosity of AGN jets and the X-ray cooling luminosity within the CC subsample. This finding is supported by bootstrap resampling and flux-flux analyses. The correlation observed in our CC subsample indicates that AGN feedback is ineffective in high-luminosity (high-mass) clusters. At a cooling luminosity of $L_{\mathrm{X},\,r} \lt \mathrm{R}_{\mathrm{cool}}\approx 5.50\times10^{43}\,\mathrm{erg\,s^{-1}}$, on average, AGN feedback appears to contribute only about $13\%-22\%$ of the energy needed to offset the radiative losses in the ICM.

We present the Evolutionary Map of the Universe (EMU) survey conducted with the Australian Square Kilometre Array Pathfinder (ASKAP). EMU aims to deliver the touchstone radio atlas of the southern hemisphere. We introduce EMU and review its science drivers and key science goals, updated and tailored to the current ASKAP five-year survey plan. The development of the survey strategy and planned sky coverage is presented, along with the operational aspects of the survey and associated data analysis, together with a selection of diagnostics demonstrating the imaging quality and data characteristics. We give a general description of the value-added data pipeline and data products before concluding with a discussion of links to other surveys and projects and an outline of EMU’s legacy value.

To meet the specific education needs of ethics committee members (primarily full-time healthcare professionals), the Regional Ethics Department of Kaiser Permanente Northern California (KPNCAL) and Washington State University’s Elson Floyd School of Medicine have partnered to create a one-academic year Medical Ethics Certificate Program. The mission-driven nature of the KPNCAL-WSU’s Certificate Program was designed to be a low-cost, high-quality option for busy full-time practitioners who may not otherwise opt to pursue additional education.

This article discusses the specific competency-focused methodologies and pedagogies adopted, as well as how the Certificate Program made permanent changes in response to the global pandemic. This article also discusses in detail one of the Program’s signature features, its Practicum—an extensive simulated clinical ethics consultation placing students in the role of ethics consultant, facilitating a conflict between family members played by paid professional actors. This article concludes with survey data responses from Program alumni gathered as part of a quality study.

We present radio observations of the galaxy cluster Abell S1136 at 888 MHz, using the Australian Square Kilometre Array Pathfinder radio telescope, as part of the Evolutionary Map of the Universe Early Science program. We compare these findings with data from the Murchison Widefield Array, XMM-Newton, the Wide-field Infrared Survey Explorer, the Digitised Sky Survey, and the Australia Telescope Compact Array. Our analysis shows the X-ray and radio emission in Abell S1136 are closely aligned and centered on the Brightest Cluster Galaxy, while the X-ray temperature profile shows a relaxed cluster with no evidence of a cool core. We find that the diffuse radio emission in the centre of the cluster shows more structure than seen in previous low-resolution observations of this source, which appeared formerly as an amorphous radio blob, similar in appearance to a radio halo; our observations show the diffuse emission in the Abell S1136 galaxy cluster contains three narrow filamentary structures visible at 888 MHz, between $\sim$80 and 140 kpc in length; however, the properties of the diffuse emission do not fully match that of a radio (mini-)halo or (fossil) tailed radio source.

OBJECTIVES/GOALS: Contingency management (CM) procedures yield measurable reductions in cocaine use. This poster describes a trial aimed at using CM as a vehicle to show the biopsychosocial health benefits of reduced use, rather than total abstinence, the currently accepted metric for treatment efficacy. METHODS/STUDY POPULATION: In this 12-week, randomized controlled trial, CM was used to reduce cocaine use and evaluate associated improvements in cardiovascular, immune, and psychosocial well-being. Adults aged 18 and older who sought treatment for cocaine use (N=127) were randomized into three groups in a 1:1:1 ratio: High Value ($55) or Low Value ($13) CM incentives for cocaine-negative urine samples or a non-contingent control group. They completed outpatient sessions three days per week across the 12-week intervention period, totaling 36 clinic visits and four post-treatment follow-up visits. During each visit, participants provided observed urine samples and completed several assays of biopsychosocial health. RESULTS/ANTICIPATED RESULTS: Preliminary findings from generalized linear mixed effect modeling demonstrate the feasibility of the CM platform. Abstinence rates from cocaine use were significantly greater in the High Value group (47% negative; OR = 2.80; p = 0.01) relative to the Low Value (23% negative) and Control groups (24% negative;). In the planned primary analysis, the level of cocaine use reduction based on cocaine-negative urine samples will serve as the primary predictor of cardiovascular (e.g., endothelin-1 levels), immune (e.g., IL-10 levels) and psychosocial (e.g., Addiction Severity Index) outcomes using results from the fitted models. DISCUSSION/SIGNIFICANCE: This research will advance the field by prospectively and comprehensively demonstrating the beneficial effects of reduced cocaine use. These outcomes can, in turn, support the adoption of reduced cocaine use as a viable alternative endpoint in cocaine treatment trials.

Aviation passenger screening has been used worldwide to mitigate the translocation risk of SARS-CoV-2. We present a model that evaluates factors in screening strategies used in air travel and assess their relative sensitivity and importance in identifying infectious passengers. We use adapted Monte Carlo simulations to produce hypothetical disease timelines for the Omicron variant of SARS-CoV-2 for travelling passengers. Screening strategy factors assessed include having one or two RT-PCR and/or antigen tests prior to departure and/or post-arrival, and quarantine length and compliance upon arrival. One or more post-arrival tests and high quarantine compliance were the most important factors in reducing pathogen translocation. Screening that combines quarantine and post-arrival testing can shorten the length of quarantine for travelers, and variability and mean testing sensitivity in post-arrival RT-PCR and antigen tests decrease and increase with the greater time between the first and second post-arrival test, respectively. This study provides insight into the role various screening strategy factors have in preventing the translocation of infectious diseases and a flexible framework adaptable to other existing or emerging diseases. Such findings may help in public health policy and decision-making in present and future evidence-based practices for passenger screening and pandemic preparedness.

Newcastle disease (ND) is a notifiable disease affecting chickens and other avian species caused by virulent strains of Avian paramyxovirus type 1 (APMV-1). While outbreaks of ND can have devastating consequences, avirulent strains of APMV-1 generally cause subclinical infections or mild disease. However, viruses can cause different levels of disease in different species and virulence can evolve following cross-species transmission events. This report describes the detection of three cases of avirulent APMV-1 infection in Great Britain (GB). Case 1 emerged from the ‘testing to exclude’ scheme in chickens in Shropshire while cases 2 and 3 were made directly from notifiable avian disease investigations in chicken broilers in Herefordshire and on premises in Wiltshire containing ducks and mixed species, respectively). Class II/genotype I.1.1 APMV-1 from case 1 shared 99.94% identity to the Queensland V4 strain of APMV-1. Class II/genotype II APMV-1 was detected from case 2 while the class II/genotype I.2 virus from case 3 aligned closely with strains isolated from Anseriformes. Exclusion of ND through rapid detection of avirulent APMV-1 is important where clinical signs caused by avirulent or virulent APMV-1s could be ambiguous. Understanding the diversity of APMV-1s circulating in GB is critical to understanding disease threat from these adaptable viruses.

A semigroup S is said to be right pseudo-finite if the universal right congruence can be generated by a finite set $U\subseteq S\times S$, and there is a bound on the length of derivations for an arbitrary pair $(s,t)\in S\times S$ as a consequence of those in U. This article explores the existence and nature of a minimal ideal in a right pseudo-finite semigroup. Continuing the theme started in an earlier work by Dandan et al., we show that in several natural classes of monoids, right pseudo-finiteness implies the existence of a completely simple minimal ideal. This is the case for orthodox monoids, completely regular monoids, and right reversible monoids, which include all commutative monoids. We also show that certain other conditions imply the existence of a minimal ideal, which need not be completely simple; notably, this is the case for semigroups in which one of the Green’s preorders ${\leq _{\mathcal {L}}}$ or ${\leq _{\mathcal {J}}}$ is left compatible with multiplication. Finally, we establish a number of examples of pseudo-finite monoids without a minimal ideal. We develop an explicit construction that yields such examples with additional desired properties, for instance, regularity or ${\mathcal {J}}$-triviality.

University students have long played an important role in latin american politics. Preceding by several decades the first signs of youthful protest in the United States, student activism in Latin America has been persistent and often decisive. For example, student groups were instrumental in the overthrow of regimes in Cuba (1933, 1959), Guatemala (1944), Venezuela (1958), and Bolivia (1964). At one time or another, virtually every governing strongman in the region has had to contend with varying opposition from student groups. Indeed, as Robert Alexander has noted, “in the past four decades they have constituted one of the most important pressure groups in twenty republics.”

The Hierarchical Taxonomy of Psychopathology (HiTOP) has emerged out of the quantitative approach to psychiatric nosology. This approach identifies psychopathology constructs based on patterns of co-variation among signs and symptoms. The initial HiTOP model, which was published in 2017, is based on a large literature that spans decades of research. HiTOP is a living model that undergoes revision as new data become available. Here we discuss advantages and practical considerations of using this system in psychiatric practice and research. We especially highlight limitations of HiTOP and ongoing efforts to address them. We describe differences and similarities between HiTOP and existing diagnostic systems. Next, we review the types of evidence that informed development of HiTOP, including populations in which it has been studied and data on its validity. The paper also describes how HiTOP can facilitate research on genetic and environmental causes of psychopathology as well as the search for neurobiologic mechanisms and novel treatments. Furthermore, we consider implications for public health programs and prevention of mental disorders. We also review data on clinical utility and illustrate clinical application of HiTOP. Importantly, the model is based on measures and practices that are already used widely in clinical settings. HiTOP offers a way to organize and formalize these techniques. This model already can contribute to progress in psychiatry and complement traditional nosologies. Moreover, HiTOP seeks to facilitate research on linkages between phenotypes and biological processes, which may enable construction of a system that encompasses both biomarkers and precise clinical description.