Background: Epilepsy has significant implications to quality of life (QOL) beyond the seizures themselves. While research has investigated QOL among people with epilepsy (PwE) from around the globe, minimal research exists on QOL among PwE living in Canada. Methods: People with drug-resistant epilepsy admitted to the Epilepsy Monitoring Unit in London, Ontario completed the “Quality of Life in Neurological Disorders” questionnaire (Neuro-QOL), a scale evaluating 13 QOL domains. We assessed objective cognition using a battery called Creyos. Results: Participants (N=42) scored significantly worse than the reference populations on the anxiety, satisfaction with social roles and activities, and cognitive functioning Neuro-QOL domains (p<.05). Scores on these domains, as well as depression and positive affect/well-being were unrelated to age (mean=39.3 years, SD=16.9), sex (28 females), education level, epilepsy duration, and age of epilepsy onset (p>.05). There were no correlations between scores on these Neuro-QOL domains and Creyos performance in short-term memory, reasoning, and verbal processing (p>.05). Conclusions: PwE living in Canada experience negative QOL in anxiety, social satisfaction, and subjective cognition, unrelated to the clinical factors or cognitive domains investigated. More attention is needed in Canadian clinical care and research to assess and address these affected attributes of QOL for all PwE.

Next generation high-power laser facilities are expected to generate hundreds-of-MeV proton beams and operate at multi-Hz repetition rates, presenting opportunities for medical, industrial and scientific applications requiring bright pulses of energetic ions. Characterizing the spectro-spatial profile of these ions at high repetition rates in the harsh radiation environments created by laser–plasma interactions remains challenging but is paramount for further source development. To address this, we present a compact scintillating fiber imaging spectrometer based on the tomographic reconstruction of proton energy deposition in a layered fiber array. Modeling indicates that spatial resolution of approximately 1 mm and energy resolution of less than 10% at proton energies of more than 20 MeV are readily achievable with existing 100 μm diameter fibers. Measurements with a prototype beam-profile monitor using 500 μm fibers demonstrate active readouts with invulnerability to electromagnetic pulses, and less than 100 Gy sensitivity. The performance of the full instrument concept is explored with Monte Carlo simulations, accurately reconstructing a proton beam with a multiple-component spectro-spatial profile.

In this current study, we report only the preliminary result of the SiO v=0 Ј=5→4 emission toward W49 N at 230 GHz, observed using the ALMA telescope on September 29, 2018. The position–velocity diagram of the SiO emission shows a structure of a bipolar outflow and has a face-on orientation with an inclination angle of 36.4±0.4 degrees with respect to the line of sight. Here we summarize the calculated physical properties of its outflow.

Masturbation is a common sexual practice in men, and saliva is often used as a lubricant during masturbation by men who have sex with men. However, the role of saliva use during masturbation in the transmission of chlamydia is still unclear. We developed population-level, susceptible-infected-susceptible compartmental models to explore the role of saliva use during masturbation on the transmission of chlamydia at multiple anatomical sites. In this study, we simulated both solo masturbation and mutual masturbation. Our baseline model did not include masturbation but included transmission routes (anal sex, oral-penile sex, rimming, kissing and sequential sexual practices) we have previously validated (model 1). We added masturbation to model 1 to develop the second model (model 2). We calibrated the model to five clinical datasets separately to assess the effects of masturbation on the prevalence of site-specific infection. The inclusion of masturbation (model 2) significantly worsened the ability of the models to replicate the prevalence of C. trachomatis. Using model 2 and the five data sets, we estimated that saliva use during masturbation was responsible for between 3.9% [95% confidence interval (CI) 2.0–6.8] and 6.2% (95% CI 3.8–10.5) of incident chlamydia cases at all sites. Our models suggest that saliva use during masturbation is unlikely to play a major role in chlamydia transmission between men, and even if it does have a role, about one in seven cases of urethral chlamydia might arise from masturbation.

The SPARC tokamak is a critical next step towards commercial fusion energy. SPARC is designed as a high-field ($B_0 = 12.2$ T), compact ($R_0 = 1.85$ m, $a = 0.57$ m), superconducting, D-T tokamak with the goal of producing fusion gain $Q>2$ from a magnetically confined fusion plasma for the first time. Currently under design, SPARC will continue the high-field path of the Alcator series of tokamaks, utilizing new magnets based on rare earth barium copper oxide high-temperature superconductors to achieve high performance in a compact device. The goal of $Q>2$ is achievable with conservative physics assumptions ($H_{98,y2} = 0.7$) and, with the nominal assumption of $H_{98,y2} = 1$, SPARC is projected to attain $Q \approx 11$ and $P_{\textrm {fusion}} \approx 140$ MW. SPARC will therefore constitute a unique platform for burning plasma physics research with high density ($\langle n_{e} \rangle \approx 3 \times 10^{20}\ \textrm {m}^{-3}$), high temperature ($\langle T_e \rangle \approx 7$ keV) and high power density ($P_{\textrm {fusion}}/V_{\textrm {plasma}} \approx 7\ \textrm {MW}\,\textrm {m}^{-3}$) relevant to fusion power plants. SPARC's place in the path to commercial fusion energy, its parameters and the current status of SPARC design work are presented. This work also describes the basis for global performance projections and summarizes some of the physics analysis that is presented in greater detail in the companion articles of this collection.

The distribution of the minor impurities, aluminium and silicon, between co-existing phases in altered ilmenite grains from three Western Australian localities has been investigated using SEM and electronmicroprobe analyses. A striking dependence of the impurity levels on the Ti/(Ti + Fe) fraction is observed. For compositions with Ti/(Ti + Fe) between 0.45 and 0.60, i.e. between ferrian-ilmenite and pseudorutile, the impurity content is virtually independent of Ti/(Ti + Fe), and is very low (0.2 wt. % Al2O3. 0.05 wt. % SiO2). For compositions between those of rutile and pseudorutile, there is a direct correlation between the impurity contents and the Ti content of the alteration phase. The impurity levels increase with increasing Ti/(Ti+Fe) to about 3 wt. % Al2O3 and 1 wt. % SiO2 for compositions close to TiO2. Thus during the latter stages of ilmenite alteration, alumina and silica are extracted from the ambient environment and are coprecipitated with, or adsorbed on to, the alteration products. The observed dependence of the alumina and silica contents on extent of alteration is consistent with a two-stage alteration mechanism earlier proposed (Grey and Reid, 1975).

Introduction: Online medical education resources are widely used in emergency medicine (EM), but strategies to assess quality remain elusive. We previously derived the Medical Education Translational Resources: Impact and Quality (METRIQ) 8 instrument to evaluate quality in medical education blog posts. Methods: As part of a subsequent validation study (The METRIQ Blog Study), a mixed-methods usability analysis was performed to obtain user feedback on the quality assessment instrument in order to improve its clarity and reliability. Participants in the METRIQ Study were first asked to rate five blog posts using the METRIQ-8 Score. They then evaluated the METRIQ-8 instruments ease of use and likelihood of being recommended to others using a 7-point Likert scale and free text comments. Participants were also asked to flag and comment on items within the score that they felt were unclear. Global usability ratings were summarized using median scores or percent rated unclear. We used ANOVA to test associations between ease of use and demographic factors. A thematic analysis was performed on the comments. Results: 309 EM medical students, residents, and attendings completed the survey. Global ratings were generally very favorable (median 2 [IQR 2-3], with 7 being the lowest score) for ease of use and likelihood of recommendation, and did not vary by participants country of origin, frequency of blog use, or learner level. Participants stated that the score was structured, systematic, and straightforward. They found it useful for junior learners and for guiding blog creation. Four questions in the score (questions 2, 4, 5, and 7) were identified by 10% of subjects to be unclear. Thematic analysis of comments identified suggested four main themes for improving the score: adding clearer definitions with marking rubrics; shortening the 7-point scale; adding items evaluating blog post presentation and utility; and, rephrasing the wording of certain questions for clarity. Conclusion: A mixed methods usability analysis of the METRIQ-8 instrument for assessing blog quality was globally well received by EM medical students, residents, and attendings. Qualitative analyses revealed multiple areas to improve the instruments clarity and usability. The METRIQ score is a promising instrument for evaluating the quality of blogs; further development and testing is needed to improve its utility.

In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean–atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010–2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5.

We investigated the developmental and hydrological history of a Sphagnum-dominated, kettle peatland in Upper Michigan using testate amoebae, plant macrofossils, and pollen. Our primary objective was to determine if the paleohydrological record of the peatland represents a record of past climate variability at subcentennial to millennial time scales. To assess the role of millennial-scale climate variability on peatland paleohydrology, we compared the timing of peatland and upland vegetation changes. To investigate the role of higher-frequency climate variability on peatland paleohydrology, we used testate amoebae to reconstruct a high-resolution, hydrologic history of the peatland for the past 5100 years, and compared this record to other regional records of paleoclimate and vegetation. Comparisons revealed coherent patterns of hydrological, vegetational, and climatic changes, suggesting that peatland paleohydrology responded to climate variability at millennial to sub-centennial time scales. Although ombrotrophic peatlands have been the focus of most high-resolution peatland paleoclimate research, paleohydrological records from Sphagnum-dominated, closed-basin peatlands record high-frequency and low-magnitude climatic changes and thus represent a significant source of unexplored paleoclimate data.

During 1990 we surveyed the southern sky using a multi-beam receiver at frequencies of 4850 and 843 MHz. The half-power beamwidths were 4 and 25 arcmin respectively. The finished surveys cover the declination range between +10 and −90 degrees declination, essentially complete in right ascension, an area of 7.30 steradians. Preliminary analysis of the 4850 MHz data indicates that we will achieve a five sigma flux density limit of about 30 mJy. We estimate that we will find between 80 000 and 90 000 new sources above this limit. This is a revised version of the paper presented at the Regional Meeting by the first four authors; the surveys now have been completed.

Debris and pyroclastic flows often have bouldery flow fronts, which act as a natural dam resisting further advance. Counter intuitively, these resistive fronts can lead to enhanced run-out, because they can be shouldered aside to form static levees that self-channelise the flow. At the heart of this behaviour is the inherent process of size segregation, with different sized particles readily separating into distinct vertical layers through a combination of kinetic sieving and squeeze expulsion. The result is an upward coarsening of the size distribution with the largest grains collecting at the top of the flow, where the flow velocity is greatest, allowing them to be preferentially transported to the front. Here, the large grains may be overrun, resegregated towards the surface and recirculated before being shouldered aside into lateral levees. A key element of this recirculation mechanism is the formation of a breaking size-segregation wave, which allows large particles that have been overrun to rise up into the faster moving parts of the flow as small particles are sheared over the top. Observations from experiments and discrete particle simulations in a moving-bed flume indicate that, whilst most large particles recirculate quickly at the front, a few recirculate very slowly through regions of many small particles at the rear. This behaviour is modelled in this paper using asymmetric segregation flux functions. Exact non-diffuse solutions are derived for the steady wave structure using the method of characteristics with a cubic segregation flux. Three different structures emerge, dependent on the degree of asymmetry and the non-convexity of the segregation flux function. In particular, a novel ‘lens-tail’ solution is found for segregation fluxes that have a large amount of non-convexity, with an additional expansion fan and compression wave forming a ‘tail’ upstream of the ‘lens’ region. Analysis of exact solutions for the particle motion shows that the large particle motion through the ‘lens-tail’ is fundamentally different to the classical ‘lens’ solutions. A few large particles starting near the bottom of the breaking wave pass through the ‘tail’, where they travel in a region of many small particles with a very small vertical velocity, and take significantly longer to recirculate.

Two new conulariid species, Conularia clarkei Babcock and C. paraguayensis Babcock from the Vargas Peña Shale, are the first Silurian conulariids to be described from Paraguay. They increase to three the number of Silurian species to be described from South America. The concept of Conularia Miller in Sowerby, 1820, is emended. It includes as junior synonyms Conularia (Plectoconularia) Bouček, 1939, Diconularia Sinclair, 1952, and Yangoconularia Xu and Li, 1985. The age of the Vargas Peña Shale has long been disputed, but conclusions based on organic-walled microfossils indicate an Early Silurian (Llandoverian) age for the unit.

The 2013 multistate outbreaks contributed to the largest annual number of reported US cases of cyclosporiasis since 1997. In this paper we focus on investigations in Texas. We defined an outbreak-associated case as laboratory-confirmed cyclosporiasis in a person with illness onset between 1 June and 31 August 2013, with no history of international travel in the previous 14 days. Epidemiological, environmental, and traceback investigations were conducted. Of the 631 cases reported in the multistate outbreaks, Texas reported the greatest number of cases, 270 (43%). More than 70 clusters were identified in Texas, four of which were further investigated. One restaurant-associated cluster of 25 case-patients was selected for a case-control study. Consumption of cilantro was most strongly associated with illness on meal date-matched analysis (matched odds ratio 19·8, 95% confidence interval 4·0–∞). All case-patients in the other three clusters investigated also ate cilantro. Traceback investigations converged on three suppliers in Puebla, Mexico. Cilantro was the vehicle of infection in the four clusters investigated; the temporal association of these clusters with the large overall increase in cyclosporiasis cases in Texas suggests cilantro was the vehicle of infection for many other cases. However, the paucity of epidemiological and traceback information does not allow for a conclusive determination; moreover, molecular epidemiological tools for cyclosporiasis that could provide more definitive linkage between case clusters are needed.

The Dominion Radio Astrophysical Observatory (DRAO) is carrying out a survey as part of an international collaboration to image the northe, at a common resolution, in emission from all major constituents of the interstellar medium; the neutral atomic gas, the molecular gas, the ionised gas, dust and relativistic plasma. For many of these constituents the angular resolution of the images (1 arcmin) will be more than a factor of 10 better than any previous studies. The aim is to produce a publicly-available database of high resolution, high-dynamic range images of the Galaxy for multi-phase studies of the physical states and processes in the interstellar medium. We will sketch the main scientific motivations as well as describe some preliminary results from the Canadian Galactic Plane Survey/Releve Canadien du Plan Galactique (CGPS/RCPG).

The chemicals cis (Z) and trans (E)11-tetradecenyl acetate (11–14:Ac), trans 11-tetradecen-1-ol (E11–14:OH) and trans 11-tetradecenal (E11–14:Ald) were isolated from unmated female Choristoneura orae Freeman and shown to be highly attractive when used as lures in sticky traps. The identification of these components of the sex pheromone facilitates the separation of C. orae from other Pinaceae-feeding Choristoneura in the same area.

Investigation of the European pine shoot moth pheromone has revealed three components in addition to the previously identified E-9-dodecenyl acetate (E9-12:Ac): E-9-dodecenol, dodecyl acetate, and dodecanol. Inclusion of E-9-dodecenol makes lures more attractive to the moth than unmated females or E9-12:Ac alone. Dodecyl acetate had no apparent effect when added to this more attractive mixture whereas dodecanol had an inhibitory effect. Dodecyl acetate appeared to mask the inhibitory effect of dodecanol when 0.3% or more of the former component is present in the lure. Relative proportions of components are critical in comparative testing or monitoring populations of the moth.

Alcohol consumption during pregnancy remains common in many countries. Exposure to even low amounts of alcohol (i.e. ethanol) in pregnancy can lead to the heterogeneous fetal alcohol spectrum disorders (FASD), while heavy alcohol consumption can result in the fetal alcohol syndrome (FAS). FAS is characterized by cerebral dysfunction, growth restriction and craniofacial malformations. However, the effects of lower doses of alcohol during pregnancy, such as those that lead to FASD, are less well understood. In this article, we discuss the findings of recent studies performed in our laboratories on the effects of fetal alcohol exposure using sheep, in which we investigated the effects of late gestational alcohol exposure on the developing brain, arteries, kidneys, heart and lungs. Our studies indicate that alcohol exposure in late gestation can (1) affect cerebral white matter development and increase the risk of hemorrhage in the fetal brain, (2) cause left ventricular hypertrophy with evidence of altered cardiomyocyte maturation, (3) lead to a decrease in nephron number in the kidney, (4) cause altered arterial wall stiffness and endothelial and smooth muscle function and (5) result in altered surfactant protein mRNA expression, surfactant phospholipid composition and pro-inflammatory cytokine mRNA expression in the lung. These findings suggest that fetal alcohol exposure in late gestation can affect multiple organs, potentially increasing the risk of disease and organ dysfunction in later life.