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Gcd-graphs over the ring of integers modulo n are a natural generalization of unitary Cayley graphs. The study of these graphs has foundations in various mathematical fields, including number theory, ring theory, and representation theory. Using the theory of Ramanujan sums, it is known that these gcd-graphs have integral spectra; i.e., all their eigenvalues are integers. In this work, inspired by the analogy between number fields and function fields, we define and study gcd-graphs over polynomial rings with coefficients in finite fields. We establish some fundamental properties of these graphs, emphasizing their analogy to their counterparts over ${\mathbb {Z}}.$
This paper reports an expansion of the English as a second language (L2) component of the Multilingual Eye Movement Corpus (MECO L2), an international database of eye movements during text reading. While the previous Wave 1 of the MECO project (Kuperman et al., 2023) contained English as a L2 reading data from readers with 12 different first language (L1) backgrounds, the newly collected dataset adds eye-tracking data on English text reading from 13 distinct L1 backgrounds (N = 660) as well as participants’ scores on component skills of English proficiency and information about their demographics and language background and use. The paper reports reliability estimates, descriptive statistics, and correlational analyses as means to validate the expansion dataset. Consistent with prior literature and the MECO Wave 1, trends in the MECO Wave 2 data include a weak correlation between reading comprehension and oculomotor measures of reading fluency and a greater L1-L2 contrast in reading fluency than reading comprehension. Jointly with Wave 1, the MECO project includes English reading data from more than 1,200 readers representing a diversity of native writing systems (logographic, abjad, abugida, and alphabetic) and 19 distinct L1 backgrounds. We provide multiple pointers to new venues of how L2 reading researchers can mine this rich publicly available dataset.
Cells of magnetotactic bacteria are used as model systems for studying the magnetic properties of ferrimagnetic nanocrystals. Each individual bacterial strain produces magnetosomes (membrane-bounded magnetic crystals) that have distinct sizes, shapes, crystallographic orientations and spatial arrangements, thereby providing nanoparticle systems whose unique magnetic properties are unmatched by synthetic chemically-produced crystals. Here, we use off-axis electron holography in the transmission electron microscope to study the magnetic properties of isolated and closely-spaced bullet-shaped magnetite (Fe3O4) magnetosomes biomineralized by the following magnetotactic bacterial strains: the cultured Desulfovibrio magneticus RS-1 and the uncultured strains LO-1 and HSMV-1. These bacteria biomineralize magnetite crystals whose crystallographic axes of elongation are parallel to <100> (RS-1 and LO-1) or <110> (HSMV-1). We show that the individual magnetosome crystals are single magnetic domains and measure their projected in-plane magnetization distributions and magnetic dipole moments. We use analytical modelling to assess the interplay between shape anisotropy and the magnetically preferred <111> magneto-crystalline easy axis of magnetite.
Viscosity and light-transmission measurements of dilute suspensions of montmorillonites having different exchangeable cations were used to calculate relative particle sizes as a function of cation composition, where particle size is expressed as the number of clay plates per tactoid relative to the number of plates per tactoid for Li-montmorillonite, after exchange of Li, Na, K, Cs, and Mg by Ca. Tactoid sizes increased in the order Li < Na < K < Mg < Ca, with the number of plates per tactoid relative to Li-montmorillonite varying from 1.5 for Na- to 6.1 for Ca-montmorillonite. The results for tactoid sizes derived from light transmission and those derived from viscosity data are in reasonable agreement with each other and with literature data for similar systems. Upon exchange of Ca-counterions for Li-, Na-, or K-coun-terions, a sharp initial decrease in tactoid size was observed over approximately the first 30% of cation exchange. Upon further exchange, tactoid sizes changed only slightly, but when Ca was exchanged for Cs or Mg, a much more gradual decrease in particle size was observed.
In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we collected data on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) lifetime MDD diagnosis in 132,850 Dutch individuals. Currently, N = 66,684 of these also have genomewide single nucleotide polymorphism (SNP) data. We initiated this project because the complex genetic basis of MDD requires large population-wide studies with uniform in-depth phenotyping. For standardized phenotyping we developed the LIDAS (LIfetime Depression Assessment Survey), which then was used to measure MDD in 11 Dutch cohorts. Data from these cohorts were combined with diagnostic interview depression data from 5 clinical cohorts to create a dataset of N = 29,650 lifetime MDD cases (22%) meeting DSM-5 criteria and 94,300 screened controls. In addition, genomewide genotype data from the cohorts were assembled into a genomewide association study (GWAS) dataset of N = 66,684 Dutch individuals (25.3% cases). Phenotype data include DSM-5-based MDD diagnoses, sociodemographic variables, information on lifestyle and BMI, characteristics of depressive symptoms and episodes, and psychiatric diagnosis and treatment history. We describe the establishment and harmonization of the BIONIC phenotype and GWAS datasets and provide an overview of the available information and sample characteristics. Our next step is the GWAS of lifetime MDD in the Netherlands, with future plans including fine-grained genetic analyses of depression characteristics, international collaborations and multi-omics studies.
Frequency-modulated continuous-wave radar systems profit from increasing the absolute bandwidths of the generated frequency chirps to improve range resolution. As the relative bandwidth of SiGe-voltage-controlled oscillators (VCOs) is limited to about 80%, increasing the center frequency fundamentally or via frequency multiplication is the most direct way to increase that absolute bandwidth. However, as some applications require penetration depth, which dramatically decreases with frequency, other solutions are necessary. Therefore, state-of-the-art concepts rely on the down-conversion of generated frequency chirps via two separately stabilized frequency sources. This article implements a novel architecture, offering relative bandwidths of >100% within a single phase-locked loop (PLL). Therefore, two VCOs at different center frequencies are fed into a down-conversion mixer, whose output is directly stabilized via that PLL with one loop filter generating both tuning voltages. Those circuit blocks can be summarized as one equivalent VCO, offering a higher relative bandwidth and a significantly more linear tuning curve. Thereby, a solution to limited relative bandwidths with high VCO gain variation of single VCO synthesizers is offered while substantially reducing the hardware and implementation effort compared to the state-of-the-art.
In 2022, highly pathogenic avian influenza (HPAI) A(H5N1) virus clade 2.3.4.4b became enzootic and caused mass mortality in Sandwich Tern Thalasseus sandvicensis and other seabird species across north-western Europe. We present data on the characteristics of the spread of the virus between and within breeding colonies and the number of dead adult Sandwich Terns recorded at breeding sites throughout north-western Europe. Within two months of the first reported mortalities, 20,531 adult Sandwich Terns were found dead, which is >17% of the total north-western European breeding population. This is probably an under-representation of total mortality, as many carcasses are likely to have gone unnoticed and unreported. Within affected colonies, almost all chicks died. After the peak of the outbreak, in a colony established by late breeders, 25.7% of tested adults showed immunity to HPAI subtype H5. Removal of carcasses was associated with lower levels of mortality at affected colonies. More research on the sources and modes of transmission, incubation times, effective containment, and immunity is urgently needed to combat this major threat for colonial seabirds.
Warthin's tumours are the second most common benign parotid tumours in the UK. The World Health Organization states that 5–14 per cent of patients have bilateral Warthin's tumours. This study aimed to: assess the presence of contralateral Warthin's tumours in patients who underwent surgery over the past 16 years at a head and neck unit in England, and perform the first systematic literature review on bilateral Warthin's tumours.
Methods
A retrospective analysis was conducted on patients diagnosed with Warthin's tumour based on histology between 2005 and 2020. Additionally, a systematic review (International Prospective Register of Systematic Reviews (‘PROSPERO’) registration number: CRD42022326846) was performed using PubMed and the Cochrane Library.
Results
Among 290 patients diagnosed with Warthin's tumours based on histology following surgery, 24.5 per cent had bilateral Warthin's tumours. The systematic review identified 157 papers, with 14 meeting the inclusion criteria.
Conclusion
This study revealed that 24.5 per cent of patients had bilateral Warthin's tumours, deviating from the suggested range. These findings are of interest to surgeons discussing the disease with patients.
Wind energy’s ability to liberate the world from conventional sources of energy relies on lowering the significant costs associated with the maintenance of wind turbines. Since icing events on turbine rotor blades are a leading cause of operational failures, identifying icing in advance is critical. Some recent studies have utilized deep learning (DL) techniques to predict icing events with high accuracy by leveraging rotor blade images, but these studies only focus on specific wind parks and fail to generalize to unseen scenarios (e.g., new rotor blade designs). In this paper, we aim to facilitate ice prediction on the face of lack of ice images in new wind parks. We propose the utilization of synthetic data augmentation via a generative artificial intelligence technique—the neural style transfer algorithm to improve the generalization of existing ice prediction models. We also compare the proposed technique with the CycleGAN as a baseline. We show that training standalone DL models with augmented data that captures domain-invariant icing characteristics can help improve predictive performance across multiple wind parks. Through efficient identification of icing, this study can support preventive maintenance of wind energy sources by making them more reliable toward tackling climate change.
Sea level rise contributions from the Pine Island Glacier (PIG) are strongly modulated by the backstress that its floating extension – Pine Island Ice Shelf (PIIS) – exerts on the adjoining grounded ice. The front of PIIS has recently retreated significantly via calving, and satellite and theoretical analyses have suggested further retreat is inevitable. As well as inducing an instantaneous increase in ice flow, retreat of the PIIS front may result in increased ocean melting, by relaxing the topographic barrier to warm ocean water that is currently provided by a prominent seabed ridge. Recently published research (Bradley and others, 2022a) has shown that PIIS may exhibit a strong melting response to calving, with melting close to the PIG grounding line always increasing with ice front retreat. Here, we summarise this research and, additionally, place the results in a glaciological context by comparing the impact of melt-induced and ice-dynamical changes in the ice shelf thinning rate. We find that while PIG is expected to experience rapid acceleration in response to further ice front retreat, the mean instantaneous thinning response is set primarily by changes in melting, rather than ice dynamics. Overall, further ice front retreat is expected to lead to enhanced ice-shelf thinning, with potentially detrimental consequences for ice shelf stability.
Loneliness and social isolation are important social determinants of wellbeing of older adults. Conversational exchanges can promote connectedness between older adults, however, conversations may not always come easy. Research shows that exposure to nature-based stimuli such as pictures and videos can stimulate social aspirations and trigger associations that could facilitate conversations, in particular when nature scenery is perceived as fascinating, mysterious, spacious and suited for social interaction. Therefore, this study investigated whether exposure to these nature characteristics (high versus low) lead to associations that could act as conversational material. A randomised factorial design, using a virtual reality-based approach for experimental control, led to 17 different virtual representations of nature (VN). In total, 150 participants (60 years and older) were recruited for an online survey. Spontaneous associations were coded on personal engagement and valence. The number of associations was measured with one multiple-choice question. VN exposure successfully triggered personally engaging and positively valenced associations and were related to multiple associations, in particular when the VN were high on mystery. Furthermore, positive effects of VN exposure was more pronounced for participants with high (rather than low) levels of nature relatedness and many (rather than few) available nature opportunities. These findings indicate that VN exposure provides fertile ground for conversations as a means to promote connectedness and social wellbeing of older adults.
People with severe mental illness (SMI) die earlier than the general population, primarily because of physical disorders.
Aims
We estimated the prevalence of physical health conditions, health risk behaviours, access to healthcare and health risk modification advice in people with SMI in Bangladesh, India and Pakistan, and compared results with the general population.
Method
We conducted a cross-sectional survey in adults with SMI attending mental hospitals in Bangladesh, India and Pakistan. Data were collected on non-communicable diseases, their risk factors, health risk behaviours, treatments, health risk modification advice, common mental disorders, health-related quality of life and infectious diseases. We performed a descriptive analysis and compared our findings with the general population in the World Health Organization (WHO) ‘STEPwise Approach to Surveillance of NCDs’ reports.
Results
We recruited 3989 participants with SMI, of which 11% had diabetes, 23.3% had hypertension or high blood pressure and 46.3% had overweight or obesity. We found that 70.8% of participants with diabetes, high blood pressure and hypercholesterolemia were previously undiagnosed; of those diagnosed, only around half were receiving treatment. A total of 47% of men and 14% of women used tobacco; 45.6% and 89.1% of participants did not meet WHO recommendations for physical activity and fruit and vegetable intake, respectively. Compared with the general population, people with SMI were more likely to have diabetes, hypercholesterolemia and overweight or obesity, and less likely to receive tobacco cessation and weight management advice.
Conclusions
We found significant gaps in detection, prevention and treatment of non-communicable diseases and their risk factors in people with SMI.
Radio telescopes are among the applications with the highest demands on a local oscillator (LO), which is used to receive and process the signals coming from the sky. Therefore the modules providing the required LO signal have traditionally been big and complicated. To overcome this disadvantage, we implement our own integrated frequency synthesizer inside a small LO module in this article. With this synthesizer we are able to achieve a jitter of only 50 fs integrated from 10 Hz to 2.5 GHz offset at a carrier frequency of 75 GHz. This is in part achieved by a very low in-band phase noise of −111.8 dBc at 10 kHz offset. The stabilizable frequency range is 62–88 GHz. Thus achieving promising results to fulfill this very demanding task with integrated frequency synthesizers in the future.
Wearable robotic devices (WRD) are still struggling to fulfill their vast potential. Inadequate daily life usability is one of the main hindrances to increased technology acceptance. Improving usability evaluation practices during the development of WRD could help address these limitations. In this work, we present the design and validation of a novel online platform aiming to fill this gap, the Interactive Usability Toolbox (IUT). This platform consists of a public website that offers an interactive, context-specific search within a database of 154 user research methods and educational information about usability. In a dedicated study, the effect of this platform to support usability evaluation was investigated. Twelve WRD experts were asked to complete the task of defining usability evaluation protocols for two specific use cases. The platform was provided to support one of the use cases. The quality and composition of the proposed protocols were assessed by (i) two blinded reviewers, (ii) the participants themselves, and (iii) the study coordinators. We showed that using the IUT significantly affected the proposed evaluation focus, shifting protocols from mainly effectiveness-oriented to more user-focused studies. The protocol quality, as rated by the external reviewers, remained equivalent to those designed with conventional strategies. A mixed-method usability evaluation of the platform yielded an overall positive image, with detailed suggestions for further improvements. The IUT is expected to positively affect the evaluation and development of WRD through its educational value, the context-specific recommendations supporting ongoing benchmarking endeavors, and highlighting the value of qualitative user research.
Owing to drifting snow processes, snow accumulation and surface density in polar environments are variable in space and time. We present new field data of manual measurements, repeat terrestrial laser scanning and snow micro-penetrometry from Dronning Maud Land, Antarctica, showing the density of new snow accumulations. We combine these data with published drifting snow mass flux observations, to evaluate the performance of the 1-D, detailed, physics-based snow cover model SNOWPACK in representing drifting snow and surface density. For two sites in East Antarctica with multiple years of data, we found a coefficient of determination for the simulated drifting snow of r2 = 0.42 and r2 = 0.50, respectively. The field observations show the existence of low-density snow accumulations during low wind conditions. Successive high wind speed events generally erode these low-density layers while producing spatially variable erosion/deposition patterns with typical length scales of a few metres. We found that a model setup that is able to represent low-density snow accumulating during low wind speed conditions, as well as subsequent snow erosion and redeposition at higher densities during drifting snow events was mostly able to describe the observed temporal variability of surface density in the field.
In response to the recession brought about by the COVID-19 pandemic, EU-wide macroeconomic policy has launched an unprecedented coordinated fiscal expansion across the EU (Next Generation EU or NGEU), financed by issuing common debt. Given NGEU’s nature, it is essential to take fiscal spillovers into consideration when assessing the overall macroeconomic effects of this fiscal expansion. We quantify the effects of the additional public investment for all Member States in a rich macro-model with a trade structure. Our model suggests that, on average, GDP effects are around one-third larger when explicitly accounting for the spillover effects from individual-country measures. For small open economies with smaller NGEU allocations, spillover effects account for the bulk of the GDP impact. We also quantify key transmission channels.
Pacific Island Countries and Areas (PICs) represent some of the most remote and logistically challenging locations – with thousands of islands covering vast ocean territory. Since 2017, Pacific Ministries of Health have been developing EMTs, and all have worked to train team members to be deployment-ready.1
Objectives:
To describe an EMT training package specifically tailored to PIC contexts, including curated content, practical exercises, and “talanoa” discussions to improve EMT readiness, with a focus on logistics in remote and austere PIC contexts.
Method/Description:
WHO leveraged EMT training materials developed globally and regionally to continuously tailor an in-person EMT training package, emphasizing readiness for the deployment of light, mobile clinical teams for disaster-prone small island/large ocean countries. Emphasis was placed on practical learning exercises focusing on skills and competencies needed to manage complex Pacific deployments, and to care for populations on remote, difficult-to-reach islands with limited resources and referral options.
Results/Outcomes:
The Pacific EMT training program includes a mix of didactic and practical sessions coupled with a full-scale simulation exercise; it was designed with and for Pacific EMTs. The effectiveness of the training package has been evidenced through many successful national EMT deployments in several PICs, as well as through consistently positive participant feedback.
Conclusion:
Tailoring training materials to specific country contexts is essential. In the Pacific, core EMT training content with an emphasis on practical activities and simulations and “talanoa” discussions reflecting on previous deployments in remote islands has been viewed by participants as critical to preparing them for real-world deployments.
Pacific Island Countries and Areas (PICs) represent some of the most logistically challenging locations, covering vast ocean territory and remote islands. Light, mobile clinical response capability is critical in the disaster-prone Pacific. Beginning in January 2021, WHO researched, tailored, and procured EMT cache “kits” specifically for Pacific Island contexts, based on the core standards of the global EMT initiative.
Objectives:
To research, tailor, and procure cache “kits” to ensure self-sufficiency and high-quality out-patient mobile medical care for national EMTs in PICs.
Method/Description:
WHO facilitated the development of national cache kits for 10 PICs EMTs. A need for specialized equipment and supplies or “cache” for team self-reliance is critical. Through a consultative process, including Pacific EMT leadership and team members, EMT mentors, and regional partners, WHO curated and procured cache kits for 10 PICs EMTs.
Results/Outcomes:
The Pacific EMT cache kit is designed for four-to-six-person teams with the capacity to deploy for a minimum of three days, with full self-sufficiency. Because of the complex and remote access to many Pacific Islands, EMT cache must be practical for transport on small aircrafts and maritime vessels. A consultative process resulted in a curated cache list for Pacific national EMTs of over 125 items, estimated to weigh approximately 440 kilograms per kit. By the end of 2022, a total 31 kits will be delivered to EMTs in ten countries.
Conclusion:
The design, development, and procurement of Pacific EMT cache for national response operations will allow for increased speed and agility for response to disasters and public health emergencies.
The course over time of religious delusions (RDs) in late-life schizophrenia and psychotic depression may be relevant to know how long certain aspects of RDs may affect treatment. The present study examines (1) the 1-year follow-up of RDs and other prevalent delusions, (2) the association between RDs and the clinical course of psychotic depression and schizophrenia compared to those without RDs, and (3) associations of RDs and other prevalent delusions with “indicators of complexity” (e.g., suicidality, refusing medication).
Design:
Prospective study (half year and 1-year follow-up combined).
Setting:
Outpatients and inpatients in Geriatric Psychiatry Institution of Yulius, South-Holland, the Netherlands.
Participants:
One hundred and thirty seven older adult patients, mean age 76.3 (s.d. 8.1).
Intervention:
Natural follow-up study.
Measurements:
Diagnostic interview measures included Schedules for Clinical Assessment in Neuropsychiatry (SCAN 2.1), positive psychosis items of the Community Assessment of Psychic Experiences-42 (CAPE), and the 20-item measures from the Centre for Epidemiologic Studies Depression Scale (CES-D).
Results:
Although RDs in older adults decline in the clinical course of psychotic depression, the course is unfavorable compared to psychotic depression without RDs with regard to depressive symptom severity as measured by CES-D. No significant differences were noted in relation to clinical course of positive psychotic symptoms for both psychotic depression and schizophrenia. In schizophrenia, RDs persist more frequently compared to the most prevalent delusions. No significant difference was observed between patients with RDs compared to patients without RDs regarding indicators of clinical complexity.
Conclusions:
RDs predicting a less favorable course over time in psychotic depression. In schizophrenia, RDs appears to be relatively pervasive.