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This study’s primary objective was to test the feasibility of using the online personal utility function (OPUF) approach and develop a preliminary utility tariff for the EQ-5D-5L based on a South African community sample.
Methods
The need for an ethnically and socioeconomically diverse sample was seen as essential. This led to the need for interviewer assistance during completion of the survey instrument and translation of the instrument into multiple languages. English, Zulu, Tswana, and Afrikaans were chosen to allow the vast majority of a community sample people to participate. A sample size of sixty respondents was based on a previous OPUF pilot valuation study for the EQ-5D-5L, and a pilot study of twenty respondents was undertaken using the English language version of OPUF.
Results
There were sixty-one respondents in the main study with most respondent characteristics being well matched with national figures, except for language. Personal utility functions could be calculated for sixty respondents, with the mean tariff showing monotonically declining utility decrements within each dimension. An examination of individual functions showed two contrasting sets of preferences that were driven by the respondents’ rating of death. A separate subgroup analysis also showed preference heterogeneity based on the home language of the respondents.
Conclusions
Our study showed that the application of the OPUF approach is possible in a socioeconomically diverse population in South Africa. The examination of individual personal utility functions shows marked heterogeneity of preferences that needs to be explored further so that the source of this can be established.
Paleontology provides insights into the history of the planet, from the origins of life billions of years ago to the biotic changes of the Recent. The scope of paleontological research is as vast as it is varied, and the field is constantly evolving. In an effort to identify “Big Questions” in paleontology, experts from around the world came together to build a list of priority questions the field can address in the years ahead. The 89 questions presented herein (grouped within 11 themes) represent contributions from nearly 200 international scientists. These questions touch on common themes including biodiversity drivers and patterns, integrating data types across spatiotemporal scales, applying paleontological data to contemporary biodiversity and climate issues, and effectively utilizing innovative methods and technology for new paleontological insights. In addition to these theoretical questions, discussions touch upon structural concerns within the field, advocating for an increased valuation of specimen-based research, protection of natural heritage sites, and the importance of collections infrastructure, along with a stronger emphasis on human diversity, equity, and inclusion. These questions offer a starting point—an initial nucleus of consensus that paleontologists can expand on—for engaging in discussions, securing funding, advocating for museums, and fostering continued growth in shared research directions.
INDUCT (Interdisciplinary Network for Dementia Using Current Technology), and DISTINCT (Dementia Inter-sectorial strategy for training and innovation network for current technology) are two Marie Sklodowska-Curie funded International Training Networks that aimed to develop a multi-disciplinary, inter-sectorial educational research framework for Europe to improve technology and care for people with dementia, and to provide the evidence to show how technology can improve the lives of people with dementia.
Methods:
In INDUCT (2016-2020) 15 Early Stage Researchers worked on projects in the areas of Technology to support everyday life; technology to promote meaningful activities; and healthcare technology. In DISTINCT (2019-2023) 15 Early Stage Researchers worked on technology to promote Social health in three domains: fulfilling ones potential and obligations in society, managing one’s own life, and participation in social and other meaningful activities.
Both networks adopted three transversal objectives: 1) To determine practical, cognitive and social factors needed to make technology more useable for people with dementia; 2) To evaluate the effectiveness of specific contemporary technology; 3) To trace facilitators and barriers for implementation of technology in dementia care.
Results:
The main recommendations resulting from all research projects are integrated in a web-based digital Best Practice Guidance on Human Interaction with Technology in Dementia which was recently updated (Dec 2022 and June 2023) and will be presented at the congress. The recommendations are meant for different target groups, i.e. people in different stages of dementia, their (in)formal carers, policy makers, designers and researchers, who can easily find the recommendations relevant to them in the Best Practice Guidance by means of a digital selection tool.
Conclusions:
The INDUCT/DISTINCT Best Practice Guidance informs on how to improve the development, usage, impact and implementation of technology for people with dementia in various technology areas. This Best Practice Guidance is the result of intensive collaborative partnership of INDUCT and DISTINCT with academic and non-academic partners as well as the involvement of representatives of the different target groups throughout the projects.
Assessing the cost utility of health technologies for pediatric patients requires robust utility values for child health states, but the methods for valuing these pediatric health states are much less established than those for valuing adult health states. This is partly because the elicitation of preferences for child health states poses many normative, ethical, and practical challenges.
Methods
This presentation examines the conceptual issues in the valuation of health states in children by addressing the following questions.
(i) Normative theories of health state values: What are we attempting to elicit?
(ii) Sources of preferences: Whose preferences should we elicit, and from which perspective?
(iii) Valuation methodologies: How should we elicit preferences?
(iv) Attaching different values to child and adult health: Is a lack of consistency problematic?
To answer these questions, we used desk research (non-systematic literature reviews) and findings from a two-part workshop held in April 2021. The workshop included 25 participants with expertise in health economics, health state valuation, child health, health technology assessment (HTA) decision-making, and ethics.
Results
We identified a lack of consensus on what is being elicited for both adults and children. Many HTA agencies recommend that the public be involved in utility generation exercises, but some criteria for defining who constitutes a member of the public exclude children. Of the many candidate sample types, perspectives, and methodologies, only a few were deemed relevant, acceptable, and feasible for use in the child health context. In addition, there were diverging views on whether it is possible to compare and integrate adult and child value sets with different properties.
Conclusions
Several questions remain to be answered before the public and other stakeholders can have confidence in child health state valuation protocols. We propose a research agenda, including both empirical and conceptual work, to inform future methodological development and to help HTA agencies make recommendations about how child utility values should be generated.
The Jurassic to Cretaceous strata exposed in the Rollrock Section, Sverdrup Basin, Arctic Canada, represent one of the northernmost continuous outcrops spanning this poorly understood transition. The Oxfordian–Valanginian mudstones of the Rollrock Section were deposited in a shallow marine environment and, as such, provide the ideal lithology to investigate the response of high latitude dinoflagellate cyst populations to the frequent environmental perturbations of this time. Using a multivariate statistical approach, distinct palaeoecologically significant groups are identified and directly linked to time and palaeoenvironments, allowing for the reconstruction of underlying long term palaeoenvironmental trends. These palaeoenvironmental trends are identified to be driven by sequence stratigraphic cycles. For the first time, fourth order sequences are recorded from this pivotal period in the Sverdrup Basin and reveal an additional level of short term climatic events that complicate the identification of long term trends. The relationship existing between marine phytoplankton and climate is utilised to decipher the interplay of long-term and short-term climate fluctuations, distinguishing them from evolutionary trends. Two groups of dinoflagellate cysts, identified by process morphology, are recorded to act as environmental proxies. High percentages of proximochorate dinoflagellate cysts, such as Trichodinium erinaceoides, indicate more proximal, high energy, nutrient rich conditions and are dominant in fourth order transgressive systems tracts. High percentages of chorate dinoflagellate cysts, such as Oligosphaeridium complex, signify distal, low energy, nutrient depleted conditions and are dominant in fourth order highstand systems tracts.
In any attempt to “rethink” biodiversity governance, we need to consider that defining nature (and related concepts such as biodiversity, ecosystems, landscapes or green infrastructure) is not merely an objective scientific exercise. In reality, context-specific, subjective, normative and dynamic worldviews and values are at play in any definition of nature, whether explicitly or implicitly. Being aware of this pluralism is essential for avoiding “objective” definitional attitudes that risk disregarding and marginalizing the plurality of values and worldviews connected to different definitions of nature. In fact, paternalistic positions can create breeding grounds for fruitless dialogues between stakeholders, and thus pluralistic approaches help open up spaces for discussion.
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
Aims
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Method
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Results
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
Conclusions
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
In the study of electoral politics and political behavior in the developing world, India is often considered to be an exemplar of the centrality of contingency in distributive politics, the role of ethnicity in shaping political behavior, and the organizational weakness of political parties. Whereas these axioms have some empirical basis, the massive changes in political practices, the vast variation in political patterns, and the burgeoning literature on subnational dynamics in India mean that such generalizations are not tenable. In this article, we consider research on India that compels us to rethink the contention that India neatly fits the prevailing wisdom in the comparative politics literature. Our objective is to elucidate how the many nuanced insights about Indian politics can improve our understanding of electoral behavior both across and within other countries, allowing us to question core assumptions in theories of comparative politics.
In recent years, the discovery of massive quasars at $z\sim7$ has provided a striking challenge to our understanding of the origin and growth of supermassive black holes in the early Universe. Mounting observational and theoretical evidence indicates the viability of massive seeds, formed by the collapse of supermassive stars, as a progenitor model for such early, massive accreting black holes. Although considerable progress has been made in our theoretical understanding, many questions remain regarding how (and how often) such objects may form, how they live and die, and how next generation observatories may yield new insight into the origin of these primordial titans. This review focusses on our present understanding of this remarkable formation scenario, based on the discussions held at the Monash Prato Centre from November 20 to 24, 2017, during the workshop ‘Titans of the Early Universe: The Origin of the First Supermassive Black Holes’.
The Upper Cretaceous Kanguk Formation of the Sverdrup Basin, Canadian Arctic Islands, contains numerous diagenetically altered volcanic ash layers (bentonites). Eleven bentonites were sampled from an outcrop section on Ellesmere Island for U–Pb zircon secondary ion mass spectrometry dating and whole-rock geochemical analysis. Two distinct types of bentonite are identified from the geochemical data. Relatively thick (0.1 to 5 m) peralkaline rhyolitic to trachytic bentonites erupted in an intraplate tectonic setting. These occur throughout the upper Turonian to lower Campanian (c. 92–83 Ma) outcrop section and are likely associated with the alkaline phase of the High Arctic Large Igneous Province. Two thinner (<5 cm) subalkaline dacitic to rhyolitic bentonites of late Turonian to early Coniacian age (c. 90–88 Ma) are also identified. The geochemistry of these bentonites is consistent with derivation from volcanoes within an active continental margin tectonic setting. The lack of nearby potential sources of subalkaline magmatism, together with the thinner bed thickness of the subalkaline bentonites and the small size of zircon phenocrysts therein (typically 50–80 μm in length) are consistent with a more distal source area. The zircon U–Pb age and whole-rock geochemistry of these two subalkaline bentonites correlate with an interval of intense volcanism in the Okhotsk–Chukotka Volcanic Belt, Russia. It is proposed that during late Turonian to early Coniacian times intense volcanism within the Okhotsk–Chukotka Volcanic Belt resulted in widespread volcanic ash dispersal across Arctic Alaska and Canada, reaching as far east as the Sverdrup Basin, more than 3000 km away.
A lasting legacy of the International Polar Year (IPY) 2007–2008 was the promotion of the Permafrost Young Researchers Network (PYRN), initially an IPY outreach and education activity by the International Permafrost Association (IPA). With the momentum of IPY, PYRN developed into a thriving network that still connects young permafrost scientists, engineers, and researchers from other disciplines. This research note summarises (1) PYRN’s development since 2005 and the IPY’s role, (2) the first 2015 PYRN census and survey results, and (3) PYRN’s future plans to improve international and interdisciplinary exchange between young researchers. The review concludes that PYRN is an established network within the polar research community that has continually developed since 2005. PYRN’s successful activities were largely fostered by IPY. With >200 of the 1200 registered members active and engaged, PYRN is capitalising on the availability of social media tools and rising to meet environmental challenges while maintaining its role as a successful network honouring the legacy of IPY.
This article investigates to what extent austerity-oriented measures introduced in the Portuguese health sector during the recent economic crisis were associated with changes in the public opinion on healthcare. We conducted multivariate regression analyses of cross-sectional, biannual data from the European Social Survey (2002–2015) for 13,271 individuals living in private households in Portugal. In line with our expectations, healthcare evaluations of the general population improved until 2010 but declined with the implementation of comprehensive austerity measures introduced under the Memorandum of Understanding after 2011. Healthcare evaluations of vulnerable social groups – older and retired individuals, individuals with poor health, low income and education – declined particularly strongly. In addition, differences in healthcare evaluations between more and less vulnerable social groups were more pronounced after 2011. Interestingly, healthcare evaluations of the general population and of some of the most vulnerable groups ‘recovered’ in 2015, when most of the Memorandum measures were implemented. Our findings contribute to the literature on the effects of austerity measures on welfare attitudes and stress the need to analyse the differential impact of crisis-induced welfare state reforms across social groups.
We examined the radiocarbon (14C) reservoir effect in Lake Kutubu using tephrochronology and terrestrial plant material to deliver a precise age-depth profile and sedimentation rates for this lake. Based on the presence of two tephra horizons (Tibito and Olgaboli), we found a reservoir age offset in sediments of between 1490 and 2280 14C yr using the sediment ages derived from the lead-210 (210Pb) dating method. The live submerged biological samples collected exhibited a higher reservoir age offset than the sediment. This is most likely a result of delayed transport of “bomb” 14C from the atmosphere to aquatic and sedimentary system. The 14C reservoir effect increased with distance from the lake inlet and also decreased with depth. Dissolution of 14C-depleted carbon from surrounding limestone and direct in-wash of old soil or vegetation remnants from the catchment are the most likely causes of the 14C reservoir effect. Based on limestone areas mapped in Papua New Guinea, we indicate lakes which may be subject to a significant 14C reservoir effect. The results of this study demonstrate the magnitude of the 14C reservoir effect in lakes and provide insights to the correct interpretation of past environmental and archaeological events in PNG.
Data on the efficacy of alternative fumigants to methyl bromide for weed control in perennial crop nurseries in California are needed because few herbicides are registered for this purpose. Field studies were conducted from 2003 to 2006 in four commercial perennial crop nurseries in California. Treatments included a nonfumigated control; methyl bromide (98%) (MeBr) with high-density polyethylene (HDPE) film; iodomethane (50%) + chloropicrin (50%) with HDPE film; 1,3-dichloropropene (1,3-D) with HDPE film; 1,3-D (61%) + chloropicrin (35%) with HDPE film; 1,3-D (62%) + chloropicrin (35%) subsurface drip; and 1,3-D (61%) + chloropicrin (35%) with virtually impermeable film (VIF). All the fumigants reduced the seed viability of common purslane, johnsongrass, and tall morningglory but were not as effective on little mallow and field bindweed. Although total weed densities and the level of control provided by each fumigant differed between locations, weed density was generally reduced by all the fumigation treatments, compared to the nonfumigated control. At three locations, alternative fumigation treatments usually resulted in hand-weeding time similar to MeBr. Reductions in weed seed viability, weed emergence, and weed densities suggest that these alternative fumigants will provide weed control similar to MeBr in perennial nurseries.
Larval and juvenile growth stages of myoconchid bivalves (family Kalenteridae) are illustrated and described for the first time. Excellently preserved shells of Myoconcha crassa J. Sowerby, 1824 from the middle Bathonian (Middle Jurassic) clay/silt deposits of southern Poland reveal that the prodissoconch in this taxon is large (exceeding 350 µm in length) and characterized by a prominent, collar-like structure arising from the demarcation to the dissoconch. Similar prodissoconch morphology has not been described previously in any other bivalve genus. The large size and absence of a prodissoconch II strongly suggest a non-planktotrophic development of the larvae, indicating either simple lecithotrophy or long-term brooding and parental care for the larvae in this species. Consequently, the new discovery constitutes the earliest well-documented record of non-planktotrophic development in the Bivalvia. The shell of Myoconcha crassa is composed of an outer cross-lamellar layer and an inner complex cross-lamellar layer. This composition suggests that the Kalenteridae may be included in the Carditida rather than the Palaeoheterodonta or Anomalodesmata. The genus Pseudomyoconcha Rossi Ronchetti and Allasinaz, 1966 is rejected herein and considered as a junior synonym of Myoconcha J. Sowerby, 1824.
Information technology (IT) is no longer the exclusive domain of engineers operating out of basement server rooms. It is part of every worker's daily life and the invisible platform on which they perform. Although the role of the systems librarian emerged when librarians first moved from card catalogues to online public access catalogues (OPACs) there has traditionally been a firm division between the library or information service and the IT department. The one provides information, the other behind-the-scenes back-up and development. Yet, as the name might suggest, the information relies on the technology and, as far as the end-user is concerned, they provide the same product or service. There is every advantage in having a good relationship between an information service and an IT department to make sure that the two work together seamlessly. A more recent development is the information professional with strong IT skills who takes on a hybrid role, whether formally, as part of their job description, or simply as a practical means of delivering information services. The authors of this chapter both define themselves as information professionals, but have used their technical skills to inhabit or create hybrid IT roles combining elements of ‘info pro’ and ‘IT pro’. They draw on their experience and that of an increasing network of similar hybrids to share the advantages and possible approaches to working with technology as an information professional.
The rise of the cyborgs
‘Technology is everywhere.’ How often have you heard this phrase, which evokes such an immediate affirmation from those with whom you communicate? We are surrounded by technology and we want to take it with us everywhere, with increasing use of mobile devices and wearable computing contributing to this trend. The ultimate purpose of all of that technology, especially mobile technology, is to bring information and knowledge to users on demand.
More informally, increasing numbers of information professionals are people whose lives are integrated with and supplemented by the technologies they use every day. The growth in the adoption of ever-present devices like smart phones and tablets, and the development of fully ubiquitous computing, sometimes called ‘everyware’ (Greenfield, 2006) like Apple’s iWatch or augmented reality products like Google Glass, will lead to further technological and informational integration.
The B fields in OB stars (BOB) survey is an ESO large programme collecting spectropolarimetric observations for a large number of early-type stars in order to study the occurrence rate, properties, and ultimately the origin of magnetic fields in massive stars. As of July 2014, a total of 98 objects were observed over 20 nights with FORS2 and HARPSpol. Our preliminary results indicate that the fraction of magnetic OB stars with an organised, detectable field is low. This conclusion, now independently reached by two different surveys, has profound implications for any theoretical model attempting to explain the field formation in these objects. We discuss in this contribution some important issues addressed by our observations (e.g., the lower bound of the field strength) and the discovery of some remarkable objects.
Although there is much written on the emotional labour of nursing, there is little research grounded in the experience of so-called ‘unqualified’ care assistants. This paper is drawn from an ethnographic study conducted with care assistants on three dementia care wards in one mental health trust within the United Kingdom National Health Service (NHS). We describe the emotional labour carried out by care assistants in their attempts to provide personalised care for people whose cognitive degeneration renders conventional relationship-building very difficult, produces unpredictable ‘challenging behaviour’ and calls into question the notion of ‘feeling rules’. This context requires the ability to strike a balance between emotional engagement and detachment, and it is the complexities of this relationship that are the focus of this paper, arguing that a degree of detachment is a prerequisite to engagement in this context. In conclusion, we argue that the contribution of care assistants in this context needs to be better acknowledged, supported and remunerated.