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Cumulative stress exposure is extensively involved in carcinogenesis. However, cancer risk associated with allostatic load (AL), a valid measure of chronic stress, has not been comprehensively evaluated in large cohorts, and the combined effect of AL and personality trait on cancer risk remains unknown.
Methods
This prospective cohort study was conducted based on 245,683 participants from the UK Biobank, with a median follow-up of 13.5 years. The AL score was calculated based on 11 biomarkers. Personality traits were constructed and categorized into two clusters. Multivariable Cox regression model was used to assess the risk of incident cancer according to AL and personality clusters, and multiplicative and additive interactions were evaluated.
Results
High AL was associated with an increased cancer risk compared to low AL (hazard ratio [HR] = 1.06, 95% confidence interval [CI]: 1.04–1.09), particularly for cancers of stomach, liver, kidney, esophageal, lung, colorectal, breast, and leukemia (HR ranged from 1.08 to 1.43). Personality clusters was associated with risk of lung cancer (HR = 1.14, 95% CI: 1.05–1.23), but not overall cancer. Significant synergistic interaction was observed between high AL and ‘nervous-dominant’ personality for overall cancer risk, with the strongest association observed for liver cancer (HR = 1.58, 95% CI: 1.24–2.02).
Conclusions
High AL was related to higher risks of overall cancer and site-specific cancers, particularly when combined with nervous-dominant personality, highlighting the interplay between chronic physiological stress and psychological factors in cancer development.
Oxidative stress is an important pathomechanism in psoriasis, and the oxidative balance score (OBS) serves as a standardised metric for assessing systemic oxidative status, but its association with psoriasis is unclear. This study included 18 023 adults from the National Health and Nutrition Examination Survey to investigate the relationship between OBS and psoriasis. After using a complex sampling weighting method, we performed multi-model logistic regression and stratified analysis with OBS as the exposure and psoriasis as the outcome for the primary analysis. Restricted cubic spline (RCS) plots were used to evaluate potential non-linear associations between OBS and psoriasis. In addition, we performed replication analyses using two 24-h dietary records data as a sensitivity test to ensure robustness of the results. Multi-model logistic regression analyses revealed no statistically meaningful link between OBS and psoriasis prevalence when accounting for all confounders (P > 0·05), but in stratified analyses, OBS demonstrated a significant association with reduced risk of psoriasis in individuals aged 60–80 years (OR = 0·27–0·35, P < 0·05). As part of the overall OBS, moderate dietary OBS demonstrated an association with reduced psoriasis risk in 60- to 80-year-olds (OR = 0·39–0·43, P < 0·05). Lifestyle OBS (LOBS) indicates a significant negative correlation with psoriasis risk among the ‘Other Hispanic’ group. (Q3 OR = 0·23, P < 0·05). The RCS showed a non-linear relationship between LOBS and psoriasis (non-linear P = 0·013). This study provides the first systematic confirmation of an association between OBS and a reduced risk of psoriasis in elderly populations and specific ethnic groups. These findings offer new insights and directions for the prevention and treatment of psoriasis.
This study examines the interplay between welfare stigma and need in the decision to claim social welfare benefits in Hong Kong, a liberal welfare city where self-reliance and family obligations are highly valued. Our interviews with seventeen low-income parents, suggest that first, their availability and ability to work influence their self-perceived ‘deservingness’ of aid. This, in turn, affects their anticipated self-stigma and their assessment of needs. Second, having children influences parents’ decisions to claim social welfare benefits through both anticipated stigma and childcare needs. Finally, low-income parents are trapped in an impossible triangle of being a ‘good’ parent, caught between fulfilling parental responsibilities, providing for their children financially, and modeling self-reliance to protect them from welfare stigma. Claiming benefits fulfills the first two but sacrifices self-reliance, while choosing not to claim fulfills the latter two but sacrifices parental responsibilities. Both choices carry emotional consequences that can undermine parent-child relationships.
To advance the understanding of how e-government resources drive e-participation, the current research conducts a meta-analysis on the relationship above from the perspective of citizen experience. This meta-analysis synthesizes 517 effect sizes from 126 empirical studies to examine how e-government resources influence citizens’ e-participation intention. The findings highlight several key variables that moderate this effect. Specifically: (1) From the perspective of the experience channel, e-government resources are more effective in facilitating citizen e-participation intention when delivered through social (vs. official) channels. (2) From the perspective of the experience affair, e-government resources exert a stronger impact on citizen e-participation intention when targeting specific (vs. general) public affairs and when focusing on regional (vs. national) government affairs. (3) From the perspective of the experience environment, the effect of e-government resources on e-participation intention is stronger in developing (vs. developed) countries. Based on these findings, this study offers implications for governments and researchers and suggests directions for future research.
Social scientists have quickly adopted large language models (LLMs) for their ability to annotate documents without supervised training, an ability known as zero-shot classification. However, due to their computational demands, cost, and often proprietary nature, these models are frequently at odds with open science standards. This article introduces the Political Domain Enhanced BERT-based Algorithm for Textual Entailment (DEBATE) language models: Foundation models for zero-shot, few-shot, and supervised classification of political documents. As zero-shot classifiers, the models are designed to be used for common, well-defined tasks, such as topic and opinion classification. When used in this context, the DEBATE models are not only as good as state-of-the-art LLMs at zero-shot classification, but are orders of magnitude more efficient and completely open source. We further demonstrate that the models are effective few-shot learners. With a simple random sample of 10–25 documents, they can outperform supervised classifiers trained on hundreds or thousands of documents and state-of-the-art generative models. Additionally, we release the PolNLI dataset used to train these models—a corpus of over 200,000 political documents with highly accurate labels across over 800 classification tasks.
This study uses a coupled lattice Boltzmann and discrete element method to perform interface-resolved simulations of turbulent channel flow laden with finite-size cylindrical particles. The aim is to investigate interactions between wall-bounded turbulence and non-spherical particles with sharp edges. The particle-to-fluid density ratio is unity and gravity is neglected. Comparative analyses are conducted among long (length-to-diameter aspect ratio 2), unit (1) and short ($ 1/2 $) cylinders, along with spheres and literature data for spheroids. Results reveal both shared and distinct dynamic behaviours of cylinders and their effects on turbulence modulation. Notably, disk-like short cylinders can remain trapped near the wall due to their flat faces aligning closely with it – a behaviour unique to particles with sharp edges. Long and unit cylinders, as well as spheres, preferentially accumulate in high-speed streaks, while short cylinders cluster in low-speed streaks, demonstrating a strong aspect-ratio effect. Near the wall, long cylinders align their axis with the streamwise direction, while short cylinders orient perpendicular to the wall. Rotationally, long cylinders primarily spin, whereas short ones predominantly tumble. These trends arise from orientation preferences and differences in axial and spanwise moments of inertia. Cylindrical particles increase wall drag compared with the single-phase case, with short cylinders causing the greatest enhancement due to strong near-wall accumulation. Overall, the influence of aspect ratio on particle dynamics and turbulence modulation is more pronounced for cylindrical particles than for spheroidal ones.
Drawing on insights from sociology and new institutional economics, Extralegal Governance provides the first comprehensive account of China's illegal markets by applying a socio-economic approach. It considers social legitimacy and state repression in examining the nature of illegal markets. It examines how power dynamics and varying levels of punishment shape exchange relationships between buyers and sellers. It identifies context-specific risks and explains how private individuals and organizations address these risks by developing extralegal governance institutions to facilitate social cooperation across various illegal markets. Adopting a multiple-case study design to sample China's illegal markets, this book utilizes four cases - street vending, small-property-rights housing, corrupt exchanges, and online loan sharks - to examine how market participants foster cooperation and social order in illegal markets.
Aerothermal issues in hypersonic transitional swept shock wave/boundary-layer interactions (SBLIs) are critical for the structural safety of high-speed vehicles but remain poorly understood. In this work, previously scarce, high-resolution heat transfer distributions of the hypersonic transitional swept SBLIs, are obtained from fast-responding temperature-sensitive paint (fast TSP) measurements. A series of $34^\circ$ compression ramps with sweep angles ranging from $0^\circ$ to $45^\circ$ are tested in a Mach 12.1 shock tunnel, with a unit Reynolds number of 3.0 $\times$ 10$^{6}$ m$^{-1}$. The fast TSP provides a global view of the three-dimensional aerothermal effects on the ramps, allowing in-depth analysis on the sweep effects and the symmetry of heat transfer. The time-averaged results reveal that the heat flux peak near reattachment shifts upstream with decreasing amplitude as the sweep angle increases, and a second peak emerges in the $45^\circ$ swept ramp due to a type V shock–shock interaction. Downstream of reattachment, the heat flux streaks induced by Görtler-like vortices weaken with increasing sweep angle, whereas their dominant projected wavelengths show little dependence on sweep angle or spanwise location. Away from the ramp’s leading side, the transition onset of the reattached boundary layer gradually approaches the reattachment point. Finally, a general quasi-conical aerothermal symmetry is identified upstream of reattachment, although spanwise variations in transition onset, shock–shock interaction and heat flux streaks are found to disrupt this symmetry downstream of reattachment with varying degrees.
The study aimed to utilise internet big data to quantify the taste preferences of residents in Fujian Province and to explore the relationship between dietary taste preferences and hospitalisation rates for digestive system cancers.
Design:
The study employed an associative design using internet big data to analyse dietary behaviour and its association with hospitalisation rates for digestive system cancers. GeoDetector methods were used to compare the association between rural residents’ hospitalisation rates and their taste preferences.
Setting:
This study utilised internet recipe data to collect cuisines taste information. By integrating this with categorised restaurant data from point of interest sources across various regions in Fujian province, it quantitatively analysed the regional taste preferences of people.
Participants:
Data from seventy-two counties in Fujian cover most of the province. Included 154 686 hospitalisation records for digestive system cancers (2010–2016) from the New Rural Cooperative Medical Scheme database, 16 363 recipes from Internet and data from 30 984 restaurants through Amap.
Results:
The study found pungent to be the prevalent taste in Fujian, with salty, spicy and sour following. Coastal areas favoured stronger tastes. Spatial analysis showed taste preferences clustered geographically, with Sour and Fat tastes having an association with liver and colorectal cancer (CC) hospitalisations, though with modest association values (0·110–0·199).
Conclusions:
The study found significant spatial clustering of taste preferences in Fujian Province and an association between Sour and Fat tastes preference and hospitalisation rates for liver and CC, suggesting a dietary taste–cancer link.
Recent advancements in random distributed feedback Raman fiber lasers have promoted random Raman fiber lasers (RRFLs) as a novel laser source with significant progress. However, fully open cavity RRFLs suffer from suboptimal Stokes conversion efficiency and output power due to mode mismatch limitations. In this paper, we demonstrate the impact of end feedback and mode control on output Stokes wave characteristics. The random laser model incorporating multimode Raman interactions was established to theoretically simulate end feedback and output modal properties. Experimental studies were demonstrated through the construction of a fully open cavity RRFL. Higher end feedback reduces forward-propagating Stokes waves while amplifying backward-propagating light intensity. Transmission modes were effectively controlled through the design and optimization of tapered fiber. Consequently, 2081 W random Raman lasing was achieved in the fully open cavity RRFL. At maximum power, spectral purity exceeded 90%, representing the maximum output power reported for fully open cavity random lasers. This work provides important guidance for high-power laser generation and investigations of multimode nonlinear effects.
The emergence, on the Loess Plateau of Central China, of settlements enclosed by circular ditches has engendered lively debate about the function of these (often extensive) ditch systems. Here, the authors report on a suite of new dates and sedimentological analyses from the late Yangshao (5300–4800 BP) triple-ditch system at the Shuanghuaishu site, Henan Province. Exploitation of natural topographic variations, and evidence for ditch maintenance and varied water flows, suggests a key function in hydrological management, while temporal overlap in the use of these three ditches reveals the large scale of this endeavour to adapt to the pressures of the natural environment.
This paper presents the first reported design of a balanced nonreciprocal bandpass filter with both common-mode (CM) and differential-mode (DM) reflectionless characteristics. The nonreciprocal behavior is achieved using a time-modulated resonator, which isolates in-band backward interference signals, thereby protecting preceding circuits from their negative effects. To solve the negative effects of reflected waves of the reflection-based CM noise suppression and reflection-based DM stopband attenuation, CM and DM reflectionless structures are integrated at both the input and output ports, ensuring reflectionless operation for both CM and DM signals. Meanwhile, the implementation of DM reflectionless characteristics effectively addresses the issue of reflection zero degradation typically observed in time-modulated resonator-based nonreciprocal filters. The proposed filter exclusively transmits differential forward signals, which will greatly improve the anti-interference ability and stability of the balanced RF circuits. To validate the concept experimentally, a 1.5-GHz microstrip prototype is designed, simulated, fabricated, and characterized.
Natural enemies serve a crucial role in crop protection through the regulation of pest population dynamics. Cyrtorhinus lividipennis is an important natural enemy of rice planthoppers. Fatty acid synthase (FAS), a multifunctional enzyme crucial for fatty acid biosynthesis, serves as a vital energy source for insect reproduction. However, the function of FAS in the reproductive processes of C. lividipennis remains incompletely understood. In this study, the ClFAS gene was successfully cloned from C. lividipennis. The open reading frame of ClFAS was 7224 bp, encoding a putative protein of 2407 amino acids. The expression levels of ClFAS were notably elevated in the fifth-instar nymphs, adults, as well as in the fat body and ovaries of female individuals. Silencing of ClFAS resulted in a reduction of 58.4%, 34.6%, and 49.0% in the expression levels of ClVg at 1-, 2-, and 3-days post-dsRNA injection, respectively. Furthermore, RNA interference (RNAi)-mediated depletion of ClFAS not only suppressed the Vg protein expression but also significantly impaired oocyte maturation and ovarian development. The fecundity of dsFAS-treated C. lividipennis females was markedly reduced by 49.5%, accompanied by significant decreases of 32.7% in oviposition duration and 26.3% in female adult lifespan. Our findings showed that ClFAS positively regulates the reproduction of C. lividipennis by promoting vitellogenesis and ovarian development, which provides valuable insights into how lipid metabolism governs fecundity in predatory insects.