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In this paper, we numerically investigate the orbit dynamics of three-dimensional symmetric Janus drops in shear flow using an improved ternary-fluids phase field method, focusing on how drop deformation and initial orientation affect the orbit drift of two configurations of Janus drops: dumbbell-shaped and near-spherical. We find that the motion of dumbbell-shaped drops eventually evolves into tumbling, while near-spherical drops attain stable spinning. We attribute this bifurcation in orbit drift to contrasting deformation dynamics and shape-dependent hydrodynamics of the two configurations. Specifically, the drift bifurcation is closely related to the aspect ratio of Janus drops at equilibrium, giving rise to two distinct mechanisms: (1) coupling between outer interface deformation and the surrounding flow field; and (2) interplay between inner interface deformation and vortices enclosed within the drop. In addition, we observe that for the dumbbell-shaped Janus drops with different aspect ratios, their tumbling dynamics resembles ellipsoids in shear flow. Moreover, the trajectories of the dumbbell-shaped Janus drops during orbit drift collapse onto a universal curve, independent of their initial orientations, and significant deformation and inertia accelerate the orbit transition. To quantitatively evaluate the effect of drop deformation on the orbit drift of the dumbbell-shaped Janus drops, we propose an effective aspect ratio model based on the drop shapes at equilibrium and at the maximum elongation. By incorporating the effective aspect ratio into Jeffery’s theory for solid particles, we accurately predict the rotation period and angular velocity of Janus drops in the tumbling regime and during the orbit drift, especially for drops with linear deformation. Moreover, the orbit parameter $C$ is found to vary exponentially with time for drops with linear deformation, while the time variation of $C$ transits from one exponential function to another for drops with nonlinear deformation.
This study uses a coupled lattice Boltzmann and discrete element method to perform interface-resolved simulations of turbulent channel flow laden with finite-size cylindrical particles. The aim is to investigate interactions between wall-bounded turbulence and non-spherical particles with sharp edges. The particle-to-fluid density ratio is unity and gravity is neglected. Comparative analyses are conducted among long (length-to-diameter aspect ratio 2), unit (1) and short ($ 1/2 $) cylinders, along with spheres and literature data for spheroids. Results reveal both shared and distinct dynamic behaviours of cylinders and their effects on turbulence modulation. Notably, disk-like short cylinders can remain trapped near the wall due to their flat faces aligning closely with it – a behaviour unique to particles with sharp edges. Long and unit cylinders, as well as spheres, preferentially accumulate in high-speed streaks, while short cylinders cluster in low-speed streaks, demonstrating a strong aspect-ratio effect. Near the wall, long cylinders align their axis with the streamwise direction, while short cylinders orient perpendicular to the wall. Rotationally, long cylinders primarily spin, whereas short ones predominantly tumble. These trends arise from orientation preferences and differences in axial and spanwise moments of inertia. Cylindrical particles increase wall drag compared with the single-phase case, with short cylinders causing the greatest enhancement due to strong near-wall accumulation. Overall, the influence of aspect ratio on particle dynamics and turbulence modulation is more pronounced for cylindrical particles than for spheroidal ones.
Cosmogenic 7Be and 10Be are effective tracers for studying atmospheric dynamics and Earth’s surface processes, with over 90% of these isotopes reaching the surface via wet deposition. However, the characteristics and influencing factors of 7Be and 10Be wet deposition remain unclear in different regions, limiting the precision of these nuclides as tracers of environmental change. This study analyzes the annual variation of 7Be and 10Be wet deposition in Xi’an and examines the impact of precipitation on their deposition. Ultra-trace levels of 7Be and 10Be in precipitation were synchronously measured using state-of-the-art accelerator mass spectrometry. One-year (July 30, 2020 to September 3, 2021), high-frequency (individual rain events) and time-synchronized series of observations of 7Be and 10Be wet deposition data (n = 49) were analyzed. The total annual wet deposition fluxes of 7Be and 10Be in central China (34.22°N, 109.01°E) for 2020/21 were (218 ± 24) × 108 atoms·m–2·yr–1 and (314 ± 16) × 108 atoms·m–2·yr–1, respectively. Precipitation amount, intensity, and duration were quantitatively analyzed for their effects on total wet deposition flux, mean concentration, washout ratio, deposition velocity, and scavenging coefficient of 7Be and 10Be during individual rain events. The results indicate that precipitation amount is the most significant factor influencing the wet deposition flux of both nuclides.
In this work, we conduct particle-resolved direct numerical simulations to investigate the influence of particle inertia on the settling velocity of finite-size particles at low volume fraction in homogeneous isotropic turbulence across various settling numbers. Our results for finite-size particles show only reductions of settling velocity in turbulence compared to the corresponding laminar case. Although increased particle inertia significantly reduces the lateral motion of particles and fluctuations in settling velocity, its effect on the mean settling velocity is not pronounced, except when the settling effect is strong, where increased particle inertia leads to a noticeable reduction. Mechanistically, the nonlinear drag effect, which emphasises contributions from large turbulent scales, cannot fully account for the reduction in settling velocity. The influence of small-scale turbulence, particularly through interactions with the particle boundary layer, should not be overlooked. We also analyse the dependency of turbulence’s modification on particle settling velocity within a broader parameter space, encompassing both sub-Kolmogorov point particles and finite-size particles. Additionally, we develop a qualitative model to predict whether turbulence enhances or retards the settling velocity of particles.
The cycling of carbon in riverine systems is a critical component of global carbon cycle research. However, the sources and performances of riverine carbon in the Qinling Mountains, a pivotal hydrological nexus in China, remain poorly understood. This study investigates the seasonal variations of dissolved organic carbon (DOC) concentration in the Tianyu River within the Qinling Mountains. By utilizing a combination of carbon isotopic signatures (Δ14C-δ13C) and the stepped-combustion method, we examined the sources of DOC and the contribution ratio of each end-member. Our findings reveal that: (1) the concentrations and dual carbon isotope ratios of DOC in the Tianyu River are influenced by regional climatic factors, exhibiting distinct seasonal patterns; (2) the 14C age of DOC in the Tianyu River is comparatively older than the global average for rivers but younger than that of China’s three major rivers (the Yellow, Yangtze, and Pearl Rivers); and (3) the DOC mainly comes from exogenous sources, with a proportion of about 85.8%–88.4%. Vegetation and riverine sediments are identified as primary contributors. These findings suggest that exemplary ecological preservation exists within the Qinling region while operating within an efficient carbon cycling system. This investigation provides initial insights into how regional climatic conditions influence riverine carbon cycles and enhances our understanding of biogeochemical processes related to carbon.
Taihe silk chicken (Gallus gallus domesticus Brisson) are prized for their nutritional value but face challenges like low productivity and feed efficiency. Broussonetia papyrifera (BP), rich in nutrients, is mainly used in ruminant feed. This study investigates the effects of fermented BP (FBP) on the laying performance, egg quality, and gut microbiota of Taihe silk chicken during peak laying period. A total of 240 chickens were randomly assigned to four treatments (five replicates/treatments) with a basal diet (CON), a basal diet + 2% FBP (T2), a basal diet + 4% FBP (T4), and a basal diet + 8% FBP (T8) for 75 d. Results showed that the average daily feed intake and yolk color in the 8% FBP group were significantly increased by 12.21% and 11.78%, respectively (P < 0.05). Yolk folate content of the 4% and 8% FBP groups was significantly increased by 32.73% and 59.76%, respectively (P < 0.05). Zinc content in the yolk of the 8% FBP group was significantly increased by 14.22% (P< 0.05). The FBP group influenced the fatty acid composition of the yolk, and 8% FBP significantly decreased the n-6 unsaturated fatty acid (PUFA) to n-3 PUFA ratio (P< 0.05). FBP also increased the ratio of villus height, and crypt depth significantly increased in the duodenum, jejunum and ileum (P< 0.05). The 16S rRNA sequencing revealed that FBP altered cecal microbiota, increasing the relative abundance of Bacteroides, Rikenellaceae_RC9_gut_group, and Alistipes, while reducing the relative abundance of Olsenella and Ruminococcaceae UCG-005. Correlation analysis suggests that the FBP may enhance the growth performance and egg composition by modulating gut microbiota. In conclusion, this study confirms that adding FBP to the diet improves egg quality, composition, intestinal structure, and gut microbiota in Taihe silk chicken. These insights are valuable for optimizing FBP utilization in Taihe silk chicken production.
The ubiquitous marine radiocarbon reservoir effect (MRE) constrains the construction of reliable chronologies for marine sediments and the further comparison of paleoclimate records. Different reference values were suggested from various archives. However, it remains unclear how climate and MREs interact. Here we studied two pre-bomb corals from the Hainan Island and Xisha Island in the northern South China Sea (SCS), to examine the relationship between MRE and regional climate change. We find that the MRE from east of Hainan Island is mainly modulated by the Southern Asian Summer Monsoon-induced precipitation (with 11.4% contributed to seawater), rather than wind induced upwelling. In contrast, in the relatively open seawater of Xisha Island, the MRE is dominated by the East Asian Winter Monsoon, with relatively more negative (lower) ΔR values associated with high wind speeds, implying horizontal transport of seawater. The average SCS ΔR value relative to the Marine20 curve is –161±39 14C years. Our finding highlights the essential role of monsoon in regulating the MRE in the northern SCS, in particularly the tight bond between east Asian winter monsoon and regional MRE.
Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.
Aims
Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.
Method
We examined average and modal controllability of the brain's functional connectome in 161 patients with schizophrenia, 37 unaffected siblings and 96 healthy controls during a two-back task. We use one-way analysis of variance to detect the regions with group differences, and correlated aberrant controllability to task performance and clinical characteristics. Regions affected in both unaffected siblings and patients were selected for gene and functional annotation analysis.
Results
Both average and modal controllability during the two-back task are reduced in patients compared to healthy controls and siblings, indicating a disruption in both proximal and distal state transitions. Among patients, reduced average controllability was prominent in auditory, visual and sensorimotor networks. Reduced modal controllability was prominent in default mode, frontoparietal and salience networks. Lower modal controllability in the affected networks correlated with worse task performance and higher antipsychotic dose in schizophrenia (uncorrected). Both siblings and patients had reduced average controllability in the paracentral lobule and Rolandic operculum. Subsequent out-of-sample gene analysis revealed that these two regions had preferential expression of genes relevant to bioenergetic pathways (calmodulin binding and insulin secretion).
Conclusions
Aberrant control of brain state transitions during task execution marks working memory deficits in patients and their siblings.
The stability of Taylor–Couette flow modulated by oscillatory wall suction/blowing is investigated using Floquet linear stability analysis. The growth rate and stability mode are obtained by numerical calculation and asymptotic expansion. By calculating the effect of wall suction/blowing on the critical mode of steady Taylor–Couette flow, it is found that for most suction/blowing parameters, the maximum disturbance growth rate of the critical mode decreases and the flow becomes more stable. Only in a very small parameter region, wall suction/blowing increases the maximum disturbance growth rate of the critical mode, resulting in flow instability when the gap between the cylinders is large. The asymptotic results for small suction/blowing amplitudes indicate that the change of flow instability is mainly due to the steady correction of the basic flow induced by the modulation. A parametric study of the critical inner Reynolds number and the associated critical wavenumber is performed. It is found that the flow is stabilized by the modulation for most of the parameter ranges considered. For a wide gap between the cylinders, it is possible for the system to be mildly destabilized by weak suction/blowing.
In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.
Methods
To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities. We hypothesize that individualized ALFF abnormalities can be portrayed as a unique linear combination of shared differential factors. Our study involved two large multi-center datasets, comprising 2424 patients with MDD and 2183 healthy controls. In patients, individualized ALFF abnormalities were derived through normative modeling and further deconstructed into differential factors using non-negative matrix factorization.
Results
Two positive and two negative factors were identified. These factors were closely linked to clinical characteristics and explained group-level ALFF abnormalities in the two datasets. Moreover, these factors exhibited distinct associations with the distribution of neurotransmitter receptors/transporters, transcriptional profiles of inflammation-related genes, and connectome-informed epicenters, underscoring their neurobiological relevance. Additionally, factor compositions facilitated the identification of four distinct depressive subtypes, each characterized by unique abnormal ALFF patterns and clinical features. Importantly, these findings were successfully replicated in another dataset with different acquisition equipment, protocols, preprocessing strategies, and medication statuses, validating their robustness and generalizability.
Conclusions
This research identifies shared differential factors underlying individual spontaneous neural activity abnormalities in MDD and contributes novel insights into the heterogeneity of spontaneous neural activity abnormalities in MDD.
The aim of this 4-year follow-up study was to examine the predictive effects of demographics, three types of sexual stigma, three types of self-identity confusion, anxiety, depression, family support and problematic Internet use before the coronavirus disease 2019 (COVID-19) pandemic on new-onset suicide risk and persistent suicide risk in young adult lesbian, gay and bisexual individuals who experienced the COVID-19 pandemic in Taiwan.
Methods
Baseline data were collected from 1,000 lesbian, gay and bisexual individuals in 2018 and 2019. Outcome data on suicide risk were collected again in 2023. The suicide module of the Mini International Neuropsychiatric Interview was used to assess suicide risk in terms of thoughts of death, desire to self-harm, thoughts of suicide, plans for suicide and suicide attempts in the preceding month at the initial and follow-up assessments. Baseline three types of sexual stigma, self-identity disturbance, depression, anxiety and problematic Internet use were used to examine their prediction of new-onset suicide risk and persistent suicide risk at follow-up.
Results
In total, 673 individuals participated in the follow-up survey. Notably, 16.5% of the participants who had no suicide risk at baseline had new-onset suicide risk at follow-up; 46.4% of the participants who had suicide risk at baseline also had suicide risk at follow-up. Participants who were transgender (p = .003), who perceived greater levels of microaggression (p < .001), and who had greater levels of problematic Internet use at baseline (p = .024) were more likely to have new-onset suicide risk at follow-up. Participants who had greater levels of self-identity confusion were more likely to have persistent suicide risk at follow-up (p = .023).
Conclusion
Intervention strategies for reducing suicide risk in lesbian, gay and bisexual individuals should be developed with consideration of the predictors identified in this study.
This study conducts particle-resolved direct numerical simulations to analyse how finite-size spherical particles affect the decay rate of turbulent kinetic energy in non-sustained homogeneous isotropic turbulence. The decaying particle-laden homogeneous isotropic turbulence is generated with two set-ups, i.e. (1) releasing particles into a single-phase decaying homogeneous isotropic turbulence and (2) switching off the driving force of a sustained particle-laden homogeneous isotropic turbulence. With both set-ups, the decay of turbulent kinetic energy follows a power-law when the flow is fully relaxed, similar to their single-phase counterparts. The dependence of the power-law decay exponent $n$ on the particle-to-fluid density ratio, particle size and volume fraction is also investigated, and a predictive model is developed. We find that the presence of heavier particles slows down the long-time power-law decay exponent.
Although both psychological resilience and social support are widely believed to be effective in alleviating post-traumatic psychiatric symptoms in individuals with traumatic events, there has been a lack of comparative analysis of their intervention effects on different post-traumatic psychiatric symptoms. Furthermore, previous studies have mostly failed to control for potential confounding effects caused by different traumatic events.
Aims
We used the novel network analysis approach to examine the differential moderating effects of psychological resilience and social support on post-traumatic psychiatric symptoms, controlling for the confounding effects of traumatic events.
Method
We recruited 264 front-line rescuers who experienced the same traumatic event. Quantified edge weights and bridge expected influence (BEI) were applied to compare the alleviating effects of psychological resilience and social support.
Results
Our study revealed distinct correlations in a sample of front-line rescuers: social support negatively correlates more with psychosomatic symptoms, notably fatigue in depressive networks and sleep disturbance in post-traumatic stress disorder (PTSD) networks, whereas psychological resilience shows fewer such correlations. Quantitative analysis using BEI indicated that psychological resilience more effectively suppresses depressive and anxiety symptom networks, whereas social support more significantly inhibits PTSD symptom networks.
Conclusions
The current study represents the first attempt to examine the differential effects of psychological resilience and social support on post-traumatic outcomes in real-world emergency rescuers, controlling for the confounding effect of traumatic events. Our results can act as the theoretical reference for future precise and efficient post-trauma psychological interventions.
Head-up tilt test (HUTT) is an important tool in the diagnosis of pediatric vasovagal syncope. This research will explore the relationship between syncopal symptoms and HUTT modes in pediatric vasovagal syncope.
Methods:
A retrospective analysis was performed on the clinical data of 2513 children aged 3–18 years, who were diagnosed with vasovagal syncope, from Jan. 2001 to Dec. 2021 due to unexplained syncope or pre-syncope. The average age was 11.76 ± 2.83 years, including 1124 males and 1389 females. The patients were divided into the basic head-up tilt test (BHUT) group (596 patients) and the sublingual nitroglycerine head-up tilt test (SNHUT) group (1917 patients) according to the mode of positive HUTT at the time of confirmed pediatric vasovagal syncope.
Results:
(1) Baseline characteristics: Age, height, weight, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and composition ratio of syncope at baseline status were higher in the BHUT group than in the SNHUT group (all P < 0.05). (2) Univariate analysis: Age, height, weight, HR, SBP, DBP, and syncope were potential risk factors for BHUT positive (all P < 0.05). (3) Multivariate analysis: syncope was an independent risk factor for BHUT positive, with a probability increase of 121% compared to pre-syncope (P<0.001).
Conclusion:
The probability of BHUT positivity was significantly higher than SNHUT in pediatric vasovagal syncope with previous syncopal episodes.
SiO2 sols were made unstable by addition of Ca2+ ions. The resulting states of instability were classified as gelation, flocculation, and precipitation by means of observation, by checking the Tyndall effects on the supernatant or suspending solution, as appropriate, and by measuring the apparent densities of flocculated mass. The concentrations of free Ca2+ ions left in solution were measured by means of a Ca2+ ion selective electrode. The amounts sorbed onto SiO2 particles were then calculated by material balance. It was found that while the amount sorbed dictates the limit of stability, the SiO2 concentration in the mixture is an important factor deciding the state of instability. Depending on the SiO2 concentration, there were two distinct flocs with the apparent floc density of 6 ± 1 and 12 ± 1 mg SiO2/ml.
The preference for particles to accumulate at specific regions in the near-wall part is a widely observed phenomenon in wall-bounded turbulence. Unlike small particles more frequently found in low-speed streaks, finite-size particles can accumulate in either low-speed or high-speed streaks. However, mechanisms and influencing factors leading to the different preferential concentration locations still need to be clarified. The present study conducts particle-resolved direct numerical simulations of particle-laden turbulent channel flows to provide a better understanding of this seemingly puzzling behaviour of preferential accumulation. These simulations cover different particle-to-fluid density ratios, particle volume fractions, particle sizes and degrees of sedimentation intensity. We find that the large particle size is the crucial factor that results in particles accumulating in high-speed streaks. Large particles not only are difficult to be conveyed by the quasi-streamwise vortices to low-speed streaks but also can escape from the near-wall region before moving spanwisely out from high-speed streaks. The sedimentation effect allows particles to gather closer to the channel wall and stay longer in the near-wall regions, reinforcing the sweeping mechanism of quasi-streamwise vortices that transport particles from high- to low-speed streaks. As a result, sedimenting particles tend to accumulate in the low-speed streaks.
Accurately predicting neurosyphilis prior to a lumbar puncture (LP) is critical for the prompt management of neurosyphilis. However, a valid and reliable model for this purpose is still lacking. This study aimed to develop a nomogram for the accurate identification of neurosyphilis in patients with syphilis. The training cohort included 9,504 syphilis patients who underwent initial neurosyphilis evaluation between 2009 and 2020, while the validation cohort comprised 526 patients whose data were prospectively collected from January 2021 to September 2021. Neurosyphilis was observed in 35.8% (3,400/9,504) of the training cohort and 37.6% (198/526) of the validation cohort. The nomogram incorporated factors such as age, male gender, neurological and psychiatric symptoms, serum RPR, a mucous plaque of the larynx and nose, a history of other STD infections, and co-diabetes. The model exhibited good performance with concordance indexes of 0.84 (95% CI, 0.83–0.85) and 0.82 (95% CI, 0.78–0.86) in the training and validation cohorts, respectively, along with well-fitted calibration curves. This study developed a precise nomogram to predict neurosyphilis risk in syphilis patients, with potential implications for early detection prior to an LP.
Aphis spiraecola Patch is one of the most economically important tree fruit pests worldwide. The pyrethroid insecticide lambda-cyhalothrin is commonly used to control A. spiraecola. In this 2-year study, we quantified the resistance level of A. spiraecola to lambda-cyhalothrin in different regions of the Shaanxi province, China. The results showed that A. spiraecola had reached extremely high resistance levels with a 174-fold resistance ratio (RR) found in the Xunyi region. In addition, we compared the enzymatic activity and expression level of P450 genes among eight A. spiraecola populations. The P450 activity of A. spiraecola was significantly increased in five regions (Xunyi, Liquan, Fengxiang, Luochuan, and Xinping) compared to susceptible strain (SS). The expression levels of CYP6CY7, CYP6CY14, CYP6CY22, P4504C1-like, P4506a13, CYP4CZ1, CYP380C47, and CYP4CJ2 genes were significantly increased under lambda-cyhalothrin treatment and in the resistant field populations. A L1014F mutation in the sodium channel gene was found and the mutation rate was positively correlated with the LC50 of lambda-cyhalothrin. In conclusion, the levels of lambda-cyhalothrin resistance of A. spiraecola field populations were associated with P450s and L1014F mutations. Our combined findings provide evidence on the resistance mechanism of A. spiraecola to lambda-cyhalothrin and give a theoretical basis for rational and effective control of this pest species.
This study presents novel findings on stochastic electron heating via a random electron cyclotron wave (ECW) in a spherical tokamak. Hard x ray measurements demonstrate the time evolution of hard x ray counts at different energy bands, consistent with predictions from the stochastic heating model. The ECW heating rate shows a positive correlation with applied power, confirming the effectiveness of stochastic heating. Remarkably, the ECW-driven plasma current remains insensitive to ECW incidence angle, consistent with model predictions. The observed stochastic heating of electrons offers potential for exploring innovative non-inductive current drive modes in spherical tokamaks. This research contributes to the understanding of plasma behaviour and motivates the development of new models for non-inductive current drive in fusion devices.
Lower limb exoskeletons (LLEs) have demonstrated their potential in delivering quantified repetitive gait training for individuals afflicted with gait impairments. A critical concern in robotic gait training pertains to fostering active patient engagement, and a viable solution entails harnessing the patient’s intrinsic effort to govern the control of LLEs. To address these challenges, this study presents an innovative online gait learning approach with an appropriate control strategy for rehabilitation exoskeletons based on dynamic movement primitives (DMP) and an Assist-As-Needed (AAN) control strategy, denoted as DMP-AAN. Specifically tailored for post-stroke patients, this approach aims to acquire the gait trajectory from the unaffected leg and subsequently generate the reference gait trajectory for the affected leg, leveraging the acquired model and the patient’s personal exertion. Compared to conventional AAN methodologies, the proposed DMP-AAN approach exhibits adaptability to diverse scenarios encompassing varying gait patterns. Experimental validation has been performed using the lower limb rehabilitation exoskeleton HemiGo. The findings highlight the ability to generate suitable control efforts for LLEs with reduced human-robot interactive force, thereby enabling highly patient-controlled gait training sessions to be achieved.