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There is no clear evidence about how to support people with borderline personality disorder (BPD) during the perinatal period. Perinatal emotional skills groups (ESGs) may be helpful, but their efficacy has not been tested.
Aims
To test the feasibility of conducting a randomised controlled trial (RCT) of perinatal ESGs for women and birthing people with BPD.
Method
Two-arm parallel-group feasibility RCT. We recruited people from two centres, aged over 18 years, meeting DSM-5 diagnostic criteria for BPD, who were pregnant or within 12 months of a live birth. Eligible individuals were randomly allocated on a 1:1 ratio to ESGs + treatment as usual (TAU), or to TAU. Outcomes were assessed at 4 months post randomisation.
Results
A total of 100% of the pre-specified sample (n = 48) was recruited over 6 months, and we obtained 4-month outcome data on 92% of randomised participants. In all, 54% of participants allocated to perinatal ESGs attended 75% of the full group treatment (median number of sessions: 9 (interquartile range 6–11). At 4 months, levels of BPD symptoms (adjusted coefficient −2.0, 95% CI −6.2 to 2.1) and emotional distress (−2.4, 95% CI −6.2 to 1.5) were lower among those allocated to perinatal ESGs. The directionality of effect on well-being and social functioning also favoured the intervention. The cost of delivering perinatal ESGs was estimated to be £918 per person.
Conclusions
Perinatal ESGs may represent an effective intervention for perinatal women and birthing people with BPD. Their efficacy should be tested in a fully powered RCT, and this is a feasible undertaking.
Childhood adversity is associated with increased later mental health problems and suicidal behaviour. Opportunities for earlier healthcare identification and intervention are needed.
Aim
To determine associations between hospital admissions for childhood adversity and mental health in children who later die by suicide.
Method
Population-based longitudinal case-control study. Scottish in-patient general and psychiatric records were summarised for individuals born 1981 or later who died by suicide between 1991 and 2017 (cases), and matched controls (1:10), for childhood adversity and mental health (broadly defined as psychiatric diagnoses and general hospital admissions for self-harm and substance use).
Results
Records were extracted for 2477 ‘cases’ and 24 777 ‘controls’; 2106 cases (85%) and 13 589 controls (55%) had lifespan hospitalisations. Mean age at death was 23.7; 75.9% were male. Maltreatment or violence-related childhood adversity codes were recorded for 7.6% cases aged 10–17 (160/2106) versus 2.7% controls (371/13 589), odds ratio = 2.9 (95% CI, 2.4–3.6); mental health-related admissions were recorded for 21.7% cases (458/2106), versus 4.1% controls (560/13 589), odds ratio = 6.5 (95% CI, 5.7–7.4); 80% of mental health admissions were in general hospitals. Using conditional logistic models, we found a dose-response effect of mental health admissions <18y, with highest adjusted odds ratio (aOR) for three or more mental health admissions: aORmale = 8.17 (95% CI, 5.02–13.29), aORfemale = 15.08 (95% CI, 8.07–28.17). We estimated that each type of childhood adversity multiplied odds of suicide by aORmale = 1.90 (95% CI, 1.64–2.21), aORfemale = 2.65 (95% CI, 1.94–3.62), and each mental health admission by aORmale = 2.06 (95% CI, 1.81–2.34), aORfemale = 1.78 (95% CI, 1.50–2.10).
Conclusions
Our lifespan study found that experiencing childhood adversity (primarily maltreatment or violence-related admissions) or mental health admissions increased odds of young person suicide, with highest odds for those experiencing both. Healthcare practitioners should identify and flag potential ‘at-risk’ adolescents to prevent future suicidal acts, especially those in general hospitals.
Taking conflicts over new solar energy projects on the agricultural landscape in the global North as its backdrop, the chapter demonstrates how work and labour (including that performed in the North by workers from the global South) are erased both by the opponents and the proponents of such projects. The erasure is consistent with prevailing ways of knowing the human-environment nexus, shaped by an underlying political economy derivative of how international law has constructed and maintained the foundational liberal mythology that separates labour from land. Grounded in our commitment to pursuing a ‘just transition’ to decarbonisation – that is to say, a transition that attends to the distributional effects and disproportionate impacts of decarbonisation on workers and communities – we strive to reconceptualise work and labour as embodied practices of working and living on the land. Everyday socio-spatial practices structured by law implicate ordinary people in the making of landscapes and continuing relations of settler capitalism, shaping how ‘we’ live together on the land, including who belongs and who gets to decide.
Despite the numerous advantages of central venous catheters (CVCs), they have been associated with a variety of complications. Surveillance for mechanical complications of CVCs is not routine, so the true incidence and impact of this adverse patient outcome remains unclear.
Setting and methods:
Prospectively collected CVC data on mechanical complications were reviewed from a centralized database for all in-hospital patient days at our tertiary-care hospital from January 2001 to June 2016 in patients aged <19 years. Patient demographics, CVC characteristics, and rates of mechanical complications per 1,000 days of catheter use were described.
Results:
In total, 8,747 CVCs were placed in 5,743 patients during the study period, which captured 780,448 catheter days. The overall mechanical complication rate was 6.1 per 1,000 catheter days (95% confidence interval [CI], 5.9–6.3). The highest complication rates were in nontunneled lines; this was consistent throughout the 15-year study period. Also, 521 CVCs (∼6%) were removed due to mechanical complications before therapy termination. Catheters with tip location in the superior vena cava or right atrium had the fewest complications.
Conclusions:
Mechanical complications of CVCs are a common and significant event in the pediatric population. We propose that CVC-associated mechanical complications become a routinely reported patient safety outcome.
There is growing involvement of Indigenous communities in renewable energy development across their traditional territories in what is now called Canada.1 Here, we explore Indigenous participation in large-scale “green” energy generation as a response to encroachment, displacement, and dispossession wrought by the extractivist orientation of contemporary settler capitalism.
Small food store interventions show promise to increase healthy food access in under-resourced areas. However, none have tested the impact of price discounts on healthy food supply and demand. We tested the impact of store-directed price discounts and communications strategies, separately and combined, on the stocking, sales and prices of healthier foods and on storeowner psychosocial factors.
Design
Factorial design randomized controlled trial.
Setting
Twenty-four corner stores in low-income neighbourhoods of Baltimore City, MD, USA.
Subjects
Stores were randomized to pricing intervention, communications intervention, combined pricing and communications intervention, or control. Stores that received the pricing intervention were given a 10–30 % price discount by wholesalers on selected healthier food items during the 6-month trial. Communications stores received visual and interactive materials to promote healthy items, including signage, taste tests and refrigerators.
Results
All interventions showed significantly increased stock of promoted foods v. control. There was a significant treatment effect for daily unit sales of healthy snacks (β=6·4, 95 % CI 0·9, 11·9) and prices of healthy staple foods (β=–0·49, 95 % CI –0·90, –0·03) for the combined group v. control, but not for other intervention groups. There were no significant intervention effects on storeowner psychosocial factors.
Conclusions
All interventions led to increased stock of healthier foods. The combined intervention was effective in increasing sales of healthier snacks, even though discounts on snacks were not passed to the consumer. Experimental research in small stores is needed to understand the mechanisms by which store-directed price promotions can increase healthy food supply and demand.
Covering the basics of X-rays, CT, PET, nuclear medicine, ultrasound, and MRI, this textbook provides senior undergraduate and beginning graduate students with a broad introduction to medical imaging. Over 130 end-of-chapter exercises are included, in addition to solved example problems, which enable students to master the theory as well as providing them with the tools needed to solve more difficult problems. The basic theory, instrumentation and state-of-the-art techniques and applications are covered, bringing students immediately up-to-date with recent developments, such as combined computed tomography/positron emission tomography, multi-slice CT, four-dimensional ultrasound, and parallel imaging MR technology. Clinical examples provide practical applications of physics and engineering knowledge to medicine. Finally, helpful references to specialised texts, recent review articles, and relevant scientific journals are provided at the end of each chapter, making this an ideal textbook for a one-semester course in medical imaging.
Atom probe tomography is used to investigate the clustering of Y-Ti-O in a 14%Cr-2%W-0.3%Ti & 0.3% Y2O3 ODS steel. The clusters in the consolidated material are compared to clusters observed in the powder prior to consolidation. A higher density of smaller clusters is observed in the powder, and the clusters are found to contain more O and less Y.
Of all the standard clinical imaging techniques ultrasound is by far the least expensive and most portable (including handheld units smaller than a laptop computer), and can acquire continuous images at a real-time frame rate with few or no safety concerns. In addition to morphological and structural information, ultrasound can also measure blood flow in real-time, and produce detailed maps of blood velocity within a given vessel. Ultrasound finds very wide use in obstetrics and gynaecology, due to the lack of ionizing radiation or strong magnetic fields. The real-time nature of the imaging is also important in measuring parameters such as foetal heart function. Ultrasound is used in many cardiovascular applications, being able to detect mitral valve and septal insufficiencies. General imaging applications include liver cysts, aortic aneurysms, and obstructive atherosclerosis in the carotids. Ultrasound imaging is also used very often to guide the path and positioning of a needle in tissue biopsies.
Ultrasound is a mechanical wave, with a frequency for clinical use between 1 and 15 MHz. The speed of sound in tissue is ∼1540 m/s, and so the range of wavelengths of ultrasound in tissue is between ∼0.1 and 1.5 mm. The ultrasound waves are produced by a transducer, as shown in Figure 4.1, which typically has an array of up to 512 individual active sources. In the simplest image acquisition scheme, small subgroups of these elements are fired sequentially to produce parallel ultrasound beams.
Of the four major clinical imaging modalities, magnetic resonance imaging (MRI) is the one developed most recently. The first images were acquired in 1973 by Paul Lauterbur, who shared the Nobel Prize for Medicine in 2003 with Peter Mansfield for their shared contribution to the invention and development of MRI. Over 10 million MRI scans are prescribed ever year, and there are more than 4000 scanners currently operational in 2010.
MRI provides a spatial map of the hydrogen nuclei (water and lipid) in different tissues. The image intensity depends upon the number of protons in any spatial location, as well as physical properties of the tissue such as viscosity, stiffness and protein content. In comparison to other imaging modalities, the main advantages of MRI are: (i) no ionizing radiation is required, (ii) the images can be acquired in any two- or three-dimensional plane, (iii) there is excellent soft-tissue contrast, (iv) a spatial resolution of the order of 1 mm or less can be readily achieved, and (v) images are produced with negligible penetration effects. Pathologies in all parts of the body can be diagnosed, with neurological, cardiological, hepatic, nephrological and musculoskeletal applications all being widely used in the clinic. In addition to anatomical information, MR images can be made sensitive to blood flow (angiography) and blood perfusion, water diffusion, and localized functional brain activation.
In nuclear medicine scans a very small amount, typically nanogrammes, of radioactive material called a radiotracer is injected intravenously into the patient. The agent then accumulates in specific organs in the body. How much, how rapidly and where this uptake occurs are factors which can determine whether tissue is healthy or diseased and the presence of, for example, tumours. There are three different modalities under the general umbrella of nuclear medicine. The most basic, planar scintigraphy, images the distribution of radioactive material in a single two- dimensional image, analogous to a planar X-ray scan. These types of scan are mostly used for whole-body screening for tumours, particularly bone and metastatic tumours. The most common radiotracers are chemical complexes of technetium (99mTc), an element which emits mono-energetic γ-rays at 140 keV. Various chemical complexes of 99mTc have been designed in order to target different organs in the body. The second type of scan, single photon emission computed tomography (SPECT), produces a series of contiguous two-dimensional images of the distribution of the radiotracer using the same agents as planar scintigraphy. There is, therefore, a direct analogy between planar X-ray/CT and planar scintigraphy/SPECT. A SPECT scan is most commonly used for myocardial perfusion, the so-called ‘nuclear cardiac stress test’. The final method is positron emission tomography (PET). This involves injection of a different type of radiotracer, one which emits positrons (positively charged electrons).
X-ray planar radiography is one of the mainstays of a radiology department, providing a first ‘screening’ for both acute injuries and suspected chronic diseases. Planar radiography is widely used to assess the degree of bone fracture in an acute injury, the presence of masses in lung cancer/emphysema and other airway pathologies, the presence of kidney stones, and diseases of the gastrointestinal (GI) tract. Depending upon the results of an X-ray scan, the patient may be referred for a full three-dimensional X-ray computed tomography (CT) scan for more detailed diagnosis.
The basis of both planar radiography and CT is the differential absorption of X-rays by various tissues. For example, bone and small calcifications absorb X-rays much more effectively than soft tissue. X-rays generated from a source are directed towards the patient, as shown in Figure 2.1(a). X-rays which pass through the patient are detected using a solid-state flat panel detector which is placed just below the patient. The detected X-ray energy is first converted into light, then into a voltage and finally is digitized. The digital image represents a two-dimensional projection of the tissues lying between the X-ray source and the detector. In addition to being absorbed, X-rays can also be scattered as they pass through the body, and this gives rise to a background signal which reduces the image contrast. Therefore, an ‘anti-scatter grid’, shown in Figure 2.1(b), is used to ensure that only X-rays that pass directly through the body from source-to-detector are recorded.
A clinician making a diagnosis based on medical images looks for a number of different types of indication. These could be changes in shape, for example enlargement or shrinkage of a particular structure, changes in image intensity within that structure compared to normal tissue and/or the appearance of features such as lesions which are normally not seen. A full diagnosis may be based upon information from several different imaging modalities, which can be correlative or additive in terms of their information content.
Every year there are significant engineering advances which lead to improvements in the instrumentation in each of the medical imaging modalities covered in this book. One must be able to assess in a quantitative manner the improvements that are made by such designs. These quantitative measures should also be directly related to the parameters which are important to a clinician for diagnosis. The three most important of these criteria are the spatial resolution, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). For example, Figure 1.1(a) shows a magnetic resonance image with two very small white-matter lesions indicated by the arrows. The spatial resolution in this image is high enough to be able to detect and resolve the two lesions. If the spatial resolution were to have been four times worse, as shown in Figure 1.1(b), then only the larger of the two lesions is now visible. If the image SNR were four times lower, illustrated in Figure 1.1(c), then only the brighter of the two lesions is, barely, visible.
Fish consumption has been shown to be inversely associated with CHD, which may be due to n-3 fatty acids. The n-3 fatty acids, EPA and DHA, are naturally found only in marine sources. Dietary intakes of methylmercury from certain fish have been hypothesized to increase the risk of CHD.
Objective
To investigate the relationship between 30 d fish frequency consumption (assessed by FFQ), total blood Hg concentrations and risk markers of CHD in women aged 16–49 years participating in the National Health and Nutrition Examination Survey 1999–2002.
Design
Multiple linear regression analyses were used to test (i) the relationships between 30 d fish frequency consumption and five CHD risk markers, i.e. HDL cholesterol (HDL-C), LDL cholesterol, total cholesterol, TAG and C-reactive protein (CRP); and (ii) if total blood Hg attenuated any associations between fish consumption and CHD risk markers in non-pregnant, non-diabetic females aged 16–49 years.
Results
Total 30 d fish frequency consumption was negatively associated with CRP (b = −0·10, 95 % CI −0·19, −0·02, P = 0·015) and positively associated with HDL-C (b = 1·40, 95 % CI 0·31, 2·50, P = 0·014). Adjustment for other risk factors did not significantly attenuate the associations. Despite the collinearity between fish and Hg, there is a protective association between fish intake and CHD risk factors.
Conclusions
The levels of DHA + EPA and other nutrients in fish may be adequate to offset the hypothesized risks of heart disease related to ingesting Hg from fish.
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