We consider spline-based additive models for estimation of conditional treatment effects. To handle the uncertainty due to variable selection, we propose a method of model averaging with weights obtained by minimizing a J-fold cross-validation criterion, in which a nearest neighbor matching is used to approximate the unobserved potential outcomes. We show that the proposed method is asymptotically optimal in the sense of achieving the lowest possible squared loss in some settings and assigning all weight to the correctly specified models if such models exist in the candidate set. Moreover, consistency properties of the optimal weights and model averaging estimators are established. A simulation study and an empirical example demonstrate the superiority of the proposed estimator over other methods.

China has dedicated significant efforts to preventing obesity, but the rising prevalence of overweight and obesity remains a pressing public health issue. Therefore, unique solutions are required to address this challenge in China. As a research priority, the food environment plays a pivotal role in addressing overweight and obesity. However, research on this topic in China lags behind that in other developed countries, and the conflicting global evidence on the association between the food environment and obesity cannot be directly applied to policymaking and intervention in China. In addition, the rapid advancement of digital technology has introduced complexities and uncertainties in the food environment. To address these challenges, we propose an alternative research framework through (a) dissecting the challenges associated with defining and measuring the food environment, (b) reorganising the relationship chains between the food environment and human diet/health and (c) taking into consideration digital platforms as crucial monitoring tools for studying the food environment. Our framework aims to unlock the potential of food environment research in the digital age, ultimately striving to tackle the overweight and obesity issues in China.

Although it is well established that gestational diabetes mellitus (GDM) is associated with fetal overgrowth in singleton pregnancies, little is known about its role in twins. We aimed to explore the relationship between GDM and the longitudinal fetal growth in twin pregnancies. This was a retrospective matched cohort study of GDM and non-GDM twin pregnancies delivered ≥36 weeks without other complications. All the women performed ≥3 ultrasounds after 22 weeks. Linear mixed models (LMMs) were used to explore the relationships between longitudinal fetal growth trajectories and GDM. Group-based trajectory modeling (GBTM) and generalized estimating equation (GEE) were applied to identify the latent growth patterns and investigate their relationships with GDM. In total, 215 GDM and 645 non-GDM twins were included, the majority of the patients did not require medication therapy (n = 202, GDMA1). LMM revealed that, compared with non-GDM, GDM was associated with an average increase in fetal weight of 4.36 g (95% CI [1.25, 7.48]) per week. GBTM and GEE further revealed that GDM increased the odds of fetal weight trajectory to nearly 40% of the total fetal weight trajectory, classified into the high-speed group (aOR = 1.39, 95% CI [1.03, 1.88]), associating with a 49.44 g (95% CI [11.41, 87.48]) increase in birth weight. Subgroup analysis revealed that all these differences were only significant among the GDMA1 pregnancies (p < .05). GDM (GDMA1) is significantly associated with an increase in fetal weight during gestation in twin pregnancies. However, this acceleration is mild, and its significance requires further exploration.

Lymph node tuberculosis is particularly common in regions with a high tuberculosis burden, and it has a great risk of rupture. This study aims to investigate the utility of ultrasound multimodal imaging in predicting the rupture of cervical tuberculous lymphadenitis (CTL). 128 patients with unruptured CTL confirmed by pathology or laboratory tests were included. Various ultrasonic image features, including long-to-short-axis ratio (L/S), margin, internal echotexture, coarse calcification, Color Doppler Flow Imaging (CDFI), perinodal echogenicity, elastography score, and non-enhanced area proportion in contrast-enhanced ultrasound (CEUS), were analyzed to determine their predictive value for CTL rupture within a one-year follow-up period. As a result, L/S (P < 0.001), margin (P < 0.001), internal echotexture (P < 0.001), coarse calcification (P < 0.001), perinodal echogenicity (P < 0.001), and the area of non-enhancement in CEUS (P < 0.001) were identified as significant imaging features for predicting CTL rupture. The prognostic prediction showed a sensitivity of 89.29%, specificity of 100%, accuracy of 95.31%, respectively. Imaging findings such as L/S < 2, unclear margin, heterogeneous internal echotexture, perinodal echogenicity changed, and non-enhancement area in CEUS > 1/2, are indicative of CTL rupture, while coarse calcification in the lymph nodes is associated with a favorable prognosis.

Organo-montmorillonite (OMnt) has wide applications in paints, clay-polymer nanocomposites, biomaterials, etc. In most cases, the dispersibility and swellability of OMnt dictate the performance of OMnt in the target products. Previous studies have revealed that the properties can be improved when multiple organic species are co-introduced into the interlayer space of montmorillonite (Mnt). In the present study, single surfactant erucylamide (EA), dual-surfactants cetyltrimethyl ammonium bromide (CTAB) and octadecyltrimethyl ammonium chloride (OTAC), and ternary-surfactants EA, CTAB, and OTAC were co-introduced into Mnt by solution intercalation. The resulting OMnts were characterized by powder X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, thermogravimetry-differential thermogravimetry (TG-DTG), water contact-angle tests, scanning electronic microscopy (SEM), laser particle-size analysis, and swelling indices. Mnt co-modified by ternary CTAB, OTAC, and EA led to a large d001 value (4.20 nm), surface hydrophobicity with a contact angle of 95.6°, swellability (50 mL/g) with small average particle sizes (2.1−2.8 μm) in xylene, and >99% of the OMnt particles were kept as <5 μm in deionized water. The formation of EA-modified-Mnt was proposed according to hydrophobic affinity, hydrogen bonding, and van der Waals forces. The nanoplatelets of the CTA+, OTA+, and EA co-modified OMnts in xylene were assembled into a house-of-cards structure by face-to-edge and edge-to-edge associations. The electrostatic attractions, electrostatic and steric repulsions, and hydrophobic interactions were responsible for the good dispersibility of OMnt in xylene. The ternary surfactant co-modified OMnt with high dispersion and swellability will make OMnt better suited for real-world applications.

The provenance of clays in shaley intervals across the Permian-Triassic boundary (PTB) in the Xiakou section was investigated by X-ray diffraction (XRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM), and the results suggest that the layers have three different provenances. The layer P267-b has a loose texture with an oriented arrangement of detrital clay particles, consisting mainly of illite and minor chlorite with irregular outlines or ragged edges. The dehydroxylation reaction of the clays in this layer is characterized by an intense overlapping endothermic effect at ∼600°C, produced by mixed-layer illite-smectite (I-S) consisting of a mixture of cis-vacant (cv)and trans-vacant (tv) octahedral sheets derived from weathering of detrital illite. Layer P259-b shows a more condensed texture with a dark color, and is composed mainly of I-S and minor illite and chlorite. Evidence for alteration of detrital materials to clay mineral aggregates was observed under SEM. Similar to layer P267-b, an intense dehydroxylation reaction occurs at ∼600°C, indicating clays consisting of a mixture of tv and cv sheets and, therefore, that the sediments were derived from a mixture of terrigenous and volcanic sources, combining the texture and the clay-mineral composition of those sediments. However, the undisturbed lamination and relatively small grain size in this bed indicate a low-energy depositional environment. The clay-mineral compositions of the other layers are mainly of I-S with minor amounts of illite and chlorite. Their endothermic dehydroxylation reaction, however, occurs mainly at ∼660°C, indicating that cv sheets are dominant in the clays, and thus, are derived from smectites of volcanic origin. Observations by SEM show that clay minerals grow at the expense of detrital materials, confirming the diagenetic alteration of volcanic ashes in marine sediments. Illite and chlorite are the detrital clay minerals in the clay layers across the PTB in the Xiakou section. The presence of detrital illite and chlorite in the sediments means that an arid climate prevailed in the region during the end-Permian and early Triassic period.

To explore the relationship between dietary antioxidant quality score (DAQS) and Cd exposure both alone and in combination with osteoporosis and bone mineral density (BMD) among postmenopausal women. In total, 4920 postmenopausal women from the National Health and Nutrition Examination Survey were included in this cross-sectional study. Weighted univariate and multivariate logistic regression analyses to assess the association between DAQS and Cd exposure with femur neck BMD, total femur BMD, osteoporosis among postmenopausal women, respectively, and the coexistence effect of DAQS and Cd exposure. Four hundred and ninety-nine had osteoporosis. DAQS (OR = 0·86, 95 % CI 0·77, 0·97) and high DAQS (OR = 0·60, 95 % CI 0·36, 0·99) were found to be associated with decreased odds of osteoporosis, while Cd exposure (OR = 1·34, 95 % CI 1·04, 1·72) and high Cd exposure (OR = 1·45, 95 % CI 1·02, 2·06) were related to increased odds of osteoporosis. A positive correlation was observed between high DAQS and both total femur BMD and femur neck BMD. Conversely, Cd exposure was found to be negatively correlated with total femur BMD and femur neck BMD. Additionally, taking low-Cd and high-quality DAQS group as reference, the joint effect of Cd exposure and DAQS showed greater increased odds of osteoporosis and decreased total femur BMD and femur neck BMD as Cd level and DAQS combinations worsened. There may be an interaction between Cd exposure and DAQS for femur neck BMD, total femur BMD, and osteoporosis in postmenopausal women.

The rare plant Primula esquirolii, a karst cave species in the family Primulaceae, endemic to Guizhou, China, and with a presumed extremely small population, had not previously been observed since 1910. It is categorized as Endangered on the China Species Red List. In surveys during 2018–2022, we were unable to locate the species in its type location in Pingba county, but we discovered a previously unrecorded population of 44 mature individuals, 37 of which were long homostylous and seven of which were heterostylous. These individuals were discovered in Xiuwen county in February 2022, in an area of c. 50 m2, c. 40 km from the type location. All seven heterostylous individuals showed the short-styled morph. The almost homostylous P. esquirolii potentially faces the same high genetic load as other homostylous plants, and this may have led to its small population size and potential sensitivity to habitat destruction. Field surveys and informal interviews with local people indicated that the main threats to this species are its small population size and the loss of suitable habitat as a result of human activities. The most urgent requirement for the conservation of this species is to protect the habitat of this single known extant population and to carry out ex situ conservation. Further field surveys and research are also required to improve our understanding of the status of this species.

Redesign is a widespread strategy for product improvement whose essence is the optimization of design parameters (DPs) considering the trade-off between customer satisfaction and cost concerns. Similar to the relation between customer requirements (CRs) and customer satisfaction, the sensitivity of customer satisfaction is diverse to different DPs. In this study, a sensitivity-enhanced customer satisfaction function is defined for redesign model construction. This fills the research gap in product redesign that lacking of consideration and quantification of customer satisfaction sensitivity. First, a sensitivity index is defined based on Kano indices for analyzing sensitivity of customer satisfaction in different DP categories. Second, traditional customer satisfaction function has been improved by injecting the sensitivity of customer satisfaction to the variations of DPs. Subsequently, a DP optimization model is established to maximize shared surplus between customers and enterprise. Finally, a case study involving the redesign of a braking system of automobile is implemented to demonstrate the effectiveness and rationality of the proposed approach. The results show that the improved customer satisfaction function can reflect a more nuanced relationship between customer satisfaction and fulfilment level of DPs. Additionally, the proposed redesign model helps designers determine the target values of DPs under a better trade-off and enhances enterprise competitiveness.

The codling moth Cydia pomonella is a major pest of global significance impacting pome fruits and walnuts. It threatens the apple industry in the Loess Plateau and Bohai Bay in China. Sterile insect technique (SIT) could overcome the limitations set by environmentally compatible area-wide integrated pest management (AW-IPM) approaches such as mating disruption and attract-kill that are difficult to suppress in a high-density pest population, as well as the development of insecticide resistance. In this study, we investigated the effects of X-ray irradiation (183, 366, 549 Gy) on the fecundity and fertility of a laboratory strain of C. pomonella, using a newly developed irradiator, to evaluate the possibility of X-rays as a replacement for Cobalt60 (60Co-γ) and the expanded future role of this approach in codling moth control. Results show that the 8th-day is the optimal age for irradiation of male pupae. The fecundity decreased significantly as the dosage of radiation increased. The mating ratio and mating number were not influenced. However, treated females were sub-sterile at a radiation dose of 183 Gy (20.93%), and were almost 100% sterile at a radiation dose of 366 Gy or higher. Although exposure to a radiation dose of 366 Gy resulted in a significant reduction in the mating competitiveness of male moths, our radiation biology results suggest that this new generation of X-ray irradiator has potential applications in SIT programs for future codling moth control.

The subduction model of the Neo-Tethys during the Early Cretaceous has always been a controversial topic, and the scarcity of Early Cretaceous magmatic rocks in the southern part of the Gangdese batholith is the main cause of this debate. To address this issue, this article presents new zircon U–Pb chronology, zircon Hf isotope, whole-rock geochemistry and Sr–Nd isotope data for the Early Cretaceous quartz diorite dykes with adakite affinity in Liuqiong, Gongga. Zircon U–Pb dating of three samples yielded ages of c. 141–137 Ma, indicating that the Liuqiong quartz diorite was emplaced in the Early Cretaceous. The whole-rock geochemical analysis shows that the Liuqiong quartz diorite is enriched in large-ion lithophile elements (LILEs) and light rare-earth elements (LREEs) and is depleted in high-field-strength elements (HFSEs), which are related to slab subduction. Additionally, the Liuqiong quartz diorite has high SiO2, Al2O3 and Sr contents, high Sr/Y ratios and low heavy rare-earth element (HREE) and Y contents, which are compatible with typical adakite signatures. The initial 87Sr/86Sr values of the Liuqiong adakite range from 0.705617 to 0.705853, and the whole-rock ϵNd(t) values vary between +5.78 and +6.24. The zircon ϵHf(t) values vary from +11.5 to +16.4. Our results show that the Liuqiong adakite magma was derived from partial melting of the Neo-Tethyan oceanic plate (mid-ocean ridge basalt (MORB) + sediment + fluid), with some degree of subsequent peridotite interaction within the overlying mantle wedge. Combining regional data, we favour the interpretation that the Neo-Tethyan oceanic crust was subducted at a low angle beneath the Gangdese during the Early Cretaceous.

Recently, the nature of viscoelastic drag-reducing turbulence (DRT), especially the maximum drag reduction (MDR) state, has become a focus of controversy. It has long been regarded as polymer-modulated inertial turbulence (IT), but is challenged by the newly proposed concept of elasto-inertial turbulence (EIT). This study is to repicture DRT in parallel plane channels by introducing dynamics of EIT through statistical, structural and budget analysis for a series of flow regimes from the onset of drag reduction to EIT. Some underlying mechanistic links between DRT and EIT are revealed. Energy conversion between velocity fluctuations and polymers as well as pressure redistribution effects are of particular concern, based on which a new energy self-sustaining process (SSP) of DRT is repictured. The numerical results indicate that at low Reynolds number ($Re$), weak IT flow is replaced by a laminar regime before the barrier of EIT dynamics is established with the increase of elasticity, whereas, at moderate $Re$, EIT-related SSP can get involved and survive from being relaminarized. This further explains the reason why relaminarization phenomenon is observed for low $Re$ while the flow directly enters MDR and EIT at moderate $Re$. Moreover, with the proposed energy picture, the newly discovered phenomenon that streamwise velocity fluctuations lag behind those in the wall-normal direction can be well explained. The repictured SSP certainly justifies the conjecture that IT nature is gradually replaced by that of EIT in DRT with the increase of elasticity.

Children who experience parental death are at increased risk for suicide. The Family Bereavement Program (FBP) is an upstream preventive intervention for parentally bereaved families that was found to reduce suicide risk in parentally bereaved youth up to 6 and 15 years later. We tested whether FBP-induced improvements in effective parenting led to changes in multiple proximal factors that prior theory and research implicated in the cascading pathway to suicide risk, namely, aversive self-views, caregiver connectedness, peer connectedness, complicated grief, depressive symptoms, and emotion suppression. The sample was 244 bereaved youth and their surviving caregiver from 156 families. Families were randomized into the FBP (12 group-based sessions for parents, youth, and two joint sessions) or a literature control condition. Multimethod and multiinformant data were collected at baseline, posttest, 6-year and 15-year follow-up assessments. Results showed that program-induced improvements in effective parenting at posttest were associated with reduced aversive self-views and increased caregiver connectedness at the 6-year follow-up, and each mediator was in turn associated with reduced suicide risk at the 6- and 15-year follow-up. The mediated pathways via aversive self-views remained significant while controlling for caregiver connectedness. Self-related concepts may be important targets in upstream suicide prevention for at-risk youth.

Research on identity threat has predominantly focused on the consequences of threat to some ascribed or involuntary identities, while overlooking individuals' responses to occupational identity threat. Integrating identity theory with identity threat literature, we argue that encountering occupational identity threat promotes negative emotion and feedback-seeking behavior, and negative emotion further mediates the relationship between occupational identity threat and feedback-seeking behavior. Moreover, individuals' performance self-esteem strengthens both the direct effect of occupational identity threat on negative emotion, and the indirect effect of occupational identity threat on feedback-seeking behavior through negative emotion. The results from two experimental studies and one field study provide support for these predictions. We discuss the theoretical and practical implications of our findings.

Staphylococcus aureus is a common pathogen of bovine mastitis which can induce autophagy and inhibit autophagy flux, resulting in intracellular survival and persistent infection. The aim of the current study was to investigate the role of p38α in the autophagy induced by intracellular S. aureus in bovine mammary epithelial cells. An intracellular infection model of MAC-T cells was constructed, and activation of p38α was examined after S. aureus invasion. Through activating/inhibiting p38α by anisomycin/SB203580, the autophagosomes, LC3 and p62 level were analyzed by immunofluorescence and western blot. To further study the detailed mechanism of p38α, phosphorylation of ULK1ser757 was also detected. The results showed that intracellular S. aureus activated p38α, and the activation developed in a time-dependent manner. Inhibition of p38α promoted intracellular S. aureus-induced autophagy flow, up-regulated the ratio of LC3 II/I, reduced the level of p62 and inhibited the phosphorylation of ULK1ser757, whereas the above results were reversed after activation of p38α. The current study indicated that intracellular S. aureus can inhibit autophagy flow by activating p38α in bovine mammary epithelial cells.