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This paper presents a wideband dual-polarized in-band full duplex antenna which can also suppress the higher order modes. A dual differential capacitive feeding scheme is proposed to increase the isolation between the co-located transmitter and receiver ports. The proposed design uses λ/4 resonators in close vicinity of the radiating patch to provide spurious-free characteristics. Further, a parasitic patch placed above the radiating patch at height “h” is used to enhance the input matching, impedance bandwidth, and gain of the proposed design. The key features of the proposed structure are its wide impedance bandwidth (∼20%), high inter-port isolation (>58 dB) throughout the entire operating frequency range (2.26–2.76 GHz), and simultaneous suppression of higher order modes which makes it a suitable candidate for modern wireless application. Finally, a prototype is fabricated and measurement results are in good agreement with simulation results.
A compact 8-port eighth-mode substrate-integrated waveguide (EMSIW) multiple-input multiple-output (MIMO) antenna is presented in this paper. It consists of eight EMSIW cavities placed side by side sharing their open-ended edges which are separated by rectangular slots. High isolation (>22 dB) between the antenna elements over the entire operating band is obtained by the strategic placement of rectangular slots and vias. The open-ended region of EMSIW cavity resonator and the edges of the diagonal slots help in the excitation of TE110 mode at 5.5 GHz. The simulated bandwidth of MIMO antenna is 180 MHz, while the measured bandwidth is 220 MHz. The proposed MIMO antenna system has potential applications for sub-6 GHz communication systems.
The study was conducted on indigenous Tharparkar cow (Bos indicus) to evaluate FSH stimulation on follicular attributes, oocyte recovery and morpho-molecular developmental competence parameters concerning oocyte quality. A total of 20 OPU sessions were performed, which included 10 sessions in each FSH stimulated at the dose of 130 µg divided into four sub-doses and non-stimulated. Findings on the size of follicles having ≥6 mm showed a significantly higher, however an opposite trend was observed in the case of smaller sized follicle (<6 mm) between stimulated and non-stimulated respectively. The stimulated cows had a significantly higher number as well as the percentage of oocytes of Grade A, having a diameter ≥120 µm and BCB+VE as compared to the non-stimulated cows. The relative mRNA expression profile of GDF9, BMP15, PCNA and BCL-2 genes was higher and BAX was lower in the FSH-stimulated cow. These results indicated that FSH stimulation before OPU in Bos indicus cows has a significant impact on follicle size, oocyte yield, recovery, and their quality with respect to COC’s, diameter and BCB+VE oocytes. Further, a significant increase in the relative mRNA expression levels of GDF9, BMP15 and PCNA genes in the FSH-stimulated group suggests that FSH plays a key role in modulating the expression of these important candidate genes and thus influencing oocyte quality. The higher mRNA expression of BCL-2 genes and concomitantly lower expression of BAX gene in FSH Stimulated cows indicates the protective role of these genes and preventing programmed cell death and thus promoting cell survival, quality and embryo development.
Grassland habitats currently face severe anthropogenic exploitation, thereby affecting the survival of grassland-dependent biodiversity globally. The biodiversity-rich grasslands of India lack quantitative spatiotemporal information on their status. We evaluated the status of upper Gangetic Plains grasslands in 2015 and compared it with those from 1985, 1995 and 2005. On-ground mapping and visual classifications revealed a 57% decline in these grasslands between 1985 (418 km2) and 2015 (178 km2), mostly driven by habitat conversion (74% contribution by cropland). Limited radiotelemetry data from endemic swamp deer indicated a possible grassland-dominated average home range size of 1.02 km2, and these patches were highly preferred (average Ivlev’s index = 0.85) over other land-use classes at both spatial and temporal scales. Camera-trapping within the core habitats suggests the critical use of these patches as fawning/breeding grounds. Habitat suitability analysis indicates only c. 17% of the area along the Ganges is suitable as swamp deer habitat. We recommend the protection of these critical grassland patches to maintain ‘dynamic corridors’, with restoration and other management approaches involving multiple stakeholders to ensure the survival of this critical ecosystem.
Lasers are created to study the timescale of electron motion in atoms and molecules. They also have wide applications in areas like solid state, plasma physics, nanoscience and defence technology. This book helps readers to master the large variety of physical phenomena and technological aspects involved in laser technology. Besides explaining the physical principles and common techniques of laser science and technology, it also elaborates on topics like High-harmonic Generation (HHG) and strong-field Non-sequential Double Ionization (NSDI), effects of a low energy atto-second pulse, laser spectroscopy, laser cooling and trapping, quantum optics and laser applications. Many important concepts covered include a new test system design of comprehensive characterization of non-imaging laser IR guided missiles, advanced laser and opto-electronics technologies for Low Intensity Conflict (LIC) applications and development of highly advanced laser cavity and resonator for high power chemical oxygen iodine laser at the Laser Science and Technology Centre (LASTEC).
High burden of anaemia exists amongst rural adolescent girls in India. The objective of this study was to characterise anaemia in school going adolescent girls in rural Haryana, India.
Design:
Linear and multiple logistic regression analysis of data collected prior to an intervention trial was conducted. Participants were classified into anaemic (haemoglobin <12 g/dl) and non-anaemic group and were further classified into deficiencies of Fe, folate or vitamin B12, mixed, anaemia of other causes and inflammation.
Setting:
Three schools in Ballabgarh block of Faridabad District, Haryana, India.
Participants:
One hundered and ninety-eight non-anaemic and 202 anaemic adolescent girls (12–19 years).
Results:
Anaemic girls had 29·6 % Fe deficiency, 28·1 % folate or vitamin B12 deficiency, 15·8 % mixed deficiency and 9·7 % acute inflammation. Anaemia of other causes was found in 16·8 % of the anaemic participants. Girls with Fe and isolated folate deficiency had 2·5 times and four times higher odds of developing anaemia, respectively, as compared with non-anaemic girls. Fe deficiency with no anaemia was found amongst 11 % non-anaemic girls. Non-anaemic girls had a high prevalence of combined deficiency of folate or vitamin B12 (29·5 %) and acute inflammation (14·4 %).
Conclusions:
The current strategy of Fe and folic acid supplementation alone will not suffice for achieving the desired reduction in the prevalence of anaemia as unknown causes and anaemia of inflammation contribute to a substantial proportion of anaemia. Integrating other nutrition-specific components like improving water, sanitation and hygiene practices with the ongoing micronutrient supplementation program will comprehensively tackle anaemia. Unknown causes of anaemia warrant further research.
To examine if smaller size at birth, an indicator of growth restriction in utero, is associated with lower cognition in late life, and whether this may be mediated by impaired early life brain development and/or adverse cardiometabolic programming.
Design:
Longitudinal follow-up of a birth cohort.
Setting:
CSI Holdsworth Memorial Hospital (HMH), Mysore South India.
Participants:
721 men and women (55–80 years) whose size at birth was recorded at HMH. Approximately 20 years earlier, a subset (n = 522) of them had assessments for cardiometabolic disorders in mid-life.
Measurements:
Standardized measurement of cognitive function, depression, sociodemographic, and lifestyle factors; blood tests and assessments for cardiometabolic disorders
Results:
Participants who were heavier at birth had higher composite cognitive scores (0.12 SD per SD birth weight [95% CI 0.05, 0.19] p = 0.001) in late life. Other lifecourse factors independently positively related to cognition were maternal educational level and participants’ own educational level, adult leg length, body mass index, and socioeconomic position, and negatively were diabetes in mid-life and current depression and stroke. The association of birth weight with cognition was independent cardiometabolic risk factors and was attenuated after adjustment for all lifecourse factors (0.08 SD per SD birth weight [95% CI −0.01, 0.18] p = 0.07).
Conclusions:
The findings are consistent with positive effects of early life environmental factors (better fetal growth, education, and childhood socioeconomic status) on brain development resulting in greater long-term cognitive function. The results do not support a pathway linking poorer fetal development with reduced late life cognitive function through cardiometabolic programming.
Flow of a shear-thinning fluid over curved and moving geometries demands special attention owing to its industrial and biological relevance. The present study reports a numerical simulation of the motion of a Carreau fluid over a transversely oscillating cylinder for a range of oscillation amplitudes and frequencies at Reynolds number $Re = 100$, and compares the flow behaviour with that of a Newtonian fluid. The numerical solver uses the sharp-interface immersed boundary method to reconstruct the flow variables at the intercepted cells in the vicinity of the moving cylinder geometry. Synchronized vortex shedding is observed during the locked-in oscillation mode, whereas paired counter-rotating vortices are shed during the non-locked-in mode. The generation of vorticity and enstrophy variations in the Carreau and Newtonian fluids are compared. The vortex patterns in the Carreau fluid show a strong difference from those of the Newtonian fluid at higher amplitude of oscillation ($A^{*} = 1.2$). This difference in the flow structures is explained through the behaviour of the diffusion terms in the vorticity transport equation. Further, the effect of the Carreau fluid properties on the flow structures and vorticity dynamics are also discussed.
To assess ability of National Early Warning Score 2 (NEWS2), systemic inflammatory response syndrome (SIRS), quick Sequential Organ Failure Assessment (qSOFA), and CRB-65 calculated at the time of intensive care unit (ICU) admission for predicting ICU mortality in patients of laboratory confirmed coronavirus disease 2019 (COVID-19) infection.
Methods:
This prospective data analysis was based on chart reviews for laboratory confirmed COVID-19 patients admitted to ICUs over a 1-mo period. The NEWS2, CRB-65, qSOFA, and SIRS were calculated from the first recorded vital signs upon admission to ICU and assessed for predicting mortality.
Results:
Total of 140 patients aged between 18 and 95 y were included in the analysis of whom majority were >60 y (47.8%), with evidence of pre-existing comorbidities (67.1%). The most common symptom at presentation was dyspnea (86.4%). Based upon the receiver operating characteristics area under the curve (AUC), the best discriminatory power to predict ICU mortality was for the CRB-65 (AUC: 0.720 [95% confidence interval [CI]: 0.630-0.811]) followed closely by NEWS2 (AUC: 0.712 [95% CI: 0.622-0.803]). Additionally, a multivariate Cox regression model showed Glasgow Coma Scale score at time of admission (P < 0.001; adjusted hazard ratio = 0.808 [95% CI: 0.715-0.911]) to be the only significant predictor of ICU mortality.
Conclusions:
CRB-65 and NEWS2 scores assessed at the time of ICU admission offer only a fair discriminatory value for predicting mortality. Further evaluation after adding laboratory markers such as C-reactive protein and D-dimer may yield a more useful prediction model. Much of the earlier data is from developed countries and uses scoring at time of hospital admission. This study was from a developing country, with the scores assessed at time of ICU admission, rather than the emergency department as with existing data from developed countries, for patients with moderate/severe COVID-19 disease. Because the scores showed some utility for predicting ICU mortality even when measured at time of ICU admission, their use in allocation of limited ICU resources in a developing country merits further research.
To derive scores for mental disorganization and impoverishment from commonly used rating scales, and test the hypothesis that disorganization and impoverishment, along with impaired cognition and role-function reflect a latent variable that is a plausible candidate for the putative core deficit.
Background
For more than 100 years, disorganization and impoverishment of mental activity have been recognised as fundamental symptoms of schizophrenia. These symptoms may reflect a core brain process underlying persisting disability. Delusions and hallucinations have been regarded as accessory features. The psychopathological processes predisposing to persisting disability in schizophrenia are poorly understood. The delineation of a core deficit underlying persisting disability would be potentially of great value in predicting outcome and developing improved treatment.
Method
Patients aged 18–55 years were included if: they satisfied DSM IV criteria for schizophrenia or schizoaffective disorder. Healthy controls were recruited by public advertisement and selected to match the patient group in age and sex. Study sample included 39 participants with schizophrenia, 1 with schizoaffective disorder and 44 matched healthy controls. We derived disorganization and impoverishment scores from three symptom scales: PANSS, SSPI and CASH. We computed composite scores for disorganization and for impoverishment and employed Confirmatory Factor Analysis to test the hypothesis that a single factor accounts for the relationships between disorganization, impoverishment, cognitive impairment and impaired role function. We assessed the relationship between this latent “core deficit” and diminished Post Movement Beta Rebound (PMBR), an electrophysiological measure from Magnetoencephalography (MEG), associated with persisting brain disorders.
Result
Fit indices for the single factor model from CFA indicated a good fit: χ2(2) = 1.817, p = .403; RMSEA <.001 GFI = .979. PMBR was significantly reduced in the schizophrenia group compared to healthy controls, t (68) = 3.55, p < .001. Within the patient group, PMBR was significantly and negatively correlated with the CFA factor scores representing the Core Deficit score, r=−.543, p < .01, indicating that high core deficit scores were associated with reduced PMBR. PMBR was significantly correlated with the composite Disorganization score, r=−.521, p < .001.
Conclusion
Our findings demonstrate that the shared variance between impoverishment (psychomotor poverty); disorganization; cognitive impairment; and impaired role function can be accounted for by a latent variable that can reasonably be described as the core deficit of classical schizophrenia. The demonstration that the severity of the putative core deficit is correlated with the reduction in PMBR provides evidence that the core deficit is associated with an identifiable abnormality of brain dysfunction.
A diverse set of 107 rice genotypes was evaluated for yield, shattering and dormancy traits. Analysis of variance revealed sizable variation while skewness and kurtosis values indicated near-normal distribution for most of the traits, thus quantitative nature controlled by many genes. A highly significant deviation from a normal distribution for dormancy and shattering % indicated their qualitative nature of inheritance. Four promising genotypes ‘IRGC1723’ (early with 65 days to flowering), ‘IRGC 11108’ and ‘RNR 15459’ (high grain number – 358 and low average shattering – <5%), ‘RNR 11718’ (high single plant yield – 56.73 g, low average shattering – <5% and dormancy period – 21 days) are identified. A significant positive correlation between shattering and dormancy confirms inter-relationship among domestication-related characteristics. The principal component analysis revealed the contribution of four PCs to maximum variability and hierarchical clustering grouped the genotypes into 18 divergent clusters. Five cultivars (Karimnagar Samba, Sheetal, PR 121, Pranahitha and Jagitial Samba) with a combination of low shattering ability (3.35–5.7%) and considerable dormancy period (13–20 days) falling in the same cluster can be used as donors for the improvement of rice genotypes with low shattering ability and incorporating a considerable period of dormancy so as to avoid pre-harvest sprouting due to delayed harvesting. Further, they can be crossed with ‘Pratyumna’ having less than 1 week dormancy period, a genotype of the cluster XVII with which they have a maximum genetic divergence of 51.4 and may serve as parents in the development of mapping populations for the identification of QTLs/genes for shattering and dormancy traits.
Radiation therapy has historically used margins for target volume to ensure dosimetric planning criteria. The size of margin for a given treatment site is still uncertain particularly for moving targets along with set-up variations leading to a fuzziness of target volume. In this study, we have estimated the dosimetric benefit of normal structures using biological-based optimal margins. The treatment margins are derived by knowledge-based fuzzy logic technique which is considering the radiotherapy uncertainties in treatment planning.
Materials and methods:
All treatment plans were performed using stepped increments of asymmetric margins to estimate prostate radiobiological indices such as tumour control probability (TCP) and normal tissue complication probability (NTCP). An absolute NTCP of 5% was considered to be the maximum acceptable value while TCP of 85% was considered to be the minimal acceptable limit for each volumetric modulated arc therapy (VMAT) plan of localised prostate cancer radiotherapy. Results were used to formulate rules and membership functions for Mamdani-type fuzzy inference system (FIS). In implementing the rules for the fuzzy system for ΔNTCP values above 10%, the PTV margin was not permitted to exceed 5 mm to avoid rectal complications due to margin selection. The new margins were applied in VMAT planning of prostate cancer for standard displacement errors. The dosimetric results of normal tissue predictors were estimated such as organ mean doses, rectum V60 (volume receiving 60 Gy), bladder V65 (volume receiving 65 Gy) and other clinically significant dose–volume indicators and compared with VMAT plans using current margin formulations.
Results:
Dosimetric results compared well to the results obtained by current techniques. Good agreement was obtained between proposed fuzzy model margins and currently used margins in lower error magnitude, but significant results were observed at higher error magnitude when organ toxicity concerned without compromising the target volumes.
Findings:
The new margins may be helpful to estimate possible outcomes of normal tissue complications and thus may improve complication free survival particularly when organ motion errors are inevitable, case by case.
In this study, AA5083-reinforced multiwalled carbon nanotubes (MWCNT) nanocomposites were selected as the alternate material for a redundant articulated robot (RAR) design by varying the composition of MWCNT wt%. By assigning AA5083-reinforced MWCNT as a custom material to the parts of RAR developed by Solid Works and exported to MATLAB/SimMechanics platform to convert the model into multi-body system blocks. The dynamic parameter torque was observed utilising simulation capability in a SimMechanics second-generation environment. The simulation results inferred that AA5083 reinforced with increased wt% of MWCNT has better properties suitable for RAR design.
Nipah virus (NiV) outbreak occurred in Kozhikode district, Kerala, India in 2018 with a case fatality rate of 91% (21/23). In 2019, a single case with full recovery occurred in Ernakulam district. We described the response and control measures by the Indian Council of Medical Research and Kerala State Government for the 2019 NiV outbreak. The establishment of Point of Care assays and monoclonal antibodies administration facility for early diagnosis, response and treatment, intensified contact tracing activities, bio-risk management and hospital infection control training of healthcare workers contributed to effective control and containment of NiV outbreak in Ernakulam.
This study assessed the tobacco smoking-associated risk for tuberculous pleural effusion (TPE) in India. Ninety-two patients with TPE and 184 controls were randomly selected and assessed regarding their tobacco-smoking status and type, quantity and duration of tobacco used. Odds ratios (ORs) for the association of smoking cigarette, beedi and cigarette or beedi with TPE were 19.22 (p < 0.0001), 2.89 (p = 0.0006) and 4.57 (p < 0.0001) respectively. ORs for developing TPE increased with an increase in beedi/cigarette consumption, duration and pack years of smoking (p < 0.001 each). TPE was significantly associated with confounding risk factors viz., regular alcohol use (OR = 1.89, p = 0.019), history of contact with tuberculosis (TB) patient (OR = 8.07, p < 0.0001), past history of TB (OR = 22.31, p < 0.0001), family history of TB (OR = 9.05, p = 0.0002) and underweight (OR = 3.73, p = 0.0009). Smoking (OR = 3.07, p < 0.001), regular alcohol use (OR = 2.10, p = 0.018), history of contact with TB patient (OR = 4.01, p = 0.040), family history of TB (OR = 10.80, p = 0.001) and underweight (OR = 5.04, p < 0.001) were independently associated with TPE. Thus, both cigarette- and beedi-smoking have a significant association with TPE. The risk for TPE in tobacco smokers is dose- and duration-dependent.
The design of a circular-shaped differential wideband band pass filter (BPF) is described. The proposed filter is compact and provides good common mode (CM) suppression. It consists of four ports with a circular-shaped differential mode (DM). The analysis of the filter has been carried out by bisecting it into identical two-port networks along the symmetry plane, resulting in a band stop or band pass response under CM or DM excitations, respectively. The length and width of the stubs can be tuned to obtain the desired pass band and stop band of the differential BPF. The proposed design is fabricated and measured. The results obtained using measurements are in close agreement with those obtained using simulations.
This paper presents a substrate-integrated waveguide (SIW) mixed electric and magnetic coupling structure implemented on a single-layer substrate to create finite transmission zeros (TZs), which can be used to design microwave filters with higher frequency selectivity. Mixed coupling is realized by three slot-lines on the top metal plane combined with an iris-window between two adjacent SIW cavities. The electric and magnetic coupling can be separately controlled by adjusting the dimensions of the slot-lines and the width of the iris-window, and a controllable TZ below or above the passband can be produced. Furthermore, a detailed analysis of the mixed coupling structure is presented. To demonstrate the validity of the proposed structure, third- and fourth-order cross-coupled generalized Chebyshev bandpass filters are designed and fabricated using the standard printed circuit board process. The experimental results are in good agreement with the simulation results. The filters exhibit simple structure and good frequency selectivity.
In this paper, a new family of 3-degree-of-freedom planar parallel manipulators (PPMs), namely U-shape fixed base PPMs starting with an active prismatic joint on each leg, is proposed. In order to identify the best manipulators of this family, comparative kinematic and dynamic performance studies are performed. The kinematic performances are quantified through the local performance index, namely the kinematic isotropy. From the kinematic isotropy analysis results, it is observed that PPR-PRP-PRP, PRP-PRP-PRP and PRR-PRP-PRP configurations have better kinematic design aspects compared to other configurations of this family of U-shape fixed base parallel configurations. Further, from the workspace analysis, it is observed that the PPR-PRP-PRP configuration has a higher value of workspace to the total area required ratio compared to other configurations. This paper also presents a comparative dynamic performance analysis of these top-three U-shape fixed base configurations in terms of dynamic driving performance measures, and energy requirements for three different (fixed base size of the manipulators) aspect ratios under two different loading conditions. From the analyses results, it is perceived that the PRP-PRP-PRP configuration is requiring lower energy and dynamic driving performances than others. These analyses are done with the help of multi-body dynamic software, namely MSC ADAMS, and the results are validated through the help of real-time experiments conducted on in-house fabricated prototypes of these three PPMs. In specific, the energy consumption is measured and compared in this study. Experimental results demonstrated that the PRP-PRP-PRP manipulator displays a considerably better performance in terms of minimum energy requirement.
In this paper, a novel two-stage fish spear-shaped multimode resonator (MMR)-based ultra wideband (UWB) bandpass filter (BPF) is presented. The fish spear-shaped MMR is loaded with stepped impedance resonator in order to improve the out-of-band performance of the proposed filter. The proposed UWB BPF filter has fractional bandwidth better than 110%. In order to validate the present design approach, the filter is fabricated on RT/Duroid 5880 having dielectric constant 2.2, thickness 0.787 mm and loss tangent of 0.0009. The measured passband bandwidth of the filter is from 3.3 to 11.85 GHz, with insertion loss of 1.5 dB and return loss better than 12 dB in the passband. The proposed filter has sharp selectivity and upper stopband with 20 dB attenuation from 12 to 24 GHz.