The recent discovery of polymer diffusive instability (PDI) by Beneitez et al. (2023 Phys. Rev. Fluids 8, L101901), poses challenges in implementing artificial conformation diffusion (ACD) in transition simulations of viscoelastic wall-shear flows. In this paper, we demonstrate that the unstable PDI is primarily induced by the conformation boundary conditions additionally introduced in the ACD equation system, which could be eliminated if a new set of conformation conditions is adopted. To address this issue, we begin with an asymptotic analysis of the PDI within the near-wall thin diffusive layer, which simplifies the complexity of the instability system by reducing the number of the controlling parameters from five to zero. Then, based on this simplified model, we construct a stable asymptotic solution that minimises the perturbations in the wall sublayer. From the near-wall behaviour of this solution, we derive a new set of conformation boundary conditions, prescribing a Neumann-type condition for its streamwise stretching component, $c_{11}$, and Dirichlet-type conditions for all the other conformation components. These boundary conditions are subsequently validated within the original ACD instability system, incorporating both the Oldroyd-B and the finitely extensible nonlinear elastic Peterlin constitutive models. Finally, we perform direct numerical simulations based on the traditional and the new conformation conditions, demonstrating the effectiveness of the latter in eliminating the unstable PDI. Importantly, this improvement does not affect the calculations of other types of instabilities. Therefore, this work offers a promising approach for achieving reliable polymer-flow simulations with ACD, ensuring both numerical stability and accuracy.

This paper focuses on the concept of delaying laminar–turbulent transition in hypersonic boundary layers by stabilising fundamental resonance (FR), a key nonlinear mechanism in which finite-amplitude Mack modes support the rapid growth of oblique perturbations. As a pioneering demonstration of this control strategy, we introduce surface heating applied exclusively during the nonlinear phase. Unlike traditional control methods that target the linear phase, the suppressive effect of surface heating on secondary instability modes during FR is evident across various Reynolds numbers, wall temperatures and fundamental frequencies, as confirmed by direct numerical simulations (DNS) and secondary instability analyses (SIA). To gain deeper insights into this control concept, an asymptotic analysis is conducted, revealing an almost linear relationship between the suppression effect and the heating intensity. The asymptotic predictions align overall with the DNS and SIA calculations. The asymptotic theory reveals that the suppression effect of FR is primarily influenced by modifications to the fundamental-mode profile, while mean-flow distortion has a comparatively modest yet opposing impact on this process. This research presents a promising approach to controlling transition considering the nonlinear evolution of boundary-layer perturbations, demonstrating advantages over conventional methods that are sensitive to frequency variations.

Milk fat is a crucial component for evaluating the production performance and nutritional value of goat milk. Previous research indicated that the composition of ruminal microbiota plays a significant role in regulating milk fat percentage in ruminants. Thus, this study aimed to identify key ruminal microorganisms and blood metabolites relevant to milk fat synthesis in dairy goats as a mean to explore their role in regulating milk fat synthesis. Sixty clinically healthy Xinong Saanen dairy goats at mid-lactation and of similar body weight, and similar milk yield were used in a feeding study for 15 days. Based on daily milk yield of dairy goats and the results of milk component determination on the 1st and 8th days, five goats with the highest milk fat content (H group) and five goats with the lowest milk fat content (L group) were selected for further analysis. Before the morning feeding on the 15th day of the experiment, samples of milk, blood and ruminal fluid were collected for analyses of components, volatile fatty acids, microbiota and metabolites. Results revealed that acetate content in the rumen of H group was greater compared with L group. H group had abundant beneficial bacteria including Ruminococcaceae_UCG-005, Saccharofermentans, Ruminococcaceae-UCG-002 and Prevotellaceae_UCG-3, which were important for plant cellulose and hemicellulose degradation and immune regulation. Metabolomics analysis revealed H group had greater relative concentrations of 4-acetamidobutanoic acid and azelaic acid in serum, and had lower relative concentrations of Arginyl-Alanine, SM(d18:1/12:0) and DL-Tryptophan. These altered metabolites are involved in the sphingolipid signaling pathway, arginine and proline metabolism. Overall, this study identified key ruminal microorganisms and serum metabolites associated with milk fat synthesis in dairy goats. These findings offer insights for enhancing the quality of goat milk and contribute to a better understanding of the regulatory mechanisms involved in milk fat synthesis in dairy goats.

In this paper, we study the receptivity of non-modal perturbations in hypersonic boundary layers over a blunt wedge subject to free stream vortical, entropy and acoustic perturbations. Due to the absence of the Mack-mode instability and the rather weak growth of the entropy-layer instability within the domain under consideration, the non-modal perturbation is considered as the dominant factor triggering laminar–turbulent transition. This is a highly intricate problem, given the complexities arising from the presence of the bow shock, the entropy layer and their interactions with oncoming disturbances. To tackle this challenge, we develop a highly efficient numerical tool, the shock-fitting harmonic linearised Navier–Stokes (SF-HLNS) approach, which offers a comprehensive investigation on the dependence of the receptivity efficiency on the nose bluntness and properties of the free stream forcing. The numerical findings suggest that the non-modal perturbations are more susceptible to free stream acoustic and entropy perturbations compared with the vortical perturbations, with the optimal spanwise length scale being comparable with the downstream boundary-layer thickness. Notably, as the nose bluntness increases, the receptivity to the acoustic and entropy perturbations intensifies, reflecting the transition reversal phenomenon observed experimentally in configurations with relatively large bluntness. In contrast, the receptivity to free stream vortical perturbations weakens with increasing bluntness. Additionally, through the SF-HLNS calculations, we examine the credibility of the optimal growth theory (OGT) on describing the evolution of non-modal perturbations. While the OGT is able to predict the overall streaky structure in the downstream region, its accuracy in predicting the early-stage evolution and the energy amplification proves to be unreliable. Given its high-efficiency and high-accuracy nature, the SF-HLNS approach shows great potential as a valuable tool for conducting future research on hypersonic blunt-body boundary-layer transition.

We investigate the linear instability of flows that are stable according to Rayleigh’s criterion for rotating fluids. Using Taylor–Couette flow as a primary test case, we develop large-Reynolds-number-matched asymptotic expansion theories. Our theoretical results not only aid in detecting instabilities previously reported by Deguchi (Phys. Rev. E, vol 95, 2017, p. 021102(R)) across a wide parameter range, but also clarify the physical mechanisms behind this counterintuitive phenomenon. Instability arises from the interaction between large-scale inviscid vortices and the viscous flow structure near the wall, which is analogous to Tollmien–Schlichting waves. Furthermore, our asymptotic theories and numerical computations reveal that similar instability mechanisms occur in boundary layer flows over convex walls.

Investigations are conducted on the effect of wall proximity on the flow around a cylinder under an axial magnetic field, using the electrical potential probe technology to measure the velocity of liquid metal flow. The study focused on the impact of the inlet velocity of the fluid, the magnetic field and wall proximity on the characteristics of velocity fields, particularly on the vortex-shedding mode. Based on different magnitudes of the magnetic field and the distance from the cylinder to the duct wall, three types of vortex-shedding modes are identified, (I) shear layer oscillation state, (II) quasi-two-dimensional vortex-shedding states and (III) transition of the magnetohydrodynamic to hydrodynamic Kármán street. The transitions between these modes are analysed in detail. The experimental results show that the weak wall-proximity effect leads to the formation of the Kármán vortex street, while a reverse Kármán vortex street and secondary vortices emerge under a strong wall-proximity effect. It is noticed that the Kelvin–Helmholtz instability drives vortex shedding under regime I, leading to an increase in the Strouhal number (St) with stronger magnetic fields. Additionally, under a strong axial magnetic field, the wall-proximity effect (‘Shercliff layer effect’) promotes the instability of shear layers on both sides of the cylinder. These unique coupling effects are validated by variations in modal coefficients and energy proportions under different vortex-shedding regimes using the proper orthogonal decomposition method.

In this paper, we study the effect of lateral wall vibrations on the excitation and evolution of non-modal perturbations in hypersonic boundary layers subject to low-frequency freestream vortical disturbances (FSVDs). A novel, high-efficiency numerical approach, combining the harmonic weakly nonlinear Navier–Stokes and nonlinear parabolised stability equation approaches, is developed, which is sufficient to accommodate both the rapid distortion of the perturbation in the leading-edge vicinity and the nonlinear development of finite-amplitude high-order harmonics in the downstream region. The boundary-layer response to low-frequency FSVDs shows a longitudinal streaky structure, for which the temperature perturbation shows much greater magnitude than the streamwise velocity perturbation. The lateral vibration induces a Stokes layer solution for the spanwise velocity perturbation, which interacts with the FSVD-induced perturbations and leads to a suppression of the non-modal perturbation and an enhancement of the downstream modal perturbation. The new perturbations excited by the FSVD–vibration interaction strengthen as the vibration intensifies, and they could become comparable with the FSVD-induced perturbations in downstream locations at a high vibration intensity, indicating a remarkable modification of the streaky structure and its instability property. Secondary instability (SI) analyses based on the streaky base flow indicate that the vibration could enhance or suppress the SI modes, depending on their initial phases over the vibration period. Overall, the average effect is that the low-frequency and high-frequency SI modes are stabilised and destabilised by the vibration, respectively. Since the high-frequency SI modes undergo higher amplifications, the subsequent bypass transition is likely to be promoted by relatively strong vibrations.

Artificial sweeteners are generally used and recommended to alternate added sugar for health promotion. However, the health effects of artificial sweeteners remain unclear. In this study, we included 6371 participants from the National Health and Nutrition Examination Survey with artificial sweetener intake records. Logistic regression and Cox regression were applied to explore the associations between artificial sweeteners and risks of cardiometabolic disorders and mortality. Mendelian randomisation was performed to verify the causal associations. We observed that participants with higher consumption of artificial sweeteners were more likely to be female and older and have above medium socio-economic status. After multivariable adjustment, frequent consumers presented the OR (95 % CI) for hypertension (1·52 (1·29, 1·80)), hypercholesterolaemia (1·28 (1·10, 1·50)), diabetes (3·74 (3·06, 4·57)), obesity (1·52 (1·29, 1·80)), congestive heart failure (1·89 (1·35, 2·62)) and heart attack (1·51 (1·10, 2·04)). Mendelian randomisation confirmed the increased risks of hypertension and type 2 diabetes. Moreover, an increased risk of diabetic mortality was identified in participants who had artificial sweeteners ≥ 1 daily (HR = 2·62 (1·46, 4·69), P = 0·001). Higher consumption of artificial sweeteners is associated with increased risks of cardiometabolic disorders and diabetic mortality. These results suggest that using artificial sweeteners as sugar substitutes may not be beneficial.

In the present study, we performed direct numerical simulations for a hypersonic turbulent boundary layer over the windward side of a lifting body, the HyTRV model, at Mach number $6$ and attack angle 2$^{\circ }$ to investigate the global and local turbulent features, and evaluate its difference from canonical turbulent boundary layers. By scrutinizing the instantaneous and averaged flow fields, we found that the transverse curvature on the windward side of the HyTRV model induces the transverse opposing pressure gradients that push the flow on both sides towards the windward symmetry plane, yielding significant effects of the azimuthal inhomogeneity and large-scale cross-stream circulations, moderate and azimuthal independent influences of adverse pressure gradient, and negligible impact of the mean flow three-dimensionality. Further inspecting the local turbulent statistics, we identified that the mean and fluctuating velocity become increasingly similar to the highly decelerated turbulent boundary layers over flat plates in that the mean velocity deficit is enhanced, and the outer layer Reynolds stresses are amplified as it approaches the windward symmetry plane, and prove to be self-similar under the scaling of Wei & Knopp (J. Fluid Mech., vol. 958, 2023, A9) for adverse-pressure-gradient turbulent boundary layers. Conditionally averaged Reynolds stresses based on strong sweeping and ejection events demonstrated that the Kelvin–Helmholtz instability of the strong embedded shear layer induced by the large-scale cross-stream circulations is responsible for the turbulence amplification in the outer layer. The strong Reynolds analogy that relates the mean velocity and temperature was refined to incorporate the non-canonical effects, showing considerable improvements in the accuracy of such a formula. On the other hand, the temperature fluctuations are still transported passively, as indicated by their resemblance to the velocity. The conclusions obtained in the present study provide potentially profitable information for turbulent modelling modification for the accurate predictions of skin friction and wall heat transfer.

Dilatational motions in the shape of travelling wave packets have been identified recently to be dynamically significant in hypersonic turbulent boundary layers. The present study investigates the mechanisms of their generation and their association with the solenoidal motions, especially the well-recognized near-wall self-sustaining process of the regeneration cycle between the velocity streaks and quasi-streamwise vortices. By exploiting the direct numerical simulation databases and orchestrating numerical experiments, we explore systematically the near-wall flow dynamics in the processes of the formation and transient growth of low-speed streaks. We conclude via theoretical ansatz that the nonlinearity related to the parallel density and pressure gradients close to the wall due to the restriction of the isothermal boundary condition is the primary cause of the generation of the dilatational structures at small scales. In fully developed turbulence, the formation and the existence of healthy dilatational travelling wave packets require the participation of the turbulence at scales larger than those of the near-wall regeneration cycles, especially the occurrence of the bursting events that generate vortex clusters. This is proven by the less intensified dilatational motions in the numerical experiments in which the Orr mechanism is alleviated and the vortical structures and turbulent bursts are weakened.

Aiming at the problems of small good workspace, many singular configurations, and limited carrying capacity of non-redundant parallel mechanisms, a full-redundant drive parallel mechanism is designed and developed, and its performance evaluation, good workspace identification, and scale optimization design are studied. First, the kinematics analysis of the planar 6R parallel mechanism is completed. Then, the motion/force transmission performance evaluation index of the mechanism is established, and the singularity analysis of the mechanism is completed. Based on this, the fully redundant driving mode of the mechanism is determined, and the good transmission workspace of the mechanism in this mode is identified. Then, the mapping relationship between the performance and scale of the mechanism is established by using the space model theory, and the scale optimization of the mechanism is completed. Finally, the robot prototype is made according to the optimal scale, and the performance verification is carried out based on the research of dynamics and control strategy. The results show that the fully redundant actuation parallel mechanism obtained by design optimization has high precision and large bearing capacity. The position repeatability and position accuracy are 0.053 mm and 0.635 mm, respectively, and the load weight ratio can reach 15.83%. The research results of this paper complement and improve the performance evaluation and scale optimization system of redundantly actuated parallel mechanisms.

Very-large-scale motions are commonly observed in moderate- and high-Reynolds-number wall turbulence, constituting a considerable portion of the Reynolds stress and skin friction. This study aims to investigate the behaviour of these motions in high-speed and high-Reynolds-number turbulent boundary layers at varying Mach numbers. With the aid of high-precision numerical simulations, numerical experiments and theoretical analysis, it is demonstrated that the very-large-scale motions are weakened in high-Mach-number turbulence at the same friction Reynolds numbers, leading to the reduction in turbulent kinetic energy in the outer region. Conversely, the lower wall temperature enhances the very-large-scale motions but shortens the scale separation between the structures in the near-wall and outer regions.

The fundamental resonance (FR) in the nonlinear phase of the boundary-layer transition to turbulence appears when a dominant planar instability mode reaches a finite amplitude and the low-amplitude oblique travelling modes with the same frequency as the dominant mode, together with the stationary streak modes, undergo the strongest amplification among all the Fourier components. This regime may be the most efficient means to trigger the natural transition in hypersonic boundary layers. In this paper, we aim to reveal the intrinsic mechanism of the FR in the weakly nonlinear framework based on the large-Reynolds-number asymptotic technique. It is found that the FR is, in principle, a triad resonance among a dominant planar fundamental mode, a streak mode and an oblique mode. In the major part of the boundary layer, the nonlinear interaction of the fundamental mode and the streak mode seeds the growth of the oblique mode, whereas the interaction of the oblique mode and the fundamental mode drives the roll components (transverse and lateral velocity) of the streak mode, which leads to a stronger amplification of the streamwise component of the streak mode due to the lift-up mechanism. This asymptotic analysis clearly shows that the dimensionless growth rates of the streak and oblique modes are the same order of magnitude as the dimensionless amplitude of the fundamental mode $(\bar {\epsilon }_{10})$, and the amplitude of the streak mode is $O(\bar {\epsilon }_{10}^{-1})$ greater than that of the oblique mode. The main-layer solution of the streamwise velocity, spanwise velocity and temperature of both the streak and the oblique modes become singular as the wall is approached, and so a viscous wall layer appears underneath. The wall layer produces an outflux velocity to the main-layer solution, inclusion of which leads to an improved asymptotic theory whose accuracy is confirmed by comparing with the calculations of the nonlinear parabolised stability equations (NPSEs) at moderate Reynolds numbers and the secondary instability analysis (SIA) at sufficiently high Reynolds numbers.

Childhood maltreatment is an established risk factor for psychopathology. However, it remains unclear how childhood traumatic events relate to mental health problems and how the brain is involved. This study examined the serial mediation effect of brain morphological alterations and emotion-/reward-related functions on linking the relationship from maltreatment to depression. We recruited 156 healthy adolescents and young adults and an additional sample of 31 adolescents with major depressive disorder for assessment of childhood maltreatment, depressive symptoms, cognitive reappraisal and anticipatory/consummatory pleasure. Structural MRI data were acquired to identify maltreatment-related cortical and subcortical morphological differences. The mediation models suggested that emotional maltreatment of abuse and neglect, was respectively associated with increased gray matter volume in the ventral striatum and greater thickness in the middle cingulate cortex. These structural alterations were further related to reduced anticipatory pleasure and disrupted cognitive reappraisal, which contributed to more severe depressive symptoms among healthy individuals. The above mediating effects were not replicated in our clinical group partly due to the small sample size. Preventative interventions can target emotional and reward systems to foster resilience and reduce the likelihood of future psychiatric disorders among individuals with a history of maltreatment.

In order to establish a compact all-optical Thomson scattering source, experimental studies were conducted on the 45 TW Ti: sapphire laser facility. By including a steel wafer, mixed gas, and plasma mirror into a double-exit jet, several mechanisms, such as shock-assisted ionization injection, ionization injection, and driving laser reflection, were integrated into one source. So, the source of complexity was remarkably reduced. Electron bunches with central energy fluctuating from 90 to 160 MeV can be produced. Plasma mirrors were used to reflect the driving laser. The scattering of the reflected laser on the electron bunches led to the generation of X-ray photons. Through comparing the X-ray spots under different experimental conditions, it is confirmed that the X-ray photons are generated by Thomson scattering. For further application, the energy spectra and source size of the Thomson scattering source were measured. The unfolded spectrum contains a large amount of low-energy photons besides a peak near 67 keV. Through importing the electron energy spectrum into the Monte Carlo simulation code, the different contributions of the photons with small and large emitting angles can be used to explain the origin of the unfolded spectrum. The maximum photon energy extended to about 500 keV. The total photon production was 107/pulse. The FWHM source size was about 12 μm.

This paper focuses on the linear evolution of Mack instability modes in a hypersonic boundary layer over a flat plate that is partially coated by a compliant section. The compliant section is a thin, flexible membrane covering on a porous wall consisting of micro holes. The instability pressure could induce a vibration of the membrane, leading to a feedback to the boundary-layer fluids through the transverse velocity fluctuation. Such a process is formulated by an admittance boundary condition for the boundary-layer perturbation, which is dependent on the thickness and tension of the membrane, the properties of the porous wall, and the frequency of the Mack-mode perturbation. Using this admittance condition, the impact of the compliant coating on the Mack growth rate is studied systematically by solving the compressible Orr–Sommerfeld equations. It is found that the compliant coating could suppress the Mack instability with a frequency band in the neighbourhood of the most unstable frequency, and the stabilising frequency band widens as the membrane thickness and tension decrease, indicating a more favourable effect of a softer membrane. For a Mack mode with a specified dimensional frequency – since its dimensionless frequency, normalised by the local boundary-layer thickness and oncoming velocity, increases as it propagates downstream – the second-mode frequency band usually appears in downstream locations, and so does the stabilising effect of the membrane. Thus it is favourable to apply a compliant panel at a downstream region. In this situation, the solid–compliant junction could produce an additional scattering effect on the evolution of the Mack mode due to the sudden change of its boundary condition. The scattering effect is quantified by a transmission coefficient defined by the equivalent amplitude of the compliant-wall perturbation to the solid-wall perturbation, which can be obtained by the harmonic linearised Navier–Stokes (HLNS) approach. If the admittance is weak, then the transmission coefficient can also be predicted by an analytical solution based on the residue theorem. It is found that most of the second modes are suppressed by the scattering effect as long as the argument of the admittance is in the interval $[150^\circ, 210^\circ ]$, agreeing with most of the physical situation. The analytical predictions agree well with the HLNS calculations when the modulus of the admittance is less than $O(0.1)$.

In the present study, we investigate the compressibility effects in supersonic and hypersonic turbulent boundary layers under the influence of wall disturbances by exploiting direct numerical simulation databases at Mach numbers up to 6. Such wall disturbances enforce extra Reynolds shear stress on the wall and induce mean streamline curvature in rough wall turbulence that leads to the intensification of turbulent motions in the outer region. The turbulent and fluctuating Mach numbers, the density and the velocity divergence fluctuation intensities suggest that the compressibility effects are enhanced by the increment of the free-stream Mach number and the implementation of the wall disturbances. The differences between the Reynolds and Favre average due to the density fluctuations constitute approximately $9\,\%$ of the mean velocity close to the wall and $30\,\%$ of the Reynolds stress near the edge of the boundary layer, indicating their non-negligibility in turbulent modelling strategies. The comparatively strong compressive events behaving as eddy shocklets are observed at the free-stream Mach number of $6$ only in the cases with wall disturbances. By further splitting the velocity into the solenoidal and dilatational components with the Helmholtz decomposition, we found that the dilatational motions are organized as travelling wave packets in the wall-parallel planes close to the wall and as forward inclined structures in the form of radiated waves in the vertical planes. Despite their increased magnitudes and higher portion in the Reynolds normal and shear stresses, the dilatational motions show no tendency of contributing significantly to the skin friction and the production of turbulent kinetic energy due to their mitigation by the cross-correlation between the solenoidal and dilatational velocity components.

In this paper, we present a systematic study of the nonlinear evolution of the travelling Mack modes in a Mach 3 supersonic boundary layer over a rotating cone with a $7^{\circ }$ half-apex angle using the nonlinear parabolic stability equation (NPSE). To quantify the effect of cone rotation, six cases with different rotation rates are considered, and from the same streamwise position, a pair of oblique Mack modes with the same frequency but opposite circumferential wavenumbers are introduced as the initial perturbations for NPSE calculations. As the angular rotation rate $\varOmega$ increases such that $\bar \varOmega$ (defined as the ratio of the rotation speed of the cone to the streamwise velocity at the boundary-layer edge) varies from 0 to $O(1)$, three distinguished nonlinear regimes appear, namely the oblique-mode breakdown, the generalised fundamental resonance and the centrifugal-instability-induced transition. For each regime, the mechanisms for the amplifications of the streak mode and the harmonic travelling waves are explained in detail, and the dominant role of the streak mode in triggering the breakdown of the laminar flow is particularly highlighted. Additionally, from the linear stability theory, the dominant travelling mode undergoes the greatest amplification for a moderate $\varOmega$, which, according to the $e^N$ transition-prediction method, indicates premature transition to turbulence. However, this is in contrast to the NPSE results, in which a delay of the transition onset is observed for a moderate $\varOmega$. Such a disagreement is attributed to the different nonlinear regimes appearing for different rotation rates. Therefore, the traditional transition-prediction method based on the linear instability should be carefully employed if multiple nonlinear regimes may appear.