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Ultrasound provides a unique diagnostic perspective in cerebrovascular disorders, with extremely high temporal resolution and excellent spatial display of extracranial arteries, brain structures and cerebral vessels. This comprehensive text covers the fundamentals of ultrasound physics, new technology, and clinical applications in all ages. It provides a firm grounding in hemodynamics and describes computational models for study of the cerebral circulation. Extracranial applications in assessing the carotid and vertebral arteries are discussed in detail, as are intracranial Doppler applications in stroke, subarachnoid hemorrhage, arteriovenous malformations, interventional and surgical procedures, and the detection and monitoring of cerebral microembolism. These and other topics, both clinical and technical, are presented by leading authorities in the field, with extensive illustrations, and tables are included for the standardized classification of cerebrovascular diseases based on international consensus conferences. For clinicians and clinical neuroscientists this is the definitive reference text in cerebrovascular ultrasound.
Stroke is the leading cause of permanent disability, including post-stroke dementia, pain, depression, and personality changes. While large clinical trials reflect information about large stroke populations, the presentation of each and every stroke patient is individual and special. More Case Studies in Stroke presents a new selection of stroke cases from seven countries prepared by practising stroke physicians. The book includes both common and unusual cases, as well as misleading cases of diseases mimicking stroke. The aim is to reinforce diagnostic skills through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, followed by diagnosis and discussion. The outline of the actual diagnostic process, including the use of modern diagnostic tools, decision making and course, challenge the reader at all stages of their career from medical students to neurologists and stroke physicians.
Neurologists learn from their patients, and this selection of 60 stroke cases will inform and challenge clinicians at all stages in their careers. Including both common and unusual cases, the aim is to reinforce diagnostic skills through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, usually involving imaging before a diagnosis is given. There then follows for each case a discussion of the clinical issues raised by the case, in which the main teaching points are emphasized. Selected references, frequently including the first description, are provided at the conclusion of each case. Drawing on the expertise of leading teachers and practitioners, and liberally illustrated, these case studies and the discussions that accompany them are an essential guide to learning the complexity of stroke diagnosis.
Kohlmeier-Degos' disease (KDD) is more common in white boys and men with age of onset ranging between 3 weeks of age to 67 years old, most commonly occurring in the second and third decades. The etiology and pathogenesis, although still unknown, is speculated to be immunologic dysfunction, coagulation or fibrinolysis abnormalities, or possible viral infections. Any organ system may be involved; the clinical manifestations are a result of multifocal infarctions. Laparoscopic examination, however, shows lesions similar in appearance to the skin lesions that may involve multiple areas of the small intestine. These lesions are secondary to infarction and have also been found in the esophagus, duodenum, stomach, colon, and rectum. Ischemia and infarction are key pathophysiological mechanisms of the lesions seen. Therapies that have been used include antiplatelets, anticoagulants, immunosuppressive agents, plasma exchange, and nicotine patches. Surgery is indicated in cases of intestinal perforation.