The number of published systematic reviews has increased over the last years, with a non-negligible proportion displaying methodological concerns. We aimed to develop and evaluate a tool to assess the reported methodological quality of medical systematic reviews. The developed tool (ReMarQ) consists of 26 dichotomous items. We applied an item response theory model to assess the difficulty and discrimination of the items and decision tree models to identify those items more capable of identifying systematic reviews with higher reported methodological quality. ReMarQ was applied to a representative sample of medical systematic reviews (excluding those published in the Cochrane Database of Systematic Reviews) to describe their methodological quality and identify associated factors. We assessed 400 systematic reviews published between 2010 and 2020, of which 196 (49.0%) included meta-analysis. The most discriminative items were (i) conducting a risk of bias assessment, (ii) having a published protocol and (iii) reporting methods for solving disagreements. More recent systematic reviews (adjusted yearly RR=1.03; 95%CI=1.02 −1.04, p<0.001) and those with meta-analysis (adjusted RR=1.34; 95%CI=1.25 −1.43, p<0.001) were associated with higher reported methodological quality. Such an association was not observed with the journal impact factor. The items most frequently fulfilled were (i) reporting search dates, (ii) reporting bibliographic sources and (iii) searching multiple electronic bibliographic databases. ReMarQ, consisting of dichotomous items and whose application does not require subject content expertise, may be important (i) in supporting an efficient quality assessment of systematic reviews and (ii) as the basis of automated processes to support that assessment.

In this work, the stopping power of a partially ionized helium plasma due to its free and bound electrons is analyzed for an electron temperature and density in which local thermal equilibrium (LTE) or non-local thermal equilibrium (NLTE) regimes can be possible. In particular by means of collisional-radiative models, the average ionization of the plasma as well as the abundances of different helium species (HeI, HeII, and HeIII) are analyzed in both LTE and NLTE thermodynamic states. The influence of this ionization and of the different ion abundances on the stopping power of the helium plasma is shown to be quite significant. Finally, our theoretical model is compared with experimental results on slowing down of swift argon ions in helium plasma.

The Endangered Cuvier's gazelle Gazella cuvieri is an endemic ungulate of north-western Africa. Information on the species has been based primarily on non-systematic surveys, and the corresponding status estimates are of unknown quality. We evaluate the effectiveness and efficiency of two field methods for systematic surveys of populations of Cuvier's gazelle in arid environments: distance sampling (based on sightings) and sampling indirect sign (tracks and scats). The work was carried out in the north-western Sahara Desert, in Morocco, where what is possibly the largest population of Cuvier's gazelle persists. A logistically viable survey was conducted over a total area of c. 20.000 km2 in 10 expeditions during 2011–2014. A total of 67 sites were surveyed, with 194 walking surveys (2,169 km in total). Gazelle signs were detected at 50 sites, and gazelles were sighted at 21 sites (61 individuals). We found a relationship between sightings and abundance indices based on indirect sign, which could be useful for population monitoring or ecological studies. Additionally, the data could be used in occupancy modelling. Density estimates based on distance sampling required considerable effort; however, it is possible to survey large areas during relatively short campaigns, and this proved to be the most useful approach to obtain data on the demographic structure of the population.

Thus far, little has been written concerning echocardiographic identification of the oblique vein of the left atrium, or Marshall’s vein. There is much discussion, nonetheless, on the potential significance of the vein, or its ligamentous remnant, as an arrhythmic substrate. We describe here four patients in whom transthoracic echocardiography revealed a venous structure protruding within the cavity of the left atrium. We discuss the possibility that these structures represent Marshall’s vein, albeit probably as part of a persistent left superior caval vein.

It has been traditionally assumed that medial temporal lobe (MTL) is not required for working memory (WM). However, animal lesion and electrophysiological studies and human neuropsychological and neuroimaging studies have provided increasing evidences of a critical involvement of MTL in WM. Based on previous findings, the central aim of this study was to investigate the contribution of the MTL to verbal WM encoding. Here, we used magnetoencephalography (MEG) to compare the patterns of MTL activation of 9 epilepsy patients suffering from left hippocampal sclerosis with those of 10 healthy matched controls while they performed a verbal WM task. MEG recordings allow detailed tracking of the time course of MTL activation. We observed impaired WM performance associated with changes in the dynamics of MTL activity in epilepsy patients. Specifically, whereas patients showed decreased activity in damaged MTL, activity in the contralateral MTL was enhanced, an effect that became significant in the 600- to 700-ms interval after stimulus presentation. These findings strongly support the crucial contribution of MTL to verbal WM encoding and provide compelling evidence for the proposal that MTL contributes to both episodic memory and WM. Whether this pattern is signaling reorganization or a normal use of a damaged structure is discussed. (JINS, 2009, 15, 536–546.)

A study was carried out to analyse the production and composition of milk from Malagueña goats of different genotypes for the content of αs1-casein. Twenty goats were used, half of them with a high (HG) and half with a low (LG) genetic capability for αs1-casein synthesis. Among the ten HG goats, seven had BB and three had AB genotypes, whereas there were seven EF and three FF genotypes among the LG goats. The goats were fed a diet differing in crude protein content, 136 and 177 g/kg dry matter for diet 1 (D1) and diet 2 (D2), respectively. For each genotype group, a trial was conducted, with each of the two diets in a two-period balanced change-over design, in which the milk production and composition were analysed. The genotype was found to determine milk composition, with that produced by the HG goats being higher in total solids, protein, αs1-casein, αs2-casein and fat. Analysis of milk production values and, especially, those of the yields of the different components, revealed an interaction between the factors. HG goats that consumed D1 were more productive than LG goats, but this ceased to be so when the D1 diet was replaced by D2. However, LG goats, although less productive than HG ones when the D1 diet was consumed, showed increased productive capacity when D1 was replaced by D2. The main difference for the fatty acid profile of the dairy fat is that the milk fat produced by the HG goats contained higher levels of short and medium-chain fatty acids. From these results, it is concluded that, in terms of favouring production, the advantage of replacing animals with a low capacity for αs1-casein synthesis with those of a high capacity seems to depend on the protein level in the diet. Similarly, the advantage of changing to a diet of higher protein content depended on the animal's genotype.

This paper presents molecular dynamics simulations of shear-coupled migration of tilt boundaries pinned by triple junctions in a simple model structure of columnar grains of different sizes. Simulations are for copper at 300 K. The phenomenon is of interest as a possible explanation of the Hall-Petch relationship breakdown in nano-grained polycrystals deformed at high or moderate strain rate and low-temperature.

The elastic deformation contribution can significantly affect the measurement of the strain-rate sensitivity (SRS) of the plastic flow stress by indentation methods. In this paper, the effect of such elastic contribution is critically analyzed using an extension of a previous treatment developed by the authors for the elastic effects on the indentation of strain-hardening materials [J. Alkorta et al., J. Mater. Res.20, 432 (2005)]. The analytical model is calibrated and validated through finite element calculations. The results show that when the elastic contribution to the total deformation is not negligible then the measured SRS is significantly lower than the real one. A satisfactory correction factor for the apparent SRS exponent is proposed based on parameters directly accessible to instrumented indentation test results.

Slope Water anticyclonic Oceanic eDDIES (SWODDIES) are typical mesoscale features of open-ocean waters of the southern Bay of Biscay which usually develop in winter by shedding from the seasonal poleward current flowing along the northern Spanish slope. These eddies have been intensively studied from the physical perspective. However, their effect on the distribution of biological properties and on the functioning of the pelagic ecosystem has not been assessed so far. To this aim, a sea-truth, multidisciplinary and comprehensive study of a SWODDY was carried out in summer 1998. The eddy, radius of ≈50 km, was initially centred at 45·5°N 6·0°W, being characterized by a relatively homogeneous core of water in the centre of the eddy extending from 80 to about 200 dbar. In the central region of the core, temperature (12·55–12·75°C) and salinity (≈35·70) values were higher than outside the eddy. The optical properties of the eddy also differed from those of the surrounding waters. A distinct biological signature was found associated with the eddy. Depth-integrated chlorophyll-a concentrations were 25% higher at the eddy centre where upward doming of the seasonal pycnocline (up to 30 dbar) occurred. Enhanced phytoplankton biomass was related to a higher contribution of >10 μm cells, mainly represented by diatoms and chrysophyceans. Phytoplankton and mesozooplankton species composition in and outside the eddy differed significantly reflecting the coastal origin of the water parcel trapped by the eddy. The sharp modification of the planktonic community composition, biomass and associated size-structure caused by slope water oceanic eddies are likely to exert a significant effect upon the upper trophic levels of the pelagic ecosystem of the southern Bay of Biscay.

The full paper describes an environment for the generation of non-deterministic taggers, currently used for the development of a Spanish lexicon. In relation to previous approaches, our system includes the use of verification tools in order to assure the robustness of the generated taggers. A wide variety of user defined criteria can be applied for checking the exact properties of the system.

El proceso desamortizador permitió una reestructuración capitalista del campo español al remover todo el sistema de relaciones de producción propias del Antiguo Régimen en favor de la propiedad burguesa de la tierra. Era un paso necesario para que el modo de producción capitalista pudiese desarrollarse con plenitud en España.