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While mobile gaming addiction (MGA) behavior is increasingly prevalent among children and adolescents, the role of specific emotional-behavioral profiles – particularly their latent patterns – in associating with MGA behavior remains poorly understood. This study aimed to examine these associations and age-related variations.
Methods
Data were analyzed from 507,188 participants aged 6–18 years in the Children’s Growth Environment, Lifestyle, and Physical and Mental Health Development Project, conducted in Guangzhou, China, in 2020. Latent class analysis was performed on parent-reported Strengths and Difficulties Questionnaire (SDQ) data to identify subgroups with distinct emotional and behavioral problems. Associations between SDQ dimensions, latent classes, and MGA behavior were examined using logistic regression analysis.
Results
Five latent classes were identified: ‘Low symptom’ (82.2%), ‘Internalizing’ (0.8%), ‘Peer and prosocial issues’ (4.3%), ‘High difficulties’ (5.0%), and ‘Hyperactive’ (7.6%). Compared to the ‘Low symptom’ class, all other latent classes showed significantly higher risks for MGA, with the strongest association observed in the ‘Internalizing’ class (adjusted odds ratio [AOR]: 2.84; 95% confidence interval [95% CI]: 2.67–3.02). Among SDQ subscales, conduct problems presented the highest association (AOR: 2.08; 95% CI: 2.04–2.12), though all SDQ subdimensions were significantly positively correlated with MGA behavior (all p < 0.05). Notably, these associations were consistently stronger in adolescents (aged 13–18 years) than in children (aged 6–12 years).
Conclusions
This study identifies specific SDQ-based risk characteristics for MGA behavior, with adolescents (aged 13–18 years) being the most vulnerable. Future longitudinal studies should verify these associations, and clinicians may prioritize early screening for internalizing and conduct-related difficulties.
In this paper, an ultra-wideband, low-scattering, and stable-gain Fabry–Perot antenna is proposed based on a novel hybrid metasurface. The radar cross-section (RCS) reduction is achieved by employing a 1-bit checkerboard polarization conversion metasurface (PCM) with a high polarization conversion ratio. Moreover, to enhance the antenna gain, broaden the 3-dB gain bandwidth, and maintain stable gain performance within the passband, a nonuniform reflective metasurface with a positively sloped reflection phase is strategically introduced. This metasurface, combined with the tessellated PCM layer, forms a hybrid structure featuring high transmission efficiency. Benefiting from this hybrid metasurface design, the antenna demonstrates a maximum gain enhancement of 4.7 dBi, an average gain improvement of 2.7 dBi, and a 39.8% increase in the 3-dB gain bandwidth. To validate the proposed design methodology, a prototype antenna was fabricated and experimentally measured. The measured results show good agreement with the simulated predictions. Specifically, the fabricated antenna exhibits a –10 dB impedance bandwidth of 22.47% (7.23–9.06 GHz), a 3-dB gain bandwidth of 18.2% (7–8.4 GHz), and a maximum gain of 17.25 dBi at 7.2 GHz. Additionally, the antenna achieves an RCS reduction bandwidth of 102.3%, with a maximum RCS reduction of 35.3 dB at 13.03 GHz.
Design Science is the discipline that studies the creation of artifacts – products, services, and systems and their embedding in our physical, virtual, psychological, economic, and social environments. This editorial is a collective effort of the Design Science Journal’s editorial board members, past and present. The journal’s inaugural 2015 editorial, “Design Science: Why, What and How,” reflected the thoughts and vision of that first editorial board for the new journal and the discipline it represented. The present contribution offers the reflections of editors who served the journal in the past 10 years. The individual contributions were not primed and are presented here unedited for conformity or consistency. Differently from the 2015 editorial, there is no effort to synthesize the individual contributions, leaving the task to our readers, who can draw their own conclusions about the Design Science Journal and community accomplishments to date, and the challenges ahead.
We demonstrate a high-power, flexibly tunable dual-pulse laser via temporal modulation techniques to overcome conventional systems’ fixed pulse width and temporal interval constraints, enhancing precision micro/nanofabrication and nonlinear photonics applications. By combining dispersion-engineered seed pulse shaping for adjustable pulse widths (5.6 ps and 0.38–0.47 ns) with optical-delay synchronized interval tuning (from –4 to 12.5 ns), the system achieves wide flexibility in pulse configuration. Furthermore, detailed nonlinear dynamics studies reveal the picosecond component exhibits reduced amplifier efficiency versus the nanosecond component, primarily due to peak-power-driven irreversible energy transfer to Raman-shifted wavelengths. This unique combination of features enables remarkable performance: 1092 W average power at 16 MHz with precisely tailored 15.9 ps/0.44 ns pulse widths and 4.2 ns temporal interval. This high-power tunability establishes a transformative material processing paradigm from precision machining to photonics, advancing fundamental nonlinear pulse science and setting new industrial laser standards.
As a highly aggressive tumour of the digestive tract, pancreatic cancer has a high mortality rate and poor treatment outcomes. The five-year survival rate for patients with pancreatic cancer is distressingly low, and the recurrence chance remains unacceptably high even with successful treatment. Surgical procedures and chemotherapy are the main treatments of pancreatic cancer, and surgical procedures are the only effective treatment at present. However, these cancer cells can easily develop resistance to chemotherapy agents, which leads to low treatment efficacy and high mortality in pancreatic cancer. Additionally, early diagnosis of pancreatic cancer is challenging due to the absence of obvious symptoms, making surgical intervention unattainable in early stages. However, pancreatic cancer cells show unique changes at genetic and cellular levels, which makes them sensitive to metalrelated cell death or exhibit some characteristics related to metalrelated cell death. These changes and characteristics could be utilized for treatment and diagnosis in pancreatic cancer.
Method
Therefore, our motivation is to explain the potential of metalrelated cell death in treating this aggressive cancer. This review begins by analysing the types of metal-related cell death: ferroptosis, cuproptosis and lysozincrosis. Each form is evaluated based on its unique features and related metabolic pathways.
Results
By examining the key characteristics of metal-related cell death modalities, their primary metabolic patterns and their interactions with pancreatic cancer, our aim is to point the direction to identify potential therapies and treatments.
Conclusions
Our review expands the possibilities for utilizing metal-related cell death and instils hope for its future potential in pancreatic cancer treatment.
Euthymic bipolar disorder (euBD) patients exhibit deficits in neurocognitive and social cognitive functioning compared to healthy controls (HCs). Our prior research has shown that the excitatory/inhibitory (E/I) imbalance in the default mode network (DMN) is linked to executive function in euBD. Neurocognitive impairments are associated with social cognition deficits in individuals with mental disorders. Given this connection, this study posits E/I imbalance within the DMN is associated with social cognition, with executive function as a mediator.
Methods
Seventy-five HCs and 49 euBD individuals were recruited. Using the emotion recognition task, Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version (DANVA-2-TW) and cognitive flexibility task, Wisconsin Card Sorting Test (WCST), we assessed emotion recognition and prefrontal function. Proton magnetic resonance spectroscopy (1H-MRS) measured metabolites in the posterior cingulate cortex (PCC) and medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC), quantifying excitatory glutamate+glutamine (Glx) and inhibitory GABA to calculate the E/I ratio.
Results
euBD patients showed poorer emotion recognition (p = 0.020) and poorer cognitive flexibility (fewer WCST categories completed, p = 0.002). A negative association was found between emotion recognition and the E/I ratio in the mPFC/ACC of the BD patients (r = −0.30, p = 0.034), which was significantly mediated by cognitive flexibility (Z = −2.657, p = 0.007).
Conclusion
The BD patients demonstrate deficits in emotion recognition, linked to an altered E/I balance in the prefrontal cortex, and the cognitive flexibility, a key aspect of executive function, mediates the impact of the E/I ratio on emotion recognition accuracy in euBD patients.
Late-onset depression (LOD) is featured by disrupted cognitive performance, which is refractory to conventional treatments and increases the risk of dementia. Aberrant functional connectivity among various brain regions has been reported in LOD, but their abnormal patterns of functional network connectivity remain unclear in LOD.
Methods
A total of 82 LOD and 101 healthy older adults (HOA) accepted functional magnetic resonance imaging scanning and a battery of neuropsychological tests. Static functional network connectivity (sFNC) and dynamic functional network connectivity (dFNC) were analyzed using independent component analysis, with dFNC assessed via a sliding window approach. Both sFNC and dFNC contributions were classified using a support vector machine.
Results
LOD exhibited decreased sFNC among the default mode network (DMN), salience network (SN), sensorimotor network (SMN), and language network (LAN), along with reduced dFNC of DMN-SN and SN-SMN. The sFNC of SMN-LAN and dFNC of DMN-SN contributed the most in differentiating LOD and HOA by support vector machine. Additionally, abnormal sFNC of DMN-SN and DMN-SMN both correlated with working memory, with DMN-SMN mediating the relationship between depression and working memory. The dFNC of SN-SMN was associated with depressive severity and multiple domains of cognition, and mediated the impact of depression on memory and semantic function.
Conclusions
This study displayed the abnormal connectivity among DMN, SN, and SMN that involved the relationship between depression and cognition in LOD, which might reveal mutual biomarkers between depression and cognitive decline in LOD.
In this article, we report new marine reservoir age correction (ΔR) values from the Marine20 calibration for the Penghu Islands in the Taiwan Strait over the past 6700 cal BP, derived from 14C and U-Th ages of Holocene corals. Since secondary calcite from diagenetic processes can influence coral 14C ages, we developed a pretreatment protocol that ensures low calcite content (<1%, 0.8±0.2%) using a combination of thorough physical cleaning and repeated XRD measurements. We compare our new measurements with published ΔR values from the region, recalculated to conform to the Marine20 dataset. The results show larger temporal variation (∼300 yr) in ΔR from 5500 to 6700 cal BP for the Penghu Islands and ∼400 yr variability at several SCS sites from 5500 to 8200 cal BP. Relatively smaller ΔR variability is observed from 0–5500 cal BP: ∼220 yr in the Penghu Islands and ∼320 yr for South China Sea sites. The weighted mean ΔR value of –155±59 14C yr for the past 5500 cal BP is determined as the marine reservoir age correction around Taiwan and northeastern SCS, and this value is consistent with modern values inherited from the North Equatorial Current, the upstream source of the Kuroshio Current that feeds the northeastern SCS and the Taiwan Strait.
Paleontology provides insights into the history of the planet, from the origins of life billions of years ago to the biotic changes of the Recent. The scope of paleontological research is as vast as it is varied, and the field is constantly evolving. In an effort to identify “Big Questions” in paleontology, experts from around the world came together to build a list of priority questions the field can address in the years ahead. The 89 questions presented herein (grouped within 11 themes) represent contributions from nearly 200 international scientists. These questions touch on common themes including biodiversity drivers and patterns, integrating data types across spatiotemporal scales, applying paleontological data to contemporary biodiversity and climate issues, and effectively utilizing innovative methods and technology for new paleontological insights. In addition to these theoretical questions, discussions touch upon structural concerns within the field, advocating for an increased valuation of specimen-based research, protection of natural heritage sites, and the importance of collections infrastructure, along with a stronger emphasis on human diversity, equity, and inclusion. These questions offer a starting point—an initial nucleus of consensus that paleontologists can expand on—for engaging in discussions, securing funding, advocating for museums, and fostering continued growth in shared research directions.
Data on aortic valve outcomes following surgical repair of doubly committed subarterial ventricular septal defect remain limited.
Methods:
This retrospective study included doubly committed subarterial ventricular septal defect patients who underwent surgical repair at our centre from 2013 to 2023. The primary outcome was the incidence of new-onset aortic regurgitation during follow-up.
Results:
A total of 320 patients were included, with a median age of 2.0 (0.9–7.2) years. Among them, 289 patients underwent surgical repair alone (repair group), and 31 received additional aortic valve surgery (repair + aortic valve surgery group). Preoperatively, 58 (18.1%) patients exhibited aortic regurgitation ≥ mild (10.7% in the repair group vs 87.1% in the repair + aortic valve surgery group, P < 0.001). The overall median follow-up was 40.5 (16.0–72.0) months. At the last follow-up, 23 (7.4%) patients had aortic regurgitation ≥ mild (3.8 vs 52.2%, P < 0.001), and 6 (1.9%) had aortic regurgitation > mild (0.3 vs 21.7%, P < 0.001). Sixteen (5.1%) patients developed new-onset aortic regurgitation during follow-up (1.7 vs 47.8%, log-rank P < 0.001), and 6 (1.9%) of them developed new-onset aortic regurgitation > mild (0.3 vs 21.7%, log-rank P < 0.001). Age, ventricular septal defect size, preoperative aortic regurgitation > mild, and maximum aortic valve flow velocity (AVmax) were related to concurrent aortic valve surgery and new-onset aortic regurgitation.
Conclusions:
Based on our retrospective data, the mid-term aortic valve outcomes after doubly committed subarterial ventricular septal defect repair were relatively satisfactory, with a low incidence of new-onset aortic regurgitation during follow-up. However, aortic valve outcomes for patients who received concurrent aortic valve surgery were less satisfactory.
Previous studies highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the ‘relative association’ to ascertain the optimal consumption strategy (including total intake and optimal allocation strategy) for coffee, tea and plain water associated with decreased mortality. Self-reported coffee, tea and plain water intake were used from the UK Biobank. Within a compositional data analysis framework, a multivariate Cox model was used to assess the relative associations after adjusting for a range of potential confounders. The lower mortality risk was observed with at least approximately 7–8 drinks/d of total consumption. When the total intake > 4 drinks/d, substituting plain water with coffee or tea was linked to reduced mortality; nevertheless, the benefit was not seen for ≤ 4 drinks/d. Besides, a balanced consumption of coffee and tea (roughly a ratio of 2:3) associated with the lowest hazard ratios of 0·55 (95 % CI 0·47, 0·64) for all-cause mortality, 0·59 (95 % CI 0·48, 0·72) for cancer mortality, 0·69 (95 % CI 0·49, 0·99) for CVD mortality, 0·28 (95 % CI 0·15, 0·52) for respiratory disease mortality and 0·35 (95 % CI 0·15, 0·82) for digestive disease mortality than other combinations. These results highlight the importance of the rational combination of coffee, tea and plain water, with particular emphasis on ensuring adequate total intake, offering more comprehensive and explicit guidance for individuals.
This paper examines how credit constraints shape the transmission of uncertainty shocks in business cycles. Standard models struggle to capture the simultaneous declines in output, consumption, investment, and labor hours during uncertainty spikes. We introduce collateral-based credit constraints for impatient households and entrepreneurs, linking their borrowing capacity to asset values. As uncertainty rises, higher risk premia reduce the demand for collateral assets, prompting impatient households to cut labor supply, leading to an output decline. Our model generates macroeconomic co-movements without relying on nominal rigidities. Lowering the loan-to-value (LTV) ratio, particularly for households, helps mitigate these adverse effects.
Robots need a sense of touch to handle objects effectively, and force sensors provide a straightforward way to measure touch or physical contact. However, contact force data are typically sparse and difficult to analyze, as it only appears during contact and is often affected by noise. Therefore, many researchers have consequently relied on vision-based methods for robotic manipulation. However, vision has limitations, such as occlusions that block the camera’s view, making it ineffective or insufficient for dexterous tasks involving contact. This article presents a method for robotic systems operating under quasi-static conditions to perform contact-rich manipulation using only force/torque measurements. First, the interaction forces/torques between the manipulated object and its environment are collected in advance. A potential function is then constructed from the collected force/torque data using Gaussian process regression with derivatives. Next, we develop haptic dynamic movement primitives (Haptic DMPs) to generate robot trajectories. Unlike conventional DMPs, which primarily focus on kinematic aspects, our Haptic DMPs incorporate force-based interactions by integrating the constructed potential energy. The effectiveness of the proposed method is demonstrated through numerical tasks, including the classical peg-in-hole problem.
Site-specific weed management (SSWM) provides precise weed control and reduces the use of herbicides, which not only reduces the risk of environmental damage but also improves agricultural productivity. Accurate and efficient weed detection is the foundation for SSWM. However, complex field environments and small-target weeds in fields pose challenges for their detection. To address the above limitations, we developed WeedDETR, a real-time end-to-end detection model specifically designed to enhance the detection of small-target weeds in unmanned aerial vehicle (UAV) imagery. WeedDETR incorporates RepCBNet, a backbone network optimized through structural re-parameterization, to improve fine-grained feature extraction and accelerate inference. In addition, the designed feature complement fusion module (FCFM) was used for multi-scale feature fusion to alleviate the problem of small-target weed information being ignored in the deep network. During training, varifocal loss was used to focus on high-quality weed samples. We experimented on a new dataset, GZWeed, which contains weed imagery captured by a UAV. The experimental results demonstrated that WeedDETR achieves 73.9% and 91.8% AP0.5 (average precision at 0.5 intersection over union threshold) in the weed and Chinese cabbage [Brassica rapa subsp. chinensis (L.) Hanelt] categories, respectively, while achieving an inference speed of 76.28 frames per second (FPS). In comparison to YOLOv5-L, YOLOv6-M, and YOLOv8-L, WeedDETR demonstrated superior accuracy and speed, exhibiting 3.5%, 6.3%, and 3.6% higher AP0.5 for weed categories, while FPS was 14.9%, 12.9%, and 1.4% higher, respectively. The innovative architectural design of WeedDETR significantly enhances the detection accuracy of small-target weeds, enabling efficient end-to-end weed detection. The proposed method establishes a solid technological foundation for UAV-based precision weeding systems in field conditions, advancing the development of deep learning–driven intelligent weed management.
To explore the treatment options and prognostic factors of vocal fold leukoplakia.
Methods
The study examined conservative and surgical treatment approaches, and analysed prognostic factors influencing vocal fold leukoplakia outcomes.
Results
In the conservative treatment group, lesion size (p = 0.035) and smoking (p < 0.001) were identified as independent factors influencing treatment outcomes. In the surgical treatment group, lesion size (p = 0.018) was identified as an independent factor affecting recurrence. There was no statistically significant difference in the effectiveness of conservative versus surgical treatment for patients with hyperplasia (p = 0.223), mild dysplasia (p = 0.634) and moderate dysplasia (p = 0.758).
Conclusion
Smoking and lesion size are key factors influencing the outcome of conservative treatment, while lesion size is a significant factor affecting recurrence in surgically treated patients. More importantly, conservative treatment should be prioritised for patients with moderate dysplasia and milder vocal fold leukoplakia.
Patient involvement enhances transparency, legitimacy, and responsiveness in pharmaceutical reimbursement decisions. Guided by the mosaic model, this study recognizes effective patient engagement requires diverse context-specific approaches. Despite Taiwan’s National Health Insurance Administration (NHIA) implementing policies, gaps remain between intent and practice. This study evaluates NHIA’s incorporation of patient inputs into reimbursement decisions and examines factors influencing involvement.
Methods
We analyzed pharmaceutical company-initiated reimbursement submissions for catastrophic illnesses reviewed by the Pharmaceutical Benefit and Reimbursement Scheme Joint Committee (PBRS) from 2016 to 2023. Data sources included PBRS meeting records, the Online Patient Opinion Platform (OPOP), and NHIA notification E-mails. Generalized linear models identified predictors of patient involvement. The association between patient involvement and PBRS decisions was also explored.
Results
Patient involvement occurred in 28.4 percent (80/282) of all submissions, increasing from 17 percent (2016) to 44 percent (2023). Despite aligning with OPOP criteria, patient involvement remained incomplete. Discussion-type submissions, oncology drugs, and new drug applications showed higher involvement, whereas autoimmune diseases and new indication submissions had lower involvement. Budget impact and innovation categories were not significant predictors in adjusted models. The presence of patient involvement was not significantly associated with the PBRS approval rate. Ad hoc analysis revealed increased involvement for new indications following policy expansion.
Conclusions
Despite NHIA’s efforts, patient involvement implementation remains suboptimal. Structured mechanisms and expanded patient involvement beyond high-profile submissions and PBRS are crucial to broaden patient involvement. This study provides practical insights for East Asian healthcare systems advancing patient involvement amid limited empirical research.
We investigate the dynamics of circular self-propelled particles in channel flow, modelled as squirmers using a two-dimensional lattice Boltzmann method. The simulations explore a wide range of parameters, including channel Reynolds numbers ($\textit{Re}_c$), squirmer Reynolds numbers ($\textit{Re}_s$) and squirmer-type factors ($\beta$). For a single squirmer, four motion regimes are identified: oscillatory motion confined to one side of the channel, oscillatory crossing of the channel centreline, stabilisation at a lateral equilibrium position with the squirmer tilted and stable upstream swimming near the channel centreline. For two squirmers, interactions produce not only these four corresponding regimes but also three additional ones: continuous collisions with repeated position exchanges, progressive separation and drifting apart and, most notably, the formation of a stable wedge-like conformation (regime D). A key finding is the emergence of regime D, which predominantly occurs for weak pullers ($\beta = 1$) and at moderate to high $\textit{Re}_c$ values. Hydrodynamic interactions align the squirmers with streamline bifurcations near the channel centreline, enabling stability despite transient oscillations. Additionally, the channel blockage ratio critically affects the range of $\textit{Re}_s$ values over which this regime occurs, highlighting the influence of geometric confinement. This study extends the understanding of squirmer dynamics, revealing how hydrodynamic interactions drive collective behaviours. The findings also offer insights into the design of self-propelled particles for biomedical applications and contribute to the theoretical framework for active matter systems. Future work will investigate three-dimensional effects and the stability conditions for spherical squirmers forming stable wedge-like conformations, further generalising these results.
Depression is a complex mental health disorder with highly heterogeneous symptoms that vary significantly across individuals, influenced by various factors, including sex and regional contexts. Network analysis is an analytical method that provides a robust framework for evaluating the heterogeneity of depressive symptoms and identifying their potential clinical implications.
Objective:
To investigate sex-specific differences in the network structures of depressive symptoms in Asian patients diagnosed with depressive disorders, using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants, Phase 3, which was conducted in 2023.
Methods:
A network analysis of 10 depressive symptoms defined according to the National Institute for Health and Care Excellence guidelines was performed. The sex-specific differences in the network structures of the depressive symptoms were examined using the Network Comparison Test. Subgroup analysis of the sex-specific differences in the network structures was performed according to geographical region classifications, including East Asia, Southeast Asia, and South or West Asia.
Results:
A total of 998 men and 1,915 women with depression were analysed in this study. The analyses showed that all 10 depressive symptoms were grouped into a single cluster. Low self-confidence and loss of interest emerged as the most central nodes for men and women, respectively. In addition, a significant difference in global strength invariance was observed between the networks. In the regional subgroup analysis, only East Asian men showed two distinct clustering patterns. In addition, significant differences in global strength and network structure were observed only between East Asian men and women.
Conclusion:
The study highlights the sex-specific differences in depressive symptom networks across Asian countries. The results revealed that low self-confidence and loss of interest are the main symptoms of depression in Asian men and women, respectively. The network connections were more localised in men, whereas women showed a more diverse network. Among the Asian subgroups analysed, only East Asians exhibited significant differences in network structure. The considerable effects of neurovegetative symptoms in men may indicate potential neurobiological underpinnings of depression in the East Asian population.
We develop the time-dependent regularised 13-moment equations for general elastic collision models under the linear regime. Detailed derivation shows the proposed equations have super-Burnett order for small Knudsen numbers, and the moment equations enjoy a symmetric structure. A new modification of Onsager boundary conditions is proposed to ensure stability as well as the removal of undesired boundary layers. Numerical examples of one-dimensional channel flows is conducted to verified our model.
Brown dwarfs are failed stars with very low mass (13–75 Jupiter mass) and an effective temperature lower than 2 500 K. Their mass range is between Jupiter and red dwarfs. Thus, they play a key role in understanding the gap in the mass function between stars and planets. However, due to their faint nature, previous searches are inevitably limited to the solar neighbourhood (20 pc). To improve our knowledge of the low mass part of the initial stellar mass function and the star formation history of the Milky Way, it is crucial to find more distant brown dwarfs. Using James Webb Space Telescope (JWST) COSMOS-Web data, this study seeks to enhance our comprehension of the physical characteristics of brown dwarfs situated at a distance of kpc scale. The exceptional sensitivity of the JWST enables the detection of brown dwarfs that are up to 100 times more distant than those discovered in the earlier all-sky infrared surveys. The large area coverage of the JWST COSMOS-Web survey allows us to find more distant brown dwarfs than earlier JWST studies with smaller area coverages. To capture prominent water absorption features around 2.7 ${\unicode{x03BC}}$m, we apply two colour criteria, $\text{F115W}-\text{F277W}+1\lt\text{F277W}-\text{F444W}$ and $\text{F277W}-\text{F444W}\gt\,0.9$. We then select point sources by CLASS_STAR, FLUX_RADIUS, and SPREAD_MODEL criteria. Faint sources are visually checked to exclude possibly extended sources. We conduct SED fitting and MCMC simulations to determine their physical properties and associated uncertainties. Our search reveals 25 T-dwarf candidates and 2 Y-dwarf candidates, more than any previous JWST brown dwarf searches. They are located from 0.3 to 4 kpc away from the Earth. The spatial number density of 900–1 050 K dwarf is $(2.0\pm0.9) \times10^{-6}\text{ pc}^{-3}$, 1 050–1 200 K dwarf is $(1.2\pm0.7) \times10^{-6}\text{ pc}^{-3}$, and 1 200–1 350 K dwarf is $(4.4\pm1.3) \times10^{-6}\text{ pc}^{-3}$. The cumulative number count of our brown dwarf candidates is consistent with the prediction from a standard double exponential model. Three of our brown dwarf candidates were detected by HST, with transverse velocities $12\pm5$, $12\pm4$, and $17\pm6$ km s$^{-1}$. Along with earlier studies, the JWST has opened a new window of brown dwarf research in the Milky Way thick disk and halo.