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Gas turbine maintenance strategy relies heavily on accurate estimation of critical component life consumption of gas turbine engines during their operations. The equivalent operating hours (EOH) is a useful concept to measure the engine life consumption and support condition-based maintenance planning for gas turbine engines and their critical components. However, the current EOH calculation methods are mostly empirical and engine-specific, relying on vast operating data and experience. This paper introduces a novel physics-based method to estimate the EOH of the high-pressure turbine rotor blades of a gas turbine engine based on the damages caused by creep and low-cycle fatigue (creep-LCF) interactions. The method has been applied to a typical turbofan engine taking both 440-minute long-haul flight at one flight per day and 60-minute short-haul flight at two flights per day. A comparison of the predicted damages and life consumptions indicates that the creep EOH and also the creep damage of the engine of the short-haul aircraft is about 1.38 times that of the engine of the long-haul aircraft, the LCF equivalent operating cycles (EOC) and also the LCF damage of the engine of the short-haul aircraft is about 2.0 times that of the engine of the long-haul aircraft, and the total damages are more affected by the creep damage than the LCF damage with the creep damage being 6.78 times the LCF damage for the engine of the short-haul aircraft and 9.81 times for the engine of the long-haul aircraft. In addition, the total EOH or the total damage of the engine of the short-haul aircraft is about 1.44 times that of the engine of the long-haul aircraft. The proposed method shows a great potential to provide a quick estimate of the life consumption of gas turbine engines for condition monitoring, and it can be applied to other types of gas turbine engines.
Accurate and up-to-date epidemiological data on the prevalence and treatment of common mental disorders are essential for evidence-based healthcare policy and resource allocation. However, large-scale, representative epidemiological surveys on common mental disorders in China—particularly those incorporating insomnia disorder and applying the latest diagnostic criteria alongside validated assessment tools—remain notably lacking.
Methods
We conducted a population-based, cross-sectional epidemiological survey to assess the prevalence and treatment of common mental disorders among adults in Beijing, China, using a multistage clustered probability sampling design (n = 10,778). Licensed psychiatrists administered standardized diagnostic interviews based on DSM-5 criteria to assess both lifetime and current mental disorders through a single-stage assessment protocol.
Results
Among all lifetime mental disorders assessed, depressive disorders constituted the most prevalent diagnostic category (7.7%), with major depressive disorder representing the most common specific diagnosis (5.4%). Individuals aged 65 years and older exhibited significantly higher 1-month prevalence of both depressive disorders and insomnia disorder compared with younger age groups. Alcohol-related disorder was more prevalent in men than in women, and in urban residents than in rural residents. Help-seeking patterns revealed a predominant reliance on informal support over professional services among individuals with lifetime mental disorders. Only 13.4% sought help from mental health professionals, and 12.7% received mental health professional treatment.
Conclusions
The improved access to treatment did not translate into a reduction in population-level mental disorder prevalence, which may be attributable to the low rate of professional mental health treatment. Governments must optimize mental healthcare access.
This study presents a comprehensive analysis of the frequency response characteristics in a gas generator cycle liquid rocket engine, employing modular decomposition and linearised frequency-domain modeling to simulate dynamic behaviours under forced oscillations. The engine is dissected into key subsystems, including liquid pipelines, turbopump assembly, valves, flow regulation components, thrust chamber, gas generator and pyrotechnic starter, highlighting features such as centrifugal pump pressurisation, staged combustion and cavitation mitigation via venturis. Three oscillation scenarios are examined: supply system responses to thrust chamber pressure disturbances, combustion component responses to fluid disturbances and combustion component responses to pump speed disturbances. Simulations over 0–2000 Hz reveal acoustic-dominated traits in the thrust chamber with oxidiser pathway dominance, low-frequency emphasis in the gas generator driven by fuel disturbances, and heightened instability risks from pump pulsations. Parametric analyses demonstrate that increased pipeline lengths shift resonant frequencies downward, elevated injector pressure drops enhance stability margins by 1.6% with a 20% pressure drop increase, and chamber structural/gas parameter variations erode system stability. These insights, validated against benchmark models, inform strategies for mitigating combustion instability, optimising design parameters, and improving reliability in high-thrust propulsion applications.
Shanlan upland rice, as a unique local rice germplasm resource in Hainan comprises abundant genetic diversity. One hundred and sixty two Shanlan upland rice accessions collected from diverse ecological regions in Hainan were systematically characterized based on 11 agronomic traits. The rich genetic diversity was confirmed by phenotypic data from two consecutive years (2023 and 2024). Coefficient of variation ranged from 14.11% to 46.04% in 2023 and from 11.45% to 44.82% in 2024, with panicle-related traits (number of primary branches, grain number of primary branches, number of secondary branches, grain number of secondary branches and grain number per main panicle) exhibiting particularly high variation. Correlation analysis revealed highly significant synergistic effects among yield-related traits. Cluster analysis of the 162 accessions consistently classified them into five major groups across both growing seasons. Through grain number per main panicle and seed setting rate investigation, three excellent resources were selected that demonstrated stable and superior performance in both seasons. Notably, Line 69 exhibited outstanding “large panicles with high seed-setting rate,” producing 261.4 and 305 grains per main panicle in 2023 and 2024, respectively, with seed-setting rates reaching 93.79% and 90.07%. This study presents phenotypic data for Shanlan upland rice, offers high-quality breeding materials for subsequent research, and lays a theoretical groundwork for conserving and exploiting Hainan’s rice resources.
The digital transformation of Chinese companies offers a new frontier for organizational research. Widespread use of workplace platforms creates rich archives of unobtrusive data, providing continuous, real-time insights into organizational life that traditional surveys cannot capture. The central challenge for scholars is turning this data abundance into meaningful theory. This special issue highlights three studies that meet this challenge by using innovative methods to convert granular data into valuable knowledge. The papers employ digital-context experiments, real-time behavioral tracking, and machine-learning-assisted theory building to study phenomena from interpersonal dynamics to crisis productivity. Looking ahead, we explore the potential of unstructured multimodal data and new AI tools to make complex analysis more accessible. We conclude with a research agenda calling for methodological rigor, interdisciplinary collaboration, and a firm balance between technological innovation and theoretical depth.
This study aimed to investigate the individual characteristics of intolerance of uncertainty (IU) and its association with mental health symptoms among Chinese college students during COVID-19.
Methods
In total, 86,767 students completed the online survey in Guangdong province in June 2021. Data collected including socio-demographic and COVID-19-related information, IU, and mental health symptoms (depression, anxiety, insomnia, and suicidal ideation). Latent profile analysis was used to classify IU subgroups. Logistic regression was used to identify IU risk factors.
Results
Four IU subgroups were identified, named low IU (n = 9,197, 10.6%), medium-low IU (n = 25,514, 29.4%), medium-high IU (n = 38,805, 44.7%), and high IU (n = 13,251, 15.3%). Scores of mental health symptoms varied from the degree of IU in the latent profiles. Mental health status was the worst in the high IU group. In addition, females, freshmen, and those perceiving more impacts from COVID-19 and spending longer time surfing COVID-19 information online were at risk of high IU.
Conclusions
Our findings showed that individuals differ in the total degree of intolerance of the uncertainties. Students with high IU were associated with worse mental health symptoms. Thus, taking actions to target individuals with high IU and developing their adaptive coping strategies are imperative during pandemics.
Recent research on zoonotic diseases has increasingly focused on tick-borne illnesses due to their high prevalence in northwestern China. This study aimed to determine the prevalence of tick-borne pathogens in yaks (Bos grunniens) within Qinghai Province. A total of 299 blood samples were collected from yaks in Xining City of Qinghai Province and analysed using polymerase chain reaction. Results indicated the absence of several significant zoonotic pathogens, including Borrelia burgdorferi sensu lato, Anaplasma spp. and Coxiella burnetii. However, rickettsiae were detected in the sampled yaks. The overall prevalence of spotted fever group rickettsiae was 46·5%, with a significant difference between females (68·3%) and males (9·09%). Age was also identified as a significant factor influencing infection rates. Furthermore, sequencing analysis revealed that the obtained rickettsial sequences shared 99·04–100% nucleotide identity with Rickettsia raoultii, a species endemic to Qinghai, China. Phylogenetic analysis based on the ompA and gltA genes confirmed that these sequences clustered within the R. raoultii clade. This study demonstrates a high prevalence of R. raoultii infection in yaks from Qinghai. Consequently, the implementation of preventive and therapeutic measures for yaks is recommended to mitigate the risk of transmission. This study did not collect tick samples simultaneously, so the transmission vector cannot be identified. Additionally, uneven sample distribution across some age groups may affect the representativeness of the results.
Butachlor is a herbicide extensively employed in rice (Oryza sativa L.) cultivation but historically under-investigated for its toxicological impacts on terrestrial vegetation. This study examines the dose-dependent effects of butachlor on the germination and antioxidant defense mechanisms in the seeds of Asian tape grass [Vallisneria natans (Lour.) H. Hara], an important submerged plant species widely distributed in the agricultural ponds. In a hydroponic setup, seeds were exposed to four concentrations of butachlor (0, 20, 200, and 2,000 μg ai L−1), and cultivated under controlled light conditions to quantify germination rates and assess oxidative stress responses. Our findings showed that butachlor concentrations up to 20 μg L−1 had no effect on the germination rate of V. natans seeds, while germination rates decreased by 6.0% and 8.7% at 200 and 2,000 μg L−1, respectively. At 2,000 μg L−1, malondialdehyde (MDA) content increased by 5.7 nmol g−1 FW, and catalase (CAT) activity declined by 21%, indicating oxidative damage. Additionally, the antioxidants proline (Pro) and glutathione (GSH) were upregulated under 20 μg L−1 butachlor treatment after 12 h, contributing to reactive oxygen species (ROS) scavenging and cellular stability. This study highlights the nuanced interactions between butachlor exposure and the antioxidant defenses in V. natans, providing valuable insights into the ecological impacts of herbicide pollution. Understanding these interactions is crucial for development of sustainable agricultural practices and management of herbicide resistance in aquatic systems.
Excellent products often contain profound cultural connotations. To improve the quality of cultural products, it is important to study how typical cultural carriers can be more promptly and efficiently identified and incorporated into products through a detailed and easy-to-use design process. In this article, we propose an approach from three different levels to assist designers in incorporating cultural features into products, including: (1) the integrated framework of the composition and division of cultural carriers, (2) the extraction and translation model from cultural carriers, cultural elements to cultural features and (3) the cultural product design process. The proposed approach was applied in a large and complex cultural product case, that is, inter-city train design. The evaluation of the recognition of culture features indicated that the approach contributed to conferring culture on products through thoughtful design and could ensure that the product schemes reflect cultural features as well as interesting cultural connotations.
Nowadays, artificial intelligence (AI) is becoming a powerful tool to process huge volumes of data generated in scientific research and extract enlightening insights to drive further explorations. The recent trend of human-in-loop AI has promoted the paradigm shift in scientific research by enabling the interactive collaboration between AI models and human experts. Inspired by these advancements, this chapter explores the transformative role of AI in accelerating scientific discovery across various disciplines such as mathematics, physics, chemistry, and life sciences. It provides a comprehensive overview of how AI is reshaping the scientific research – enabling more efficient data analysis, enhancing predictive modeling, and automating experimental processes. Through the examination of case studies and recent developments, this chapter underscores AI’s potential to revolutionize scientific discovery, providing insights into current applications and future directions. It also addresses the ethical challenges associated with AI in science. Through this comprehensive analysis, the chapter aims to provide a nuanced understanding of how AI is facilitating scientific discovery and its potential to accelerate innovations while maintaining rigorous ethical standards.
With the increased prevalence of major depressive episodes with mixed features specifier (MDE-MFS), the pharmacological treatment for MDE-MFS has attracted great clinical attention. This study aimed to investigate the efficacy and safety of medication use for MDE-MFS.
Methods
Commonly used databases were searched for the meta-analysis. Primary efficacy outcomes included response rate and the change in the Young Mania Rating Scale scores; the primary safety outcome was the rate of treatment-emergent hypomania/mania. Effects were expressed as relative risk (RR) or standardized mean difference (SMD).
Results
In patients with MDE-MFS, antipsychotics significantly improved depressive (RR = 1.46 [95% CI: 1.31, 1.61]) and manic (SMD = −0.35 [95% CI: −0.53, −0.17]) symptoms without increasing the risk of manic switch (RR = 0.91 [95% CI: 0.53, 1.55]). However, subgroup analysis of bipolar disorder (BD) patients with MDE-MFS indicated that antipsychotics had limited effects on manic symptoms. Mood stabilizers, especially valproate, demonstrated significant effects in BD patients with MDE-MFS by relieving depressive and manic symptoms. For MDE-MFS in patients with major depressive disorder, trazodone has shown potential effectiveness in retrospective studies, while the effectiveness of antidepressants on BD patients with MDE-MFS lacked evidence.
Conclusions
While antipsychotics are first options for MDE-MFS, their effect on manic symptoms in BD patients with MDE-MFS is still unclear. Mood stabilizers may also be considered, and the use of antidepressants remains a topic of controversy. Since our findings are mostly based on post-hoc analyses, the evidence remains preliminary, highlighting the need for further research to produce more conclusive evidence.
In this paper, a wideband reconfigurable reflectarray antenna (RRA) using 1-bit resolution for beam scanning with two-dimensional (2D) capability is presented at Ku-band. A 1-bit RRA element with a rectangular patch embedded with slots is proposed for broadband operation. Each element is equipped with a single PIN diode, allowing for resonance tuning while ensuring low cost and minimal power consumption. According to the simulation results, the proposed element is capable of 1-bit phase resolution with a phase difference of ${180^\circ \pm 20^\circ}$ stability from 11.27 to 13.74 GHz, which corresponds to an approximate bandwidth of 19.75%. To demonstrate its capabilities, we developed, fabricated, and tested a wideband electronically RRA with ${14 \times 14}$ elements. The experimental results demonstrate that the realized maximum gain in the broadside direction is 21.1 dB with a peak aperture efficiency of 20.9%. 2D beam scanning within ${\pm50^\circ}$ angular range are obtained and the scan gain reduction is 1.88 dB for ${-50^\circ}$ scanned beam in E-plane while 2.21 dB for ${50^\circ}$ scanned beam in H-plane. The 1-dB gain bandwidth of the RRA is 15.1%.
Prior research indicates that both structural and functional networks are compromised in older adults experiencing depressive symptoms. However, the potential impact of abnormal interactions between brain structure and function remains unclear. This study investigates alterations in structural–functional connectivity coupling (SFC) among older adults with depressive symptoms, and explores how these changes differ depending on the presence of physiological comorbidities.
Methods
We used multimodal neuroimaging data (dMRI/rs-fMRI) from 415 older adults with depressive symptoms and 415 age-matched normal controls. Subgroups were established within the depressive group based on the presence of hypertension, hyperlipidemia, diabetes, cerebrovascular disease, and sleep disorders. We examined group and subgroup differences in SFC and tracked its alterations in relation to symptom progression.
Results
Older adults with depressive symptoms showed significantly increased SFC in the ventral attention network compared with normal controls. Moreover, changes in SFC within the subcortical network, especially in the left amygdala, were closely linked to symptom progression. Subgroup analyses further revealed heterogeneity in SFC changes, with certain physiological health factors, such as metabolic diseases and sleep disorders, contributing to distinct neural mechanisms underlying depressive symptoms in this population.
Conclusions
This study identifies alterations in SFC related to depressive symptoms in older adults, primarily within the ventral attention and subcortical networks. Subgroup analyses highlight the heterogeneous SFC changes associated with metabolic diseases and sleep disorders. These findings highlight SFC may serve as potential markers for more personalized interventions, ultimately improving the clinical management of depression in older adults.
Flapping-wing robots, inspired by natural flyers, have gained significant attention for surveillance and environmental monitoring applications. This study presents the design and analysis of a bat-inspired flapping-wing robot with foldable wings, aiming to enhance flight efficiency and maneuverability. The robot features silicone-based, stretchable membrane wings, with a wingspan of 1.4 m and a total mass of 620 g. A one-degree-of-freedom (DOF) revolute-spherical-spherical-revolute mechanism is used to reproduce the flapping motion, while a one-DOF Watt six-bar linkage mechanism enables dynamic wing folding, allowing adaptive wing shape modulation during flight. Explicit solutions for joint angle of the wing were expressed through analytical method. Flight tests were conducted to validate the effectiveness of the flapping-folding mechanism. Results show that the robot successfully replicates bat wing kinematics, with folding during the upstroke and unfolding during the downstroke. This research offers insights into bio-inspired wing designs for next-generation flapping-wing robots.
Aiming at the issues of more difficult to solve and lower precision of six-axis robotic arm in inverse kinematics (IK) solution, a multi-strategy improved dung beetle optimization algorithm (ECDBO) is proposed. It improves performance in four aspects: population initiation, global search capability, search direction perturbation and jumping out of local optima. Sobol sequence strategy was introduced to initialize the dung beetle population, resulting in a more even distribution of individual dung beetles and increasing the diversity of initial population. Boundary optimization strategy is adopted to balance the requirements on search capability at different times. This approach enhances global search capability at the beginning and local search capability at the end of an iteration. Propose hybrid directional perturbation strategy to change the search direction of rolling dung beetles and stealing dung beetles. It allows for more detailed exploration and improves convergence accuracy. The Levy flight strategy is incorporated to perturb current optimal solution, enhancing algorithm’s ability to jump out of the local optimum. In order to verify performance of ECDBO algorithm, CEC2017 function tests and robotic arm IK solving experiments were conducted and compared with other algorithms. ECDBO ranked first on 21 functions in the 30 dimensions tested in CEC2017 and on 27 functions in the 100 dimensions. ECDBO performs well in the IK solving experiments of two robotic arms with better accuracy than other algorithms. The experimental results show that the ECDBO algorithm significantly improves the convergence and accuracy, and also performs excellently on the IK solving problem.
High-concentrate diets are commonly used to enhance lamb growth performance; however, their long-term impacts on metabolic health, particularly fat deposition and liver function, remain a challenge. This study utilized an integrative multi-omics approach to explore the role of keystone rumen microbiota in modulating the rumen-liver-tail adipose axis under high-concentrate diets. Keystone rumen bacterial taxa, including Ruminococcus_gauvreauii, Syntrophococcus, Solobacterium, Bifidobacterium, and Ruminococcaceae_UCG-010, were identified as critical mediators linking dietary changes to tail fat deposition. Liver transcriptomic analysis revealed disrupted folate biosynthesis, regulated by key members of the AKR1C3 family (AKR1C23, AKR1C1, and PGFS), which played a pivotal role in glucose and fatty acid metabolism through the action of tetrahydrobiopterin. In tail adipose tissue, pathways associated with vitamin B6 metabolism and fatty acid elongation were significantly enriched, with pyridoxal 5’-phosphate and elongation-related genes (ELOVL3, HSD17B12, and FADS2) contributing to lipid biosynthesis and deposition. These findings establish a mechanistic framework for the rumen-liver-tail adipose axis, highlighting the influence of keystone rumen microbiota on host metabolism. This study offers novel insights into dietary interventions and microbial strategies to improve ruminant healthy production efficiency and meat quality.
Plant-based diets may improve mental health among older adults by alleviating depression and improving life satisfaction. This study aimed to explore the associations between plant-based dietary pattern trajectories (PDPT), depression and life satisfaction in Chinese older adults. Data of participants from the 2008–2018 Chinese Longitudinal Healthy Longevity Survey were analysed. We utilised group-based trajectory modelling to identify the PDPT. Logistic and linear regression models were used to analyse the associations between PDPT, depression and life satisfaction. In total, 1835 participants were divided into three groups based on plant-based dietary index (PDI), healthy plant-based dietary index (HPDI) or unhealthy plant-based dietary index (UPDI) trajectories, respectively, and the PDPT were maintained at stable levels. PDI trajectory was not significantly associated with depression or life satisfaction. HPDI trajectory had no significant association with depression. However, compared with low HPDI trajectory, participants in the high (β = 0·185, 95 % CI: 0·032, 0·337) HPDI trajectories had higher life satisfaction. Compared with the low UPDI trajectory, participants in the high UPDI trajectory groups were associated with a higher risk of depression (OR = 1·793, 95 % CI: 1·124, 2·861). Further, the medium (β = −0·145, 95 % CI: −0·273, −0·018) and high (β = −0·335, 95 % CI: −0·478, −0·191) UPDI trajectory were associated with poor life satisfaction. Dietary interventions should be prioritised to address the persistent unhealthy dietary habits among Chinese older adults, with particular emphasis on reducing UPDI to enhance mental health by promoting intake of healthy plant-based and animal-based foods while avoiding unhealthy plant-based foods.
Cyber breaches pose a significant threat to both enterprises and society. Analyzing cyber breach data is essential for improving cyber risk management and developing effective cyber insurance policies. However, modeling cyber risk is challenging due to its inherent characteristics, including sparsity, heterogeneity, heavy tails, and dependence. This work introduces a cluster-based dependence model that captures both temporal and cross-group dependencies, providing a more accurate representation of multivariate cyber breach risks. The proposed framework employs a cluster-based kernel approach to model breach severity, effectively handling heterogeneity and extreme values, while a copula-based method is used to capture multivariate dependence. Our findings, validated through both empirical and synthetic studies, demonstrate that the proposed model effectively captures the statistical characteristics of multivariate cyber breach risks and outperforms commonly used models in predictive accuracy. Furthermore, we show that our approach can enhance cyber insurance pricing by generating more profitable insurance contracts.