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The reconfiguration of flexible aquatic vegetation and the associated forces have been extensively studied under two-dimensional flow conditions – such as unidirectional currents, pure waves and co-directional wave–current flows. However, behaviour under more complex, orthogonal wave–current flows remains largely unexplored. In coastal environments, such orthogonal flows arise when waves propagate perpendicular to a longshore current. To improve understanding of how aquatic vegetation helps protect coastlines and attenuates waves, we extended existing effective-length scaling laws that were validated in pure currents, pure waves, and co-directional waves and currents to orthogonal wave–current conditions by introducing new definitions of the Cauchy number. Experiments were conducted in a wave–current basin, where cylindrical rubber stems were mounted on force transducers to measure hydrodynamic forces. Stem velocities were extracted from video recordings to compute the relative velocity between the flow and the stems. Incorporating the phase shift between flow and stem velocities into the force models significantly improved predictions. Comparison of predicted and measured forces showed good agreement for both pure wave and wave–current scenarios, underscoring the importance of phase shifts and velocity reduction for force estimation. Our hypothesised effective-length scaling parameters under wave–current conditions were validated, but with a higher scaling coefficient due to inertial effects from the larger material aspect ratio. These findings offer new insights into the hydrodynamics of flexible structures under complex coastal flow conditions.
In this article, we consider a fully nonlinear equation associated with the Christoffel–Minkowski problem in hyperbolic space. By using the full rank theorem, we establish the existence of h-convex solutions when the prescribed functions on the right-hand side are under some appropriate assumption.
An experimental study was conducted to investigate the impingement of a vortex ring onto a porous wall by laser-induced fluorescence and particle image velocimetry. The effects of different Reynolds numbers (${{Re}}_{\it\Gamma } = 700$ and $1800$) and hole diameters ($d_{h}^{*} = 0.067$, $0.10$, $0.133$ and $0.20$) on the flow characteristics were examined at a constant porosity ($\phi = 0.75$). To characterise fluid transport through a porous wall, we recall the model proposed by Naaktgeboren, Krueger & Lage (2012, J. Fluid Mech., vol. 707, 260–286), which shows rough agreement with the experimental results due to the absence of vortex ring characteristics. This highlights the need for a more accurate model to correlate the losses in kinetic energy ($\Delta E^{*}$) and impulse ($\Delta I^{*}$) resulting from the vortex ring–porous wall interaction. Starting from Lamb’s vortex ring model and considering the flow transition from the upstream laminar state to the downstream turbulent state caused by the porous wall disturbance, a new model is derived theoretically: $\Delta E^{*} = 1 - k(1 - \Delta I^{*})^2$, where $k$ is a parameter dependent on the dimensionless core radius $\varepsilon$, with $k = 1$ when no flow state change occurs. This new model effectively correlates $\Delta E^{*}$ and $\Delta I^{*}$ across more than 70 cases from current and previous experiments, capturing the dominant flow physics of the vortex ring–porous wall interaction.
In this article, we focus on the systemic expected shortfall and marginal expected shortfall in a multivariate continuous-time risk model with a general càdlàg process. Additionally, we conduct our study under a mild moment condition that is easily satisfied when the general càdlàg process is determined by some important investment return processes. In the presence of heavy tails, we derive asymptotic formulas for the systemic expected shortfall and marginal expected shortfall under the framework that includes wide dependence structures among losses, covering pairwise strong quasi-asymptotic independence and multivariate regular variation. Our results quantify how the general càdlàg process, heavy-tailed property of losses, and dependence structures influence the systemic expected shortfall and marginal expected shortfall. To discuss the interplay of dependence structures and heavy-tailedness, we apply an explicit order 3.0 weak scheme to estimate the expectations related to the general càdlàg process. This enables us to validate the moment condition from a numerical perspective and perform numerical studies. Our numerical studies reveal that the asymptotic dependence structure has a significant impact on the systemic expected shortfall and marginal expected shortfall, but heavy-tailedness has a more pronounced effect than the asymptotic dependence structure.
To investigate the association of dietary patterns (DP) with prediabetes and type 2 diabetes (T2D) among Tibetan adults, first to identify DP associated with abdominal obesity and examine their relationships with prediabetes and T2D. Additionally, the study aims to investigate the mediating effects of body fat distribution and altitude on the associations between these DP and the prevalence of prediabetes and T2D.
Design:
An open cohort among Tibetans.
Setting:
Community-based.
Participants:
The survey recruited 1003 participants registered for health check-ups from November to December 2018 and 1611 participants from December 2021 to May 2022. During the baseline and follow-up data collection, 1818 individuals participated in at least one of the two surveys, with 515 of them participating in both.
Results:
Two DP were identified by reduced rank regression. DP1 had high consumption of beef and mutton, non-caloric drink and offal and low intake in tubers and roots, salty snacks, onion and spring onion, fresh fruits, desserts and nuts and seeds; DP2 had high intake of whole grains, Tibetan cheese, light-coloured vegetables and pork and low intake of sugar-sweetened beverages, whole-fat dairy products and poultry. Individuals in the highest tertile of DP1 showed higher risks of prediabetes (OR 95 % CI) 1·35 (1·05, 1·73) and T2D 1·36 (1·05, 1·76). The highest tertile of DP2 exhibited an elevated risk of T2D 1·63 (1·11, 2·40) in full adjustment.
Conclusion:
Abdominal adiposity-related DP are positively associated with T2D. Promoting healthy eating should be considered to prevent T2D among Tibetan adults.
An actively controllable cascaded proton acceleration driven by a separate 0.8 picosecond (ps) laser is demonstrated in proof-of-principle experiments. MeV protons, initially driven by a femtosecond laser, are further accelerated and focused into a dot structure by an electromagnetic pulse (EMP) on the solenoid, which can be tuned into a ring structure by increasing the ps laser energy. An electrodynamics model is carried out to explain the experimental results and show that the dot-structured proton beam is formed when the outer part of the incident proton beam is optimally focused by the EMP force on the solenoid; otherwise, it is overfocused into a ring structure by a larger EMP. Such a separately controlled mechanism allows precise tuning of the proton beam structures for various applications, such as edge-enhanced proton radiography, proton therapy and pre-injection in traditional accelerators.
Carbon storage in saline aquifers is a prominent geological method for reducing CO2 emissions. However, salt precipitation within these aquifers can significantly impede CO2 injection efficiency. This study examines the mechanisms of salt precipitation during CO2 injection into fractured matrices using pore-scale numerical simulations informed by microfluidic experiments. The analysis of varying initial salt concentrations and injection rates revealed three distinct precipitation patterns, namely displacement, breakthrough and sealing, which were systematically mapped onto regime diagrams. These patterns arise from the interplay between dewetting and precipitation rates. An increase in reservoir porosity caused a shift in the precipitation pattern from sealing to displacement. By incorporating pore structure geometry parameters, the regime diagrams were adapted to account for varying reservoir porosities. In hydrophobic reservoirs, the precipitation pattern tended to favour displacement, as salt accumulation occurred more in larger pores than in pore throats, thereby reducing the risk of clogging. The numerical results demonstrated that increasing the gas injection rate or reducing the initial salt concentration significantly enhanced CO2 injection performance. Furthermore, identifying reservoirs with high hydrophobicity or large porosity is essential for optimising CO2 injection processes.
Depression has been linked to disruptions in resting-state networks (RSNs). However, inconsistent findings on RSN disruptions, with variations in reported connectivity within and between RSNs, complicate the understanding of the neurobiological mechanisms underlying depression.
Methods
A systematic literature search of PubMed and Web of Science identified studies that employed resting-state functional magnetic resonance imaging (fMRI) to explore RSN changes in depression. Studies using seed-based functional connectivity analysis or independent component analysis were included, and coordinate-based meta-analyses were performed to evaluate alterations in RSN connectivity both within and between networks.
Results
A total of 58 studies were included, comprising 2321 patients with depression and 2197 healthy controls. The meta-analysis revealed significant alterations in RSN connectivity, both within and between networks, in patients with depression compared with healthy controls. Specifically, within-network changes included both increased and decreased connectivity in the default mode network (DMN) and increased connectivity in the frontoparietal network (FPN). Between-network findings showed increased DMN–FPN and limbic network (LN)–DMN connectivity, decreased DMN–somatomotor network and LN–FPN connectivity, and varied ventral attention network (VAN)–dorsal attentional network (DAN) connectivity. Additionally, a positive correlation was found between illness duration and increased connectivity between the VAN and DAN.
Conclusions
These findings not only provide a comprehensive characterization of RSN disruptions in depression but also enhance our understanding of the neurobiological mechanisms underlying depression.
Vessel collision risk estimation is crucial in navigation manoeuvres, route planning, risk control, safety management and forewarning issues. The interaction possibility is a good method to quantify the near-miss collision risks of multi-ships. Current models, however, are mostly concerned about the movements in an unrestricted isotropic travel environment or network environment. This article simultaneously addresses these issues by developing a novel environment–kinetic compound space–time prism to capture potential spatial–temporal interactions of multi-ships in constrained dynamic environments. The approach could significantly reduce the overestimation of the individual vessel’s potential travel area and the interaction possibility of encountering vessels in restricted water. The proposed environmental–kinetical compound space–time prism (EKC-STP)-based method enables identifying where and when multi-ships possibly interacted in the constraint water area, as well as how the interaction possibility pattern changed from day to day. The collision risk evaluation results were validated through comparison with other methods. The full picture of hierarchical collision risk distribution in port areas is determined and could be employed to provide quantifiable references for efficient and practical anti-collision measures establishment.
The presence of dispersed-phase droplets can result in a notable increase in a system's drag. However, our understanding of the mechanism underlying this phenomenon remains limited. In this study, we use three-dimensional direct numerical simulations with a modified multi-marker volume-of-fluid method to investigate liquid–liquid two-phase turbulence in a Taylor–Couette geometry. The dispersed phase has the same density and viscosity as the continuous phase. The Reynolds number $Re\equiv r_i\omega _i d/\nu$ is fixed at 5200, the volume fraction of the dispersed phase is up to $40\,\%$, and the Weber number $We\equiv \rho u^2_\tau d/\sigma$ is approximately 8. It is found that the increase in the system's drag originates from the contribution of interfacial tension. Specifically, droplets experience significant deformation and stretching in the streamwise direction due to shear near the inner cylinder. Consequently, the rear end of the droplets lags behind the fore head. This causes opposing interfacial tension effects on the fore head and rear end of the droplets. For the fore head of the droplets, the effect of interfacial tension appears to act against the flow direction. For the rear end, the effect appears to act in the flow direction. The increase in the system's drag is attributed primarily to the effect of interfacial tension on the fore head of the droplets which leads to the hindering effect of the droplets on the surrounding continuous phase. This hindering effect disrupts the formation of high-speed streaks, favouring the formation of low-speed ones, which are generally associated with higher viscous stress and drag of the system. This study provides new insights into the mechanism of drag enhancement reported in our previous experiments.
This study demonstrates a kilowatt-level, spectrum-programmable, multi-wavelength fiber laser (MWFL) with wavelength, interval and intensity tunability. The central wavelength tuning range is 1060–1095 nm and the tunable number is controllable from 1 to 5. The wavelength interval can be tuned from 6 to 32 nm and the intensity of each channel can be adjusted independently. Maximum output power up to approximately 1100 W has been achieved by master oscillator power amplifier structures. We also investigate the wavelength evolution experimentally considering the difference of gain competition, which may give a primary reference for kW-level high-power MWFL spectral manipulation. To the best of our knowledge, this is the highest output power ever reported for a programmable MWFL. Benefiting from its high power and flexible spectral manipulability, the proposed MWFL has great potential in versatile applications such as nonlinear frequency conversion and spectroscopy.
Growing evidence indicates a link between diet and depression risk. We aimed to examine the association between an inflammatory diet index and depression utilising extensive data from UK biobank cohort. The energy-adjusted dietary inflammation index (E-DII) was calculated to quantify the potential of daily diet, with twenty-seven food parameters utilised. The E-DII scores were classified into two categories (low v. high) based on median value. To mitigate bias and ensure comparability of participant characteristics, propensity score matching was employed. To ascertain the robustness of these associations, sensitivity analyses were conducted. Subgroup analyses were performed to evaluate the consistency of these associations within different subpopulations. Totally, 152 853 participants entered the primary analyses with a mean age of 56·11 (sd 7·98) years. Employing both univariate and multivariate logistic regression models, adjustments were made for varying degrees of confounding factors (socio-demographics, lifestyle factors, common chronic medical conditions including type 2 diabetes and hypertension). Results consistently revealed a noteworthy positive correlation between E-DII and depression. In the context of propensity score matching, participants displaying higher E-DII scores exhibited an increased likelihood of experiencing incident depression (OR = 1·12, 95 % CI: 1·05, 1·19; P = 0·000316). Subgroup analysis results demonstrated variations in these associations across diverse subpopulations. The E-value for the point-estimate OR calculated from the propensity score matching dataset was 1·48. Excluding individuals diagnosed with type 2 diabetes or hypertension, the findings consistently aligned with the positive association in the primary analysis. These findings suggested that consumption of a diet with higher pro-inflammatory potential might associated with an increase of future depression risk.
The flexible flat cable (FFC) assembly task is a prime challenge in electronic manufacturing. Its characteristics of being prone to deformation under external force, tiny assembly tolerance, and fragility impede the application of robotic assembly in this field. To achieve reliable and stable robotic automation assembly of FFC, an efficient assembly skill acquisition strategy is presented by combining a parallel robot skill learning algorithm with adaptive impedance control. The parallel robot skill learning algorithm is proposed to enhance the efficiency of FFC assembly skill acquisition, which reduces the risk of damaging FFC and tackles the uncertain influence resulting from deformation during the assembly process. Moreover, FFC assembly is also a complex contact-rich manipulation task. An adaptive impedance controller is designed to implement force tracking during the assembly process without precise environment information, and the stability is also analyzed based on the Lyapunov function. Experiments of FFC assembly are conducted to illustrate the efficiency of the proposed method. The experimental results demonstrate that the proposed method is robust and efficient.
Although numerous neuroimaging studies have depicted neural alterations in individuals with obsessive–compulsive disorder (OCD), a psychiatric disorder characterized by intrusive cognitions and repetitive behaviors, the molecular mechanisms connecting brain structural changes and gene expression remain poorly understood.
Methods
This study combined the Allen Human Brain Atlas dataset with neuroimaging data from the Meta-Analysis (ENIGMA) consortium and independent cohorts. Later, partial least squares regression and enrichment analysis were performed to probe the correlation between transcription and cortical thickness variation among adults with OCD.
Results
The cortical map of case-control differences in cortical thickness was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms preferentially expressed across different cell types and cortical layers. These genes were specifically expressed in brain tissue, spanning all cortical developmental stages. Protein–protein interaction analysis revealed that these genes coded a network of proteins encompassing various highly interactive hubs.
Conclusions
The study findings bridge the gap between neural structure and transcriptome data in OCD, fostering an integrative understanding of the potential biological mechanisms.
The Chinese Loess Plateau (CLP), recognized as the world's largest loess plateau, has been a subject of ongoing debate regarding the continuity of its sedimentary loess sequence due to its intricate depositional environment. In this study, we conducted dating on a 9.8-m-long Malan loess core obtained from the Sanmen Gorge in the southern CLP using optically stimulated luminescence (OSL). The OSL dates indicate loess deposition between 52.4 and 11.3 ka, with no apparent hiatus on a millennial scale, and a sedimentation rate (SR) exhibiting six distinct episodes. Additionally, a comprehensive review of 613 OSL ages from 18 sections at 14 sites across the CLP was conducted. The results reveal loess deposition at most sites shows no apparent hiatus on a millennial scale over the past 60 ka, except for two specific locations. High SR episodes during Marine Isotope Stage (MIS) 3 across the CLP were attributed to heightened dust emissions from the source region and an enhanced dust deposition efficiency, while MIS 2 deposits were influenced by an intensified East Asian winter monsoon. Low SR episodes during MIS 1 at most sites were likely associated with reduced atmospheric transportation and pedogenesis. Spatially heterogeneous SR variations across the CLP might be influenced by local depositional environments.
To assess the efficacy and safety of two different modes of administration, external ear canal filling and smearing, in the treatment of otomycosis.
Methods
A computerised search of relevant published studies in the China National Knowledge Infrastructure, China Biology Medicine, Web of Science, PubMed, Embase and Cochrane Library databases that include randomised controlled trials or clinically controlled trials on the same drug in different modes of administration for the treatment of otomycosis.
Results
Seven studies with 934 patients were included. The filled group had a higher clinical efficacy (relative risk = 1.18, 95 per cent confidence interval (CI) 1.12–1.24, p < 0.0001) and a lower recurrence rate (relative risk = 0.29, 95 per cent CI 0.18–0.47, p < 0.0001) compared with the smear group, and there was no significant difference in the adverse effects (relative risk = 0.61, 95 per cent CI 0.34–1.12, p = 0.11).
Conclusion
Current evidence suggests that the efficacy of the delivery modality of the external auditory canal filling treatment is significantly better than external auditory canal smearing.
Seed germination is a pivotal period of plant growth and development. This process can be divided into four major stages, swelling absorption, seed coat dehiscence, radicle emergence and radicle elongation. Cupressus gigantea, a tree native to Tibet, China, is characterized by its resistance to stresses such as cold, and drought, and has a high economic and ecological value. Nevertheless, given its unique geographic location, its seeds are difficult to germinate. Therefore, it is crucial to explore the mechanisms involved in seed germination in this species to improve the germination efficiency of its seeds, thereby protecting this high-quality resource. Here, our findings indicate that seed germination was enhanced when exposed to a 6-h/8-h light/dark photoperiod, coupled with a temperature of 20°C. Furthermore, the application of exogenous GA3 (1 mg/ml, about 2.9 mM) stimulated the germination of C. gigantea seeds. Subsequently, proteomics was used to detect changes in protein expression during the four stages of seed germination. We identified 34 differentially expressed proteins (DEPs), including 13 at the radicle pre-emergence stage, and 17 at the radicle elongation stage. These DEPs were classified into eight functional groups, cytoskeletal proteins, energy metabolism, membrane transport, stress response, molecular chaperones, amino acid metabolism, antioxidant system and ABA signalling pathway. Most of them were found to be closely associated with amino acid metabolism. Combined, these findings indicate that, along with temperature and light, exogenous GA3 can increase the germination efficiency of C. gigantea seeds. Our study also offers insights into the changes in protein expression patterns in C. gigantea seeds during germination.
The presence of a dispersed phase can significantly modulate the drag in turbulent systems. We derived a conserved quantity that characterizes the radial transport of azimuthal momentum in the fluid–fluid two-phase Taylor–Couette turbulence. This quantity consists of contributions from advection, diffusion and two-phase interface, which are closely related to density, viscosity and interfacial tension, respectively. We found from interface-resolved direct numerical simulations that the presence of the two-phase interface consistently produces a positive contribution to the momentum transport and leads to drag enhancement, while decreasing the density and viscosity ratios of the dispersed phase to the continuous phase reduces the contribution of local advection and diffusion terms to the momentum transport, respectively, resulting in drag reduction. Therefore, we concluded that the decreased density ratio and the decreased viscosity ratio work together to compete with the presence of a two-phase interface for achieving drag modulation in fluid–fluid two-phase turbulence.