The First Large Absorption Survey in H i (FLASH) is a large-area radio survey for neutral hydrogen in and around galaxies in the intermediate redshift range $0.4\lt z\lt1.0$, using the 21-cm H i absorption line as a probe of cold neutral gas. The survey uses the ASKAP radio telescope and will cover 24,000 deg$^2$ of sky over the next five years. FLASH breaks new ground in two ways – it is the first large H i absorption survey to be carried out without any optical preselection of targets, and we use an automated Bayesian line-finding tool to search through large datasets and assign a statistical significance to potential line detections. Two Pilot Surveys, covering around 3000 deg$^2$ of sky, were carried out in 2019-22 to test and verify the strategy for the full FLASH survey. The processed data products from these Pilot Surveys (spectral-line cubes, continuum images, and catalogues) are public and available online. In this paper, we describe the FLASH spectral-line and continuum data products and discuss the quality of the H i spectra and the completeness of our automated line search. Finally, we present a set of 30 new H i absorption lines that were robustly detected in the Pilot Surveys, almost doubling the number of known H i absorption systems at $0.4\lt z\lt1$. The detected lines span a wide range in H i optical depth, including three lines with a peak optical depth $\tau\gt1$, and appear to be a mixture of intervening and associated systems. Interestingly, around two-thirds of the lines found in this untargeted sample are detected against sources with a peaked-spectrum radio continuum, which are only a minor (5–20%) fraction of the overall radio-source population. The detection rate for H i absorption lines in the Pilot Surveys (0.3 to 0.5 lines per 40 deg$^2$ ASKAP field) is a factor of two below the expected value. One possible reason for this is the presence of a range of spectral-line artefacts in the Pilot Survey data that have now been mitigated and are not expected to recur in the full FLASH survey. A future paper in this series will discuss the host galaxies of the H i absorption systems identified here.

Medical researchers are increasingly prioritizing the inclusion of underserved communities in clinical studies. However, mere inclusion is not enough. People from underserved communities frequently experience chronic stress that may lead to accelerated biological aging and early morbidity and mortality. It is our hope and intent that the medical community come together to engineer improved health outcomes for vulnerable populations. Here, we introduce Health Equity Engineering (HEE), a comprehensive scientific framework to guide research on the development of tools to identify individuals at risk of poor health outcomes due to chronic stress, the integration of these tools within existing healthcare system infrastructures, and a robust assessment of their effectiveness and sustainability. HEE is anchored in the premise that strategic intervention at the individual level, tailored to the needs of the most at-risk people, can pave the way for achieving equitable health standards at a broader population level. HEE provides a scientific framework guiding health equity research to equip the medical community with a robust set of tools to enhance health equity for current and future generations.

The development of wearable technology, which enables motion tracking analysis for human movement outside the laboratory, can improve awareness of personal health and performance. This study used a wearable smart sock prototype to track foot–ankle kinematics during gait movement. Multivariable linear regression and two deep learning models, including long short-term memory (LSTM) and convolutional neural networks, were trained to estimate the joint angles in sagittal and frontal planes measured by an optical motion capture system. Participant-specific models were established for ten healthy subjects walking on a treadmill. The prototype was tested at various walking speeds to assess its ability to track movements for multiple speeds and generalize models for estimating joint angles in sagittal and frontal planes. LSTM outperformed other models with lower mean absolute error (MAE), lower root mean squared error, and higher R-squared values. The average MAE score was less than 1.138° and 0.939° in sagittal and frontal planes, respectively, when training models for each speed and 2.15° and 1.14° when trained and evaluated for all speeds. These results indicate wearable smart socks to generalize foot–ankle kinematics over various walking speeds with relatively low error and could consequently be used to measure gait parameters without the need for a lab-constricted motion capture system.

We present the data and initial results from the first pilot survey of the Evolutionary Map of the Universe (EMU), observed at 944 MHz with the Australian Square Kilometre Array Pathfinder (ASKAP) telescope. The survey covers $270 \,\mathrm{deg}^2$ of an area covered by the Dark Energy Survey, reaching a depth of 25–30 $\mu\mathrm{Jy\ beam}^{-1}$ rms at a spatial resolution of $\sim$11–18 arcsec, resulting in a catalogue of $\sim$220 000 sources, of which $\sim$180 000 are single-component sources. Here we present the catalogue of single-component sources, together with (where available) optical and infrared cross-identifications, classifications, and redshifts. This survey explores a new region of parameter space compared to previous surveys. Specifically, the EMU Pilot Survey has a high density of sources, and also a high sensitivity to low surface brightness emission. These properties result in the detection of types of sources that were rarely seen in or absent from previous surveys. We present some of these new results here.

The Rapid ASKAP Continuum Survey (RACS) is the first large-area survey to be conducted with the full 36-antenna Australian Square Kilometre Array Pathfinder (ASKAP) telescope. RACS will provide a shallow model of the ASKAP sky that will aid the calibration of future deep ASKAP surveys. RACS will cover the whole sky visible from the ASKAP site in Western Australia and will cover the full ASKAP band of 700–1800 MHz. The RACS images are generally deeper than the existing NRAO VLA Sky Survey and Sydney University Molonglo Sky Survey radio surveys and have better spatial resolution. All RACS survey products will be public, including radio images (with $\sim$ 15 arcsec resolution) and catalogues of about three million source components with spectral index and polarisation information. In this paper, we present a description of the RACS survey and the first data release of 903 images covering the sky south of declination $+41^\circ$ made over a 288-MHz band centred at 887.5 MHz.

Breakthrough Listen is a 10-yr initiative to search for signatures of technologies created by extraterrestrial civilisations at radio and optical wavelengths. Here, we detail the digital data recording system deployed for Breakthrough Listen observations at the 64-m aperture CSIRO Parkes Telescope in New South Wales, Australia. The recording system currently implements two modes: a dual-polarisation, 1.125-GHz bandwidth mode for single-beam observations, and a 26-input, 308-MHz bandwidth mode for the 21-cm multibeam receiver. The system is also designed to support a 3-GHz single-beam mode for the forthcoming Parkes ultra-wideband feed. In this paper, we present details of the system architecture, provide an overview of hardware and software, and present initial performance results.

The combination of sensitivity and large sky coverage of the ALFALFA HI survey has enabled the detection of difficult to observe low mass galaxies in large numbers, including dwarf galaxies overlooked in optical surveys. Three different, but connected, studies of dwarf galaxies from the ALFALFA survey are of particular interest: SHIELD (Survey of HI in Extremely Low-mass Dwarfs), candidate gas-rich ultra-faint dwarf galaxies, and the (Almost) Dark population. SHIELD is a systematic multiwavelength study of all dwarf galaxies from ALFALFA with MHI < 107.2M⊙ and clear optical counterparts. Candidate gas-rich ultra-faint dwarf galaxies extend the dwarf galaxy population to even lower masses. These galaxies are identified as isolated HI clouds with no discernible optical counterpart but subsequent observations reveal that some are extremely faint, gas-dominated galaxies. Leo P, discovered first as an HI detection, and then found to be an actively star-forming galaxy, bridges the gap between these candidate galaxies and the SHIELD sample. The (Almost) Dark sample consists of galaxies whose optical counterparts are overlooked in current optical surveys but which are clear detections in ALFALFA. This sample includes field gas-rich ultra-diffuse galaxies. Coma P, with a peak surface brightness of only ∼26.4 mag arcsec−2 in g’, demonstrates the sort of extreme low surface brightness galaxy that can be discovered in an HI survey.

The equilibration time $\unicode[STIX]{x1D70F}$ in response to a change in flux from $Q$ to $\unicode[STIX]{x1D6EC}Q$ after an injection period $T$ applied to either a low-Reynolds-number gravity current or one propagating through a porous medium, in both axisymmetric and one-dimensional geometries, is shown to be of the form $\unicode[STIX]{x1D70F}=Tf(\unicode[STIX]{x1D6EC})$ , independent of all the remaining physical parameters. Numerical solutions are used to investigate $f(\unicode[STIX]{x1D6EC})$ for each of these situations and compare very well with experimental results in the case of an axisymmetric current propagating over a rigid horizontal boundary. Analysis of the relaxation towards self-similarity provides an illuminating connection between the excess (deficit) volume from early times and an asymptotically equivalent shift in time origin, and hence a good quantitative estimate of $\unicode[STIX]{x1D70F}$ . The case $\unicode[STIX]{x1D6EC}=0$ of equilibration after ceasing injection at time $T$ is a singular limit. Extensions to high-Reynolds-number currents and to the case of a constant-volume release followed by constant-flux injection are discussed briefly.

The ‘voice quality symbols’ (VoQS) transcription system for voice quality was introduced some 20 years ago, and no major revision has been undertaken since then. In this account we describe the first major revision of the VoQS chart, these changes being mostly in the form of additions to the section on phonation types, but include also changes to the layout of the supralaryngeal settings section. These reflect recent developments in the understanding of the physiological underpinnings of sounds produced in the larynx including certain phonation types.

Farmers grow crops in the dryland region of the Pacific Northwest (PNW) using tillage practices ranging from moldboard plowing to no-tillage. The objective of this study was to determine the effect of tillage on persistence of imazamox herbicide in intermediate and high precipitation zones of the inland PNW. Along with a nontreated control, imazamox was applied to imidazolinone-tolerant winter wheat in the fall and spring at one, two, and three times the maximum labeled rate at locations near Genesee, ID, Davenport, WA, and Pendleton, OR. Moldboard plow, chisel plow, and no-till tillage treatments were implemented soon after wheat harvest and yellow mustard was planted the following season to determine crop response. Experiments were conducted at each location in 2005 to 2007 and 2006 to 2008. There were significant location by year and year and location interactions. There was no significant tillage by imazamox rate interaction, except at Pendleton in year 2, for all measured yellow mustard responses (crop injury, biomass, and yield). Genesee was colder than Pendleton and had more precipitation than Davenport, resulting in more injury to yellow mustard at Genesee than at Pendleton but less than at Davenport. Davenport had greater injury than the other two locations, likely due to lower soil pH, higher organic matter (OM), and cooler, drier climate, which allowed imazamox to persist longer in the soil. Overall, Pendleton had the least yellow mustard injury, which likely was related to its warmer, wetter climate and the concomitant rapid soil dissipation of imazamox. Tillage did not reduce the persistence of imazamox. Yellow mustard had the lowest injury and had greater mature biomass and seed yield in no-till seeded plots when averaged across imazamox rates compared to moldboard and chisel-plowed plots.

Purification of amyloid plaque core proteins (APCP) from Alzheimer's disease brains to complete homogeneity and in high yield permitted its chemical fractionation and characterization of its components. APCP is mainly made of β-amyloid (βA) and an assortment of glycoproteins (accounting for 20%) rich in carbohydrates compatible with N-and O-linked saccharides. When added to tissue culture of sympathetic and sensory neurons APCP and βA inhibited neuritic sprouting, a reversible phenomenon at low doses. Higher concentrations of both substances kill the neurons in culture. APCP is significantly more toxic than βA, suggesting the minor components may play an important role in increasing the toxicity of βA. If the observed toxic effects of APCP in situ are occurring in vivo during the course of AD, then the accumulation of these extracellular proteins could be largely responsible for some of the neuronal death observed in this neuropathology.

This article examines how intensive family interventions in England since 1997, including the Coalition government's Troubled Families programme, are situated in a contemporary problem figuration of ‘anti-social’ or ‘troubled’ families that frames and justifies the utilisation of different models of intensive family intervention. The article explores how techniques of classification and estimation, combined with the controversial use of ‘research’ evidence in policy making, are situated within a ‘rational fiction’ that constructs ‘anti-social’ families in particular ways. The article illustrates how this problem figuration has evolved during the New Labour and Coalition administrations in England, identifying their similarities and differences. It then presents findings from a study of intensive family intervention strategies and mechanisms in a large English city to illustrate how this national level discourse and policy framework relates to developing localised practice, and the tensions and ambiguities that arise.