To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Adolescence is a period marked by high vulnerability to onset of depression. Neuroimaging studies have revealed considerableatrophy of brain structure in patients with major depressive disorder (MDD). However, the causal structural networks underpinning gray matter atrophies in depressed adolescents remain unclear. This study aimed to examine the initial gray matter alterations in MDD adolescents and investigate their causal relationships of abnormalities within brain structural networks.
Methods
First-episode adolescent patients with MDD (n = 80, age = 15.57 ± 1.78) and age- and sex-matched healthy controls (n = 82, age = 16.11 ± 2.76) were included. We analyzed T1-weighted structural images using voxel-based morphometry to identify gray matter alterations in patients and the disease stage-specific abnormalities. Granger causality analysis was then conducted to construct causal structural covariance networks. We also identified potential pathways between the causal source and target.
Results
Compared to controls, MDD patients with shorter illness duration showed gray matter atrophy in localized brain regions such as ventral medial prefrontal cortex (vmPFC), anterior cingulate cortex, and insula. With a prolonged course of MDD, gray matter atrophy extended to widespread brain areas. Causal network results demonstrated that early abnormalities had positive effects on the default mode, frontoparietal networks, and reward circuits. Moreover, vmPFC demonstrated the highest out-degree value, possibly representing the initial source of brain abnormality in adolescent depression.
Conclusions
These findings revealed the progression of gray matter atrophy in adolescent depression and demonstrated the directional influences between initial localized alterations and subsequent deterioration in widespread brain networks.
In this paper, a millimeter-wave (mmWave) wideband high-gain low-temperature co-fired ceramic (LTCC) phased array using ridged substrate integrated waveguide (RSIW) element is proposed, which can cover n257/n258 bands (24.25–29.5 GHz). First, a novel widebeam and high-gain RSIW slot antenna subarray is designed, which is constructed by staggered longitudinal slot that incorporated with additional radiating elements on the non-scanning plane. Further, the proposed widebeam antenna subarray is applied to construct a 1 × 4 array integrated in an LTCC package with small element spacing of about 0.41λ0. Moreover, by adding isolation slots and metal vias between adjacent array elements, the isolation of ports thereby is reduced below −15 dB, and the scanning range is increased up to ±7°. A wideband and low-loss feeding network is realized by series-parallel combined feeding, further improving isolation and scanning performance after assembly. The simulation and measurement demonstrate that the antenna array possesses satisfied beam-scanning capabilities over wide bandwidth of ∼20%, achieving maximum scanning angle up to ±62° while maintaining desirable gain above 14.5 dBi. Furthermore, within the entire operating bandwidth, the scanning angles extend to ±55° with minimal variation. These features show that the proposed antenna array is promising for 5G mmWave communications.
Direct numerical simulations are performed to explore the impact of surface roughness on inter-scale energy transfer and interaction in a turbulent open-channel flow over differently arranged rough walls. With friction Reynolds number approximately 540, six distinct configurations of roughness arrangements are examined. The results show that the clustered roughness arrangements yield notable changes in large-scale secondary-flow structures, which manifest in the profiles of dispersive stresses, predominantly near the roughness elements. They are marked by the presence of spanwise alternating high-momentum pathways and low-momentum pathways. From the outer peak in the spanwise energy spectra, the size and intensity of turbulent secondary flows are shown to be related to the spanwise spacing of the roughness heterogeneity. The emergence of turbulent secondary flows serves to suppress the original large-scale structures in the outer region of smooth-wall turbulence, paving the way for the development of new turbulent structures at the second harmonic scale. Furthermore, the spanwise triadic interaction analysis reveals the mutual energy exchange between the secondary harmonic scale and the secondary-flow scale. These findings elucidate the underlying mechanisms behind the attenuation of large-scale structures in the outer region influenced by roughness, offering new insights into the dynamic interplay of scale interactions in rough-wall turbulence.
Carbon storage in saline aquifers is a prominent geological method for reducing CO2 emissions. However, salt precipitation within these aquifers can significantly impede CO2 injection efficiency. This study examines the mechanisms of salt precipitation during CO2 injection into fractured matrices using pore-scale numerical simulations informed by microfluidic experiments. The analysis of varying initial salt concentrations and injection rates revealed three distinct precipitation patterns, namely displacement, breakthrough and sealing, which were systematically mapped onto regime diagrams. These patterns arise from the interplay between dewetting and precipitation rates. An increase in reservoir porosity caused a shift in the precipitation pattern from sealing to displacement. By incorporating pore structure geometry parameters, the regime diagrams were adapted to account for varying reservoir porosities. In hydrophobic reservoirs, the precipitation pattern tended to favour displacement, as salt accumulation occurred more in larger pores than in pore throats, thereby reducing the risk of clogging. The numerical results demonstrated that increasing the gas injection rate or reducing the initial salt concentration significantly enhanced CO2 injection performance. Furthermore, identifying reservoirs with high hydrophobicity or large porosity is essential for optimising CO2 injection processes.
Hand, foot, and mouth disease (HFMD) shows spatiotemporal heterogeneity in China. A spatiotemporal filtering model was constructed and applied to HFMD data to explore the underlying spatiotemporal structure of the disease and determine the impact of different spatiotemporal weight matrices on the results. HFMD cases and covariate data in East China were collected between 2009 and 2015. The different spatiotemporal weight matrices formed by Rook, K-nearest neighbour (KNN; K = 1), distance, and second-order spatial weight matrices (SO-SWM) with first-order temporal weight matrices in contemporaneous and lagged forms were decomposed, and spatiotemporal filtering model was constructed by selecting eigenvectors according to MC and the AIC. We used MI, standard deviation of the regression coefficients, and five indices (AIC, BIC, DIC, R2, and MSE) to compare the spatiotemporal filtering model with a Bayesian spatiotemporal model. The eigenvectors effectively removed spatial correlation in the model residuals (Moran’s I < 0.2, p > 0.05). The Bayesian spatiotemporal model’s Rook weight matrix outperformed others. The spatiotemporal filtering model with SO-SWM was superior, as shown by lower AIC (92,029.60), BIC (92,681.20), and MSE (418,022.7) values, and higher R2 (0.56) value. All spatiotemporal contemporaneous structures outperformed the lagged structures. Additionally, eigenvector maps from the Rook and SO-SWM closely resembled incidence patterns of HFMD.
where $b\,:\, \mathbb{R}^d \rightarrow \mathbb{R}^d$ is a Lipschitz-continuous function, $A \in \mathbb{R}^{d \times d}$ is a positive-definite matrix, $(Z_t)_{t\geqslant 0}$ is a d-dimensional rotationally symmetric $\alpha$-stable Lévy process with $\alpha \in (1,2)$ and $x\in\mathbb{R}^{d}$. We use two Euler–Maruyama schemes with decreasing step sizes $\Gamma = (\gamma_n)_{n\in \mathbb{N}}$ to approximate the invariant measure of $(X_t)_{t \geqslant 0}$: one uses independent and identically distributed $\alpha$-stable random variables as innovations, and the other employs independent and identically distributed Pareto random variables. We study the convergence rates of these two approximation schemes in the Wasserstein-1 distance. For the first scheme, under the assumption that the function b is Lipschitz and satisfies a certain dissipation condition, we demonstrate a convergence rate of $\gamma^{\frac{1}{\alpha}}_n$. This convergence rate can be improved to $\gamma^{1+\frac {1}{\alpha}-\frac{1}{\kappa}}_n$ for any $\kappa \in [1,\alpha)$, provided b has the additional regularity of bounded second-order directional derivatives. For the second scheme, where the function b is assumed to be twice continuously differentiable, we establish a convergence rate of $\gamma^{\frac{2-\alpha}{\alpha}}_n$; moreover, we show that this rate is optimal for the one-dimensional stable Ornstein–Uhlenbeck process. Our theorems indicate that the recent significant result of [34] concerning the unadjusted Langevin algorithm with additive innovations can be extended to stochastic differential equations driven by an $\alpha$-stable Lévy process and that the corresponding convergence rate exhibits similar behaviour. Compared with the result in [6], our assumptions have relaxed the second-order differentiability condition, requiring only a Lipschitz condition for the first scheme, which broadens the applicability of our approach.
In this paper, we investigate the number of customers that overlap or coincide with a virtual customer in an Erlang-A queue. Our analysis starts with the fluid and diffusion limit differential equations to obtain the mean and variance of the queue length. We then develop precise approximations for waiting times using fluid limits and the polygamma function. Building on this, we introduce a novel approximation scheme to calculate the mean and variance of the number of overlapping customers. This method facilitates the assessment of transient overlap risks in complex service systems, offering a useful tool for service providers to mitigate significant overlaps during pandemic seasons.
In this paper, on–off switching digitization of a W-band variable gain power amplifier (VGPA) with above 60 dB dynamic range is introduced for large-scale phased array. Digitization techniques of on–off switching modified stacking transistors with partition are proposed to optimize configuration of control sub-cells. By the proposed techniques, gain control of a radio frequency variable gain amplifier (VGA) could be highly customized for both coarse and fine switching requirements instead of using additional digital-to-analog converters to tune the overall amplifier bias. The designed VGA in 130 nm SiGe has achieved switchable gain range from −46.4 to 20.6 dB and power range from −25.0 to 15.7 dBm at W band. The chip size of the fabricated VGPA is about 0.31 mm × 0.1 mm.
We document firms often determine CEO equity grants based on a predetermined dollar value (value-based equity grant) instead of on the number of shares (share-based grant). Value-based equity grants weaken the relationship between stock performance and CEO equity pay, lower CEO portfolio delta, and slow firms’ investment in R&D. We find that retention pressure is a key reason for the use of value-based equity pay, while governance could also matter. Overall, this paper alerts boards to the unintended consequences of pursuing a target pay level or pay structure because such practices can lead to value-based equity grants in CEO compensation.
Transcription of DNA into RNA is a fundamental cellular process upon which life depends. It is tightly regulated in several different ways, and among the most important mechanisms are protein-induced topological changes in DNA such as looping. In vivo neither transcription, nor protein-induced looping dynamics exhibited by individual molecules are easily monitored. In vitro single-molecule approaches do offer that possibility, but assays are conducted in rarefied, saline buffer conditions which greatly differ from the crowded intracellular environment. In the following, we describe monitoring both transcription and lac repressor-mediated DNA looping of single DNA molecules in the presence of different concentrations of crowders to bridge the gap between in vitro and in vivo experimentation. We found that crowding shifts the preferred orientation of DNA strands in the looped complex. Crowding also attenuates the rate of transcript elongation and enhances readthrough at the terminator. Clearly, the activities of proteins involved in gene regulation are modified in surprising ways by crowding.
Childhood trauma (CT) increases rates of psychiatric disorders and symptoms, however, the lasting effect of CT into adulthood has little exploration using large-scale samples.
Objectives
This study estimated the prevalence of CT in a large sample of Chinese young adults, examining the risk factors of current psychological symptoms among those with CT experiences.
Methods
117,769 college students were divided into CT and non-CT groups. The propensity score matching method balanced the confounding sociodemographic factors between the two groups, compared to 16 self-reported psychiatric disorders (e.g., depression, anxiety, eating disorder, obsessive-compulsive disorder, autism, social anxiety disorder, post-traumatic stress disorder), and seven current psychiatric symptoms. Hierarchical regression employed the significant risk factors of the seven current psychiatric symptoms.
Results
The prevalence of CT among young adults was 28.76% (95% CI: 28.47–29.04%). Youths with CT experiences reported higher psychiatric disorder rates and current symptom scores (P < 0.001). Sociodemographic factors (females, family disharmony, low socioeconomic status, poor relationship with parents, lower father’s education level) and lifestyle factors (smoking status, alcohol consumption, lack of exercise) were significantly associated with current psychiatric symptoms.
Results
Public health departments and colleges should develop strategies to promote mental health among those who have experienced CT.
Adolescence is a period marked by highest vulnerability to the onset of depression, with profound implications for adult health. Neuroimaging studies have revealed considerable atrophy in brain structure in these patients with depression. Of particular importance are regions responsible for cognitive control, reward, and self-referential processing. However, the causal structural networks underpinning brain region atrophies in adolescents with depression remain unclear.
Objectives
This study aimed to investigate the temporal course and causal relationships of gray matter atrophy within the brains of adolescents with depression.
Methods
We analyzed T1-weighted structural images using voxel-based morphometry in first-episode adolescent patients with depression (n=80, 22 males; age = 15.57±1.78) and age, gender matched healthy controls (n=82, 25 males; age = 16.11±2.76) to identify the disease stage-specific gray matter abnormalities. Then, with granger causality analysis, we arranged the patients’ illness duration chronologically to construct the causal structural covariance networks that investigated the causal relationships of those atypical structures.
Results
Compared to controls, smaller volumes in ventral medial prefrontal cortex (vmPFC), dorsal anterior cingulate cortex (dACC), middle cingulate cortex (MCC) and insula areas were identified in patients with less than 1 year illness duration, and further progressed to the subgenual ACC, regions of default, frontoparietal networks in longer duration. Causal network results revealed that dACC, vmPFC, MCC and insula were prominent nodes projecting exerted positive causal effects to regions of the default mode and frontoparietal networks. The dACC, vmPFC and insula also had positive projections to the reward network, which included mainly the thalamus, caudate and putamen, while MCC also exerted a positive causal effect on the insula and thalamus.
Conclusions
These findings revealed the progression of structural atrophy in adolescent patients with depression and demonstrated the causal relationships between regions involving cognitive control, reward and self-referential processes.
Whether material deprivation-related childhood socio-economic disadvantages (CSD) and care-related adverse childhood experiences (ACE) have different impacts on depressive symptoms in middle-aged and older people is unclear.
Methods
In the Guangzhou Biobank Cohort Study, CSD and ACE were assessed by 7 and 5 culturally sensitive questions, respectively, on 8,716 participants aged 50+. Depressive symptoms were measured by 15-item Geriatric Depression Scale (GDS). Multivariable linear regression, stratification analyses, and mediation analyses were done.
Results
Higher CSD and ACE scores were associated with higher GDS score in dose-response manner (P for trend <0.001). Participants with one point increment in CSD and ACE had higher GDS score by 0.11 (95% confidence interval [CI], 0.09–0.14) and 0.41 (95% CI, 0.35–0.47), respectively. The association of CSD with GDS score was significant in women only (P for sex interaction <0.001; women: β (95% CI)=0.14 (0.11–0.17), men: 0.04 (−0.01 to 0.08)). The association between ACE and GDS score was stronger in participants with high social deprivation index (SDI) (P for interaction = 0.01; low SDI: β (95% CI)=0.36 (0.29–0.43), high SDI: 0.64 (0.48–0.80)). The proportion of association of CSD and ACE scores with GDS score mediated via education was 20.11% and 2.28%.
Conclusions
CSD and ACE were associated with late-life depressive symptoms with dose-response patterns, especially in women and those with low adulthood socio-economic status. Education was a major mediator for CSD but not ACE. Eliminating ACE should be a top priority.
Seed germination is a pivotal period of plant growth and development. This process can be divided into four major stages, swelling absorption, seed coat dehiscence, radicle emergence and radicle elongation. Cupressus gigantea, a tree native to Tibet, China, is characterized by its resistance to stresses such as cold, and drought, and has a high economic and ecological value. Nevertheless, given its unique geographic location, its seeds are difficult to germinate. Therefore, it is crucial to explore the mechanisms involved in seed germination in this species to improve the germination efficiency of its seeds, thereby protecting this high-quality resource. Here, our findings indicate that seed germination was enhanced when exposed to a 6-h/8-h light/dark photoperiod, coupled with a temperature of 20°C. Furthermore, the application of exogenous GA3 (1 mg/ml, about 2.9 mM) stimulated the germination of C. gigantea seeds. Subsequently, proteomics was used to detect changes in protein expression during the four stages of seed germination. We identified 34 differentially expressed proteins (DEPs), including 13 at the radicle pre-emergence stage, and 17 at the radicle elongation stage. These DEPs were classified into eight functional groups, cytoskeletal proteins, energy metabolism, membrane transport, stress response, molecular chaperones, amino acid metabolism, antioxidant system and ABA signalling pathway. Most of them were found to be closely associated with amino acid metabolism. Combined, these findings indicate that, along with temperature and light, exogenous GA3 can increase the germination efficiency of C. gigantea seeds. Our study also offers insights into the changes in protein expression patterns in C. gigantea seeds during germination.
The assessment of seed quality and physiological potential is essential in seed production and crop breeding. In the process of rapid detection of seed viability using tetrazolium (TZ) staining, it is necessary to spend a lot of labour and material resources to explore the pretreatment and staining methods of hard and solid seeds with physical barriers. This study explores the TZ staining methods of six hard seeds (Tilia miqueliana, Tilia henryana, Sassafras tzumu, Prunus subhirtella, Prunus sibirica, and Juglans mandshurica) and summarizes the TZ staining conditions required for hard seeds by combining the difference in fat content between seeds and the kinship between species, thus providing a rapid viability test method for the protection of germplasm resources of endangered plants and the optimization of seed bank construction. The TZ staining of six species of hard seeds requires a staining temperature above 35 °C and a TZ solution concentration higher than 1%. Endospermic seeds require shorter staining times than exalbuminous seeds. The higher the fat content of the seeds, the lower the required incubation temperature and TZ concentration for staining, and the longer the staining time. And the closer the relationship between the two species, the more similar their staining conditions become. The TZ staining method of similar species can be predicted according to the genetic distance between the phylogenetic trees, and the viability of new species can be detected quickly.
Hippocampal disruptions represent potential neuropathological biomarkers in depressed adolescents with cognitive dysfunctions. Given heterogeneous outcomes of whole-hippocampus analyses, we investigated subregional abnormalities in depressed adolescents and their associations with symptom severity and cognitive dysfunctions.
Methods
MethodsSeventy-nine first-episode depressive patients (ag = 15.54 ± 1.83) and 71 healthy controls (age = 16.18 ± 2.85) were included. All participants underwent T1 and T2 imaging, completed depressive severity assessments, and performed cognitive assessments on memory, emotional recognition, cognitive control, and attention. Freesurfer was used to segment each hippocampus into 12 subfields. Multivariable analyses of variance were performed to identify overall and disease severity-related abnormalities in patients. LASSO regression was also conducted to explore the associations between hippocampal subfields and patients’ cognitive abilities.
Results
Depressed adolescents showed decreases in dentate gyrus, CA1, CA2/3, CA4, fimbria, tail, and molecular layer. Analyses of overall symptom severity, duration, self-harm behavior, and suicidality suggested that severity-related decreases mainly manifested in CA regions and involved surrounding subfields with disease severity increases. LASSO regression indicated that hippocampal subfield abnormalities had the strongest associations with memory impairments, with CA regions and dentate gyrus showing the highest weights.
Conclusions
Hippocampal abnormalities are widespread in depressed adolescents and such abnormalities may spread from CA regions to surrounding areas as the disease progresses. Abnormalities in CA regions and dentate gyrus among these subfields primarily link with memory impairments in patients. These results demonstrate that hippocampal subsections may serve as useful biomarkers of depression progression in adolescents, offering new directions for early clinical intervention.
Various magmatisms during the subduction-collision process are crucial to reveal the long-term tectonic evolution of the eastern Central Asian Orogenic Belt. In this paper, we present major and trace elements of whole-rock, zircon U-Pb dating and Hf isotope of the Shanmen pluton. Results imply that the Shanmen pluton consists of quartz diorite and mylonitic granite, with zircon U-Pb ages of 263.7–259.6 Ma. The studied quartz diorite contains high Sr/Y (51.19–90.87) and (La/Yb)N (7.82–13.62) ratios, and belongs to adakitic rocks. Coupled with the positive εHf(t) values of +5.71 to +12.8 with no obvious Eu anomaly, we propose that quartz diorite is the product of the interaction between different degrees of slab melt and the overlying mantle wedge. In contrast, the mylonitic granite has lower MgO (0.28 wt% – 0.47 wt%) contents and positive εHf(t) values of +7.79 to +10.15, indicating an affinity with I-type granite originated by partial melting of the intermediate-basic lower crust. The geochemical characteristics and lithological assemblages, along with the Permian magmatic rocks in the Changchun-Kaiyuan area displaying arc rocks affinity, propose their formation is related to the southward subduction of the Paleo-Asian Ocean (PAO). Based on this study and previous evidence, we lean towards adopting a middle-late Permian slab break-off model, wherein the PAO did not close until the late Permian.
A new ferrous phyllosilicate, meifuite, has been discovered in the Yinachang Fe-Cu-REE (rare-earth element) deposit in China. The structural formula, calculated using averaged electron probe microanalysis (EPMA) results, is K0.72Na0.20(Fe5.56Mg0.31Mn0.13)Σ6.00(Si6.95Al1.04)Σ7.99O18.84(OH)4.84 Cl1.33, with an ideal formula of KFe6(AlSi7)O19(OH)4Cl2. The structure of meifuite has a space group symmetry, with unit-cell parameters of a = 22.7773(13) Å, b = 9.5553(5) Å, c =14.3282(8) Å, α = 99.258(4)°, β = 136.750(3)°, γ = 89.899(4)°, Z = 2, and V = 2077.9(2) Å3. Meifuite has a strip-modulated 2:1 layer (T–O–T) structure similar to that of minnesotaite. About 1/8 of the tetrahedra in the T sheet are occupied by Al instead of Si, and the interlayer cavities are partially occupied by K and Na. Some of the OH sites in the octahedral sheet in the layer structure are fully or partially substituted by Cl, which is apparently the primary reason for the meifuite structure being more stable than stilpnomelane, the most common ferrous layer silicate mineral found at similar temperature and pressure conditions. An updated, more accurate structure model of minnesotaite is also provided for comparison with the meifuite structure. The mineral is named after Meifu Zhou in honor of his outstanding contributions to the field of economic geology.
A wideband tunable balanced phase shifter is achieved by utilizing varactor-loaded coupled lines (VLCLs)-embedded multistage branch-line structure. The tunable phase shift with low in-band phase deviation is attributed to the regulation in phase shift of the VLCLs and the horizontal microstrip lines in series. The wideband differential-mode (DM) impedance matching and common-mode (CM) suppression are due to multiple DM transmission poles and CM transmission zeros, which are brought about by the cascade of VLCLs and a microstrip line with short-circuited stubs in the DM-equivalent circuit and open-circuited stubs in the CM-equivalent circuit, respectively. Compared with the state-of-the-art tunable balanced phase shifters, the proposed design not only has the advantages of wide operating bandwidth (BW) with low in-band phase deviation but also has low insertion loss and easily fabricated structure. Theoretical analysis and design procedure were conducted, resulting in a prototype covering the frequency of 1.8 GHz. This prototype offers a tunable phase shift capability ranging from 0° to 90°. The prototype exhibits an operating BW of 45%, with a maximum phase deviation of ±6°. It also achieves a 10 dB DM return loss and CM suppression, while maintaining a maximum insertion loss of 2.5 dB.