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In this paper, we numerically investigate the orbit dynamics of three-dimensional symmetric Janus drops in shear flow using an improved ternary-fluids phase field method, focusing on how drop deformation and initial orientation affect the orbit drift of two configurations of Janus drops: dumbbell-shaped and near-spherical. We find that the motion of dumbbell-shaped drops eventually evolves into tumbling, while near-spherical drops attain stable spinning. We attribute this bifurcation in orbit drift to contrasting deformation dynamics and shape-dependent hydrodynamics of the two configurations. Specifically, the drift bifurcation is closely related to the aspect ratio of Janus drops at equilibrium, giving rise to two distinct mechanisms: (1) coupling between outer interface deformation and the surrounding flow field; and (2) interplay between inner interface deformation and vortices enclosed within the drop. In addition, we observe that for the dumbbell-shaped Janus drops with different aspect ratios, their tumbling dynamics resembles ellipsoids in shear flow. Moreover, the trajectories of the dumbbell-shaped Janus drops during orbit drift collapse onto a universal curve, independent of their initial orientations, and significant deformation and inertia accelerate the orbit transition. To quantitatively evaluate the effect of drop deformation on the orbit drift of the dumbbell-shaped Janus drops, we propose an effective aspect ratio model based on the drop shapes at equilibrium and at the maximum elongation. By incorporating the effective aspect ratio into Jeffery’s theory for solid particles, we accurately predict the rotation period and angular velocity of Janus drops in the tumbling regime and during the orbit drift, especially for drops with linear deformation. Moreover, the orbit parameter $C$ is found to vary exponentially with time for drops with linear deformation, while the time variation of $C$ transits from one exponential function to another for drops with nonlinear deformation.
We investigate a novel Marangoni-induced instability that arises exclusively in diffuse fluid interfaces, that is absent in classical sharp-interface models. Using a validated phase-field Navier–Stokes–Allen–Cahn framework, we linearise the governing equations to analyse the onset and development of interfacial instability driven by solute-induced surface tension gradients. A critical interfacial thickness scaling inversely with the Marangoni number, $\delta _{\textit{cr}} \sim \textit{Ma}^{-1}$, emerges from the balance between advective and diffusive transport. Unlike sharp-interface scenarios where matched viscosity and diffusivity stabilise the interface, finite thickness induces asymmetric solute distributions and tangential velocity shifts that destabilise the system. We identify universal power-law scalings of velocity and concentration offsets with a modified Marangoni number $\textit{Ma}_\delta$, independent of capillary number and interfacial mobility. A critical crossover at $ \textit{Ma}_\delta \approx 590$ distinguishes diffusion-dominated stabilisation from advection-driven destabilisation. These findings highlight the importance of diffuse-interface effects in multiphase flows, with implications for miscible fluids, soft matter, and microfluidics where interfacial thickness and coupled transport phenomena are non-negligible.
Individuals with first-episode psychosis (FEP) face markedly increased excess mortality, yet the long-term trends and key contributing factors remain insufficiently characterized. This study aimed to examine long-term mortality patterns, standardized mortality ratios (SMRs), and associated factors in a FEP cohort.
Methods
This population-based cohort study included 1,389 individuals diagnosed with FEP, followed for up to 25 years. Mortality outcomes were obtained from Hong Kong’s centralized hospital database (CMS) and coroner’s court reports, with SMRs calculated. Baseline sociodemographic and clinical, as well as long-term treatment-related factors of all-cause, natural, and unnatural mortality were analyzed.
Results
Among 1,389 participants, 137 deaths (9.86%) occurred during the follow-up period with the overall SMR of 6.56 (95% CI, 5.50–7.71). The cumulative incidence rate of unnatural mortality increased sharply over the first 10 years and that of the natural cause of death started to increase after the first decade of the illness. Male gender and poorer social functioning were associated with increased all-cause mortality risk, while male gender, lower education, and baseline hospitalization raised unnatural mortality risk. Greater monthly antipsychotic variability during the first 10 years increased all-cause mortality risk in the period after the initial 10 years.
Conclusions
This 25-year follow-up study of FEP highlighted the changes in the long-term mortality pattern of FEP and thus the phase-specific needs of individuals with FEP. Therefore, it is important to integrate physical care into mental health services, as well as stage-specific and individualized care for patients with psychotic disorders to reduce long-term excess mortality.
which arises from the iterated Laguerre operator on functions. We will prove the sequence $\{a_n\}$ of a unified form given by Griffin, Ono, Rolen and Zagier asymptotically satisfies this inequality while the Maclaurin coefficients of the functions in Laguerre-Pólya class have not to possess this inequality. We also prove the companion version of this inequality. As a consequence, we show the Maclaurin coefficients of the Riemann Ξ-function asymptotically satisfy this property. Moreover, we make this approach effective and give the exact thresholds for the positivity of this inequalityfor the partition function, the overpartition function and the smallest part function.
This focused textbook demonstrates cutting-edge concepts at the intersection of machine learning (ML) and wireless communications, providing students with a deep and insightful understanding of this emerging field. It introduces students to a broad array of ML tools for effective wireless system design, and supports them in exploring ways in which future wireless networks can be designed to enable more effective deployment of federated and distributed learning techniques to enable AI systems. Requiring no previous knowledge of ML, this accessible introduction includes over 20 worked examples demonstrating the use of theoretical principles to address real-world challenges, and over 100 end-of-chapter exercises to cement student understanding, including hands-on computational exercises using Python. Accompanied by code supplements and solutions for instructors, this is the ideal textbook for a single-semester senior undergraduate or graduate course for students in electrical engineering, and an invaluable reference for academic researchers and professional engineers in wireless communications.
In this paper, the upper bounds of non-real eigenvalues of indefinite Sturm–Liouville (S-L) problems with boundary conditions depend on the eigenparameter are studied. The upper bounds of real parts, imaginary parts and absolute values of non-real eigenvalues are given under the condition that the coefficients are integrable.
Flapping-wing robots, inspired by natural flyers, have gained significant attention for surveillance and environmental monitoring applications. This study presents the design and analysis of a bat-inspired flapping-wing robot with foldable wings, aiming to enhance flight efficiency and maneuverability. The robot features silicone-based, stretchable membrane wings, with a wingspan of 1.4 m and a total mass of 620 g. A one-degree-of-freedom (DOF) revolute-spherical-spherical-revolute mechanism is used to reproduce the flapping motion, while a one-DOF Watt six-bar linkage mechanism enables dynamic wing folding, allowing adaptive wing shape modulation during flight. Explicit solutions for joint angle of the wing were expressed through analytical method. Flight tests were conducted to validate the effectiveness of the flapping-folding mechanism. Results show that the robot successfully replicates bat wing kinematics, with folding during the upstroke and unfolding during the downstroke. This research offers insights into bio-inspired wing designs for next-generation flapping-wing robots.
This study aimed to explore clinical characteristics and treatment efficacy in patients with posterior canal benign paroxysmal positional vertigo and different sleep qualities.
Methods
Patients with posterior canal benign paroxysmal positional vertigo were divided into high and low sleep quality groups based on Pittsburgh Sleep Quality Index scores.
Results
No significant baseline differences existed between low (n = 53) and high (n = 39) sleep quality groups. However, the proportion of cupulolithiasis was higher in the low sleep quality group (60.38 per cent vs. 35.90 per cent; p < 0.05). Additionally, the low sleep quality group had a longer median duration of upbeat nystagmus during the Dix-Hallpike test (63.50 seconds vs. 26.80 seconds; p < 0.05) and a lower cured rate in initial repositioning (9.43 per cent vs. 56.41 per cent) compared to high sleep quality group. Repositioning therapy significantly improved depressive and anxiety symptoms in all patients with posterior canal benign paroxysmal positional vertigo, with a more pronounced improvement in depressive symptoms in the low sleep quality group.
Conclusion
Poor sleep quality is associated with higher cupulolithiasis prevalence and treatment resistance, with residual symptoms mainly affecting social functioning.
Precise control of the laser focal position in the relativistic laser–plasma interaction is crucial for electron acceleration, inertial confinement fusion, high-order harmonic generation, etc. However, conventional methods are characterized by limited tunability and rapid divergence of the relativistic laser pulse after passing through a single focal point. In this work, we propose a novel plasma lens with a density gradient to achieve laser focusing in a tunable focal volume. The capacity depends on the modification of the phase velocity of the incident seed laser propagating in plasma. By modifying the plasma density gradient, one can even achieve an off-axis focusing plasma lens, allowing the laser to be focused further at an adjustable focus. Based on this new type of optical device, a beam-splitting array is also proposed to leverage this unique focusing mechanism for the generation of strong axial magnetic fields (>1000 T). Three-dimensional particle-in-cell simulations demonstrate that the seed laser with a focal spot of $9\ \unicode{x3bc} \mathrm{m}$ passing through the density varying plasma lens exhibits a focused laser with a focal spot of approximately $2.3\ \unicode{x3bc} \mathrm{m}$ and an 18 times enhancement of the laser intensity. The approach has considerable potential for applications in several areas, including laser-driven particle acceleration, X/$\gamma$-ray emission, strong magnetic field generation, etc.
Insomnia disorder, characterized by chronic sleep disruption, often co-occurs with maladaptive emotional memory processing. However, much remains unknown regarding the evolution of emotional memories and their neural representations over time among individuals with insomnia disorder.
Method
We examined the electroencephalographic (EEG) activities during emotional memory encoding, post-encoding sleep, and multiple retrieval phases – including immediate post-encoding, post-sleep, and a 7-day delayed retrieval – among 34 participants with insomnia disorder and 35 healthy control participants.
Results
Healthy controls exhibited adaptive dissipation of emotional memory: memory declined over time, accompanied by reduced subjective feelings toward negative memories. In contrast, participants with insomnia exhibited impaired dissipation: they retained both the emotional content and affective tone of the memories, with diminished time-dependent declines in memory and affect. Beyond behavioral performance, only participants with insomnia maintained stable neural representations of emotion over time, a pattern absent in healthy controls. Additionally, during the post-encoding sleep, slow-wave sleep (SWS), and rapid eye movement (REM) sleep durations predicted the adaptive dissipation of emotional memory over time, but only among healthy participants.
Conclusion
These findings highlight abnormalities in emotional memory processing among individuals with insomnia disorder and underscore the important function of SWS and REM sleep in facilitating adaptive emotional memory processing.
Large-scale spanwise motions in shock wave–turbulent boundary-layer interactions over a $ 25^{\circ }$ compression ramp at Mach 2.95 are investigated using large-eddy simulations. Spectral proper orthogonal decomposition (SPOD) identifies coherent structures characterised by low-frequency features and a large-scale spanwise wavelength of $ O(15\delta _{0})$, where $ \delta _{0}$ is the incoming boundary-layer thickness. The dominant frequency is at least one order of magnitude lower than that of the shock motions. These large-scale spanwise structures are excited near the shock foot and are sustained along the separation shock. Global stability analysis (GSA) is then employed to investigate the potential mechanisms driving these structures. The GSA identifies a stationary three-dimensional (3-D) mode at a wavelength of $ 15\delta _{0}$ with a similar perturbation field, particularly near the separation shock. Good agreement is achieved between the leading SPOD mode and the 3-D GSA mode both qualitatively and quantitatively, which indicates that global instability is primarily responsible for the large-scale spanwise structures surrounding the shock. The reconstructed turbulent separation bubble (TSB) using the 3-D global mode manifests as spanwise undulations, which directly induce the spanwise rippling of the separation shock. Furthermore, the coupled TSB motions in the streamwise and spanwise directions are examined. The TSB oscillates in the streamwise direction while simultaneously exhibiting spanwise undulations. The filtered wall-pressure signals indicate the dominant role of the streamwise motions.
Social determinants of health (SDHs) exert a significant influence on various health outcomes and disparities. This study aimed to explore the associations between combined SDHs and mortality, as well as adverse health outcomes among adults with depression.
Methods
The research included 48,897 participants with depression from the UK Biobank and 7,771 from the US National Health and Nutrition Examination Survey (NHANES). By calculating combined SDH scores based on 14 SDHs in the UK Biobank and 9 in the US NHANES, participants were categorized into favourable, medium and unfavourable SDH groups through tertiles. Cox regression models were used to evaluate the impact of combined SDHs on mortality (all-cause, cardiovascular disease [CVD] and cancer) in both cohorts, as well as incidences of CVD, cancer and dementia in the UK Biobank.
Results
In the fully adjusted models, compared to the favourable SDH group, the hazard ratios for all-cause mortality were 1.81 (95% CI: 1.60–2.04) in the unfavourable SDH group in the UK Biobank cohort; 1.61 (95% CI: 1.31–1.98) in the medium SDH group and 2.19 (95% CI: 1.78–2.68) in the unfavourable SDH group in the US NHANES cohort. Moreover, higher levels of unfavourable SDHs were associated with increased mortality risk from CVD and cancer. Regarding disease incidence, they were significantly linked to higher incidences of CVD and dementia but not cancer in the UK Biobank.
Conclusions
Combined unfavourable SDHs were associated with elevated risks of mortality and adverse health outcomes among adults with depression, which suggested that assessing the combined impact of SDHs could serve as a key strategy in preventing and managing depression, ultimately helping to reduce the burden of disease.
The incorporation of trace metals into land snail shells may record the ambient environmental conditions, yet this potential remains largely unexplored. In this study, we analyzed modern snail shells (Cathaica sp.) collected from 16 sites across the Chinese Loess Plateau to investigate their trace metal compositions. Our results show that both the Sr/Ca and Ba/Ca ratios exhibit minimal intra-shell variability and small inter-shell variability at individual sites. A significant positive correlation is observed between the shell Sr/Ca and Ba/Ca ratios across the plateau, with higher values being recorded in the northwestern sites where less monsoonal rainfall is received. We propose that shell Sr/Ca and Ba/Ca ratios, which record the composition of soil solution, may be controlled by the Rayleigh distillation in response to prior calcite precipitation. Higher rainfall amounts may lead to a lower degree of Rayleigh distillation and thus lower shell Sr/Ca and Ba/Ca ratios. This is supported by the distinct negative correlation between summer precipitation and shell Sr/Ca and Ba/Ca ratios, enabling us to reconstruct summer precipitation amounts using the Sr/Ca and Ba/Ca ratios of Cathaica sp. shells. The potential application of these novel proxies may also be promising for other terrestrial mollusks living in the loess deposits globally.
Existing evidence on the association between combined lifestyle and depressive symptoms is limited to the general population and is lacking in individuals with subthreshold depression, a high-risk group for depressive disorders. Furthermore, it remains unclear whether an overall healthy lifestyle can mitigate the association between childhood trauma (CT) and depressive symptoms, even in the general population. We aimed to explore the associations of combined lifestyle, and its interaction with CT, with depressive symptoms and their subtypes (i.e. cognitive-affective and somatic symptoms) among adults with subthreshold depression.
Methods
This dynamic cohort was initiated in Shenzhen, China in 2019, including adults aged 18–65 years with the Patient Health Questionnaire-9 (PHQ-9) score of ≥ 5 but not diagnosed with depressive disorders at baseline. CT (present or absent) was assessed with the Childhood Trauma Questionnaire-Short Form. Combined lifestyle, including no current drinking, no current smoking, regular physical exercise, optimal sleep duration and no obesity, was categorized into 0–2, 3 and 4–5 healthy lifestyles. Depressive symptoms were assessed using the PHQ-9 during follow-up. This cohort was followed every 6 months, and as of March 2023, had been followed for 3.5 years.
Findings
This study included 2298 participants (mean [SD] age, 40.3 [11.1] years; 37.7% male). After fully adjusting for confounders, compared with 0–2 healthy lifestyles, 3 (β coefficient, −0.619 [95% CI, −0.943, −0.294]) and 4–5 (β coefficient, −0.986 [95% CI, −1.302, −0.671]) healthy lifestyles were associated with milder depressive symptoms during follow-up. There exists a significant synergistic interaction between a healthy lifestyle and the absence of CT. The CT-stratified analysis showed that compared with 0–2 healthy lifestyles, 3 healthy lifestyles were associated with milder depressive symptoms in participants with CT, but not in those without CT, and 4–5 healthy lifestyles were associated with milder depressive symptoms in both participants with and without CT, with a stronger association in those with CT. The lifestyle-stratified analysis showed that CT was associated with more severe depressive symptoms in participants with 0–2 healthy lifestyles, but not in those with 3 or 4–5 healthy lifestyles. Cognitive-affective and somatic symptoms showed similar results.
Conclusions
In this 3.5-year longitudinal study of adults with subthreshold depression, an overall healthy lifestyle was associated with subsequent milder depressive symptoms and their subtypes, with a stronger association in adults with CT than those without CT. Moreover, an overall healthy lifestyle mitigated the association of CT with depressive symptoms and their subtypes.
Le Liang, Southeast University, Nanjing,Shi Jin, Southeast University, Nanjing,Hao Ye, University of California, Santa Cruz,Geoffrey Ye Li, Imperial College of Science, Technology and Medicine, London
Le Liang, Southeast University, Nanjing,Shi Jin, Southeast University, Nanjing,Hao Ye, University of California, Santa Cruz,Geoffrey Ye Li, Imperial College of Science, Technology and Medicine, London
Le Liang, Southeast University, Nanjing,Shi Jin, Southeast University, Nanjing,Hao Ye, University of California, Santa Cruz,Geoffrey Ye Li, Imperial College of Science, Technology and Medicine, London
Le Liang, Southeast University, Nanjing,Shi Jin, Southeast University, Nanjing,Hao Ye, University of California, Santa Cruz,Geoffrey Ye Li, Imperial College of Science, Technology and Medicine, London