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1 results

  • Anterior cingulate grey-matter deficits and cannabis use infirst-episode schizophrenia

  • Philip R. Szeszko, Delbert G. Robinson, Serge Sevy, Sanjiv Kumra, Claudia I. Rupp, Julia D. Betensky, Todd Lencz, Manzar Ashtari, John M. Kane, Anil K. Malhotra, Handan Gunduz-Bruce, Barbara Napolitano, Robert M. Bilder
  • Journal:
    The British Journal of Psychiatry / Volume 190 / Issue 3 / March 2007
    Published online by Cambridge University Press:
    02 January 2018, pp. 230-236
    Print publication:
    March 2007
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  • Background

    Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia.

    Aims

    To investigate prefrontal grey and white matter regions in patients experiencing a first episode of schizophrenia with an additional diagnosis of cannabis use or dependence (n=20) compared with similar patients with no cannabis use (n=31) and healthy volunteers (n=56).

    Method

    Volumes of the superior frontal gyrus, anterior cingulate gyrus and orbital frontal lobe were outlined manually from contiguous magnetic resonance images and automatically segmented into grey and white matter.

    Results

    Patients who used cannabis had less anterior cingulate grey matter compared with both patients who did not use cannabis and healthy volunteers.

    Conclusions

    A defect in the anterior cingulate is associated with a history of cannabis use among patients experiencing a first episode of schizophrenia and could have a role in poor decision-making and in choosing more risky outcomes.