Attention Deficit Hyperactivity Disorder (ADHD) is a serious risk factor for co-occurring psychiatric disorders and negative psychosocial consequences in adulthood. Given this background, there is great need for an effective treatment of adult ADHD patients.

Therefore, our research group has conducted a first controlled randomized multicenter study on the evaluation of disorder-tailored DBT-based group program in adult ADHD compared to a psychophar-macological treatment.

Between 2007 and 2010, in a four-arm-design 433 patients were randomized to a manualized dialectical behavioural therapy (DBT) based group program plus methylphenidate or placebo or clinical management plus methylphenidate or placebo with weekly sessions in the first twelve weeks and monthly sessions thereafter. Therapists are graduated psychologists or physicians. Treatment integrity is established by independent supervision. Primary endpoint (ADHD symptoms measured by the Conners Adult ADHD Rating Scale) is rated by interviewers blind to the treatment allocation (Current Controlled Trials ISRCTN54096201). The trial is funded by the German Federal Ministry of Research and Education (01GV0606) and is part of the German network for the treatment of ADHD in children and adults (ADHD-NET). In the lecture the first data of our interim analysis are presented (baseline data, results of treatment compliance and adherence).

Exercise during pregnancy has beneficial effects on maternal and offspring’s health in humans and mice. The underlying mechanisms remain unclear. This comparative study aimed to determine the long-term effects of an exercise program on metabolism, weight gain, body composition and changes in hormones [insulin, leptin, brain-derived neurotrophic factor (BDNF)]. Pregnant women (n=34) and mouse dams (n=44) were subjected to an exercise program compared with matched controls (period I). Follow-up in the offspring was performed over 6 months in humans, corresponding to postnatal day (P) 21 in mice (period II). Half of the mouse offspring was challenged with a high-fat diet (HFD) for 6 weeks between P70 and P112 (period III). In period I, exercise during pregnancy led to 6% lower fat content, 40% lower leptin levels and an increase of 50% BDNF levels in humans compared with controls, which was not observed in mice. After period II in humans and mice, offspring body weight did not differ from that of the controls. Further differences were observed in period III. Offspring of exercising mouse dams had significantly lower fat mass and leptin levels compared with controls. In addition, at P112, BDNF levels in offspring were significantly higher from exercising mothers while this effect was completely blunted by HFD feeding. In this study, we found comparable effects on maternal and offspring’s weight gain in humans and mice but different effects in insulin, leptin and BDNF. The long-term potential protective effects of exercise on biomarkers should be examined in human studies.

Nineteen different genera of weeds encompassing twelve plant families were surveyed for hydrolytic enzymes which were able to metabolize the amide bonds in several groups of herbicides. Propanil (3′,4′-dichloropropionanilide), 1,1-dimethyl-3-phenylurea (fenuron), and isopropyl carbanilate (propham) were employed as enzyme substrates, representing the amide, urea, and carbamate classes. Propanil was hydrolyzed at widely diverse rates by approximately 70% of the plants tested. Only one plant showed a hydrolysis of propham and fenuron. The study demonstrates a widespread distribution of hydrolytic enzymes capable of degrading the herbicide, propanil. An apparent lack of hydrolytic enzymes able to metabolize propham and fenuron was also noted.

The inclusion of winter cereals in spring-annual rotations in the northern Great Plains may reduce weed populations and herbicide requirements. A broad range of spring and winter cereals were compared for ability to suppress weeds and maximize grain yield at Lacombe (2002 to 2005) and Lethbridge (2003 to 2005), Alberta, Canada. High seeding rates (≥ 400 seeds/m2) were used in all years to maximize crop competitive ability. Spring cereals achieved high crop-plant densities (> 250 plants/m2) at most sites, but winter cereals had lower plant densities due to winterkill, particularly at Lethbridge in 2004. All winter cereals and spring barley were highly effective at reducing weed biomass at Lacombe for the first 3 yr of the study. Weed suppression was less consistently affected by winter cereals in the last year at Lacombe and at Lethbridge, primarily due to poor winter survival. Grain yields were highest for spring triticale and least for spring wheat at Lacombe, with winter cereals intermediate. At Lethbridge, winter cereals had higher grain yields in 2003 whereas spring cereals had higher yields in 2004 and 2005. Winter cereals were generally more effective at suppressing weed growth than spring cereals if a good crop stand was established, but overlap in weed-competitive ability among cultivars was considerable. This information will be used to enhance the sustainable production of winter and spring cereals in traditional and nontraditional agro-ecological zones.

Complications from systemic inflammation are reported in neonates following exposure to cardiopulmonary bypass. Although the use of asanguinous primes can reduce these complications, in neonates, this can result in significant haemodilution, requiring addition of blood. This study investigates whether the addition of blood after institution of bypass alters the inflammatory response compared with a blood prime. Neonatal swine were randomised into four groups: blood prime, blood after bypass but before cooling, blood after cooling but before low flow, and blood after re-warming. All groups were placed on central bypass, cooled, underwent low flow, and then re-warmed for a total bypass time of 2 hours. Although haematocrit values between groups varied throughout bypass, all groups ended with a similar value. Although they spent time with a lower haematocrit, asanguinous prime groups did not have elevated lactate levels at the end of bypass compared with blood prime. Asanguinous primes released less tumour necrosis factor α than blood primes (p=0.023). Asanguinous primes with blood added on bypass produced less interleukin 10 and tumour necrosis factor α (p=0.006, 0.019). Animals receiving blood while cool also showed less interleukin 10 and tumour necrosis factor α production than those that received blood warm (p=0.026, 0.033). Asanguinous primes exhibited less oedema than blood primes, with the least body weight gain noted in the end cool group (p=0.011). This study suggests that using an asanguinous prime for neonates being cooled to deep hypothermia is practical, and the later addition of blood reduces inflammation.

The multicomponent Dry Creek site, located in the Nenana Valley, central Alaska, is arguably one of the most important archaeological sites in Beringia. Original work in the 1970s identified two separate cultural layers, called Components 1 and 2, thought to date to the terminal Pleistocene and suggesting that the site was visited by Upper Paleolithic huntergatherers between about 13,000 and 12,000 calendar years before present (cal B.P.). The oldest of these became the typeassemblage for the Nenana complex. Recently, some have questioned the geoarchaeological integrity of the site's early deposits, suggesting that the separated cultural layers resulted from natural postdepositional disturbances. In 2011, we revisited Dry Creek to independently assess the site's age and formation. Here we present our findings and reaffirm original interpretations of clear separation of two terminal Pleistocene cultural occupations. For the first time, we report direct radiocarbon dates on cultural features associated with both occupation zones, one dating to 13,485-13,305 and the other to 11,060-10,590 cal B.P.

We present a preliminary analysis of the self-absorbed [CII]-spectra observed with SOFIA/GREAT towards NGC 2024. Together with the detected [13CII] hyperfine satellites, the observed spectra require surprisingly high column densities of C+, both in the warm core and the foreground absorption component. Such high column densities are a challenge to explain with present state-of-the-art PDR models of the UV/molecular cloud interaction.

A cross-sectional parasitological study of a population of wild olive baboons (Papio cynocephalus anubis), consisting of 5 troops, was conducted in Gombe Stream National Park. Baboons were individually recognizable. Information on age, sex, troop membership, reproductive status, social rank and life-history of each individual baboon could be related to parasite infection. Seven helminth taxa and 2 protozoan taxa were found. All baboons were parasitized by at least 1 taxon. Distributions of helminths were aggregated among hosts. There were significant differences among troops in the prevalence of all but 2 of the recorded helminths. Age had a significant impact on the prevalence and intensity of Strongyloides sp. No significant effect of sex on the prevalence of infection could be detected. There was some indication that female reproductive status was related to Trichuris egg output. In contrast to a previous study, no significant correlations between parasite infection and social rank could be found. Troop membership constituted the predominant factor contributing to heterogeneity of prevalence of infection. This suggests that spatial location and/or genetics may be important in determining levels of parasite infection.

The CON+Deuterium Observations Receiver (CONDOR) is a heterodyne receiver that operates between 1250–1530 GHz. Its primary goal is to observe star-forming regions in CO, N+, and H2D+ emission.

CONDOR, the CO, N+, Deuterium Observations Receiver, is designed to make velocity-resolved observations of the CO, [NII], and p-H2D+ lines in the 1.4 THz (200-240μm) atmospheric windows. CONDOR's first light observations were made with the APEX telescope in November 2005. The CONDOR beam on APEX (at ν = 1.5 THz) was expected to consist of a 4.3″ main beam and a 73″ error beam; this beam structure was verified from scans of Mars. The pointing accuracy, also determined from Mars scans, was better than 7″. The average atmospheric transmission during our Orion observations (elev~57°) was 19 ± 4% along the line-of-sight. A forward efficiency of Feff = 0.8 was determined from sky dips, and observations of the Moon and Mars were used to couple the CONDOR beam to sources of different sizes (ηc = 0.40 and ~0.10, respectively). For more information, see Wiedner et al. 2006.

The development of new acaricides is a long and very expensive process. Worryingly, there is increasing resistance to available acaricides worldwide leading to the real possibility that our dwindling supply of effective acaricides will be exhausted unless action is taken to increase the number of new acaricidal products and reduce the rate of resistance development. In 1995, eight major animal health pharmaceutical companies formed the Veterinary Parasite Resistance Group (VPRG) to act as an expert consultative group to guide the FAO in resistance management and collaborate in the prudent use of acaricides. In this paper, members of the VPRG discuss the problems and processes in acaricide development, resistance in the field to commonly used acaricides and the different considerations when targeting the cattle and pet market, and give their view of the future for tick control from the perspective of the animal health industry.

Experimental results on sediment erosion (scour) by a plane turbulent wall jet, issuing from a sluice gate, are presented which show clearly – it seems for the first time – that the turbulent wall layer is destabilized by the concave curvature of the water/sediment interface. The streamwise Görtler vortices which emerge create sediment streaks or longitudinal sediment ridges. The analysis of the results in terms of Görtler instability of the wall layer indicates that the strength of these curvature-excited streamwise vortices is such that the sediment transport is primarily due to turbulence created by these vortices. Their contribution to the wall shear stress is taken to be of the same form as the normal turbulent wall shear stress. For this reason, the model developed by Hogg et al. (J. Fluid Mech. Vol. 338, 1997, p. 317) remains valid; only the numerical coefficients are affected. The logarithmic dependency of the time evolution of the scour-hole depth predicted by this model is shown to be in good agreement with experiments. New scaling laws for the quasi-steady state depth and the associated time, inspired by the Hogg et al. (1997) model are proposed. Furthermore, it is emphasized that at least two scouring regimes must be distinguished: a short-time regime after which a quasi-steady state is reached, followed by a long-time regime, leading to an asymptotic state of virtually no sediment transport.