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War, captives, and human sacrifice were parts of Late Postclassic (AD 1250–1524) Maya culture in highland Guatemala. Las Casas (1958:152) wrote that the supreme lord “put the heads of the sacrificed on some poles on a certain altar dedicated only to this, where they had these for some time, after which they buried them.” These cultural aspects show up in human remains excavated at Iximche’, the Kaqchikel Maya capital. Here, we integrate previously published and unpublished results of stable isotope analyses and explore their implications for diets and the geographic origins of individuals who were buried at the site on the eve of the Spanish conquest. Data from Iximche’ are compared with available results from other ancient Maya sites.
FoodRx is a 12-month healthy food prescription incentive program for people with type 2 diabetes (T2DM) and experiences of household food insecurity. In this study, we aimed to explore potential users’ prospective acceptability (acceptability prior to program use) of the design and delivery of the FoodRx incentive and identify factors influencing prospective acceptability.
Design:
We used a qualitative descriptive approach and purposive sampling to recruit individuals who were interested or uninterested in using the FoodRx incentive. Semi-structured interviews were guided by the theoretical framework of acceptability, and corresponding interview transcripts were analysed using differential qualitative analysis guided by the socioecological model.
Setting:
Individuals living in Alberta, Canada.
Participants:
In total, fifteen adults with T2DM and experiences of household food insecurity.
Results:
People who were interested in using the FoodRx incentive (n 10) perceived it to be more acceptable than those who were uninterested (n 5). We identified four themes that captured factors that influenced users’ prospective acceptability: (i) participants’ confidence, views and beliefs of FoodRx design and delivery and its future use (intrapersonal), (ii) the shopping routines and roles of individuals in participants’ social networks (interpersonal), (iii) access to and experience with food retail outlets (community), and (iv) income and food access support to cope with the cost of living (policy).
Conclusion:
Future healthy food prescription programs should consider how factors at all levels of the socioecological model influence program acceptability and use these data to inform program design and delivery.
Because of their structural versatility, fast redox reactivity, high storage capacity, sustainability, and environmental friendliness, soluble organic redox molecules have emerged as materials that have potential for use in energy-storage systems. Considering these advantages, this paper reviews recent progress in implementing such materials in aqueous soluble organic redox flow batteries and organic alkali metal/air batteries. We identify and discuss major challenges associated with molecular structures, cell configurations, and electrochemical parameters. Hopefully, we provide a general guidance for the future development of soluble organic redox materials for emerging energy-storage devices used in the electricity grid.
A study conducted as part of the development of the Eleventh International Classification of Mental Disorders for Primary Health Care (ICD-11 PHC) provided an opportunity to test the relationships among depressive, anxious and somatic symptoms in PHC.
Method
Primary care physicians participating in the ICD-11 PHC field studies in five countries selected patients who presented with somatic symptoms not explained by known physical pathology by applying a 29-item screening on somatic complaints that were under study for bodily stress disorder. Patients were interviewed using the Clinical Interview Schedule-Revised and assessed using two five-item scales that measure depressive and anxious symptoms. Structural models of anxious-depressive symptoms and somatic complaints were tested using a bi-factor approach.
Results
A total of 797 patients completed the study procedures. Two bi-factor models fit the data well: Model 1 had all symptoms loaded on a general factor, along with one of three specific depression, anxiety and somatic factors [x2 (627) = 741.016, p < 0.0011, RMSEA = 0.015, CFI = 0.911, TLI = 0.9]. Model 2 had a general factor and two specific anxious depression and somatic factors [x2 (627) = 663.065, p = 0.1543, RMSEA = 0.008, CFI = 0.954, TLI = 0.948].
Conclusions
These data along with those of previous studies suggest that depressive, anxious and somatic symptoms are largely different presentations of a common latent phenomenon. This study provides support for the ICD-11 PHC conceptualization of mood disturbance, especially anxious depression, as central among patients who present multiple somatic symptoms.
Lowering the costs of healthcare and increasing its accessibility is acritical need of today’s society. Miniaturized electronic sensors area possible way to both improve healthcare and lower the cost of medicaldiagnostics. Their small size and portability can lead to integration intopersonalized diagnostics tools and emergency care. In addition, faster,smaller and more efficient sensors can greatly impact chemical andbiological safety.
The rapid progress demonstrated in the computer industry and in genomics isstirring interest for growth and applications in healthcare and safety. Therelentless progress and developments in microfabrication predicted byMoore’s law, which forecast that the number of transistors on anintegrated circuit would double every two years, has until now beencontinually producing faster, cheaper, and smaller consumer electronics. Ananalogous exponential growth in DNA sequencing is even faster thanMoore’s law. Ten years ago, it would have taken many months tosequence a human genome. Today, the same task can be completed within oneday. This impressive progress is possible owing to innovative applicationsof microfabrication technologies. If this can be applied to healthcare, itcould stimulate a similar evolution, with applications such as early stagedetection of biological infection outbreaks and chemical hazards, whichcould mitigate epidemics tremendously.
Although some rebel groups work hard to foster collaborative ties with civilians, others engage in egregious abuses and war crimes. We argue that foreign state funding for rebel organizations greatly reduces incentives to “win the hearts and minds” of civilians because it diminishes the need to collect resources from the population. However, unlike other lucrative resources, foreign funding of rebel groups must be understood in principal-agent terms. Some external principals—namely, democracies and states with strong human rights lobbies—are more concerned with atrocities in the conflict zone than others. Multiple state principals also lead to abuse because no single state can effectively restrain the organization. We test these conjectures with new data on foreign support for rebel groups and data on one-sided violence against civilians. Most notably, we find strong evidence that principal characteristics help influence agent actions.
We evaluated auditory working memory in 41 HIV-seropositive (HIV+) and 37 HIV-seronegative (HIV−) male drug users, employing a modified version of the Letter-Number Span Task developed by Gold and colleagues. We added a control condition to the standard task in order to evaluate more directly the contribution of the processing component to the working memory deficits with the effects of storage demands minimized. HIV+ subjects performed significantly more poorly compared to controls on an index of working memory processing derived from raw scores obtained under the two testing conditions. These findings are consistent with our previous reports that HIV-related working memory deficits are evident across multiple informational domains; further, the deficit appears to involve multiple-component functions of working memory. Converging findings from recent working memory studies and from primate and neuroimaging investigations suggest that functional abnormalities of prefrontal cortex should receive greater emphasis in models of neurocognitive aspects of HIV-1 infection, which have typically emphasized “subcortical” deficits. (JINS, 2001, 7, 20–26.)
Alumina formed by the electrochemical anodization of bulk aluminum has a regular porous structure [1]. Sub-100 nm pores with aspect ratios as high as 1000:1 can easily be formed [2] without elaborate processing. Anodization of aluminum thus provides the basis for the inexpensive, high throughput microfabrication of structures with near vertical sidewalls [2]. In this work we explore the patterned anodic oxidation of deposited aluminum thin films, facilitating the integration of this technique with established microfabrication tools. An anodization barrier of polymethylmethacrylate (PMMA) is deposited onto 300 nm thick aluminum films. The barrier film is subsequently patterned and the exposed aluminum anodized in a 10% sulfuric acid solution. Barrier patterning techniques utilized in this study include optical exposure, ion-beam milling and nano-imprint lithography. Sharp edge definition on micron scale patterns has been achieved using optical methods. Extension of this technique to smaller dimensions by ion-beam milling and nano-imprint lithography is presented. We further report on the observation of contrast reversal of anodization with very thin PMMA barriers, which provides a novel means of pattern transfer. Potential applications and challenges will be discussed.
Cyclic voltammetry (CV) was used to study the reduction potentials of 2,5-di(ethynylphenyl)-4-nitroaniline and 2,5-di(ethynylphenyl)nitrobenzene. Although no absolute reduction potentials can be used in the correlation between solution (CV) and solid state (nanopore) embodiments, each CV plot showed two reductions. The first and second reduction might correspond to switching events of recently reported molecular electronic devices in a nanopore. Cyclic voltammetry results are also reported for other potential molecular scale electronic devices.
Cyclic voltammetry (CV) was used to study the reduction potentials of 2,5- di(ethynylphenyl)-4-nitroaniline and 2,5-di(ethynylphenyl)nitrobenzene. Although no absolute reduction potentials can be used in the correlation between solution (CV) and solid state (nanopore) embodiments, each CV plot showed two reductions. The first and second reduction might correspond to switching events of recently reported molecular electronic devices in a nanopore. Cyclic voltammetry results are also reported for other potential molecular scale electronic devices.
The effect of dietary intake level on in vivo plasma leucine and plasma palmitate flux rates and on the response to a bolus injection of bovine growth hormone (GH) was investigated in six young steers. Animals were fed on a pelleted diet of dried grass–barley (0.7:0.3, w/w) in quantities sufficient to supply 0.8, 1.2, 1.6, 2.0, 2.4 or 2.65 × maintenance energy requirement, offered in hourly portions. Continuous intravenous infusions of [1-13C]leucine or [1-13C]palmi-tate were used to determine the flux of amino acid and fatty acid through the plasma pool before, immediately (1–3 h) after and 22–24 h after a subcutaneous injection of bovine GH (0.55 mg/kg body weight). Hourly blood samples were taken for 27 h to monitor the temporal responses of circulating hormones and metabolites following GH administration. The animal on the lowest plane of nutrition had elevated plasma GH and reduced insulin-like growth factor-1 concentrations compared with those fed on higher intake levels. Plasma leucine flux and leucine concentration increased with intake while palmitate flux and plasma non-esterified fatty acid (NEFA) concentrations were inversely related to intake. Leucine flux rate decreased in the animals fed on the two highest intake levels in response to GH 22–24 h after administration, but plasma leucine concentrations were reduced in all animals at this time. Only the animal fed on the lowest intake level showed an immediate response to GH (within 3 h of administration) with increased palmitate flux and plasma NEFA concentrations but a lipolytic response was apparent in other animals 22–24 h post-administration although the magnitude of the response was markedly reduced at high intakes. We conclude that lipid and protein metabolism are differentially responsive to GH and nutritional status.