Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.

NASA’s all-sky survey mission, the Transiting Exoplanet Survey Satellite (TESS), is specifically engineered to detect exoplanets that transit bright stars. Thus far, TESS has successfully identified approximately 400 transiting exoplanets, in addition to roughly 6 000 candidate exoplanets pending confirmation. In this study, we present the results of our ongoing project, the Validation of Transiting Exoplanets using Statistical Tools (VaTEST). Our dedicated effort is focused on the confirmation and characterisation of new exoplanets through the application of statistical validation tools. Through a combination of ground-based telescope data, high-resolution imaging, and the utilisation of the statistical validation tool known as TRICERATOPS, we have successfully discovered eight potential super-Earths. These planets bear the designations: TOI-238b (1.61$^{+0.09} _{-0.10}$ R$_\oplus$), TOI-771b (1.42$^{+0.11} _{-0.09}$ R$_\oplus$), TOI-871b (1.66$^{+0.11} _{-0.11}$ R$_\oplus$), TOI-1467b (1.83$^{+0.16} _{-0.15}$ R$_\oplus$), TOI-1739b (1.69$^{+0.10} _{-0.08}$ R$_\oplus$), TOI-2068b (1.82$^{+0.16} _{-0.15}$ R$_\oplus$), TOI-4559b (1.42$^{+0.13} _{-0.11}$ R$_\oplus$), and TOI-5799b (1.62$^{+0.19} _{-0.13}$ R$_\oplus$). Among all these planets, six of them fall within the region known as ‘keystone planets’, which makes them particularly interesting for study. Based on the location of TOI-771b and TOI-4559b below the radius valley we characterised them as likely super-Earths, though radial velocity mass measurements for these planets will provide more details about their characterisation. It is noteworthy that planets within the size range investigated herein are absent from our own solar system, making their study crucial for gaining insights into the evolutionary stages between Earth and Neptune.

Antarctic soils provide an excellent setting to test biogeographical patterns across spatial and environmental scales given their relatively simple communities and the dominance of physical factors that create strong environmental gradients. Additional urgency is given by the fact that their unique terrestrial communities are the subject of conservation efforts in a rapidly changing environment. We investigated relationships of soil community assembly and alpha and beta diversity with climatic and environmental parameters across regional and local scales in Maritime Antarctica. We sampled from a regional gradient of sites that differ in habitat severity, ranging from relatively favourable to harsher physicochemical conditions. At the regional scale, bacterial community characteristics and microarthropod abundance varied along this severity gradient, but most measures of fungal communities did not. Microarthropod and microbial communities differed in which soil and climate parameters were most influential, and the specific parameters that influenced each taxon differed across broad and fine spatial scales. This suggests that conservation efforts will need to focus on a large variety of habitat characteristics to successfully encompass diversity across taxa. Because beta diversity was the result of species turnover, conservation efforts also cannot focus on only the most biodiverse sites to effectively preserve all aspects of biodiversity.

A rare case of unique and previously unreported variant of transposition of great arteries with bilateral coni, ventricular septal defect, and triple-chambered left ventricle which led to an unexpected and accelerated post-natal cardiac anatomical and physiologic deviation from prenatal and immediate postnatal diagnosis altering the surgical management and patient outcome.

A terrestrial (lacustrine and fluvial) palaeoclimate record from Hoxne (Suffolk, UK) shows two temperate phases separated by a cold episode, correlated with MIS 11 subdivisions corresponding to isotopic events 11.3 (Hoxnian interglacial period), 11.24 (Stratum C cold interval), and 11.23 (warm interval with evidence of human presence). A robust, reproducible multiproxy consensus approach validates and combines quantitative palaeotemperature reconstructions from three invertebrate groups (beetles, chironomids, and ostracods) and plant indicator taxa with qualitative implications of molluscs and small vertebrates. Compared with the present, interglacial mean monthly air temperatures were similar or up to 4.0°C higher in summer, but similar or as much as 3.0°C lower in winter; the Stratum C cold interval, following prolonged nondeposition or erosion of the lake bed, experienced summers 2.5°C cooler and winters between 5°C and 10°C cooler than at present. Possible reworking of fossils into Stratum C from underlying interglacial assemblages is taken into account. Oxygen and carbon isotopes from ostracod shells indicate evaporatively enriched lake water during Stratum C deposition. Comparative evaluation shows that proxy-based palaeoclimate reconstruction methods are best tested against each other and, if validated, can be used to generate more refined and robust results through multiproxy consensus.

Concern over partisan resentment and hostility has increased across Western democracies. Despite growing attention to affective polarization, existing research fails to ask whether who serves in office affects mass-level interparty hostility. Drawing on scholarship on women’s behavior as elected representatives and citizens’ beliefs about women politicians, we posit the women MPs affective bonus hypothesis: all else being equal, partisans display warmer affect toward out-parties with higher proportions of women MPs. We evaluate this claim with an original dataset on women’s presence in 125 political parties in 20 Western democracies from 1996 to 2017 combined with survey data on partisans’ affective ratings of political opponents. We show that women’s representation is associated with lower levels of partisan hostility and that both men and women partisans react positively to out-party women MPs. Increasing women’s parliamentary presence could thus mitigate cross-party hostility.

Callery pear (Pyrus calleryana Decne.) is rapidly spreading in the United States, gaining attention in the last two decades as a serious invasive pest. Recommended control methods include foliar, basal bark, cut stump, and hack-and-squirt application of herbicides, but there are few published studies with replicated data on efficacy. Four readily available herbicidal active ingredients and a combination of two active ingredients were tested for control efficacy against P. calleryana in old-field areas and loblolly pine (Pinus taeda L.) understory. Basal bark applications (triclopyr, triclopyr + aminopyralid), foliar applications (glyphosate, imazapyr), and a soil application (hexazinone) effectively killed P. calleryana with the exception of hexazinone at one site, where rainfall may not have been optimal. Foliar application of glyphosate provided the most consistent control. Our results demonstrate efficacy of registered herbicide formulations for P. calleryana control in two geographic locations and two habitat types. The need for development of integrated pest management programs for P. calleryana is discussed.

Galois connections are a foundational tool for structuring abstraction in semantics, and their use lies at the heart of the theory of abstract interpretation. Yet, mechanization of Galois connections using proof assistants remains limited to restricted modes of use, preventing their general application in mechanized metatheory and certified programming. This paper presents constructive Galois connections, a variant of Galois connections that is effective both on paper and in proof assistants; is complete with respect to a large subset of classical Galois connections; and enables more general reasoning principles, including the “calculational” style advocated by Cousot. To design constructive Galois connections, we identify a restricted mode of use of classical ones which is both general and amenable to mechanization in dependently typed functional programming languages. Crucial to our metatheory is the addition of monadic structure to Galois connections to control a “specification effect.” Effectful calculations may reason classically, while pure calculations have extractable computational content. Explicitly moving between the worlds of specification and implementation is enabled by our metatheory. To validate our approach, we provide two case studies in mechanizing existing proofs from the literature: the first uses calculational abstract interpretation to design a static analyzer, and the second forms a semantic basis for gradual typing. Both mechanized proofs closely follow their original paper-and-pencil counterparts, employ reasoning principles not captured by previous mechanization approaches, support the extraction of verified algorithms, and are novel.

When the English blues scholar Paul Oliver, who died in 2017 aged 90, was interviewed for a special issue of Popular Music in his honour, on the occasion of his 80th birthday (issue 26/1, January 2007), it was striking how much of the conversation revolved around a recurring flow of ideas for future research, to be undertaken by him or by anyone else who came with credentials appropriate to the enterprise (such as musicology, a discipline that he never considered himself well enough versed in to allow engagement). It didn't enter his mind that he might become a research subject himself. Now, with Christian O'Connell's book, he has; and it is his own methods that are under scrutiny, not, or not directly, the blues that he spent a long adult lifetime investigating (and for which he was such a knowledgeable and, for many who read his books or heard him speak live or on air, inspiring advocate), nor the social and economic life of the African American working class who created the music that continued to fascinate him. What is under the microscope is how he depicted both of those things.

We present a new approach to automated reasoning about higher-order programs by endowing symbolic execution with a notion of higher-order, symbolic values. To validate our approach, we use it to develop and evaluate a system for verifying and refuting behavioral software contracts of components in a functional language, which we call soft contract verification. In doing so, we discover a mutually beneficial relation between behavioral contracts and higher-order symbolic execution. Contracts aid symbolic execution by providing a rich language of specifications serving as a basis of symbolic higher-order values; the theory of blame enables modular verification and leads to the theorem that verified components can't be blamed; and the run-time monitoring of contracts enables soft verification whereby verified and unverified components can safely interact. Conversely, symbolic execution aids contracts by providing compile-time verification and automated test case generation from counter-examples to verification. This relation between symbolic exuection and contracts engenders a virtuous cycle encouraging the gradual use of contracts.

Our approach is able to analyze first-class contracts, recursive data structures, unknown functions, and control-flow-sensitive refinements of values, which are all idiomatic in dynamic languages. It makes effective use of off-the-shelf solvers to decide problems without heavy encodings. Counterexample search is sound and relatively complete with respect to a first-order solver for base type values and counter-examples are reported as concrete values, including functions. Therefore, it can form the basis of automated verification and bug-finding tools for higher-order programs. The approach is competitive with a range of existing tools—including type systems, flow analyzers, and model checkers—on their own benchmarks. We have built a prototype to analyze programs written in Racket and report on its effectiveness in verifying and refuting contracts.

The Mediterranean diet has been reported to be inversely associated with incident metabolic syndrome (MetSyn) among older adults; however, this association has not been studied in young African American and white adults. The objective of the present study was to evaluate the association of a modified Mediterranean diet (mMedDiet) score with the 25-year incidence of the MetSyn in 4713 African American and white adults enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study. A diet history questionnaire was used to assess dietary intake at baseline, year 7 and year 20 and a mMedDiet score was created. Cardiovascular risk factors were measured at multiple examinations over 25 years. The MetSyn was defined according to the National Cholesterol Education Program Adult Treatment Panel III (ATP III) criteria. Cox proportional-hazards regression analysis was use to evaluate associations for incident MetSyn across the mMedDiet score categories adjusting for demographic characteristics, lifestyle factors and BMI. Higher mMedDiet scores represented adherence to a dietary pattern rich in fruit, vegetables, whole grains, nuts and fish, but poor in red and processed meat and snack foods. The incidence of MetSyn components (abdominal obesity, elevated TAG concentrations and low HDL-cholesterol concentrations) was lower in those with higher mMedDiet scores than in those with lower scores. Furthermore, the incidence of the MetSyn was lower across the five mMedDiet score categories; the hazard ratios and 95 % CI from category 1 to category 5 were 1·0; 0·94 (0·76, 1·15); 0·84 (0·68, 1·04); 0·73 (0·58, 0·92); and 0·72 (0·54, 0·96), respectively (P trend= 0·005). These findings suggest that the risk of developing the MetSyn is lower when consuming a diet rich in fruit, vegetables, whole grains, nuts and fish.

The use of analytics has been emerging as a way to better understand the complex dynamics and resulting trends that occur when social and technical systems intersect. For instance, web analytics studies the intersection between society and the Internet to better understand use patterns and preferences. Business analytics studies the interfaces between human capital and technical systems in the context of corporate management and industrial production. Engineering design is ripe with such sociotechnical systems where consumers and engineered systems intersect producing a complex sociotechnical system marked by difficult to predict behavior and trends. In this paper, the paradigm of design analytics is further developed and used to study a diverse sociotechnical product. The product is a refrigerator that is hypothetically equipped with sensors and feedback mechanisms, and a simulator models the interactions of a population of 1000 users. Analyzing this sociotechnical product using design analytics demonstrates the ability to extract valuable insights at the juncture of people and technology. Insights into the leading behaviors of different populations are presented, and it is shown that design analytics and the associated tools can provide a platform for designers to develop better performing products that meet both explicit and implicit customer needs.