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Callery pear (Pyrus calleyana Decne.) is a problematic woody invasive plant in eastern North America that invades old fields, forests, and disturbed sites. While management guidance typically suggests foliar, basal bark, cut stump, and hack-and-squirt applications of herbicides for P. calleryana, there is a dearth of studies focusing on the efficacy of specific treatments. We evaluated seven herbicide treatments for control of midstory P. calleryana. Cut stump and hack and squirt applications of glyphosate, imazapyr, and triclopyr and a soil application of hexazinone were repeated at six sites within Georgia, Kansas, and South Carolina, and all study trees were monitored for approximately one year after herbicide application. Cut stump applications of glyphosate, imazapyr, and triclopyr provided the most consistent control with no resprouting and 100% mortality. Hack-and-squirt applications of glyphosate and triclopyr resulted in approximately 80% probability of mortality one year after treatment, while hack-and-squirt application of imazapyr and soil application of hexazinone averaged only 20 and 25% probability of mortality, respectively. Our results demonstrate the efficacy of seven treatment options for P. calleryana control in three geographic locations with varied habitat types, and our data suggest that cut stump applications of glyphosate, imazapyr, or triclopyr or hack-and-squirt application of glyphosate or triclopyr may be useful for reducing populations of P. calleryana. that have grown past the sapling stage.
Daniel James, a preeminent historian of the Argentine working class and Peronism, has fundamentally transformed how we understand Latin American labor history. This oral history interview, conducted by four of his former doctoral students, explores the personal, intellectual, and methodological foundations of his pioneering work. James discusses his working-class upbringing in post-war England as the son of Communist Party militants, his formative experiences at Oxford during the late 1960s, and his introduction to Argentina during the politically charged early 1970s. The conversation traces his evolution from the social history approach of Resistance and Integration: Peronism and the Argentine Working Class (1988) through his methodological innovations in oral history with Doña María’s Story (2000) to his recent collaborative work on photography and memory in Paisajes del pasado (2025). James reflects candidly on the influence of E. P. Thompson, Walter Benjamin, and the Latin American Labor History Workshop on his scholarship, while emphasizing the centrality of relationships, empathy, and historical imagination in his approach to working-class history. The interview also addresses his teaching philosophy, his commitment to graduate mentorship, and his view of history as a moral enterprise aimed at rescuing ordinary people “from the enormous condescension of posterity.” James concludes by outlining two prospective research projects on Argentine photography and political exile.
Planamandibulus nevadensis n. gen n. sp. is a newly discovered exceptionally preserved Laurentian phosphatocopid crustacean described from the upper Windfall Formation (Furongian, Stage 10) in Nevada. Planamandibulus nevadensis has closest affinity with the Baltic and Avalonian taxon Cyclotron. Its occurrence in sedimentary facies associated with dysoxia on the Laurentian paleocontinent fills in a gap in the global distribution of phosphatocopid crustaceans, facilitating a paleoenvironmental synthesis of this Cambrian group. We assess 75 taxa from nine paleocontinental areas spanning Cambrian stages 3 to 10 (~521–486.9 Ma). Comparison of these data with paleoclimate model simulations suggests that phosphatocopid distribution is explained partly by biogeography and ocean temperature patterns. Dabashanella species (e.g., D. hemicyclica Huo et al., 1983) are found across the low paleolatitude (<35°) paleocontinents of East Gondwanan (Australia), South China, and the central Asian terranes, spanning marine shelf carbonates to deeper marine black shale lithofacies, but are absent from mid- and high-paleolatitude sites, suggesting a warmer water preference. A similar warm-water preference is inferred for endemic taxa (e.g., Ulopsis, Parashergoldopsis) of East Gondwana, and perhaps for the newly described Laurentian Planamandibulus. By contrast, the mid- to high-paleolatitude paleocontinents Baltica and Avalonia are characterized by Veldotron, Cyclotron, Bidimorpha, Waldoria, Vestrogothia, Falites, and Trapezilites species, which occur in deep-shelf, cooler-water settings, typically below storm wave base. Hesslandona species sensu lato occur in mid-depth (likely above storm-wave base) warm tropical marine waters but are more typically found in deeper shelf and cooler waters in mid to high paleolatitudes. Phosphatocopids are also associated with sedimentary deposits characteristic of low environmental oxygen concentrations; this is emphasized by a peak in occurrences in the Guzhangian (Miaolingian) and Paibian (Furongian) stages, around the interval of the Steptoean Positive Carbon Isotope Excursion (SPICE) and its associated expansion of anoxic water masses onto shallow marine shelves. Our data compilation and data–model comparison support the environmental preference of phosphatocopids for low-oxygen, but not anoxic, water masses, and the new occurrence of Planamandibulus is consistent with this pattern.
Over 15 million children in the United States have been infected with COVID-19; nearly 2,000 have died. Approval of COVID-19 vaccines for children enabled reductions in disease severity and mortality. Disparities in vaccine adoption exist along racial, ethnic, and rural–urban lines, with lower uptake among medically underserved populations (e.g. Black, non-Hispanic White rural populations) compared to urban White populations. This study examined efforts to recruit and engage a diverse cohort as part of a vaccine communication randomized trial conducted across 15 states and compared demographic characteristics of the enrolled cohort to the broader US population. To enhance recruitment of diverse populations, eligible clinics had to serve a significant proportion of medically underserved individuals based on race, ethnicity, or geographic location. Coordinators used both traditional (in-person daily clinic schedule review) and retrospective (EHR and billing data review) recruitment methods adapted to enrich engagement with focus populations. Demographic characteristics were compared to national statistics obtained from the CDC’s Household Pulse Survey. In total, 2999 parents/caregivers were screened; 725 were randomized (24.1%). Comparing enrolled subjects to the demographics of participating states, 17.3% vs 9.8% self-identified as Hispanic, 39.6% vs 13.0% as Black. Additionally, 34.3% self-described as living in a rural area. Of the 725 randomized, 512 (70.6%) completed the baseline survey. Of these 512, 422 (82.4%) also completed the final survey of the 24-week study. This analysis demonstrates the Institutional Development Award States Pediatric Clinical Trials Network can successfully recruit and engage populations from diverse and underrepresented populations in research.
Obsessive–compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent intrusive thoughts and ritualized behaviors, often aimed at reducing distress. OCD is heterogeneous in its presentation and many patients with OCD experience a variety of different symptoms throughout their course of illness. Efforts to understand symptom domains in OCD have typically identified three to five symptom domains, such as the domains of doubt/checking, contamination, superstitions/rituals, symmetry/hoarding, and taboo thoughts. Recent studies in the genetics of OCD have suggested a common OCD dimension may provide additional information above and beyond the previously identified symptom domains. Thus, we sought to test a hierarchical model of lifetime OCD symptoms and evaluate the utility of the inclusion of a common OCD dimension.
Methods
Participants included 999 individuals participating in the OCD Collaborative Genetics Study (OCGS) and an additional 2363 individuals participating in the OCD Genetic Association Study (OCGAS). We evaluated unidimensional, 5-factor, and hierarchical models of lifetime OCD symptom presentation using confirmatory factor analysis.
Results
Results suggested that the hierarchical model best fit the data. Further evaluation of these models using a Bayesian testlet response model showed that lifetime presence of specific OCD symptoms was differentially associated with lifetime OCD severity. Moreover, symptoms associated with greater lifetime severity were generally reported less frequently than symptoms present at lower levels of lifetime severity. Implications of these findings and future directions are discussed.
Inappropriate urine cultures (UCs) are common and lead to inappropriate antimicrobial use. Urinalyses (UAs) have been increasingly incorporated into diagnostic stewardship interventions, but the impact of these interventions nationally has not been assessed. We describe UA and UC utilization practices using a nationwide dataset of patients admitted to acute care hospitals.
Methods:
Design, Setting and Participants: We performed a retrospective cohort study of index UCs and their associated UAs performed for adult patients (age ≥ 18 years) admitted in U.S. acute care hospitals, participating in the PINC AI™ Healthcare Database (PHD) from January 1, 2017, through December 31, 2020. A positive UA was defined as >10 leukocytes per high power field, positive leukocyte esterase, or positive nitrite.
Results:
The overall rate of UCs in this study was 124.7 per 1000 discharges and annual UC rates decreased from 2017 (129.2) to 2020 (120.0). The proportion of UCs that had a positive UA increased from 60.5% in 2017 to 68.1% in 2020; UCs without a UA decreased from 19.3% to 10.5%, and UCs with a negative UA did not significantly change (20.2% to 21.5%). A multivariate multinomial logistic regression model identified male sex, age <65, and a diagnosis of cancer to be predictors of having a UC with a negative UA or no UA.
Conclusions:
UC utilization decreased over the study period. The proportion of UCs with a positive UA increased. This may suggest a positive impact of diagnostic stewardship practices at the national level although further progress is needed.
Important concepts from the diverse fields of physics, mathematics, engineering and computer science coalesce in this foundational text on the cutting-edge field of quantum information. Designed for undergraduate and graduate students with any STEM background, and written by a highly experienced author team, this textbook draws on quantum mechanics, number theory, computer science technologies, and more, to delve deeply into learning about qubits, the building blocks of quantum information, and how they are used in quantum computing and quantum algorithms. The pedagogical structure of the chapters features exercises after each section as well as focus boxes, giving students the benefit of additional background and applications without losing sight of the big picture. Recommended further reading and answers to select exercises further support learning. Written in approachable and conversational prose, this text offers a comprehensive treatment of the exciting field of quantum information while remaining accessible to students and researchers within all STEM disciplines.
Postdischarge antibiotics are often sub-optimal or unnecessary. This study sought to measure the risk of diarrhea in recently hospitalized patients treated with postdischarge antibiotics
Design:
Retrospective cohort study.
Setting:
125 acute-care hospitals in the Veterans Health Administration (VHA).
Patients:
Patients hospitalized within VHA during 2018–2021.
Methods:
The primary exposure was postdischarge antibiotics. The primary outcome was time to C. difficile testing, which served as a surrogate marker for clinically significant diarrhea. Only tests that were performed during the 30 days after discharge and before all-cause hospital readmission were captured. We constructed a final Cox proportional hazards model with 27 fixed-effect predictors as well as a random intercept for each hospital.
Results:
There were 1,686,819 qualifying admissions, and 333,310 (19.8%) received postdischarge antibiotics. There were 13,387 patients (0.8%) who had a test for C. difficile done. Among those tested, the median time to testing was 6.7 days for those tested while on postdischarge antibiotics and 14.1 days for those tested while not on postdischarge antibiotics. Compared to patients not on postdischarge antibiotics, the hazard ratio for testing was 1.40 (95% CI, 1.29–1.51) among patients on low-risk postdischarge antibiotics and 1.56 (95% CI, 1.42–1.71) among those on high-risk postdischarge antibiotics.
Conclusions:
In this national VHA hospital cohort, patients prescribed postdischarge antibiotics had a 40–56% increased risk of C. difficile testing compared to those not prescribed postdischarge antibiotics. Efforts to optimize antibiotic-prescribing at hospital discharge, particularly by reducing excessive duration and avoiding high-risk agents, may help mitigate these risks.
This Element offers the first comprehensive study of Hegel's views on European colonialism. In surprisingly detailed discussions scattered throughout much of his mature oeuvre, Hegel offers assessments that legitimise colonialism in the Americas, the enslavement of Africans, and British rule in India. The Element reconstructs these discussions as being held together by a systematic account of colonialism as racial domination, underpinned by central elements of his philosophy and situated within long-overlooked contexts, including Hegel's engagement with British abolitionism and Scottish four-stages theories of social development. Challenging prevailing approaches in scholarship, James and Knappik show that Hegel's accounts of issues like freedom, personhood and the dialectic of lordship and bondage are deeply entangled with his disturbing views on colonialism, slavery, and race. Lastly, they address Hegel's ambivalent legacy, examining how British Idealists and others adopted his pro-colonial ideas, while thinkers like C. L. R. James and Angela Davis transformed them for anti-colonial purposes. This title is also available as open access on Cambridge Core.
Advances in molecular engineering, materials science, and other key fields has afforded the ability to bring newly minted nano-scale science to the bedside in all medical specialties, notwithstanding neurosurgery. Modern neurosurgery has implemented a handful of available nanotechnologies to enhance clinical practice. However, the current implementation of nanotechnology has barely scratched the surface of its widespread potential application in neurosurgery, neuroimaging and neuro-oncology. Most of the technology is still relegated to the laboratory, but many recent developments have made these technologies more clinically applicable. Nanoparticles are increasingly used for drug delivery across a wide variety of neurologic disorders, new radiographic contrast agents and in vivo cell labeling, and numerous enhancements in neurosurgical hardware, including batteries, microelectrodes, spinal instrumentation and endovascular equipment. We still have much to learn about the clinical use of these technologies and the upcoming hurdles, such as cost, that may still limit technology as they become ready for everyday use. The future of nanotechnology in neurosurgery is happening now and will bring incredibly exciting and impactful applications to patient care.
Industrial upper limb exoskeletons offload the upper limb during overhead tasks to help prevent musculoskeletal disorders to the shoulder. Although numerous studies showed reduced shoulder muscle activity during upper limb exoskeleton use for overhead postures, it remains unknown whether and how upper limb exoskeletons provide support over a large shoulder workspace beyond overhead work. Therefore, this study evaluated the Ottobock Paexo Shoulder over a large shoulder workspace from overhead to hip height with shoulder abduction and adduction. Upper body kinematics, muscle activity, and subjective user feedback were obtained by three-dimensional motion capture, surface EMG, and questionnaires, respectively, and captured while participants performed static and dynamic work tasks with an electric screwdriver. Participants completed these tasks (1) without the exoskeleton, (2) with a disengaged exoskeleton, (3) with moderate exoskeleton support, and (4) with high exoskeleton support. Exoskeleton support reduced deltoid muscle activity (−9 to −24 s%, p ≤ .001) in postures with an abducted shoulder, including nonoverhead postures. Exoskeleton support modestly decreased shoulder flexion (−3 to −5°, p ≤ .001) and increased shoulder abduction (2 to 5°, p ≤ .032), but the movement patterns during the dynamic task were unaffected. Additionally, exoskeleton-related effects increased with increasing support, but the subjective perception of change also increased, and perceived comfort decreased. Our results indicate that the tested exoskeleton provides support beyond overhead work and that there is a trade-off between exoskeleton support and subjective perception. Accordingly, further optimization of user–exoskeleton interaction is warranted for long-term prevention of musculoskeletal disorders in overhead workers.
Diagnostic stewardship of urine cultures is a recognized tool for CAUTI prevention, yet few diagnostic algorithms have been validated. This study of a novel diagnostic CAUTI algorithm showed a significant and durable improvement in urine culturing, catheter exchange, and CAUTI rate, supporting this algorithm as an effective diagnostic stewardship tool.
We developed a clinical care pathway for the detection and management of frailty for older adults living in long-term care (LTC) homes.
Methods
We utilized a modified Delphi with residents of LTC homes experiencing frailty, their caregivers, and care providers. The pathway was created using existing literature and input from key LTC experts.
Findings
Fifty-two panelists completed round one of the Delphi, and 55.8% of these respondents completed round two. Both rounds had high agreement and ratings. We added six new statements following analysis of round two, and 15 statements were modified/updated to reflect panelist feedback. The final pathway included 28 statements and promotes a resident-centered approach that highlights caregiver involvement and inter-professional teamwork to identify and manage frailty, as well as initiate palliative care earlier.
Conclusion
Implementing this pathway will allow health care providers to adopt screening measures and adapt care to a resident’s frailty severity.
Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.
Methods
In 17,130 individuals with lifetime depression or anxiety from the Genetic Links to Anxiety and Depression (GLAD) Study, we analyzed total scores from the Patient Health Questionnaire-9 (depression symptoms), Generalized Anxiety Disorder-7 (anxiety symptoms), and Work and Social Adjustment Scale (functional impairment). Genome-wide association analyses were performed with REGENIE. Heritability was estimated using GCTA-GREML and genetic correlations with bivariate-GREML.
Results
The phenotypic correlations were moderate across the three measures (Pearson’s r = 0.50–0.69). All three scales were found to be under low but significant genetic influence (single-nucleotide polymorphism-based heritability [h2SNP] = 0.11–0.19) with high genetic correlations between them (rg = 0.79–0.87).
Conclusions
Among individuals with lifetime depression or anxiety from the GLAD Study, the genetic variants that underlie symptom severity largely overlap with those influencing functional impairment. This suggests that self-reported functional impairment, while clinically relevant for diagnosis and treatment outcomes, does not reflect substantial additional genetic liability beyond that captured by symptom-based measures of depression or anxiety.
Next-generation X-ray satellite telescopes such as XRISM, NewAthena and Lynx will enable observations of exotic astrophysical sources at unprecedented spectral and spatial resolution. Proper interpretation of these data demands that the accuracy of the models is at least within the uncertainty of the observations. One set of quantities that might not currently meet this requirement is transition energies of various astrophysically relevant ions. Current databases are populated with many untested theoretical calculations. Accurate laboratory benchmarks are required to better understand the coming data. We obtained laboratory spectra of X-ray lines from a silicon plasma at an average spectral resolving power of $\sim$7500 with a spherically bent crystal spectrometer on the Z facility at Sandia National Laboratories. Many of the lines in the data are measured here for the first time. We report measurements of 53 transitions originating from the K-shells of He-like to B-like silicon in the energy range between $\sim$1795 and 1880 eV (6.6–6.9 Å). The lines were identified by qualitative comparison against a full synthetic spectrum calculated with ATOMIC. The average fractional uncertainty (uncertainty/energy) for all reported lines is ${\sim}5.4 \times 10^{-5}$. We compare the measured quantities against transition energies calculated with RATS and FAC as well as those reported in the NIST ASD and XSTAR’s uaDB. Average absolute differences relative to experimentally measured values are 0.20, 0.32, 0.17 and 0.38 eV, respectively. All calculations/databases show good agreement with the experimental values; NIST ASD shows the closest match overall.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
We compare the Emory 10-item, 4-choice Rey Complex Figure (CF) Recognition task with the Meyers and Lange (M&L) 24-item yes/no CF Recognition task in a large cohort of healthy research participants and in patients with heterogeneous movement disorder diagnoses. While both tasks assess CF recognition, they differ in key aspects including the saliency of target and distractor responses, self-selection versus forced-choice formats, and the length of the item sets.
Participants and Methods:
There were 1056 participants from the Emory Healthy Brain Study (EHBS; average MoCA = 26.8, SD = 2.4) and 223 movement disorder patients undergoing neuropsychological evaluation (average MoCA = 24.3, SD = 4.0).
Results:
Both recognition tasks differentiated between healthy and clinical groups; however, the Emory task demonstrated a larger effect size (Cohen’s d = 1.02) compared to the M&L task (Cohen’s d = 0.79). d-prime scoring of M&L recognition showed comparable group discrimination (Cohen’s d = 0.81). Unidimensional two-parameter logistic item response theory analysis revealed that many M&L items had low discrimination values and extreme difficulty parameters, which contributed to the task’s reduced sensitivity, particularly at lower cognitive proficiency levels relevant to clinical diagnosis. Dimensionality analyses indicated the influence of response sets as a potential contributor to poor item performance.
Conclusions:
Emory CF Recognition task demonstrates superior psychometric properties and greater sensitivity to cognitive impairment compared to the M&L task. Its ability to more precisely measure lower levels of cognitive functioning, along with its brevity, suggests it may be more effective for diagnostic use, especially in clinical populations with cognitive decline.
For Stokes waves in finite depth within the neighbourhood of the Benjamin–Feir stability transition, there are two families of periodic waves, one modulationally unstable and the other stable. In this paper we show that these two families can be joined by a heteroclinic connection, which manifests in the fluid as a travelling front. By shifting the analysis to the setting of Whitham modulation theory, this front is in wavenumber and frequency space. An implication of this jump is that a permanent frequency downshift of the Stokes wave can occur in the absence of viscous effects. This argument, which is built on a sequence of asymptotic expansions of the phase dynamics, is confirmed via energetic arguments, with additional corroboration obtained by numerical simulations of a reduced model based on the Benney–Roskes equation.
Threat sensitivity, an individual difference construct reflecting variation in responsiveness to threats of various types, predicts physiological reactivity to aversive stimuli and shares heritable variance with anxiety disorders in adults. However, no research has been conducted yet with youth to examine the heritability of threat sensitivity or evaluate the role of genetic versus environmental influences in its relations with mental health problems. The current study addressed this gap by evaluating the psychometric properties of a measure of this construct, the 20-item Trait Fear scale (TF-20), and examining its phenotypic and genotypic correlations with different forms of psychopathology in a sample of 346 twin pairs (121 monozygotic), aged 9–14 years. Analyses revealed high internal consistency and test-retest reliability for the TF-20. Evidence was also found for its convergent and discriminant validity in terms of phenotypic and genotypic correlations with measures of fear-related psychopathology. By contrast, the TF-20’s associations with depressive conditions were largely attributable to environmental influences. Extending prior work with adults, current study findings provide support for threat sensitivity as a genetically-influenced liability for phobic fear disorders in youth.