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Generative artificial intelligence (GenAI) applications in job scheduling are expected to help schedulers embed their requirements into scheduling models in a more user-friendly way to generate customized scheduling results. However, there are still very few such applications, while using existing general-purpose GenAI services is inconvenient and prone to data leakage risks. To solve these problems, this study established a GenAI job scheduling system. By hosting the GenAI job scheduling system locally, schedulers can avoid the leakage of order- or recipe-related information that may occur when uploading to the cloud-based GenAI service. In the GenAI job scheduling system, a user interface is designed for users to enter queries in natural language. The user’s query is then analyzed to extract his/her requirements related to the scheduling task, thereby building an extended three-field notation (ETFN) of the scheduling problem. A customized genetic algorithm (GA) is generated to help solve the mathematical programming (MP) model corresponding to the ETFN, thereby updating invalid code or adding new code to the basic GA application. The effectiveness of the GenAI job scheduling system has been tested in a flexible job shop case.
Significant changes in Taiwan’s psychiatric services over recent decades include expansion of community-based clinics and implementation of the Schizophrenia Pay-for-Performance programme.
Aims
This study aimed to assess the trend of the quality of healthcare for individuals with schizophrenia, using various indicators of the treatment process and outcomes between 2010 and 2019.
Method
Individuals with schizophrenia were identified using Taiwan’s National Health Insurance claims database. The quality of healthcare for individuals with schizophrenia was assessed using treatment process and outcome indicators, including antipsychotic types, medication adherence, daily dose for antipsychotics and concurrent use of other psychotropic agents. Outcome indicators included all-cause mortality, suicide deaths, psychiatric hospitalisation, emergency department visits and employment status.
Results
Antipsychotic medication usage has shifted towards second-generation antipsychotics (SGAs) and long-acting injectable antipsychotics (LAIs), with declines in first-generation antipsychotics. The percentage of medication adherence declined, while that of individuals with an adequate daily dose increased. Concurrently, anticholinergic and benzodiazepine use decreased while antidepressant and mood stabiliser use increased. Outcome indicators showed no significant change in all-cause mortality or suicide rates over time, but there were reductions in psychiatric hospitalisations and emergency department visits. Employment rates increased overall, particularly in urban areas.
Conclusions
The quality of healthcare for individuals with schizophrenia, as measured by treatment process and outcome indicators, improved alongside changes in Taiwan’s psychiatric services; however, causality cannot be inferred from our findings. Future research should evaluate the effectiveness of psychiatric service policies and continuously monitor healthcare quality to further enhance the lives of individuals with schizophrenia.
The World Cancer Research Fund and the American Institute for Cancer Research recommend a plant-based diet to cancer survivors, which may reduce chronic inflammation and excess adiposity associated with worse survival. We investigated associations of plant-based dietary patterns with inflammation biomarkers and body composition in the Pathways Study, in which 3659 women with breast cancer provided validated food frequency questionnaires approximately 2 months after diagnosis. We derived three plant-based diet indices: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI) and unhealthful plant-based diet index (uPDI). We assayed circulating inflammation biomarkers related to systemic inflammation (high-sensitivity C-reactive protein [hsCRP]), pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, IL-13). We estimated areas (cm2) of muscle and visceral and subcutaneous adipose tissue (VAT and SAT) from computed tomography scans. Using multivariable linear regression, we calculated the differences in inflammation biomarkers and body composition for each index. Per 10-point increase for each index: hsCRP was significantly lower by 6·9 % (95 % CI 1·6%, 11·8%) for PDI and 9·0 % (95 % CI 4·9%, 12·8%) for hPDI but significantly higher by 5·4 % (95 % CI 0·5%, 10·5%) for uPDI, and VAT was significantly lower by 7·8 cm2 (95 % CI 2·0 cm2, 13·6 cm2) for PDI and 8·6 cm2 (95 % CI 4·1 cm2, 13·2 cm2) for hPDI but significantly higher by 6·2 cm2 (95 % CI 1·3 cm2, 11·1 cm2) for uPDI. No significant associations were observed for other inflammation biomarkers, muscle, or SAT. A plant-based diet, especially a healthful plant-based diet, may be associated with reduced inflammation and visceral adiposity among breast cancer survivors.
Internet addiction (IA) refers to excessive internet use that causes cognitive impairment or distress. Understanding the neurophysiological mechanisms underpinning IA is crucial for enabling an accurate diagnosis and informing treatment and prevention strategies. Despite the recent increase in studies examining the neurophysiological traits of IA, their findings often vary. To enhance the accuracy of identifying key neurophysiological characteristics of IA, this study used the phase lag index (PLI) and weighted PLI (WPLI) methods, which minimize volume conduction effects, to analyze the resting-state electroencephalography (EEG) functional connectivity. We further evaluated the reliability of the identified features for IA classification using various machine learning methods.
Methods
Ninety-two participants (42 with IA and 50 healthy controls (HCs)) were included. PLI and WPLI values for each participant were computed, and values exhibiting significant differences between the two groups were selected as features for the subsequent classification task.
Results
Support vector machine (SVM) achieved an 83% accuracy rate using PLI features and an improved 86% accuracy rate using WPLI features. t-test results showed analogous topographical patterns for both the WPLI and PLI. Numerous connections were identified within the delta and gamma frequency bands that exhibited significant differences between the two groups, with the IA group manifesting an elevated level of phase synchronization.
Conclusions
Functional connectivity analysis and machine learning algorithms can jointly distinguish participants with IA from HCs based on EEG data. PLI and WPLI have substantial potential as biomarkers for identifying the neurophysiological traits of IA.
The 1994 discovery of Shor's quantum algorithm for integer factorization—an important practical problem in the area of cryptography—demonstrated quantum computing's potential for real-world impact. Since then, researchers have worked intensively to expand the list of practical problems that quantum algorithms can solve effectively. This book surveys the fruits of this effort, covering proposed quantum algorithms for concrete problems in many application areas, including quantum chemistry, optimization, finance, and machine learning. For each quantum algorithm considered, the book clearly states the problem being solved and the full computational complexity of the procedure, making sure to account for the contribution from all the underlying primitive ingredients. Separately, the book provides a detailed, independent summary of the most common algorithmic primitives. It has a modular, encyclopedic format to facilitate navigation of the material and to provide a quick reference for designers of quantum algorithms and quantum computing researchers.
This chapter covers quantum algorithmic primitives for loading classical data into a quantum algorithm. These primitives are important in many quantum algorithms, and they are especially essential for algorithms for big-data problems in the area of machine learning. We cover quantum random access memory (QRAM), an operation that allows a quantum algorithm to query a classical database in superposition. We carefully detail caveats and nuances that appear for realizing fast large-scale QRAM and what this means for algorithms that rely upon QRAM. We also cover primitives for preparing arbitrary quantum states given a list of the amplitudes stored in a classical database, and for performing a block-encoding of a matrix, given a list of its entries stored in a classical database.
This chapter covers the multiplicative weights update method, a quantum algorithmic primitive for certain continuous optimization problems. This method is a framework for classical algorithms, but it can be made quantum by incorporating the quantum algorithmic primitive of Gibbs sampling and amplitude amplification. The framework can be applied to solve linear programs and related convex problems, or generalized to handle matrix-valued weights and used to solve semidefinite programs.
This chapter covers quantum algorithmic primitives related to linear algebra. We discuss block-encodings, a versatile and abstract access model that features in many quantum algorithms. We explain how block-encodings can be manipulated, for example by taking products or linear combinations. We discuss the techniques of quantum signal processing, qubitization, and quantum singular value transformation, which unify many quantum algorithms into a common framework.
In the Preface, we motivate the book by discussing the history of quantum computing and the development of the field of quantum algorithms over the past several decades. We argue that the present moment calls for adopting an end-to-end lens in how we study quantum algorithms, and we discuss the contents of the book and how to use it.
This chapter covers the quantum adiabatic algorithm, a quantum algorithmic primitive for preparing the ground state of a Hamiltonian. The quantum adiabatic algorithm is a prominent ingredient in quantum algorithms for end-to-end problems in combinatorial optimization and simulation of physical systems. For example, it can be used to prepare the electronic ground state of a molecule, which is used as an input to quantum phase estimation to estimate the ground state energy.
This chapter covers quantum linear system solvers, which are quantum algorithmic primitives for solving a linear system of equations. The linear system problem is encountered in many real-world situations, and quantum linear system solvers are a prominent ingredient in quantum algorithms in the areas of machine learning and continuous optimization. Quantum linear systems solvers do not themselves solve end-to-end problems because their output is a quantum state, which is one of its major caveats.
This chapter presents an introduction to the theory of quantum fault tolerance and quantum error correction, which provide a collection of techniques to deal with imperfect operations and unavoidable noise afflicting the physical hardware, at the expense of moderately increased resource overheads.
This chapter covers the quantum algorithmic primitive called quantum gradient estimation, where the goal is to output an estimate for the gradient of a multivariate function. This primitive features in other primitives, for example, quantum tomography. It also features in several quantum algorithms for end-to-end problems in continuous optimization, finance, and machine learning, among other areas. The size of the speedup it provides depends on how the algorithm can access the function, and how difficult the gradient is to estimate classically.
This chapter covers quantum algorithms for numerically solving differential equations and the areas of application where such capabilities might be useful, such as computational fluid dynamics, semiconductor chip design, and many engineering workflows. We focus mainly on algorithms for linear differential equations (covering both partial and ordinary linear differential equations), but we also mention the additional nuances that arise for nonlinear differential equations. We discuss important caveats related to both the data input and output aspects of an end-to-end differential equation solver, and we place these quantum methods in the context of existing classical methods currently in use for these problems.
This chapter covers the quantum algorithmic primitive of approximate tensor network contraction. Tensor networks are a powerful classical method for representing complex classical data as a network of individual tensor objects. To evaluate the tensor network, it must be contracted, which can be computationally challenging. A quantum algorithm for approximate tensor network contraction can provide a quantum speedup for contracting tensor networks that satisfy certain conditions.
This chapter provides an overview of how to perform quantum error correction using the surface code, which is the most well-studied quantum error correcting code for practical quantum computation. We provide formulas for the code distance—which determines the resource overhead when using the surface code—as a function of the desired logical error rate and underlying physical error rate. We discuss several decoders for the surface code and the possibility of experiencing the backlog problem if the decoder is too slow.