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This study aimed to determine the optimal Biological Effective Dose (BED)-based compensation strategy for treatment interruptions in left-sided breast cancer radiotherapy, with a focus on evaluating cardiac substructures to address a previously unmet clinical need.
Methods:
Twenty patients with left-sided breast cancer who had received radiotherapy were retrospectively enrolled.
Simulations assumed treatment interruptions (number of interruption days) occurred after the first week, ranging from 1 to 10 days. Three BED-based compensation strategies were evaluated: (A) maintaining total fractions and days while delivering twice-daily treatments; (B) maintaining total days while increasing the dose per fraction; and (C) keeping the dose per fraction constant while extending the overall treatment course. Original uninterrupted plans served as the baseline. BEDs for the planning target volume (PTV), simultaneous integrated boost (SIB), cardiac substructures and other organs at risk (OARs) were calculated. Physical and BED differences among the schemes were systematically compared.
Results:
Compared to the original scheme, physical doses to PTV and SIB were lower in Scheme B but higher in Scheme C. As interruptions increased from 1 to 10 days, PTV and SIB doses in Scheme B decreased to minimum values of 42.71 Gy and 50.58 Gy, respectively, while Scheme C resulted in maximum values of 58.60 Gy and 67.15 Gy. Analysis of BED changes (ΔBED) in OARs revealed that the left anterior descending artery (LAD) was the most affected cardiac substructure, with ΔBED values of 0.41, –1.20 and 0.60 for Schemes A, B and C, respectively, at 10 interruption days. Among other OARs, the left lung showed the highest ΔBED changes (0.39, –0.30 and 0.32, respectively). Most OAR comparisons reached statistical significance (ANOVA, p < 0.05).
Conclusion:
Compensation strategies for radiotherapy interruptions significantly influence the BED of OARs, particularly in the LAD and left lung. Scheme B most effectively reduced the BED of OARs but requires replanning. Schemes A and C offer clinical convenience at the cost of a higher BED of OARs. The choice of compensation strategy should be individualised based on clinical priorities and patient-specific anatomy.
Soybean aphids (Aphis glycines) (Hemiptera: Aphididae) pose a serious threat to global soybean production, necessitating sustainable control strategies. This study investigated silica nanoparticles (SiNPs) as an eco-friendly alternative, hypothesising they would suppress aphid populations while enhancing plant growth. Soybean plants were foliar-sprayed with SiNPs (0–1 mmol/L), and aphids were assessed across six assays: fecundity, survival, feeding preference, weight gain, olfactory response, and plant morphometrics. SiNPs significantly reduced aphid nymphal production and population growth at all concentrations but did not affect survival, weight gain, or host-seeking behaviour. Plant responses were mixed: leaf width increased at higher SiNPs doses, but plant height decreased, with no effects on leaf length, root/shoot biomass, or root length. These findings suggest that SiNPs could disrupt aphid reproduction without triggering behavioural avoidance. The absence of biomass reduction indicates potential for crop compatibility. This laboratory study reveals a novel, reproduction-targeted mode of action for SiNPs, highlighting its potential as a candidate for future development in sustainable IPM strategies. Further field-scale validation is required to confirm these effects under real-world conditions.
Single-cell tornado-like vortices (TLVs) exhibit periodic wandering fluctuations around the time-averaged vortex core, a phenomenon known as vortex wandering, which constitutes the most prominent periodic behaviour in such flows. The coupling between vortex motion and wandering creates complex swirl dynamics, posing significant analytical challenges. However, the limited availability of experimental studies on vortex wandering decomposition hampers a deeper understanding of this phenomenon. To address this gap, a tornado simulator was designed to generate a controllable single-cell TLV, and high-frequency velocity data were obtained using particle image velocimetry. A sparsity-promoting dynamic mode decomposition (sp-DMD) method was developed to decouple coherent structures and analyse dynamic characteristics. Results show that as the swirl ratio increases, the vortex structure becomes more diffuse, with significant reductions in intensity. Vortex wandering is present across all swirl conditions, with its periodicity strongly modulated by the swirl ratio. Importantly, sp-DMD identified two primary modes, the time-averaged mode (first mode), representing the dominant rotational vortex motion, and the vortex-wandering-dominated modes (second and third conjugate modes), which correspond to persistent periodic velocity fluctuations and contribute the most significant pulsations. These modes exhibit a pair of oppositely rotating vortices symmetrically revolving around the central flow axis. Visualisations of the Q criterion reveal a symmetric dipole pattern. This suggests that rotational and shear effects are likely responsible for the periodic movement of the vortex core. Furthermore, as the swirl ratio increases, the energy of the vortex-wandering-dominated modes diminishes, and motion transitions from high-energy, organised dynamics to low-energy, disordered behaviour.
Magnetite-enriched mining tailings are a cost-effective and abundant catalytic material with inherent magnetic recyclability. Yet their practical application in catalysis is often constrained by their limited surface area and sluggish reaction kinetics. To address these issues, we developed a facile one-step co-precipitation method to synthesize a magnetic nano-Fe3O4 (MNP) catalyst that exhibits enhanced surface reactivity for efficient activation of H2O2 towards tetracycline (TC) degradation. The system achieved complete (100%) removal of TC at an initial concentration of 20 mg L–1 within 90 min and demonstrated robust catalytic performance across weakly acidic to neutral pH conditions. Mechanistic investigations confirmed that ⋅OH is the primary reactive oxygen species involved, with ⋅O2⁻ and 1O2 providing supplementary contributions to the degradation. Remarkably, the intrinsic magnetic properties ensured efficient MNP catalyst recovery. This work provides a sustainable and scalable wastewater treatment strategy, leveraging mining tailings as a cost-effective resource to treat wastewater while also providing economic and environmental benefits.
The treatment response for the negative symptoms of schizophrenia is not ideal, and the efficacy of antidepressant treatment remains a matter of considerable controversy. This systematic review and meta-analysis aimed to assess the efficacy of adjunctive antidepressant treatment for negative symptoms of schizophrenia under strict inclusion criteria.
Methods
A systematic literature search (PubMed/Web of Science) was conducted to identify randomized, double-blind, effect-focused trials comparing adjuvant antidepressants with placebo for the treatment of negative symptoms of schizophrenia from database establishment to April 16, 2025. Negative symptoms were examined as the primary outcome. Data were extracted from published research reports, and the overall effect size was calculated using standardized mean differences (SMD).
Results
A total of 15 articles, involving 655 patients, were included in this review. Mirtazapine (N = 2, n = 48, SMD −1.73, CI −2.60, −0.87) and duloxetine (N = 1, n = 64, SMD −1.19, CI −2.17, −0.21) showed significantly better efficacy for negative symptoms compared to placebo. In direct comparisons between antidepressants, mirtazapine showed significant differences compared to reboxetine, escitalopram, and bupropion, but there were no significant differences between other antidepressants or between antidepressants and placebo. No publication bias for the prevalence of this condition was observed.
Conclusions
These findings suggest that adjunctive use of mirtazapine and duloxetine can effectively improve the negative symptoms of schizophrenia in patients who are stably receiving antipsychotic treatment. Therefore, incorporating antidepressants into future treatment plans for negative symptoms of schizophrenia is a promising strategy that warrants further exploration.
This study aims to explore the association between Health-Related Quality of Life (HRQoL) and people’s willingness to receive the coronavirus disease 2019 (COVID-19) vaccination.
Methods
This survey was conducted in November 2020. 1461 participants (convenient sampling method) completed the online questionnaire. HRQoL was assessed using the 12-item Short Form Survey (SF-12) which included Physical and Mental Component Summary (PCS and MCS). The relationship between HRQoL and the willingness of COVID-19 vaccination was assessed by multivariate logistic regression.
Results
25.67% of respondents intended to be vaccinated immediately, 61.05% hesitated, and 13.28% refused. The mean score of PCS was 51.27 ± 6.30 and MCS was 47.72 ± 9.26. The multivariate logistic regression analysis showed the correlation between HRQoL and the willingness of vaccination (Ρ<0.05). Based on Z-score standardization, for 1 standard deviation (SD) increase in PCS, the odds ratio (OR) was 0.854 (95% confidence interval [CI]: 0.753-0.969) for hesitant vaccination vs. immediate vaccination. For 1 SD increase in MCS, the OR was 0.810 (95% CI: 0.677-0.970) for reluctant vaccination (refusal of COVID-19 vaccination) vs immediate vaccination, and the OR was 0.808 (95% CI: 0.710-0.919) for hesitant vaccination vs immediate vaccination.
Conclusions
People with better HRQoL preferred to receive the COVID-19 vaccine immediately.
This paper presents a detailed technical overview of the femtosecond precision timing and synchronization systems implemented at the Shanghai high repetition rate XFEL and extreme light facility (SHINE). These systems are designed to deliver stabilized optical references to multiple receiver clients, ensuring high-precision synchronization between the optical master oscillator (OMO) and optical/RF subsystems. The core components include an OMO, fiber length stabilizers and laser-to-laser synchronization modules that achieve femtosecond-level accuracy. Our discussion extends to the various subsystems that comprise the synchronization infrastructure, including the OMO, fiber length stabilizer and advanced phase detection techniques. Finally, we highlight ongoing research and development efforts aimed at enhancing the functionality and efficiency of these systems, thereby contributing to the advancement of X-ray free-electron laser technology and its applications in scientific research.
In this study, we introduce a real-time pose estimation for a class of mobile robots with rectangular body (e.g., the common automatic guided vehicles), by integrating odometry and RGB-D images. First, a lightweight object detection model is designed based on the visual information. Then, a pose estimation algorithm is proposed based on the depth value variations within the target region that exhibit specific patterns due to the robot’s three-dimensional geometry and the observation perspective (termed as “differentiated depth information”). To improve the robustness of object detection and pose estimation, a Kalman filter is further constructed by incorporating odometry data. Finally, a series of simulations and experiments are conducted to demonstrate the method’s effectiveness. Experiments show that the proposed algorithm can achieve a speed over 20 Frames Per Second (FPS) together with a good estimation accuracy on a mobile robot equipped with an Nvidia Jetson Nano Developer KIT.
This study investigates the formation and evolution of fishbone patterns in oblique impinging liquid microjets through high-speed imaging experiments and numerical simulations. The results identify periodic oscillations in the upper region of the liquid sheet as the primary mechanism driving fishbone instabilities, which induce rim disturbances and lead to bifurcations into diverse fishbone morphologies. Transitions between stable and unstable flow patterns are systematically mapped across varying Weber numbers and impingement angles, providing a comprehensive framework for understanding this interfacial dynamics. Two critical transitions – marking the onset and disappearance of fishbone patterns – are characterised, offering insights into the underlying physics governing the stability and instability of these flow structures.
Human milk oligosaccharides offer unique benefits for infant growth and development. Buffalo milk, characterized by a mild flavor and high nutritional value, has attracted considerable interest. To characterize the oligosaccharide profile and composition of buffalo milk, we conducted qualitative and quantitative analysis of milk oligosaccharides at the early- and late-lactation stages of crossbred (Nili-Ravi × Murrah × local) buffaloes from Guangxi, China. The results revealed a total of 97 oligosaccharides including 17 novel oligosaccharides, with concentrations of 416.6 ± 25.86 and 368.3 ± 10.29 mg/L in milk from early- and late-lactation stages, respectively. The most abundant oligosaccharides were 3’-sialyllactose (3’-SL), difucosyllactose (DFL), 6’-sialyllactose (6’-SL), and a newly discovered compound, 2142. The oligosaccharides in crossbred (Nili-Ravi × Murrah × local) buffaloes demonstrated greater diversity than those found in the milk of other dairy animals, highlighting its potential as a high-quality nutritional resource for adults and infants.
This study aimed to compare the clinical outcomes of using refrigerated versus pre-warmed media for preparing time-lapse dishes in in vitro fertilization (IVF). Patients undergoing their first IVF/ICSI cycle were divided into two groups. The control group used pre-warmed culture media, while the experimental group used refrigerated culture media. The osmotic pressure of the culture droplets in both groups was tested. No statistical differences were found between the two groups’ basic data. The proportion of air microbubbles affecting imaging significantly decreased (4.55% vs. 37.97%, P < 0.001) when using pre-warmed media. However, the blastocyst formation rate (56.62% vs. 49.70%, P = 0.046) and total high-quality embryo rate (22.26% vs. 17.06%, P = 0.047) were significantly higher in the refrigerated media group compared to the pre-warmed media group. The higher rate of high-quality embryos in the refrigerated media group might result in a higher single embryo transfer rate (45.10% vs. 18.52%, P = 0.020) and implantation rate (58.23% vs. 34.69%, P = 0.010). From day –1 to day 1, osmolality increased, with the P-3.5 group showing a significant elevation compared to the other three groups. After 5 days of incubation, the osmotic pressure of group R-4.0 was significantly lower than that of groups P-3.5, P-4.0 and P-3.5. In conclusion, refrigerated culture media dishes helped stabilize the osmotic pressure of the culture microenvironment and reduce water evaporation. The refrigerated group showed a higher rate of high-quality embryos and live births, although pre-warmed culture media effectively reduced the occurrence of air microbubbles that affect embryo imaging in the next day’s dishes.
Ultra-thin liquid sheets generated by impinging two liquid jets are crucial high-repetition-rate targets for laser ion acceleration and ultra-fast physics, and serve widely as barrier-free samples for structural biochemistry. The impact of liquid viscosity on sheet thickness should be comprehended fully to exploit its potential. Here, we demonstrate experimentally that viscosity significantly influences thickness distribution, while surface tension primarily governs shape. We propose a thickness model based on momentum exchange and mass transport within the radial flow, which agrees well with the experiments. These results provide deeper insights into the behaviour of liquid sheets and enable accurate thickness control for various applications, including atomization nozzles and laser-driven particle sources.
An actively controllable cascaded proton acceleration driven by a separate 0.8 picosecond (ps) laser is demonstrated in proof-of-principle experiments. MeV protons, initially driven by a femtosecond laser, are further accelerated and focused into a dot structure by an electromagnetic pulse (EMP) on the solenoid, which can be tuned into a ring structure by increasing the ps laser energy. An electrodynamics model is carried out to explain the experimental results and show that the dot-structured proton beam is formed when the outer part of the incident proton beam is optimally focused by the EMP force on the solenoid; otherwise, it is overfocused into a ring structure by a larger EMP. Such a separately controlled mechanism allows precise tuning of the proton beam structures for various applications, such as edge-enhanced proton radiography, proton therapy and pre-injection in traditional accelerators.
Oasis communities across Central Asia were key to the emergence and maintenance of the ancient Silk Roads that spanned Eurasia from the late second century BC, yet our understanding of early interaction networks in this region is limited. Multi-isotopic analysis of human teeth from the Zaghunluq Cemetery, southern Xinjiang (sixth century BC to first century AD) now suggests that oasis communities established intricate exchange networks, forming strong ties with other nearby oases and mountain pastoralists and weak ties, facilitated through in migration, with more distant regions. These diverse connections, the authors argue, made possible cultural exchange across the challenging geography of eastern Central Asia.
This study combines experimental observations and numerical simulations to comprehensively analyse the interface evolution of confined droplets in microfluidic devices with flow-focusing junctions under different aspect ratios. Microchannels with aspect ratios of 1, 1/2 and 1/3 are designed, where droplets are generated at the first flow-focusing junction, and three distinct flow patterns – no breakup, single breakup and multiple breakups – are observed at the second flow-focusing junction. The relationship between droplet length and flow parameters is established, investigating the effects of capillary number and channel aspect ratio on droplet breakup behaviour. It is found that the scaling exponent of the minimum neck thickness increases with the continuous phase flow rate. Numerical simulations are carried out to illustrate the shape evolution of a droplet in three-dimensional space, allowing the calculation of the curvature distribution of the interface. The scaling exponent of the mean radius of curvature in a channel with an aspect ratio of 1 differs from that in a channel with an aspect ratio of less than 1. These findings provide theoretical support for understanding droplet breakup dynamics and lay a foundation for optimising microfluidic device design and structural innovation.
Globally, numerous infertile couples have been assisted by extensive research on mammalian fertilization and the rapid development of Assisted Reproductive Technology (ART). However, 5%–15% of the couples that are selected for in vitro fertilization (IVF) experience a total fertilization failure (TFF), where no zygotes develop despite oocytes and semen parameters appear to be normal. Notably, an essential early event in fertilization is the binding of spermatozoa to the oocyte’s external envelope, which followed by the spermatozoa-oocyte fusion. Meanwhile, oocyte activation is a crucial cellular process necessary to block polyspermy and start the development of the zygote. Improper membrane fusion of gametes has been demonstrated to be one of the mechanisms of TFF. Moreover, considering the large amount of research on sperm proteins in recent years, thus in this review, we characterize the role and molecular mechanisms of sperm proteins in the three key processes of gamete adhesion and fusion and oocyte activation, which would provide a comprehensive understanding of the role of sperm proteins in fertilization in mammals and a favourable reference for future studies in assisted reproduction due to FF.
This study presents a novel investigation into the vortex dynamics of flow around a near-wall rectangular cylinder based on direct numerical simulation at $Re=1000$, marking the first in-depth exploration of these phenomena. By varying aspect ratios ($L/D = 5$, $10$, $15$) and gap ratios ($G/D = 0.1$, $0.3$, $0.9$), the study reveals the vortex dynamics influenced by the near-wall effect, considering the incoming laminar boundary layer flow. Both $L/D$ and $G/D$ significantly influence vortex dynamics, leading to behaviours not observed in previous bluff body flows. As $G/D$ increases, the streamwise scale of the upper leading edge (ULE) recirculation grows, delaying flow reattachment. At smaller $G/D$, lower leading edge (LLE) recirculation is suppressed, with upper Kelvin–Helmholtz vortices merging to form the ULE vortex, followed by instability, differing from conventional flow dynamics. Larger $G/D$ promotes the formation of an LLE shear layer. An intriguing finding at $L/D = 5$ and $G/D = 0.1$ is the backward flow of fluid from the downstream region to the upper side of the cylinder. At $G/D = 0.3$, double-trailing-edge vortices emerge for larger $L/D$, with two distinct flow behaviours associated with two interactions between gap flow and wall recirculation. These interactions lead to different multiple flow separations. For $G/D = 0.9$, the secondary vortex (SV) from the plate wall induces the formation of a tertiary vortex from the lower side of the cylinder. Double-SVs are observed at $L/D = 5$. Frequency locking is observed in most cases, but is suppressed at $L/D = 10$ and $G/D = 0.9$, where competing shedding modes lead to two distinct evolutions of the SV.
Ice shelves affect the stability of ice sheets by supporting the mass balance of ice upstream of the grounding line. Marine ice, formed from supercooled water freezing at the base of ice shelves, contributes to mass gain and affects ice dynamics. Direct measurements of marine ice thickness are rare due to the challenges of borehole drilling. Here we assume hydrostatic equilibrium to estimate marine ice distribution beneath the Amery Ice Shelf (AIS) using meteoric ice-thickness data obtained from radio-echo sounding collected during the Chinese National Antarctic Research Expedition between 2015 and 2019. This is the first mapping of marine ice beneath the AIS in nearly 20 years. Our new estimates of marine ice along two longitudinal bands beneath the northwest AIS are spatially consistent with earlier work but thicker. We also find a marine ice layer exceeding 30 m of thickness in the central ice shelf and patchy refreezing downstream of the grounding line. Thickness differences from prior results may indicate time-variation in basal melting and freezing patterns driven by polynya activity and coastal water intrusions masses under the ice shelf, highlighting that those changes in ice–ocean interaction are impacting ice-shelf stability.
We develop the time-dependent regularised 13-moment equations for general elastic collision models under the linear regime. Detailed derivation shows the proposed equations have super-Burnett order for small Knudsen numbers, and the moment equations enjoy a symmetric structure. A new modification of Onsager boundary conditions is proposed to ensure stability as well as the removal of undesired boundary layers. Numerical examples of one-dimensional channel flows is conducted to verified our model.