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Antarctic ice-free coastal environments, like the Vestfold Hills (East Antarctica), are shaped by a complex interplay of physical processes. This study synthesizes new data and existing research from the Vestfold Hills across marine, terrestrial and cryosphere science, meteorology, geomorphology, coastal oceanography and hydrology to explore interconnected processes ranging from icescape morphology and sediment transport to ocean-floor scouring and ocean-atmosphere interactions. Coastal landforms and habitats result from the interaction of marine dynamics with the aeolian and fluvial transport of glacially derived sediments and geomorphic features. Rocky shorelines dominate the region, and extensive fjords are prominent coastal features, whereas intertidal sediments and beaches are scarce. The marine environment is characterized by slow currents, low-energy waves, annually variable land-fast ice, irregular sedimentation rates and a geomorphologically complex shoreline. Aeolian and fluvial sediment deposition into coastal waters and onto sea ice can significantly impact local ecological and physical processes. Human activity further modifies these dynamics. Ice-free coastal areas such as the Vestfold Hills are predicted to experience substantial environmental shifts due to climate change. Wind speeds, temperature and precipitation are increasing in the Vestfold Hills. Retreating grounded ice sheets are likely to expand this coastal area and increase meltwater and sediment inputs into nearshore marine systems. Concurrently, changes in sea-ice extent, thickness and/or duration may profoundly alter the structure and function of this coastal environment.
Antipsychotic (AP) medication in individuals at clinical high risk for psychosis (CHR-P) is not routinely recommended by clinical guidelines but is commonly prescribed. Since little is known about the predictors of AP inception in CHR-P, we analyzed data from two observational cohorts.
Methods
To avoid baseline predictors being confounded by previous treatment, participants were selected for analysis from the 764 participants at CHR-P enrolled in NAPLS-2 and the 710 enrolled in NAPLS-3 by excluding those with lifetime histories of AP use. Baseline clinical variables available in both studies were employed as predictors of subsequent AP inception over the next 6 months in univariable and multivariable analyses.
Results
Preliminary analyses indicated no important effects of sample. The final combined population included 79 AP inception participants and 580 participants who did not have AP inception. The AP medications most commonly prescribed were risperidone, aripiprazole, and quetiapine. Univariable analyses identified seven significant predictors of AP inception. The final logistic regression model including these variables was highly significant (χ2 = 36.53, df = 7, p = <0.001). Three variables (current major depression, fewer education years, and current benzodiazepine use) emerged as significant independent predictors of AP inception.
Conclusion
This study is the first to determine baseline characteristics that predict subsequent AP initiation in CHR-P. Some AP use in CHR-P appears to be intended as augmentation of antidepressant treatment for comorbid major depression. Some prescribers may not have detected the attenuated positive symptoms characteristic of CHR-P since their severity did not significantly predict AP inception.
The plaza is one of the most important elements of the built environment for bringing people together in the Pueblo World of the US Southwest. Yet, the myriad ways in which plazas were designed and used vary greatly through time. Although plazas have been significant components of Ancestral Pueblo site layouts for hundreds of years, nearly every research study has been based on the enclosed plazas of the Pueblo IV period. In this article, we evaluate variation in 861 plazas from the Pueblo World dating from AD 800 to 1550. Our analysis of settlement size, plaza area, and degrees of plaza accessibility demonstrates that the spacious plazas emblematic of the Pueblo IV period were built to accommodate more people than the resident population, suggesting the origins of the feast-day-type ceremonialism seen in contemporary Pueblo communities. Our analysis suggests that this is a relatively recent phenomenon, because plazas in earlier Chaco great house communities were built to be more exclusionary, and thus activities held within them were more restricted.
Cults have captivated public imagination, gained visibility in the media, and become a popular topic of discourse. While anecdotal and journalistic accounts offer compelling insights, systematic study on the structure, psychological predispositions, and relevance to clinical and legal settings are comparatively scarce. This disparity highlights a crucial need for rigorous scholarly inquiry, moving beyond media portrayals to uncover the foundational mechanisms that sustain and shape these enigmatic groups. Authored by experts in forensic psychiatry and psychology, this book consolidates the extant literature in reviewing the theoretical, sociocultural, clinical, and forensic issues surrounding cultist groups. This text applies evidence-based study to identify group subtypes and explore mediators and moderators that may be relevant in clinical and legal contexts. Authors address issues as they relate to a variety of subpopulations, comorbid mental disorders, mind-altering substances, treatment, and the and legal implications inherent to cults and persuasive leadership. This book may be especially pertinent to mental health professionals and those working in the criminal justice system.
Resolvent analysis provides a framework to predict coherent spatio-temporal structures of the largest linear energy amplification, through a singular value decomposition (SVD) of the resolvent operator, obtained by linearising the Navier–Stokes equations about a known turbulent mean velocity profile. Resolvent analysis utilizes a Fourier decomposition in time, which has thus far limited its application to statistically stationary or time-periodic flows. This work develops a variant of resolvent analysis applicable to time-evolving flows, and proposes a variant that identifies spatio-temporally sparse structures, applicable to either stationary or time-varying mean velocity profiles. Spatio-temporal resolvent analysis is formulated through the incorporation of the temporal dimension to the numerical domain via a discrete time-differentiation operator. Sparsity (which manifests in localisation) is achieved through the addition of an $l_1$-norm penalisation term to the optimisation associated with the SVD. This modified optimisation problem can be formulated as a nonlinear eigenproblem and solved via an inverse power method. We first showcase the implementation of the sparse analysis on a statistically stationary turbulent channel flow, and demonstrate that the sparse variant can identify aspects of the physics not directly evident from standard resolvent analysis. This is followed by applying the sparse space–time formulation on systems that are time varying: a time-periodic turbulent Stokes boundary layer and then a turbulent channel flow with a sudden imposition of a lateral pressure gradient, with the original streamwise pressure gradient unchanged. We present results demonstrating how the sparsity-promoting variant can either change the quantitative structure of the leading space–time modes to increase their sparsity, or identify entirely different linear amplification mechanisms compared with non-sparse resolvent analysis.
Weeds are one of the greatest challenges to snap bean (Phaseolus vulgaris L.) production. Anecdotal observation posits certain species frequently escape the weed management system by the time of crop harvest, hereafter called residual weeds. The objectives of this work were to (1) quantify the residual weed community in snap bean grown for processing across the major growing regions in the United States and (2) investigate linkages between the density of residual weeds and their contributions to weed canopy cover. In surveys of 358 fields across the Northwest (NW), Midwest (MW), and Northeast (NE), residual weeds were observed in 95% of the fields. While a total of 109 species or species-groups were identified, one to three species dominated the residual weed community of individual fields in most cases. It was not uncommon to have >10 weeds m−2 with a weed canopy covering >5% of the field’s surface area. Some of the most abundant and problematic species or species-groups escaping control included amaranth species such as smooth pigweed (Amaranthus hybridus L.), Palmer amaranth (Amaranthus palmeri S. Watson), redroot pigweed (Amaranthus retroflexus L.), and waterhemp [Amaranthus tuberculatus (Moq.) Sauer]; common lambsquarters (Chenopodium album L.); large crabgrass [Digitaria sanguinalis (L.) Scop.]; and ivyleaf morningglory (Ipomoea hederacea Jacq.). Emerging threats include hophornbeam copperleaf (Acalypha ostryifolia Riddell) in the MW and sharppoint fluvellin [Kickxia elatine (L.) Dumort.] in the NW. Beyond crop losses due to weed interference, the weed canopy at harvest poses a risk to contaminating snap bean products with foreign material. Random forest modeling predicts the residual weed canopy is dominated by C. album, D. sanguinalis, carpetweed (Mollugo verticillata L.), I. hederacea, amaranth species, and A. ostryifolia. This is the first quantitative report on the weed community escaping control in U.S. snap bean production.
This work introduces a formulation of resolvent analysis that uses wavelet transforms rather than Fourier transforms in time. Under this formulation, resolvent analysis may extend to turbulent flows with non-stationary mean states. The optimal resolvent modes are augmented with a temporal dimension and are able to encode the time-transient trajectories that are most amplified by the linearised Navier–Stokes equations. We first show that the wavelet- and Fourier-based resolvent analyses give equivalent results for statistically stationary flow by applying them to turbulent channel flow. We then use wavelet-based resolvent analysis to study the transient growth mechanism in the near-wall region of a turbulent channel flow by windowing the resolvent operator in time and frequency. The computed principal resolvent response mode, i.e. the velocity field optimally amplified by the linearised dynamics of the flow, exhibits characteristics of the Orr mechanism, which supports the claim that this mechanism is key to linear transient energy growth. We also apply this method to non-stationary parallel shear flows such as an oscillating boundary layer, and three-dimensional channel flow in which a sudden spanwise pressure gradient perturbs a fully developed turbulent channel flow. In both cases, wavelet-based resolvent analysis yields modes that are sensitive to the changing mean profile of the flow. For the oscillating boundary layer, wavelet-based resolvent analysis produces oscillating principal forcing and response modes that peak at times and wall-normal locations associated with high turbulent activity. For the turbulent channel flow under a sudden spanwise pressure gradient, the resolvent modes gradually realign themselves with the mean flow as the latter deviates. Wavelet-based resolvent analysis thus captures the changes in the transient linear growth mechanisms caused by a time-varying turbulent mean profile.
Cohort studies demonstrate that people who later develop schizophrenia, on average, present with mild cognitive deficits in childhood and endure a decline in adolescence and adulthood. Yet, tremendous heterogeneity exists during the course of psychotic disorders, including the prodromal period. Individuals identified to be in this period (known as CHR-P) are at heightened risk for developing psychosis (~35%) and begin to exhibit cognitive deficits. Cognitive impairments in CHR-P (as a singular group) appear to be relatively stable or ameliorate over time. A sizeable proportion has been described to decline on measures related to processing speed or verbal learning. The purpose of this analysis is to use data-driven approaches to identify latent subgroups among CHR-P based on cognitive trajectories. This will yield a clearer understanding of the timing and presentation of both general and domain-specific deficits.
Participants and Methods:
Participants included 684 young people at CHR-P (ages 12–35) from the second cohort of the North American Prodromal Longitudinal Study. Performance on the MATRICS Consensus Cognitive Battery (MCCB) and the Wechsler Abbreviated Scale of Intelligence (WASI-I) was assessed at baseline, 12-, and 24-months. Tested MCCB domains include verbal learning, speed of processing, working memory, and reasoning & problem-solving. Sex- and age-based norms were utilized. The Oral Reading subtest on the Wide Range Achievement Test (WRAT4) indexed pre-morbid IQ at baseline. Latent class mixture models were used to identify distinct trajectories of cognitive performance across two years. One- to 5-class solutions were compared to decide the best solution. This determination depended on goodness-of-fit metrics, interpretability of latent trajectories, and proportion of subgroup membership (>5%).
Results:
A one-class solution was found for WASI-I Full-Scale IQ, as people at CHR-P predominantly demonstrated an average IQ that increased gradually over time. For individual domains, one-class solutions also best fit the trajectories for speed of processing, verbal learning, and working memory domains. Two distinct subgroups were identified on one of the executive functioning domains, reasoning and problem-solving (NAB Mazes). The sample divided into unimpaired performance with mild improvement over time (Class I, 74%) and persistent performance two standard deviations below average (Class II, 26%). Between these classes, no significant differences were found for biological sex, age, years of education, or likelihood of conversion to psychosis (OR = 1.68, 95% CI 0.86 to 3.14). Individuals assigned to Class II did demonstrate a lower WASI-I IQ at baseline (96.3 vs. 106.3) and a lower premorbid IQ (100.8 vs. 106.2).
Conclusions:
Youth at CHR-P demonstrate relatively homogeneous trajectories across time in terms of general cognition and most individual domains. In contrast, two distinct subgroups were observed with higher cognitive skills involving planning and foresight, and they notably exist independent of conversion outcome. Overall, these findings replicate and extend results from a recently published latent class analysis that examined 12-month trajectories among CHR-P using a different cognitive battery (Allott et al., 2022). Findings inform which individuals at CHR-P may be most likely to benefit from cognitive remediation and can inform about the substrates of deficits by establishing meaningful subtypes.
Clinical implementation of risk calculator models in the clinical high-risk for psychosis (CHR-P) population has been hindered by heterogeneous risk distributions across study cohorts which could be attributed to pre-ascertainment illness progression. To examine this, we tested whether the duration of attenuated psychotic symptom (APS) worsening prior to baseline moderated performance of the North American prodrome longitudinal study 2 (NAPLS2) risk calculator. We also examined whether rates of cortical thinning, another marker of illness progression, bolstered clinical prediction models.
Methods
Participants from both the NAPLS2 and NAPLS3 samples were classified as either ‘long’ or ‘short’ symptom duration based on time since APS increase prior to baseline. The NAPLS2 risk calculator model was applied to each of these groups. In a subset of NAPLS3 participants who completed follow-up magnetic resonance imaging scans, change in cortical thickness was combined with the individual risk score to predict conversion to psychosis.
Results
The risk calculator models achieved similar performance across the combined NAPLS2/NAPLS3 sample [area under the curve (AUC) = 0.69], the long duration group (AUC = 0.71), and the short duration group (AUC = 0.71). The shorter duration group was younger and had higher baseline APS than the longer duration group. The addition of cortical thinning improved the prediction of conversion significantly for the short duration group (AUC = 0.84), with a moderate improvement in prediction for the longer duration group (AUC = 0.78).
Conclusions
These results suggest that early illness progression differs among CHR-P patients, is detectable with both clinical and neuroimaging measures, and could play an essential role in the prediction of clinical outcomes.
This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.