Maternal experiences of childhood adversity can increase the risk of emotional and behavioural problems in their children. This systematic review and meta-analysis provide the first narrative and quantitative synthesis of the mediators and moderators involved in the link between maternal childhood adversity and children's emotional and behavioural development. We searched EMBASE, PsycINFO, Medline, Cochrane Library, grey literature and reference lists. Studies published up to February 2021 were included if they explored mediators or moderators between maternal childhood adversity and their children's emotional and behavioural development. Data were synthesised narratively and quantitatively by meta-analytic approaches. The search yielded 781 articles, with 74 full-text articles reviewed, and 41 studies meeting inclusion criteria. Maternal mental health was a significant individual-level mediator, while child traumatic experiences and insecure maternal–child attachment were consistent family-level mediators. However, the evidence for community-level mediators was limited. A meta-analysis of nine single-mediating analyses from five studies indicated three mediating pathways: maternal depression, negative parenting practices and maternal insecure attachment, with pooled indirect standardised effects of 0.10 [95% CI (0.03–0.17)), 0.01 (95% CI (−0.02 to 0.04)] and 0.07 [95% CI (0.01–0.12)], respectively. Research studies on moderators were few and identified some individual-level factors, such as child sex (e.g. the mediating role of parenting practices being only significant in girls), biological factors (e.g. maternal cortisol level) and genetic factors (e.g. child's serotonin-transporter genotype). In conclusion, maternal depression and maternal insecure attachment are two established mediating pathways that can explain the link between maternal childhood adversity and their children's emotional and behavioural development and offer opportunities for intervention.

We report 3 years of data from one meteorological and three smaller stations in University Valley, a high-elevation (1677 m) site in the Dry Valleys of Antarctica with extensive dry permafrost. Mean air temperature was -23.4°C. Summer air temperatures were virtually always < 0°C and were consistent with the altitude lapse rate and empirical relationships between summer temperature, distance from the coast and elevation. The measured frost point (-22.5°C) at the 42 cm deep ice table is equal to the surface frost point and above the atmospheric frost point (-29.6°C), providing direct evidence that surface conditions control ground ice depth. Observed peak surface soil temperatures reach 6°C for ice-cemented ground > 15 cm deep but stay < 0°C when it is shallower. We develop an energy balance model tuned to this rocky and dry environment. We find that differences in peak soil surface temperatures are primarily due to the higher thermal diffusivity of ice-cemented ground compared to dry soil. Sensitivity studies show that expected natural variability is insufficient for melt to form and significant excursions from current conditions are required. The site's ice table meets the criteria for a Special Region on Mars, with 30% of the year > -18°C and water activity > 0.6.

Little is known about the relationship between socioeconomic position (SEP) and duration and patterning of objectively measured sedentary time (ST) among adults, especially adults at high risk of diabetes. The aim of this study was to examine cross-sectional associations of SEP with ST (total, prolonged ST, breaks in ST) and self-reported TV time among pregnant women at risk of gestational diabetes in the UK. At 20 weeks’ gestation, pregnant women (n=174) wore an activPAL accelerometer and reported their usual TV time. Generalized linear mixed models were used to test associations of education, household income and area-level deprivation (separately and with mutual adjustment) with total ST, prolonged ST and breaks in ST. Logistic regression models were used to test associations between SEP indicators and high (≥2h/day) TV time. Those with the lowest education, lowest household income and highest area-level deprivation had the lowest ST and lowest prolonged ST. After mutual adjustment, area-level deprivation remained associated with total ST (β=0.10 [0.01, 0.20]). There was an inverse association between area-level deprivation and breaks in sedentary time (exp(b)=1.11 [1.01, 1.22]). Education was the only SEP correlate of high TV time, with more of those with least education reporting high TV time; this association persisted after adjustment for household income and area-level deprivation. The association between SEP and total and prolonged ST (positive) was the opposite of the association between education and high TV time (negative) in this sample of high-risk pregnant women. These findings should inform interventions to reduce sedentary time.

We present 63 new multi-site radial velocity (RV) measurements of the K1III giant HD 76920, which was recently reported to host the most eccentric planet known to orbit an evolved star. We focused our observational efforts on the time around the predicted periastron passage and achieved near-continuous phase coverage of the corresponding RV peak. By combining our RV measurements from four different instruments with previously published ones, we confirm the highly eccentric nature of the system and find an even higher eccentricity of $e=0.8782 \pm 0.0025$ , an orbital period of $415.891^{+0.043}_{-0.039}\,\textrm{d}$ , and a minimum mass of $3.13^{+0.41}_{-0.43}\,\textrm{M}_{\textrm{J}}$ for the planet. The uncertainties in the orbital elements are greatly reduced, especially for the period and eccentricity. We also performed a detailed spectroscopic analysis to derive atmospheric stellar parameters, and thus the fundamental stellar parameters ( $M_*, R_*, L_*$ ), taking into account the parallax from Gaia DR2, and independently determined the stellar mass and radius using asteroseismology. Intriguingly, at periastron, the planet comes to within 2.4 stellar radii of its host star’s surface. However, we find that the planet is not currently experiencing any significant orbital decay and will not be engulfed by the stellar envelope for at least another 50–80 Myr. Finally, while we calculate a relatively high transit probability of 16%, we did not detect a transit in the TESS photometry.

As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.

Mössbauer spectroscopy obtained with the sample at low temperatures and subject to large magnetic fields is discussed in terms of its use in analysing the naturally occurring polymorphs of FeOOH and the common growth precursor, ferrihydrite. Experiments on well-characterized synthetic samples provided benchmark results. A relatively simple means of quantitative analysis was used, in which sextets of Voigtian-shaped lines were summed and least-squares fitted. The results are discussed in terms of the magnetic structures of each compound.

In the Yichun granite complex (SE China), columbite group minerals, microlite and cassiterite are the main Nb, Ta, Sn-bearing minerals. They are mainly concentrated in the uppermost albite-lepidolite granite. Rutile is the only Nb, Ta-bearing phase in the geochemically primitive muscovite-zinnwaldite granite. The chemical evolution of the columbite group minerals (the most abundant and commonly zoned Nb, Ta-bearing minerals) indicates a complex crystallization history of the host granites with: (1) fractional crystallization at depth, reflected by a strong increase of Mn/(Mn+Fe) ratios with a moderate increase of Ta/(Ta+Nb) ratios from the muscovite-zinnwaldite granite to the Li-mica granite and then the most fractionated topaz-lepidolite granite; and (2) emplacement of successive magma batches corresponding to the different units of the granite complex with progressive crystallization of each unit, mainly reflected by a strong increase of Ta/(Ta+Nb) ratios with moderate variation of Mn/(Mn+Fe) ratios during the growth of the zoned crystals. The data are compared with those from the RMG of Ezzirari (Morocco), Montebras, Beauvoir and Chèdeville (France).

The stabilities of antierite, Cu3SO4(OH)4, and a synthetic compound whose stoichiometry is here established as Cu3SO4(OH)4.2H2O, have been determined at 5°C intervals between 10°C and 45°C using solution methods. The results of the experiments show that antlerite is stable with respect to the compound Cu3SO4(OH)4.2H2O only at temperatures above 30°C Below 30°C a change in the relative stabilities of these two basic copper(II) sulfates occurs, and the compound Cu3SO4(OH)4.2H2O, although unknown at present as a mineral, instead, is stable. Under these conditions, it does not react to give antlerite if kept in contact with water. Once isolated from its mother liquor, however, the dihydrate undergoes rapid dehydration to yield antlerite. Thermodynamic quantities for the two phases have been derived from equilibrium measurements. At 298.2K, values of AfG° for the compounds Cu3SO4(OH)4.2H2O(s ) and antlerite are −1919.6(14) and −1445.0(10) kJ mol−1, respectively. The results have been used to construct stability field diagrams for the system CuO—H2O–SO3 at 25°C and at 35°C These diagrams have been used to illustrate the chemical conditions under which the two compounds might be expected to form in the oxidised zones of cupriferous base metal orebodies.

Strictly reproducible syntheses of the trimorphs of composition Cu2Cl(OH)3, atacamite, paratacamite, and botallackite, have been developed. In syntheses involving direct precipitation, or reaction of aqueous solutions with solid phases, reliable results are obtained only if the temperature and time of reaction are carefully controlled. Botallackite, the rarest of the naturally occurring trimorphs, is a key intermediate and crystallizes first under most conditions; subsequent recrystallization of this phase to atacamite or paratacamite, or of the latter from the former, depends upon the precise nature of the reaction medium. The crystallization sequence indicates that paratacamite, as has long been suspected, is the thermodynamically stable phase at ambient temperatures. Spertiniite, Cu(OH)2, can be reproducibly synthesized via one route in the non-commutative titration of aqueous copper chloride with aqueous sodium hydroxide solutions.

New stability constant data are presented for the minerals blixite, mendipite and the compound Pb7O6Cl2.2H2O at 298.2 K and P = 105 Pa. Mendipite is in fact a metastable phase at this temperature, being thermodynamically stable under the appropriate conditions at temperatures above about 29°C Kinetic influences are of some significance with respect to the sequence of formation of solid phases in the PbO-HCl-HH2O system, and these have been elucidated for some important reactions. Penfieldite and fiedlerite appear to be metastable phases at all temperatures at 105 Pa. The results have been used to reassess the conditions of formation of the lead(II) oxy- and hydroxychloride phases that are known to form as minerals and as corrosion products of lead-containing artefacts. The effect of CO2 on the system is also described.

Comparison of the infrared spectra of georgeite and a phase which can be reproducibily synthesised in the laboratory shows that the mineral is an amorphous analogue of malachite, Cu2CO3(OH)2. Synthetic studies also explain the chemical conditions under which georgeite may form, as well as those which can cause it to react to either malachite or chalconatronite. Parallels may be drawn between the laboratory observations and known mineral associations of georgeite.

The stability of synthetic connellite has been determined at 298.2K (25 °C) and 105 Pa, using solution methods. For the reaction 1/37{62H+(aq) + Cu37Cl8(SO4)2(OH)62.8H2O(s) ⇌ Cu2+(aq) + 8Cl−(aq) + 2SO42−(aq) + 70H2O(l)}, log KH+ is equal to 6.44(2). This result has been used in turn to calculate a value for ΔfG°(1/37Cu37Cl8(SO4)2(OH)62.8H2O, s, 298.2K) of −423.7±6.6 kJ mol−1. During the synthesis of connellite, claringbullite sometimes forms as a metastable phase. This solid recrystallizes to connellite if kept in contact with the reaction solution. The results have been used to construct an equilibrium model for the formation of connellite in relation to other common secondary copper (II) minerals. Connellite crystallizes from solution over an appreciable range of conditions. This result is consistent with the observed widespread occurrence of connellite, though as a very minor phase, in the oxidized zones of cupriferous sulfide ores.

Epstein Barr virus (EBV) infects 95% of the global population and is associated with up to 2% of cancers globally. Immunoglobulin G (IgG) antibody levels to EBV have been shown to be heritable and associated with developing malignancies. We, therefore, performed a pilot genome-wide association analysis of anti-EBV IgG traits in an African population, using a combined approach including array genotyping, whole-genome sequencing and imputation to a panel with African sequence data. In 1562 Ugandans, we identify a variant in human leukocyte antigen (HLA)-DQA1, rs9272371 (p = 2.6 × 10−17) associated with anti-EBV nuclear antigen-1 responses. Trans-ancestry meta-analysis and fine-mapping with European-ancestry individuals suggest the presence of distinct HLA class II variants driving associations in Uganda. In addition, we identify four putative, novel, very rare African-specific loci with preliminary evidence for association with anti-viral capsid antigen IgG responses which will require replication for validation. These findings reinforce the need for the expansion of such studies in African populations with relevant datasets to capture genetic diversity.

Introduction/Innovation Concept: Rural and remote practice of emergency medicine presents unique challenges, particularly when faced with infrequently encountered cases and procedures. Simulation-based training is a valuable tool in the acquisition and maintenance of knowledge and skills; however, simulators are often located in larger centers and they are not widely outside these centers due to geographic, cost and time constraints. Mobile tele-simulation has the potential to overcome barriers but challenges such as comfort, technical issues and ability to teach desired content via tele-simulation must be addressed. We are developing a mobile-tele-simulation unit (MTU) prototype that will enable emergency medicine practitioners and trainees to access simulation-based instruction in rural and remote settings. Methods: Through application of a mixed-methods approach with input of a multidisciplinary team we are iteratively developing an MTU prototype to assess key factors in design and function, including: technical issues, environmental features, and human factors. The Delphi method is being used to collect input from experts on key design components and feedback is also being collected from trainees after participating in trial deployments of the MTU in different educational and environmental settings. Curriculum, Tool, or Material: The effective application of the MTU in a variety of learning settings will be optimized through ongoing evaluation in the iterative design cycle. Feedback to ensure a quality learning experience in the MTU will direct features of physical design and technical performance that can be applied in deployment of the unit. In addition, challenges to the delivery of module content and instructional modality/ features of lessons to be executed will be important considerations as we move toward developing content that can effectively be taught using the MTU. Conclusion: To ensure effective use of tele-simulation in the delivery of a meaningful simulation experience to rural and remote trainees a number of important challenges must be overcome. We describe our evolving multidisciplinary mixed-methods approach to develop an effective mobile tele-simulation unit.

Oxygen isotope stage 3 (OIS3), an interstade between approximately 60,000 and 25,000 yr B.P., presents an ideal opportunity to compare high-resolution climate simulations with the geologic record. To facilitate this comparison, the results of a mesoscale climate model (RegCM2) embedded in the GENESIS GCM are utilized to drive a vegetation model (BIOME 3.5). The BIOME output is then compared with OIS3 compilations derived from pollen. The simulated biomes agree well with the pollen-based biomes in southern Europe; however, disagreements occur in the northern part of the domain. The most striking mismatch involves the distribution of tundra. The models fail to have tundra extend to its observed position as far south as 50°N in central Europe during OIS3. The model also fails to have permafrost extend southward to its observed position between 50°N and 55°N in western Europe during OIS3. A variety of sensitivity experiments are performed to investigate these mismatches. These experiments demonstrate the importance of annual and summer temperatures and the length of the winter season in creating improved matches between the model results and the inferred distributions of vegetation and permafrost in northern Europe.

The crystal character of the ice core within frost blisters supports the hypothesis that groundwater injection into residual zones of the active layer followed by rapid freezing is the primary growth mechanism for these features. The ice core is characterized by an upper zone of relatively small randomly arranged equigranular ice crystals which change with increasing depth to columnar anhedral crystals, commonly exceeding 200 mm in length, and with crystal diameters ranging between 25 and 35 mm. Petrofabric analyses show that the c-axis orientations are normal to crystal elongations, with crystal growth along the basal plane in an a-axis direction. These observations eliminate ice segregation as a possible growth mechanism, thereby distinguishing seasonal frost mounds from palsas.

Eta Carinae is one of the most massive observable binaries. Yet determination of its orbital and physical parameters is hampered by obscuring winds. However the effects of the strong, colliding winds changes with phase due to the high orbital eccentricity. We wanted to improve measures of the orbital parameters and to determine the mechanisms that produce the relatively brief, phase-locked minimum as detected throughout the electromagnetic spectrum. We conducted intense monitoring of the He ii λ4686 line in η Carinae for 10 months in the year 2014, gathering ~300 high S/N spectra with ground- and space-based telescopes. We also used published spectra at the FOS4 SE polar region of the Homunculus, which views the minimum from a different direction. We used a model in which the He ii λ4686 emission is produced by two mechanisms: a) one linked to the intensity of the wind-wind collision which occurs along the whole orbit and is proportional to the inverse square of the separation between the companion stars; and b) the other produced by the ‘bore hole’ effect which occurs at phases across the periastron passage. The opacity (computed from 3D SPH simulations) as convolved with the emission reproduces the behavior of equivalent widths both for direct and reflected light. Our main results are: a) a demonstration that the He ii λ4686 light curve is exquisitely repeatable from cycle to cycle, contrary to previous claims for large changes; b) an accurate determination of the longitude of periastron, indicating that the secondary star is ‘behind’ the primary at periastron, a dispute extended over the past decade; c) a determination of the time of periastron passage, at ~4 days after the onset of the deep light curve minimum; and d) show that the minimum is simultaneous for observers at different lines of sight, indicating that it is not caused by an eclipse of the secondary star, but rather by the immersion of the wind-wind collision interior to the inner wind of the primary.