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The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders

Published online by Cambridge University Press:  21 July 2025

Annabelle Trew Open the ORCID record for Annabelle Trew [Opens in a new window] ,
Joanne Rodda Open the ORCID record for Joanne Rodda [Opens in a new window]  and
Sukhi S. Shergill
Annabelle Trew
Affiliation:
Kent and Medway Medical School, Canterbury, UK William Harvey Hospital, East Kent Hospitals University NHS Foundation Trust, Ashford, UK
Joanne Rodda
Affiliation:
Kent and Medway Medical School, Canterbury, UK Kent and Medway NHS and Social Care Partnership Trust, Maidstone, UK
Sukhi S. Shergill*
Affiliation:
Kent and Medway Medical School, Canterbury, UK Kent and Medway NHS and Social Care Partnership Trust, Maidstone, UK Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
*
Correspondence: Sukhi S. Shergill. Email: sukhi.shergill@kcl.ac.uk
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Abstract

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Keywords

Relapsepsychosisantipsychotic discontinuationclinical outcomesillness trajectory

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Type
Commentary
Information
The British Journal of Psychiatry , Volume 227 , Issue 5 , November 2025 , pp. 819 - 820
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

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References

Jørgensen, K.T., Bøg, M., Kabra, M., Simonsen J, Adair M, Jonssön L . Predicting time to relapse in patients with schizophrenia according to patients’ relapse history: a historical cohort study using real-world data in Sweden. BMC Psychiatry 2021; 21: 634.CrossRefGoogle ScholarPubMed
Tessier, A, Roger, K, Gregoire, A, Desnavailles, P, Misdrahi, D. Family psychoeducation to improve outcome in caregivers and patients with schizophrenia: a randomized clinical trial. Front Psychiatry 2023; 14: 1171661.CrossRefGoogle ScholarPubMed
Rivelli, A., Fitzpatrick, V., Nelson, M., Laubmeier K, Zeni C, Mylavarapu S. Real-world predictors of relapse in patients with schizophrenia and schizoaffective disorder in a large health system. Schizophrenia 2024; 10: 28.CrossRefGoogle Scholar
Emsley, R, Chiliza, B, Asmal, L, Harvey, BH. The nature of relapse in schizophrenia. BMC Psychiatry 2013; 13: 50.CrossRefGoogle ScholarPubMed
Moncrieff, J, Crellin N, Stansfeld J, Cooper R, Marston L, Freemantle N, et al. Antipsychotic dose reduction and discontinuation versus maintenance treatment in people with schizophrenia and other recurrent psychotic disorders in England (the RADAR trial): an open, parallel-group, randomised controlled trial. Lancet Psychiatry 2023; 10(11): 848–59.CrossRefGoogle Scholar
Siskind, D, Orr, S, Sinha, S, Yu, O, Brijball, B, Warren, N, et al. Rates of treatment-resistant schizophrenia from first-episode cohorts: systematic review and meta-analysis. Br J Psychiatry 2022; 220(3): 115–20.CrossRefGoogle ScholarPubMed
Lally, J, Ajnakina, O, Di Forti, M, Trotta, A, Demjaha, A, Kolliakou, A, et al. Two distinct patterns of treatment resistance: clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses. Psychol Med 2016; 46(15): 3231–40.CrossRefGoogle ScholarPubMed
Ceraso, A, Lin, JJ, Schneider-Thoma, J, Siafis, S, Heres, S, Kissling, W, et al. Maintenance treatment with antipsychotic drugs in schizophrenia: a Cochrane Systematic Review and meta-analysis. Schizophr Bull 2022; 48: 738–40.CrossRefGoogle ScholarPubMed
Takeuchi, H, Siu, C, Remington, G, Fervaha, G, Zipursky, RB, Foussias, G, et al. Does relapse contribute to treatment resistance? Antipsychotic response in first-vs. second-episode schizophrenia. Neuropsychopharmacology 2019; 44:1036–42.CrossRefGoogle Scholar
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