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Infant zygosity can be assigned by parental report questionnaire data

Published online by Cambridge University Press:  21 February 2012

Thomas S Price ,
Bernard Freeman ,
Ian Craig ,
Stephen A Petrill ,
Lorna Ebersole  and
Robert Plomin
Thomas S Price*
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UKt.price@iop.kcl.ac.uk
Bernard Freeman
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
Ian Craig
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
Stephen A Petrill
Affiliation:
Wesleyan University, Middletown, CT, USA
Lorna Ebersole
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
Robert Plomin
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
*
*Correspondence: Thomas S Price, Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, SE5 8AF, UK. Tel: + 44 (0) 207 848 0961; Fax: + 44 (0) 207 848 0866

Abstract

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A parental report questionnaire posted to a population sample of 18-month-old twins correctly assigned zygosity in 95%of cases when validated against zygosity determined by identity of polymorphic DNA markers. The questionnaire was as accurate when readministered at 3 years of age, with 96% of children being assigned the same zygosity on both occasions. The results validate the use of parental report questionnaire data to determine zygosity in infancy. Twin Research (2000) 3, 129–133.

Keywords

zygositytwininfancyDNA
Type
Articles
Information
Twin Research and Human Genetics , Volume 3 , Issue 3 , 01 June 2000 , pp. 129 - 133
Copyright
Copyright © Cambridge University Press 2000