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Kraepelin revisited: a reassessment and statistical analysis of dementia praecox and manic-depressive insanity in 1908

Published online by Cambridge University Press:  09 July 2009

A. Jablensky ,
H. Hugler ,
M. Von Cranach  and
K. Kalinov
A. Jablensky*
Affiliation:
Department of Psychiatry, University of Western Australia, Perth, Australia; Department of Psychology, Humboldt University, Berlin, Regional Hospital Kaufbeuren, Germany; National Centre for Brain and Behaviour Research, Sofia, Bulgaria
H. Hugler
Affiliation:
Department of Psychiatry, University of Western Australia, Perth, Australia; Department of Psychology, Humboldt University, Berlin, Regional Hospital Kaufbeuren, Germany; National Centre for Brain and Behaviour Research, Sofia, Bulgaria
M. Von Cranach
Affiliation:
Department of Psychiatry, University of Western Australia, Perth, Australia; Department of Psychology, Humboldt University, Berlin, Regional Hospital Kaufbeuren, Germany; National Centre for Brain and Behaviour Research, Sofia, Bulgaria
K. Kalinov
Affiliation:
Department of Psychiatry, University of Western Australia, Perth, Australia; Department of Psychology, Humboldt University, Berlin, Regional Hospital Kaufbeuren, Germany; National Centre for Brain and Behaviour Research, Sofia, Bulgaria
*
1Address for correspondence: Professor Assen Jablensky, University Department of Psychiatry and Behavioural Science, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia.
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Synopsis

A meta-analysis was carried out on 53 cases of dementia praecox (DP) and 134 cases of manic-depressive insanity (MDI) originally diagnosed by Kraepelin or his collaborators in Munich in 1908. The original case material was coded in terms of Present State Examination syndromes and analysed statistically for internal consistency and discrimination between the two diagnostic entities. Kraepelin's DP and MDI were found to define homogeneous groups of disorders which could be clearly distinguished from one another. A CATEGO re-classification of the cases revealed an 80·2% concordance rate between Kraepelin's diagnoses and ICD-9. Cluster analysis of the original data reproduced closely Kraepelin's dichotomous classification of the psychoses but suggested that DP was a narrower concept than schizophrenia today, while MDI was a composite group including both ‘typical’ manic-depressive illnesses and schizoaffective disorders.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 4 , November 1993 , pp. 843 - 858
Copyright
Copyright © Cambridge University Press 1993

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