Hostname: page-component-745bb68f8f-s22k5 Total loading time: 0 Render date: 2025-01-12T13:47:02.906Z Has data issue: false hasContentIssue false
  • English
  • Français

Incorporation of NSAID Drug Gel Derived from Cellulose and Polyacrylamide

Published online by Cambridge University Press:  01 February 2011

C. A. Morales ,
M. C. Castillo ,
Z. N. Díaz ,
S. J. González  and
V. O. Kharissova
C. A. Morales
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
M. C. Castillo
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
Z. N. Díaz
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
S. J. González
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
V. O. Kharissova
Affiliation:
Facultad de Ciencias Físico Matemáticas de la Universidad Autónoma de Nuevo León
Get access

Abstract

In this paper, the incorporation and release of two types of drugs was carried out in microgels of hydroxypropylcellulose/polyacrylamide (HPC/PAAM) and hydroxyethylcellulose/polyacrylamide (HEC/PAAM). The two drugs were NSAIDs (nonsteroidal, anti-inflammatory drugs)—one antipyretic and one analgesic—acetylsalicylic acid (aspirin, ASP) and iuprofen (IBU), respectively. First, the microgels were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FTIR) in order to identify the presence of functional groups for each polymer. The incorporation of the drug was made by swelling the microgels in a drug solution and finally carrying out the release of the substances listed at 37° C. The results were obtained by UV-visible spectroscopy.

Keywords

polymeradsorptionbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1280: Nanomaterials for Biomedical Applications , 2010 , sim21-abs041
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Shibayama, M., Tanaka, T., Adv Polym Sci,, 109, 1 (1993)Google Scholar
2. Pedley, D.G., Skelly, P.J., and Tighe, B.J., “Hydrogels in Biomedical Applications”. Br. Polym. J., 12, 99., 16, 230 (1991).Google Scholar
3. Khare, A. R., Peppas, N.A., Polymer NewsGoogle Scholar
4. Parejo, C., Gallardo, A., Román, J. San, J. Rev Plast Modern, 75, 96, (1998)Google Scholar
5. Peppas, N.A., Bioact. Compat Polym., 6, 241, (1991).Google Scholar
6. Pinzón, N., Espinosa, A., Katime, I., Revista Iberoamericana de Polímeros. 2002, 3, 38.Google Scholar
7. Amashta, I.A. Katime, Katime, T., Katime, D. (2004). Los materiales inteligentes de este milenio: Los hidrogeles macromoleculares. Síntesis, propiedades y aplicaciones., Servicio Editorial de la Universidad del País Vasco. 126–127.Google Scholar
8. Sáez, V., Hernáez, E., San, L., Rev. Iberoamer. Polímeros. 2002, 3, 1.Google Scholar
9. Valderruten, N., Nuevos Materiales Polímeros: Hidrogeles termosensibles y su Aplicación en la Liberación de Fármacos. Leioa. 2001. Tesis Doctoral. Universidad del País Vasco. Facultad de Ciencias. Departamento de Química Física.Google Scholar
10. Guerrero, C.F. Castro (2009). Tesis de Doctorado “Sintesís y caracterización de nanogeles y microgeles a partir de derivados de celulosa y poliacrilatos”. Instituto Tecnológico de Ciudad Google Scholar
11. Kenawy, E.R., Sherrington, D.C., Akelah, A. (1962). “Controlled released of agrochemical molecules chemically bond to polymers”. Eur. Polym. J., 28 (8), pp. 841–862.Google Scholar
12. Risbud, M., Hardikar, A., Bhat, S., Bhonde, R., “pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery”. J. of Controlled Release 68, 23–30 (2000).Google Scholar
13. Perez, N. A. Purata (2008). Tesis de Maestría “Estudio de liberación de un fármaco en un hidrogel de PAA/CMC”. Instituto Tecnológico de Ciudad Madero.Google Scholar