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Examination of micro-superficial lesions of up to 5 mm in size in the pharyngolaryngeal region

Published online by Cambridge University Press:  02 August 2022

T Ueda Open the ORCID record for T Ueda [Opens in a new window] ,
K Yumii ,
Y Urabe ,
N Chikuie ,
M Takumida ,
T Taruya ,
T Kono ,
T Hamamoto ,
M Hattori  and
S Oka
...Show all authors
T Ueda*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
K Yumii
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Y Urabe
Affiliation:
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan
N Chikuie
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
M Takumida
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
T Taruya
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
T Kono
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
T Hamamoto
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
M Hattori
Affiliation:
Center for Medical Education Institute of Biomedical & Health Sciences, Hiroshima University, Japan
S Oka
Affiliation:
Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Japan
S Tanaka
Affiliation:
Department of Endoscopy, Hiroshima University Hospital, Japan
T Ishino
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
S Takeno
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
*
Author for correspondence: Dr T Ueda, Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan E-mail: uedatsu@hiroshima-u.ac.jp
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Abstract

Objective

For low-grade intraepithelial neoplasia cases, pharyngolaryngeal lesions equal to or less than 5 mm in size do not generally progress to invasive carcinoma. However, micro-superficial lesions equal to or less than 5 mm that showed rapid growth have been recently encountered. This study aimed to identify the characteristics of preferential progression of lesions equal to or less than 5 mm in size.

Method

Gross findings, endoscopic findings and pathological results of 55 lesions measuring equal to or less than 5 mm in diameter were retrospectively reviewed to identify factors that distinguish squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions.

Results

The overall sensitivity, specificity, accuracy, and positive and negative predictive value of background colouration and intrapapillary capillary loop pattern in differentiation of squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions were all 100 per cent.

Conclusion

Diagnosis based on background colouration and the intrapapillary capillary loop pattern on narrow-band imaging facilitates the pathological examination of lesions measuring equal to or less than 5 mm.

Keywords

Pharyngeal NeoplasmsEarly Detection Of CancerHead And Neck NeoplasmsNarrow Band Imaging
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 7 , July 2023 , pp. 749 - 756
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr T Ueda takes responsibility for the integrity of the content of the paper

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