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Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study

Published online by Cambridge University Press:  22 August 2014

M. A. Clynes ,
C. Parsons ,
M. H. Edwards ,
K. A. Jameson ,
N. C. Harvey ,
A. Aihie Sayer ,
C. Cooper  and
E. M. Dennison
M. A. Clynes*
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
C. Parsons
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
M. H. Edwards
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
K. A. Jameson
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
N. C. Harvey
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
A. Aihie Sayer
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
C. Cooper
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
E. M. Dennison
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
*
*Address for Correspondence: Dr M. A. Clynes, Southampton General Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK.(Email mclynes@doctors.org.uk)
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Abstract

Investigators have suggested a link between birth weight and both hand and lumbar spine osteoarthritis (OA). In this study, we sought to extend these observations by investigating relationships between growth in early life, and clinical and radiological diagnoses of OA at the hand, knee and hip, among participants from the Hertfordshire Cohort Study. Data were available for 222 men and 222 women. Clinical OA was defined based on American College of Rheumatology criteria. Radiographs were taken of the knees and hips, and graded for the presence of osteophytes and overall Kellgren and Lawrence (KL) score. Lower weight at year one was associated with higher rates of clinical hand OA (OR 1.396, 95% CI 1.05, 1.85, P=0.021). Individuals with lower birth weights were more likely to have hip osteophytes (OR 1.512, 95% CI 1.14, 2.00, P=0.004) and this remained robust after adjustment for confounders. Furthermore, a low weight at one year was also associated with a higher osteophyte number in the lateral compartment of the knee, after adjustment for confounders (OR 1.388, 95% CI 1.01, 1.91, P=0.043). We have found further evidence of a relationship between early life factors and adult OA. These findings accord with previous studies.

Keywords

birth weightboneosteoarthritisprogramming
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 5 , Issue 6 , December 2014 , pp. 453 - 458
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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References

1. Felson, DT, Naimark, A, Anderson, J, et al. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987; 30, 914–918.Google Scholar
2. Lawrence, RC, Felson, DT, Helmick, CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008; 58, 26–35.Google Scholar
3. Lord, J, Victor, C, Littlejohns, P, Ross, FM, Axford, JS. Economic evaluation of a primary care-based education programme for patients with osteoarthritis of the knee. Health Technol Assess. 1999; 3, 1–55.Google Scholar
4. Litwic, A, Edwards, MH, Dennison, EM, Cooper, C. Epidemiology and burden of osteoarthritis. Br Med Bull. 2013; 105, 185–199.CrossRefGoogle ScholarPubMed
5. Hutton, CW. Osteoarthritis: the cause not result of joint failure? Ann Rheum Dis. 1989; 48, 958–961.Google Scholar
6. Jordan, KM, Syddall, H, Dennison, EM, Cooper, C, Arden, NK. Birth weight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritis. J Rheumatol. 2005; 32, 678–683.Google Scholar
7. Sayer, AA, Poole, J, Cox, V, et al. Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis. Arthritis Rheum. 2003; 48, 1030–1033.Google Scholar
8. Syddall, HE, Sayer, AA, Simmonds, SJ, et al. Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study. Am J Epidemiol. 2005; 161, 1074–1080.Google Scholar
9. Barker, DJ, Winter, PD, Osmond, C, Margetts, B, Simmonds, SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989; 2, 577–580.Google Scholar
10. Altman, RD. Classification of disease: osteoarthritis. Semin Arthritis Rheum. 1991; 20, 40–47.CrossRefGoogle ScholarPubMed
11. Bellamy, N, Campbell, J, Haraoui, B, et al. Clinimetric properties of the AUSCAN Osteoarthritis Hand Index: an evaluation of reliability, validity and responsiveness. Osteoarthritis Cartilage. 2002; 10, 863–869.Google Scholar
12. Van der Pas, S, Castell, MV, Cooper, C, et al. European project on osteoarthritis: design of a six-cohort study on the personal and societal burden of osteoarthritis in an older European population. BMC Musculoskelet Disord. 2013; 14, 138.Google Scholar
13. Bellamy, N. WOMAC: a 20-year experiential review of a patient-centered self-reported health status questionnaire. J Rheumatol. 2002; 29, 2473–2476.Google Scholar
14. Altman, R, Asch, E, Bloch, D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986; 29, 1039–1049.Google Scholar
15. Kellgren, JH, Lawrence, JS. Radiological assessment of osteoarthritis. Ann Rheum Dis. 1957; 16, 494–501.CrossRefGoogle Scholar
16. Oliver, H, Jameson, KA, Sayer, AA, Cooper, C, Dennison, EM. Growth in early life predicts bone strength in late adulthood: the Hertfordshire Cohort Study. Bone. 2007; 41, 400–405.Google Scholar
17. Egger, P, Duggleby, S, Hobbs, R, Fall, C, Cooper, C. Cigarette smoking and bone mineral density in the elderly. J Epidemiol Community Health. 1996; 50, 47–50.Google Scholar
18. Lucas, A. Role of nutritional programming in determining adult morbidity. Arch Dis Child. 1994; 71, 288–290.Google Scholar
19. Uitterlinden, AG, Burger, H, van Duijn, CM, et al. Adjacent genes, for COL2A1 and the vitamin D receptor, are associated with separate features of radiographic osteoarthritis of the knee. Arthritis Rheum. 2000; 43, 1456–1464.Google Scholar
20. Uitterlinden, AG, Burger, H, Huang, Q, et al. Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee. J Clin Invest. 1997; 100, 259–263.Google Scholar
21. Burger, H, van Daele, PL, Odding, E, et al. Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The Rotterdam Study. Arthritis Rheum. 1996; 39, 81–86.CrossRefGoogle ScholarPubMed
22. Hart, DJ, Mootoosamy, I, Doyle, DV, Spector, TD. The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study. Ann Rheum Dis. 1994; 53, 158–162.Google Scholar
23. Lethbridge-Cejku, M, Tobin, JD, Scott, WW Jr., et al. Axial and hip bone mineral density and radiographic changes of osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 1996; 23, 1943–1947.Google ScholarPubMed
24. Nevitt, MC, Lane, NE, Scott, JC, et al. Radiographic osteoarthritis of the hip and bone mineral density. The Study of Osteoporotic Fractures Research Group. Arthritis Rheum. 1995; 38, 907–916.Google Scholar
25. Im, GI, Kim, MK. The relationship between osteoarthritis and osteoporosis. J Bone Miner Metab. 2014; 32, 101–109.CrossRefGoogle ScholarPubMed
26. Cooper, C, Cawley, M, Bhalla, A, et al. Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res. 1995; 10, 940–947.Google Scholar
27. Cooper, C, Fall, C, Egger, P, et al. Growth in infancy and bone mass in later life. Ann Rheum Dis. 1997; 56, 17–21.Google Scholar
28. Yarbrough, DE, Barrett-Connor, E, Morton, DJ. Birth weight as a predictor of adult bone mass in postmenopausal women: the Rancho Bernardo Study. Osteoporos Int. 2000; 11, 626–630.Google Scholar
29. Zhang, Y, Hannan, MT, Chaisson, CE, et al. Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol. 2000; 27, 1032–1037.Google Scholar