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Cannabis use and outcome of recent onset psychosis

Published online by Cambridge University Press:  16 April 2020

Anton Grech ,
Jim Van Os ,
Peter B. Jones ,
Shon W. Lewis  and
Robin M. Murray
Anton Grech*
Affiliation:
Department of Psychiatry, Mount Carmel Hospital, Malta
Jim Van Os
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, London, UK Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands
Peter B. Jones
Affiliation:
Department of Psychiatry, University of Cambridge, UK
Shon W. Lewis
Affiliation:
Department of Psychiatry, University of Manchester, UK
Robin M. Murray
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, London, UK
*
*Corresponding author. Department of Psychiatry, Mount Carmel Hospital, Attard, Malta. Tel.: +356-21-415183.E-mail address: antongrech@waldonet.net.mt (A. Grech).
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Abstract

Purpose

To test the hypothesis that recent onset psychotic patients who use cannabis will have psychotic symptoms that are more severe and more persistent than those who do not use cannabis.

Subjects and methods

We carried out a 4-year follow-up study of a cohort of 119 patients with recent onset of psychosis. The patients were divided into four groups according to duration of cannabis use, taking index admission and follow-up as reference points.

Results

Those subjects who persisted in the use of cannabis had more positive (but not negative) symptoms and a more continuous illness at follow-up.

Limitations

The main limitations of the study were: the relatively small sample size, and that the excess of male subjects and the presence of cannabis induced psychosis could have a confusing impact on the interpretation of the results.

Conclusion

It is possible that psychotic patients who use cannabis are at a greater risk of a more continuous illness with more positive symptoms than those who do not.

Keywords

CannabisPsychosisOutcome
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 4 , June 2005 , pp. 349 - 353
Copyright
Copyright © Elsevier SAS 2005

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