Hostname: page-component-745bb68f8f-grxwn Total loading time: 0 Render date: 2025-01-11T03:11:14.335Z Has data issue: false hasContentIssue false
  • English
  • Français

Purified high-dose anthocyanoside oligomer administration improves nocturnal vision and clinical symptoms in myopia subjects

Published online by Cambridge University Press:  08 March 2007

Jonghyun Lee ,
Hyung K. Lee ,
Chan Y. Kim ,
Young J. Hong ,
Chul M. Choe ,
Tae W. You  and
Gong J. Seong
Jonghyun Lee
Affiliation:
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Hyung K. Lee
Affiliation:
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Chan Y. Kim
Affiliation:
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Young J. Hong
Affiliation:
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Chul M. Choe
Affiliation:
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Tae W. You
Affiliation:
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Gong J. Seong*
Affiliation:
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
*
*Corresponding author: Dr Gong Je Seong, fax +82 2 3463 1049, email ydeye@yumc.yonsei.ac.kr
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The aim of the present study was to determine the effect of purified high-dose anthocyanoside oligomer administration on nocturnal visual function and clinical symptoms in low-to-moderate myopia subjects. The study was a randomized, double-blind, placebo-controlled trial and involved sixty subjects with asthenopia and refractive errors between −1·00 and −8·00 diopters in both eyes. Thirty subjects were administered a purified high-dose anthocyanoside oligomer (100 mg tablet comprising 85 % anthocyanoside oligomer), and thirty were given a placebo in tablet form twice daily for 4 weeks. Prior to the treatment, the placebo and anthocyanoside groups were similar in terms of age and contrast sensitivity. Before and after treatment, subjects completed a questionnaire to determine their clinical symptoms and were also assessed for nocturnal visual function using contrast sensitivity testing. Questionnaire data analysis showed that, following treatment, twenty-two (73·3 %) anthocyanoside subjects showed improved symptoms, whereas only one placebo subject showed an improvement (Fisher's exact test, P<0·0001). Contrast sensitivity levels according to each cycle per degree significantly improved in the anthocyanoside group and remained stable in the placebo group. The mean contrast sensitivity change in the anthocyanoside group was 2·41 (SD) 1·91, compared with −0·66 (SD) 2·66 dB for the placebo group (unpaired Student's t test, P<0·0001). At all cycle per degree levels, contrast sensitivity changes in the anthocyanoside group were better than in the placebo group (unpaired Student's t test, P<0·05). The present data show that the administration of anthocyanoside oligomer appears to improve subjective symptoms and objective contrast sensitivity in myopia subjects with asthenopia.

Keywords

Anthocyanoside oligomerMesopic contrast sensitivityAsthenopiaMyopia
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 6 , June 2005 , pp. 895 - 899
Copyright
Copyright © The Nutrition Society 2005

References

Barrette, EP (1999) Bilberry fruit extract for night vision. Altern Med AlertTM 2, 20–21.Google Scholar
Belleoud, L, Leluan, D & Boyer, Y (1967) Etudes des effects des glaucosides d'anthocyan sur la vision nocturne du personnel navigant. Rev Med Aeronaut Spat 6, 5–10.Google Scholar
Bravetti, G (1989) Preventive medical treatment of senile cataract with vitamin E and anthocyanosides: clinical evaluation. Ann Ottalmol Clin Ocul 115, 109.Google Scholar
Caselli, L (1985) Clinical and electroretinographic study on activity of anthocyanosides. Arch Med Int (Parma) 37, 29–35.Google Scholar
Cunio, L (1993) Vaccinium myrtillus. Aust J Med Herbalism 5, 81–85.Google Scholar
Fiorini, G, Biancacci, A & Graziano, FM (1965) Perimetric and adaptometric modifications after ingestion of myrtillin associated with β-carotene. Ann Ottalmol Clin Ocul 91, 371–386.Google Scholar
Jayle, GE & Aubert, L (1964) Action des glucosides d'anthocyanes sur la vision scotopique et mesopique du sujet normal. Therapie 19, 171–185.Google Scholar
Jayle, GE, Aubry, M, Gavini, H, Braccini, G & De la Baume, C (1965) Study concerning the action of anthocyanoside extracts of Vaccinium myrtillus on night vision. Ann Ocul (Paris) 198, 556–562.Google ScholarPubMed
Kuyk, T & Elliott, JL (1999) Visual factors and mobility in persons with age-related macular degeneration. J Rehabil Res Dev 36, 303–312.Google ScholarPubMed
Kuyk, T, Elliott, JL & Fuhr, PS (1998) Visual correlates of mobility in real world settings in old adults with low vision. Optom Vis Sci 75, 538–547.CrossRefGoogle Scholar
Lachenmayr, B, Berger, J, Buser, A & Keller, O (1998) Reduced visual capacity increases the risk of accidents in street traffic. Ophthalmologe 95, 44–50.CrossRefGoogle ScholarPubMed
Lee, HK, Koh, IH, Choe, CM, Kim, CY, Hong, YJ & Seong, GJ (2003) Reproducibility of morphoscopic contrast sensitivity testing with the Visual Capacity Analyzer. J Cataract Refract Surg 29, 1776–1779.CrossRefGoogle ScholarPubMed
Levy, Y & Glovinsky, Y (1998) The effect of anthocyanosides on night vision. Eye 12, 967–969.CrossRefGoogle ScholarPubMed
Liou, SW & Chiu, CJ (2001) Myopia and contrast sensitivity function. Curr Eye Res 22, 81–84.CrossRefGoogle ScholarPubMed
Mayser, HM & Wilhelm, H (2001) Effects of anthocyanosides on contrast vision [abstract]. Invest Ophthalmol Vis Sci 42, Suppl.63.Google Scholar
Morazzoni, P & Bombardelli, E (1996) Vaccinium myrtillus L. Fitoterapia 67, 3–29.Google Scholar
Muth, ER, Laurent, JM & Jasper, P (2000) The effect of bilberry nutritional supplement on night visual acuity and night contrast sensitivity. Altern Med Rev 5, 164–173.Google Scholar
Neumann, L (1971) Therapeutische Versuche mit Anthozyanosiden bei Langzeitbehandlungen in der Augenheilkunde. Klin Monatsbl Augenheilkd 158, 592–597.Google Scholar
Oen, FT, Lim, TH & Chung, MP (1994) Contrast sensitivity in a large adult population. Ann Acad Med Singapore 23, 322–326.Google Scholar
Ogden, TE (1994) Visual acuity and contrast sensitivity Retina 2nd ed. 149Ryan SJ: St. Louis Mosby.Google Scholar
Owsley, C & Sloane, ME (1987) Contrast sensitivity, acuity, and the perception of "real-world" targets. Br J Ophthalmol 71, 791–796.CrossRefGoogle ScholarPubMed
Pizzorno, J Jr & Murray, M, editors (1993) A Textbook of Natural Medicine, vol. 1, Seattle, WA: Bastyr University Publications.Google Scholar
Politzer, M (1977) Experiences in the medical treatment of progressive myopia. Klin Monatsbl Augenheilkd 171, 616–619.Google ScholarPubMed
Ponte, F & Lauricella, M (1969) Effect of Vaccinium myrtillus total extract on the recovery in the dark of the human electroretinogram. Atti VII Simposio ISCERG, Istanbul 355–366.Google Scholar
Puell, MC, Palomo, C, Sanchez-Ramos, C & Villena, C (2004) Normal values for photopic and mesopic letter contrast sensitivity. J Refract Surg 20, 484–488.CrossRefGoogle ScholarPubMed
Rouher, F, Sole, P, Offret, G & Bernard, JA (1972) Demonstration by adaptoelectroretinography of the action of a cyanidin on nocturnal vision. Arch Ophtalmol Rev Gen Ophtalmol 32, 531–540.Google ScholarPubMed
Scharrer, A & Ober, M (1981) Anthocyanosides in the treatment of retinopathies. Klin Monatsbl Augenheilkd 178, 368–389.Google ScholarPubMed
Sevin, R & Cuendet, JF (1966) Effets d'une association d'anthocyanosides de myrtille et de β-carotene sur la resistance capillaire des diabetiques. Ophthalmologica 152, 109–117.CrossRefGoogle Scholar
Sole, P, Rigal, D & Peyresblanques, J (1984) Effets du chlorure de cyaninosides et de Heleniene sur la vision mesopique et scotopique dans la myopie et ihemeralopie. J Fr Ophtalmol 7, 35–39.Google Scholar
Timberlake, C & Henry, B (1988) Anthocyanins as natural food colorants. In Plant Flavonoids in Biology and Medicine. II: Biochemical, Cellular, and Medicinal Properties, pp. 107–121 [Cody, V, Middleton, E Jr, Harborne, JB and Beretz, A, editors]. New York: Alan R Liss.Google Scholar
Zadok, D, Levy, Y & Glovinsky, Y (1999) The effect of anthocyanosides in a multiple oral dose on night vision. Eye 13, 734–736.CrossRefGoogle Scholar
Zavarise, G (1968) Effect of prolonged treatment with anthocyanosides on light sensitivity. Ann Ottalmol Clin Ocul 94, 209–214.Google ScholarPubMed