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175 results in Pathology and Laboratory Science

Page 1 of 9

Immunohistochemistry and Ancillary Studies in Diagnostic Dermatopathology
  • 2nd edition
  • Edited by Mai P. Hoang
  • Coming soon
  • Expected online publication date:
    June 2025
    Print publication:
    30 June 2025
  • Immunohistochemistry and ancillary studies play a crucial role in diagnostic pathology. Yet, few books cover their practicality in diagnostic dermatopathology. This book provides a practical guide to the application of rapid and cost-effective immunohistochemistry, as well as ancillary studies including immunofluorescence and molecular studies. With a focus on practicality and bridging knowledge gaps, the book covers helpful diagnostic stains and pertinent ancillary studies, organized by lines of differentiation. Each chapter includes a synopsis of antibodies, immunohistochemical panels, summary tables outlining staining patterns, and case studies. Now in its second edition, this book covers entities based on lineage, including epithelial, adnexal, melanocytic, lymphoid, and soft tissue, and discusses the role of molecular studies in the diagnosis of cutaneous neoplasms and soft tissue lesions. This comprehensive volume is an essential resource for pathologists, dermatopathologists, and residents in pathology and dermatology.

Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies
  • 2nd edition
  • Edited by Anna Porwit, Marie Christine Béné
  • Published online:
    30 January 2025
    Print publication:
    20 February 2025
  • Master the implementation of flow cytometry techniques in diagnosing complex hematologic diseases and malignancies in patients with this comprehensive and practical guide. Featuring updated recommendations on pre-analytical steps, instrument settings and panel construction, this manual offers invaluable support for those diagnosing, treating and researching hematologic malignancies. Written by leading experts in the field, this book puts flow cytometry into everyday context. Through engaging with differential diagnoses, the manual offers an accurate description of specific features of malignancies and mimicking conditions. It also places flow cytometry in the scope of integrated diagnosis according to WHO and ICC classifications. Fully updated throughout, this second edition provides new literature and concepts, and presents new AI-based analytical methods. Richly illustrated and in full colour, this book is an ideal resource for those working in flow cytometry laboratories.

Neuromuscular Disease
  • A Case-Based Approach
  • 2nd edition
  • Jessica E. Hoogendijk, Marianne de Visser, Pieter A. van Doorn, Erik H. Niks
  • Published online:
    29 November 2024
    Print publication:
    19 December 2024
  • There are over 800 neuromuscular disorders and this can leave clinicians feeling lost as they try to diagnose and manage patients. On the basis of 66 adult and paediatric neuromuscular case vignettes, readers will be walked through using case histories and clinical manifestations as a starting point for diagnosis. For each case, diagnostic tools, disease pathogenesis, prognosis and treatment options are discussed. Symptoms, signs and syndromes are cross-linked to help the reader navigate the array of disorders. Accompanying tables explain differential diagnoses and 30 videos demonstrate clinical features. This second edition has been thoroughly updated as the neuromuscular subspecialty has developed from clinically and pathologically descriptive to making use of new diagnostic technologies and therapies. Neurologists at all levels, paediatricians, internists, geneticists, rehabilitation physicians, physiotherapists and researchers in the field will find this an invaluable guide, as they seek to familiarise themselves with this complex range of disorders.

Clinical and Diagnostic Virology
  • 2nd edition
  • Tim Wreghitt, Goura Kudesia
  • Published online:
    11 April 2024
    Print publication:
    18 April 2024
  • Since the first edition was published in 2009, there have been significant advances in diagnostics and management of viral infections, as well as newly discovered viruses such as SARS-CoV-2 and Zika virus. This new edition provides up-to-date information on the key developments in clinical and diagnostic virology, especially molecular diagnosis, with guidance on new molecular and bedside tests. Effective antiviral treatments and novel combinations of treatments recently introduced are covered in depth. Infection control precautions and pandemic preparedness are discussed, with a focus on recent outbreaks. As with the first edition, coverage is succinct and practical with easily accessible information in algorithms and tables, and standardised chapter layouts organised from A to Z. This is an ideal introduction to complex topics for healthcare trainees, as well as a handy and easily accessible reference for more experienced hospital clinicians and primary care physicians.

Pediatric Pathology of Hematopoietic and Histiocytic Disorders
  • Edited by Xiayuan Liang, Bradford Siegele, Jennifer Picarsic
  • Published online:
    25 January 2024
    Print publication:
    15 February 2024
  • The presentation of hematolymphoid and histiocytic diseases can vary widely between children and adults as can age-related differential diagnoses and the consequences of treatment. Providing up to date information and classification for diseases across the hematopoietic, lymphoid and histiocytic systems, the book also covers morphologic, immunophenotypic, cytogenetic, and molecular genetic features of routine and diagnostically challenging disorders in pediatric patients. Over 200 high-quality colour illustrations aid accurate diagnosis and correct interpretations when evaluating peripheral blood, bone marrow, lymph nodes and other tissues specimens. This comprehensive yet practical guide also discusses useful ancillary tests and introduces newly recognised entities identified in the current literature, such as GATA-2 haploinsufficiency, B-ALL with DUX4-IGH and ERG deletion, and ALK-positive histiocytosis. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.

Atlas of Pediatric Hematopathology
  • Edited by Silvia Tse Bunting, Xiayuan Liang, Michele E. Paessler, Satheesh Chonat
  • Published online:
    25 November 2023
    Print publication:
    13 July 2023
  • Illustrated with over 800 colour images, this practical guide covers the unique morphology and disease spectrum in pediatric patients, ranging from normal physiologic changes to pathologic states. In addition, it covers newly described pediatric diseases, such as GATA-2 haploinsufficiency and reflects the latest WHO classification for hematolymphoid neoplasms. With the visual format of an atlas, the book provides a quick reference for trainees and physicians in hematopathology, as well as for hematologists and oncologists treating pediatric patients. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.

Pediatric Nephropathology & Childhood Kidney Tumors
  • Edited by Helen Liapis
  • Published online:
    10 August 2023
    Print publication:
    09 March 2023
  • The presentation of kidney diseases can vary widely between children and adults as can age-related differential diagnoses and the consequences of treatment. This comprehensive and practical guide to pediatric nephropathology covers a range of conditions and diseases, including abnormal kidney development, glomerular diseases, vascular diseases and transplant pathology. Special emphasis is placed on integrating mechanisms of disease to pathology and therapeutic options. The book also includes ancillary testing such as genetics, as these are fast becoming the gold standard for a number of paediatric kidney diseases. Over a hundred high-quality colour images are included, fully annotated to display the key features of the diseases discussed. Summaries of key points and knowledge gaps condense vital information for an accessible read by busy clinicians and trainees. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.

Shaken Baby Syndrome
  • Investigating the Abusive Head Trauma Controversy
  • Edited by Keith A. Findley, Cyrille Rossant, Kana Sasakura, Leila Schneps, Waney Squier, Knut Wester
  • Published online:
    07 June 2023
    Print publication:
    08 June 2023
  • Since the early 2000s, a growing body of scientific studies in neuropathology, neurology, neurosurgery, biomechanics, statistics, criminology and psychology has cast doubt on the forensic reliability of medical determinations of Shaken Baby Syndrome (SBS), more recently termed Abusive Head Trauma (AHT). Studies have increasingly documented that accidental short falls and a wide range of medical conditions, can cause the same symptoms and findings associated with this syndrome. Nevertheless, inaccurate diagnoses, unrealistic confidence expression, and wrongful convictions continue to this day. Bringing together contributions from a multidisciplinary expert panel of 32 professionals across 8 countries in 16 different specialties, this landmark book tackles the highly controversial topic of SBS, which lies at the intersection of medicine, science, and law. With comprehensive coverage across multiple disciplines, it explains the scientific evidence challenging SBS and advances efforts to evaluate how deaths and serious brain injuries in infants should be analysed and investigated.

Manual of Embryo Selection in Human Assisted Reproduction
  • Edited by Catherine Racowsky, Jacques Cohen, Nicholas Macklon
  • Published online:
    26 April 2023
    Print publication:
    26 January 2023
  • Selecting the best embryo to transfer to the uterus is key to successful in vitro fertilization (IVF). A huge amount of research has been devoted to this topic and there are numerous methods used, from simple morphological assessment to molecular biological techniques to assess the genome and metabolism of the newly fertilized embryo. For many of these techniques, an adequate evidence base is lacking, and expert opinion is valuable. Clinical imperatives require ranking all embryos in a cohort according to their viability, thereby enabling the selection of the best embryo to optimize live birth outcome: a key indicator used to measure and rate IVF Clinics worldwide. This clear and informative manual will provide embryologists and clinicians with an overview of the tools now available to assist in embryo selection, as well as evidence for their efficacy and safety and the broader considerations that must underlie these important clinical decisions.

Rockefeller Money, the Laboratory and Medicine in Edinburgh 1919-1930
  • New Science in an Old Country
  • Christopher Lawrence
  • Published by:
    Boydell & Brewer
    Published online:
    17 March 2023
    Print publication:
    24 August 2005
  • This book examines the Rockefeller Foundation's attempts to introduce the laboratory sciences, particularly biochemistry, into the Edinburgh medical world of the 1920s.

Manual of Oocyte Retrieval and Preparation in Human Assisted Reproduction
  • Edited by Rachel Cutting, Mostafa Metwally
  • Published online:
    09 November 2022
    Print publication:
    13 October 2022
  • Obtaining good quality oocytes and preparing them for in-vitro fertilization (IVF) is a key stage in assisted reproduction. This is a complex process with many pitfalls, making good clinical preparation and laboratory technique essential for success. Illustrated throughout, this book will be valuable to clinical embryologists, laboratory personnel wishing to redefine or develop technique and improve outcomes, IVF quality managers, and gynecologists performing oocyte retrieval. Featuring descriptions of the underlying science along with practical advice on methods and trouble-shooting, this comprehensive manual will aid all those involved in this complex process of oocyte retrieval and preparation in navigating towards optimal outcomes.

Leong's Manual of Diagnostic Biomarkers for Immunohistology
  • 4th edition
  • Edited by Runjan Chetty, Kumarasen Cooper, Carol Cheung, Srinivas Mandavilli
  • Published online:
    03 July 2022
    Print publication:
    21 July 2022
  • With the interest in biomarkers available for diagnostic, therapeutic, prognostic and research applications growing rapidly, it is now expected that every pathologist should be aware of the correct application of immunohistochemistry in daily practice. This fully updated fourth edition provides practical guidance about preparation, key uses and pitfalls of antibodies for immunohistology in a unique A-Z format. Seventeen full colour infographics present detail about specific biomarkers, including FOXL2, GATA3 and SOX10, pulling out information about expression in tissues and prognosis. Expanded with new biomarkers and the removal of biomarkers that are no longer in common use, each entry in this concise new edition follows a standard structure for quick and easy access by busy readers.

Immunohistochemistry
  • A Technical Guide to Current Practices
  • Edited by Trung Nguyen
  • Published online:
    16 June 2022
    Print publication:
    07 July 2022
  • This book will enable practitioners to understand the many complex intricacies of immunohistochemistry (IHC) and make best use of this powerful analytical tool. Providing a thorough grounding in the fundamentals of immunohistochemistry, the book includes several chapters on robotics and automation technology, giving key information on the design of machines and tips to maximise workflow efficiencies. The relationship between IHC and molecular pathology is explained clearly, demonstrating the increasing impact on personalized medicine and targeted therapies for cancer patients. The staining protocol is deconstructed, allowing the reader to adapt it for a variety of diagnostic and research applications. Written by experts at the forefront of hospital immunohistochemistry, there is a strong emphasis on practical guidance on a range of techniques as well as troubleshooting of common problems driven by the authors' experiences. Extensively illustrated with high-quality colour images, this is an invaluable resource to all pathology practitioners utilising the technique.

Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
  • With Other Advanced Micromanipulation Techniques to Edit the Genetic and Cytoplasmic Content of the Oocyte
  • Edited by Gianpiero D. Palermo, Zsolt Peter Nagy
  • Published online:
    02 December 2021
    Print publication:
    25 November 2021
  • For around half of the couples who have trouble conceiving the cause of infertility is sperm-related. Intracytoplasmic sperm injection (ICSI) is the most common and successful treatment for male infertility. Here, the pioneers for the technique, along with authorities in the field, describe the underlying science of ICSI and other micromanipulation techniques. Practical advice for performing the techniques is covered in depth, including sperm selection, laser-assisted ICSI, and the use of piezo in ICSI. Examining the safety of ICSI in animal models as well as the impact of ICSI on the health and well-being of the children conceived through the procedure is discussed. This manual is an essential resource for clinical embryologists and laboratory personnel wishing to refine or develop techniques and improve outcomes.

Perinatal Neuropathology
  • Mirna Lechpammer, Marc Del Bigio, Rebecca Folkerth
  • Published online:
    07 August 2021
    Print publication:
    16 September 2021
  • There is an increasing demand for high-standard fetal and infant neuropathology examinations. Novel imaging techniques, development of new diagnostic methods and advances in genetics have stimulated the interest in gaining additional knowledge on developmental, perinatal and neonatal neuropathology. Approaching the subject from a practical standpoint, diagnostic templates for reports are provided in this essential guide to aid clinicians with different areas of expertise. Each chapter will includes numerous high-quality images, accompanied by explanatory legends from the authors' own experiences. Covering autopsy and tissue processing techniques, the authors discuss a range of disorders such as neural tube defects, brain tumours, storage disorders and many others. This book provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover. Compiling the latest advances in fetal and infant diagnostics and care, this book is a highly valuable educational resource.

Manual of Embryo Culture in Human Assisted Reproduction
  • Edited by Kersti Lundin, Aisling Ahlström
  • Published online:
    15 April 2021
    Print publication:
    06 May 2021
  • Whilst assisted reproduction techniques (ART) have become increasingly successful and largely standardized, there is still only a partial understanding of what constitutes a 'true' embryo environment. Replicating the varying physiological conditions of the in-vivo environment that the embryo travels through in the in-vitro culture is still a major challenge in ART. This practical volume details how to organize and operate an IVF laboratory in order to mimic these conditions for successful embryo culture. Environments and equipment that are essential for running safe and efficient facilities such as maintaining good air quality and hygiene protocols, and utilizing an effective layout are covered in detail. Other chapters discuss the different consumables needed, optimal handling techniques and parameter monitoring systems, as well as recent advances in the area including artificial intelligence and automation. This is an indispensable guide to understanding the background science of culturing embryos, crucial to successful outcomes in ART.

Manual of Sperm Retrieval and Preparation in Human Assisted Reproduction
  • Edited by Ashok Agarwal, Ahmad Majzoub, Sandro C. Esteves
  • Published online:
    09 April 2021
    Print publication:
    10 June 2021
  • Obtaining good quality sperm for in-vitro fertilization, ICSI, or for cryopreservation can be a major problem if a man suffers from medical conditions that preclude normal collection. Major advances in sperm retrieval and preparation techniques have been witnessed in recent years, allowing a better understanding of the contribution of the sperm to a couple's fertility. This Manual is a complete guide to sperm retrieval methods performed for men with azoospermia. Covering all the basic and advanced steps for implementation of these procedures, the Manual includes descriptions of the underlying science along with detailed, practical advice on methods, including tips for optimizing outcomes and trouble-shooting, using an evidence-based approach. This will be an invaluable resource for andrologists, urologists, embryologists, male fertility specialists, gynecologists, and other healthcare workers practising reproductive medicine. It is particularly valuable for reproductive laboratory personnel wishing to refine or develop technique and improve outcomes, and for IVF Quality Managers.

Manual of Sperm Function Testing in Human Assisted Reproduction
  • Edited by Ashok Agarwal, Ralf Henkel, Ahmad Majzoub
  • Published online:
    05 April 2021
    Print publication:
    15 April 2021
  • Selecting good-quality sperm for use in in-vitro fertilization is a key step in assisted reproduction. For many years purely morphological attributes have been used to assess suitability, but increasingly biochemical and molecular biological techniques are now identifying sperm with the best chances of producing viable and healthy embryos. Focusing on modern sperm function testing, this manual provides technical details of commonly used tests and gives an overview of the laboratory techniques used to evaluate sperm samples. Covering a variety of testing methods in detail, from manual and computer-assisted semen analysis to zona pellucida binding assays, and tests assessing sperm DNA damage such as the TUNEL assay. Describing the underlying science, practical advice for performing the tests is given, including tips for optimizing outcomes and trouble-shooting. This is an essential guide for reproductive medicine specialists, clinical andrologists, urologists and gynecologists working with sub-fertile men.

A Textbook of Clinical Embryology
  • Edited by Eliezer Girsh
  • Published online:
    05 March 2021
    Print publication:
    06 May 2021
  • Personnel working in assisted reproductive technology often lack the opportunities for dedicated training in the specialized techniques and technologies required for the procedures. As such, success in the form of live birth rates can range from over 50% to less than 10% per treatment cycle. This comprehensive introductory textbook is an essential resource for trainee embryologists, medical students and nurses. The recent revolutions in biotechnology and molecular biology involved in delivering assisted reproductive services are thoroughly discussed. Basic knowledge such as the development and physiology of both male and female reproductive systems is covered, with practical aspects of IVF including gamete and embryo manipulation, cryopreservation and genetic testing explained in detail. A full description of the optimal structure and management of the IVF laboratory is given, helping ensure procedures are safe and effective. Extensive and highly detailed colour illustrations bring the content to life and aids readers in their understanding.

Differential Diagnosis in Cytopathology
  • 3rd edition
  • Edited by Ji-Weon Park, Paolo Gattuso, Vijaya B. Reddy, Shahla Masood
  • Published online:
    05 March 2021
    Print publication:
    06 May 2021
  • This fully updated edition incorporates the newest classification systems, such as the Bethesda System for reporting thyroid cytopathology; the Paris System for reporting urinary cytology, and the Milan System for reporting salivary gland cytopathology. Over 1,000 high-quality color photos illustrate the key diagnostic cytological features described. Succinct bullet points condense vital information, making the text more accessible for busy clinicians. The full spectrum of infection, inflammatory, benign and malignant processes throughout the body are presented in detail, including chapters on cervical, breast, and central nervous system diagnostic criteria. Key information pearls and differential diagnosis indicators give insight from experts in the field. Not limited to light microscopic findings, many other genetic, molecular, and immunologic diagnostic modalities are covered in this essential and comprehensive resource. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.

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