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23 results in Pharmacology

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Surviving Prescribing
  • A Practical Guide
  • 2nd edition
  • Edited by Hugh Montgomery, Robert Shulman, Mayur Murali
  • Published online:
    08 June 2020
    Print publication:
    25 June 2020
  • Safe and effective prescribing is one of the pillars of medical practice but is much more complicated than it seems. Many new prescribers find prescribing extremely challenging, and a plethora of independent, multidisciplinary prescribers are also seeking guidance. However, pharmacology textbooks are rarely practical. They warn to 'take care when prescribing erythromycin to a patient on warfarin, as the INR may rise'. But what should the prescriber actually do? Surviving Prescribing fulfils an important need by offering practical advice for real-world prescribing problems. The book complements existing educational resources but adds a new perspective. Written by experienced contributors from a variety of professional backgrounds, the content speaks directly to the problems routinely seen in hospital prescribing. And all in one, pocket-sized volume. Whether revising for the national Prescribing Safety Assessment, preparing for starting on the wards, or looking for a quick reference guide, this book is an essential companion.

Managing Discovery in the Life Sciences
  • Harnessing Creativity to Drive Biomedical Innovation
  • Philip A. Rea, Mark V. Pauly, Lawton R. Burns
  • Published online:
    19 January 2018
    Print publication:
    01 February 2018
  • In this book, distinguished scholars Philip A. Rea, Mark V. Pauly, and Lawton R. Burns explore the science and management behind marketable biomedical innovations. They look at how the science actually played out through the interplay of personalities, the cultures within and between academic and corporate entities, and the significance of serendipity not as a mysterious phenomenon but one intrinsic to the successes and failures of the experimental approach. With newly aggregated data and case studies, they consider the fundamental economic underpinnings of investor-driven discovery management, not as an obstacle or deficiency as its critics would contend or as something beyond reproach as some of its proponents might claim, but as the only means by which scientists and managers can navigate the unknowable to discover new products and decide how to sell them so as to maximize the likelihood of establishing a sustainable pipeline for still more marketable biomedical innovations.

Pharmacologia
  • Or, The History of Medicinal Substances
  • John Ayrton Paris
  • Published online:
    05 February 2015
    Print publication:
    18 December 2014
  • The physician and author John Ayrton Paris (1785–1856), several of whose other medical and popular works have been reissued in the Cambridge Library Collection, published the first edition of this book in 1812. It was immediately successful, and went into eight further editions until 1843: this reissue is of the 1820 third edition. Many volumes on materia medica existed at the time, and Paris claims in his preface that he is not disparaging these competitor works, but that they presume too much prior knowledge on the part of the reader. His own work is designed to inform the student of the properties and effects of each medicinal substance, and how they function, both alone and in combinations. This will lead to greater understanding of the efficacy of medicines, and also help to prevent their adulteration. The qualities of each ingredient are discussed, and formulae and doses provided.

The Elements of Materia Medica and Therapeutics
  • Volume 2, Part 1
  • Jonathan Pereira
  • Published online:
    05 November 2014
    Print publication:
    23 January 2014
  • After training as an apothecary and surgeon, Jonathan Pereira (1804–53) taught materia medica for many years. His lectures at the medical school in London's Aldersgate Street were highly successful and formed the basis for the first edition of his major encyclopaedic work on medicinal substances. A pioneering text in the field of pharmacology, Pereira's work, which he subsequently updated in further editions, provided pharmacists and medical professionals with a more rigorous scientific understanding of the drugs and remedies they prescribed. After Pereira's death, medical jurist Alfred Swaine Taylor (1806–80) and physician George Owen Rees (1813–89) prepared this revised and expanded fourth edition, interspersed with instructive woodcuts. Volume 2 is divided into two parts. Part 1 (1855) continues with articles on special pharmacology, moving on from inorganic compounds to discuss the medicinal properties of organic compounds.

The Elements of Materia Medica and Therapeutics
  • Volume 1
  • Jonathan Pereira
  • Published online:
    05 November 2014
    Print publication:
    23 January 2014
  • After training as an apothecary and surgeon, Jonathan Pereira (1804–53) taught materia medica for many years. His lectures at the medical school in London's Aldersgate Street were highly successful and formed the basis for the first edition of his major encyclopaedic work on medicinal substances. A pioneering text in the field of pharmacology, Pereira's work, which he subsequently updated in further editions, provided pharmacists and medical professionals with a more rigorous scientific understanding of the drugs and remedies they prescribed. After Pereira's death, medical jurist Alfred Swaine Taylor (1806–80) and physician George Owen Rees (1813–89) prepared this revised and expanded fourth edition, interspersed with instructive woodcuts. Volume 1 (1854) includes discussion of 'physical remedies' such as heat, cold and electricity, and 'hygienic remedies' of diet, exercise and climate. It then focuses on general pharmacological practice and specific drugs, describing the medicinal properties of inorganic compounds.

A Treatise of the Scurvy, in Three Parts
  • Containing an Inquiry into the Nature, Causes, and Cure, of that Disease
  • James Lind
  • Published online:
    05 November 2014
    Print publication:
    17 April 2014
  • Born in Edinburgh, with family connections to the local medical profession, James Lind (1716–94) went on to spend nine years at sea as a surgeon for the Royal Navy. His service made him familiar with one of the most common and debilitating ailments of the eighteenth century. Scurvy posed a particular problem for Britain, an island nation seeking to assert itself overseas through its navy. The symptoms of the disease had been recognised for centuries, but the causes remained elusive. First published in 1753, Lind's treatise explores the topic thoroughly, weighing the evidence and presenting a theory of the disease's aetiology, suggesting methods of prevention and treatment, and also discussing previous work on the subject, including ancient texts. Lind provided the groundwork for later investigations, his research lending support to the later practice of including the juice of citrus fruit in a sailor's diet, even though vitamin deficiency was not yet understood.

The Elements of Materia Medica and Therapeutics
  • Volume 2, Part 2
  • Jonathan Pereira
  • Published online:
    05 November 2014
    Print publication:
    23 January 2014
  • After training as an apothecary and surgeon, Jonathan Pereira (1804–53) taught materia medica for many years. His lectures at the medical school in London's Aldersgate Street were highly successful and formed the basis for the first edition of his major encyclopaedic work on medicinal substances. A pioneering text in the field of pharmacology, Pereira's work, which he subsequently updated in further editions, provided pharmacists and medical professionals with a more rigorous scientific understanding of the drugs and remedies they prescribed. After Pereira's death, medical jurist Alfred Swaine Taylor (1806–80) and physician George Owen Rees (1813–89) prepared this revised and expanded fourth edition, interspersed with instructive woodcuts. Volume 2 is divided into two parts. Part 2 (1857) contains new articles, additional illustrations and a separate index. It concludes the analysis of organic compounds, both vegetable and animal.

Historical Sketch of the Progress of Pharmacy in Great Britain
  • Jacob Bell, Theophilus Redwood
  • Published online:
    05 October 2014
    Print publication:
    13 February 2014
  • The pharmacist Jacob Bell (1810–59) spent much of his career working to raise the standards and reputation of his profession. A founder in 1841 of the Pharmaceutical Society of Great Britain, he sought to improve scientific education for practitioners as well as protect the profession through legislation. Although he served briefly in Parliament, Bell exerted his greatest influence through editing the Pharmaceutical Journal. An extended piece that he produced for the journal in 1842 forms the first part of the present work. He traces the development of pharmaceutical practice and legislation from the sixteenth century to the birth of the Pharmaceutical Society. At the behest of the society's council, Theophilus Redwood (1806–92) continued the narrative after Bell's death, concluding with the 1868 Pharmacy Act. Published in 1880, the book provides a thorough account of the gradual establishment of British pharmacy as a separate and respected profession.

Regenerative Pharmacology
  • Edited by George J. Christ, Karl-Erik Andersson
  • Published online:
    05 April 2013
    Print publication:
    15 April 2013
  • Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.

Magic Molecules
  • How Drugs Work
  • Susan Aldridge
  • Published online:
    05 August 2012
    Print publication:
    28 September 1998
  • All of us are drug users, in the broadest sense of the word. Drugs can be medicines, they can be used for pleasure, and they can also be used to protect our long-term health. It is important that we are well informed about the drugs we use - how they work, their benefits and their risks. This book is a unique guide for the general science reader to the drugs of everyday life - from the main types of medicine through to recreational drugs and food supplements. It looks at how drugs interact with their targets in the body, where they come from, how they are developed and what drugs to expect in the future. All the major pharmaceutical medicines are reviewed - painkillers, antibiotics, anti-cancer drugs, anti depressants, heart drugs, tranquillizers and hormones. However this book is much more than a consumer handbook - it also conveys the fascinating science of drug discovery in an easily accessible way.

The Cambridge Handbook of Situated Cognition
  • Edited by Philip Robbins, Murat Aydede
  • Published online:
    05 June 2012
    Print publication:
    03 November 2008
  • Since its inception some fifty years ago, cognitive science has seen a number of sea changes. Perhaps the best known is the development of connectionist models of cognition as an alternative to classical, symbol-based approaches. A more recent - and increasingly influential - trend is that of dynamical-systems-based, ecologically oriented models of the mind. Researchers suggest that a full understanding of the mind will require systematic study of the dynamics of interaction between mind, body, and world. Some argue that this new orientation calls for a revolutionary new metaphysics of mind, according to which mental states and processes, and even persons, literally extend into the environment. This book is a guide to this movement in cognitive science. Each chapter tackles either a specific area of empirical research or specific sector of the conceptual foundation underlying this research.

Principles of Pharmacogenetics and Pharmacogenomics
  • Edited by Russ B. Altman, David Flockhart, David B. Goldstein
  • Published online:
    05 June 2012
    Print publication:
    23 January 2012
  • The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.

International Handbook of Intelligence
  • Edited by Robert J. Sternberg
  • Published online:
    05 June 2012
    Print publication:
    02 February 2004
  • This book is the first international handbook of intelligence ever published. It is intended to prove a truly international perspective on the nature of intelligence. It covers intelligence theory, research, and practice from all over the globe. Areas covered include Great Britain, Australia, French-speaking countries, German-speaking countries, Spanish-speaking countries, India, Japan, Israel, Turkey, and China. Each author is an internationally recognized expert in the field of intelligence. Authors represent not just their own viewpoint, but rather, the full variety of viewpoints indigenous to the area about which they write. Each chapter deals with, for its area, definitions and theories of intelligence, history of research, current research, assessment techniques, and comparison across geographical areas. An integrative final chapter synthesizes the diverse international viewpoints.

Formal Approaches in Categorization
  • Edited by Emmanuel M. Pothos, Andy J. Wills
  • Published online:
    05 June 2012
    Print publication:
    27 January 2011
  • The process of constructing concepts underpins our capacity to encode information in an efficient and competent manner and also, ultimately, our ability to think in terms of abstract ideas such as justice, love and happiness. But what are the mechanisms which correspond to psychological categorization processes? This book unites many prominent approaches in modelling categorization. Each chapter focuses on a particular formal approach to categorization, presented by the proponent(s) or advocate(s) of that approach, and the authors consider the relation of this approach to other models and the ultimate objectives in their research programmes. The volume evaluates progress that has been made in the field and where it goes from here. This is an essential companion to any scientist interested in the formal description of categorization and, more generally, in formal approaches to cognition. It will be the definitive guide to formal approaches in categorization research for years to come.

Philosophy in a New Century
  • Selected Essays
  • John R. Searle
  • Published online:
    05 June 2012
    Print publication:
    04 December 2008
  • John R. Searle has made profoundly influential contributions to three areas of philosophy: philosophy of mind, philosophy of language, and philosophy of society. This volume gathers together in accessible form a selection of his essays in these areas. They range widely across social ontology, where Searle presents concise and informative statements of positions developed in more detail elsewhere; artificial intelligence and cognitive science, where Searle assesses the current state of the debate and develops his most recent thoughts; and philosophy of language, where Searle connects ideas from various strands of his work in order to develop original answers to fundamental questions. There are also explorations of the limitations of phenomenological inquiry, the mind-body problem, and the nature and future of philosophy. This rich collection from one of America's leading contemporary philosophers will be valuable for all who are interested in these central philosophical questions.

G Protein-Coupled Receptors
  • Structure, Signaling, and Physiology
  • Edited by Sandra Siehler, Graeme Milligan
  • Published online:
    05 June 2012
    Print publication:
    30 September 2010
  • Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.

Lignans
  • Chemical, Biological and Clinical Properties
  • David C. Ayres, John D. Loike
  • Published online:
    05 February 2012
    Print publication:
    30 November 1990
  • Lignans are widely occurring plant compounds and are closely related to lignin, which forms the woody component of trees and other plants. The lignans are characterized by their dimeric composition from cinnamic acids, and they are attracting increasing attention as a result of their pharmacological properties. The volume surveys the chemical, biological and clinical properties of lignans as well as providing information on their isolation, purification, identification and chemical synthesis. The volume also explores fully the potential use of these compounds as antiviral and antitumour agents, and thus provides a wide-ranging survey of their pharmacology and chemistry. The text is fully documented and referenced and provides the only up-to-date compilation on this subject. The volume is suitable for research scientists in the fields of organic chemistry, biochemistry, oncology, pharmacology, toxicology and botany.

Essentials of Pharmaceutical Sales Management
  • Vivek Mehrotra
  • Published by:
    Foundation Books
    Published online:
    26 October 2011
    Print publication:
    04 May 2007
  • • What is my role as a Pharmaceutical Field Manager?• How do I keep my MRs motivated?• How do I plan and provide on-the-job training?• How do I keep the customers happy?• How do I achieve my target?Are these some of the questions that worry you while working in an extremely competitive pharmaceutical market? Essentials of Pharmaceutical Sales Management attempts to answer these and many more related questions.Key topics discussed:• Joint fieldwork and on-the-job training• Management of key/difficult customers• Performance appraisal and counselling• Organising successful meetings and symposia• Interfacing with marketing department

Small Molecule Therapy for Genetic Disease
  • Edited by Jess G. Thoene
  • Published online:
    17 November 2010
    Print publication:
    23 August 2010
  • Thoene summarises the substantial work that has been accomplished in the treatment of inborn errors of metabolism with simple molecules. This handbook will enable interested clinician scientists to rapidly survey the field, thus ascertaining what has been done as well as future directions for therapeutic research. Its important introductory chapters discuss the infrastructure of the field. The book closely analyses the cofactors used to augment the function of defective enzymes and the compounds that are able to utilise an alternative pathway in order to avoid the consequences of the metabolic block present in the patient. Among other therapies, the authors discuss the use of zinc and tetrathiomolybdate to treat Wilson's disease and the use of cysteamine to treat nephropathic cystinosis.

Drug Design
  • Structure- and Ligand-Based Approaches
  • Edited by Kenneth M. Merz, Jr, Dagmar Ringe, Charles H. Reynolds
  • Published online:
    06 July 2010
    Print publication:
    31 May 2010
  • Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, linear-scaling quantum calculations, QSAR, pharmacophore methods, computational ADME-Tox, and drug discovery case studies. A variety of authors from academic and commercial institutions all over the world have contributed to this book, which is illustrated with more than 200 images. This is the only book to cover the subject of structure and ligand-based drug design, and it provides the most up-to-date information on a wide range of topics for the practising computational chemist, medicinal chemist, or structural biologist. Professor Kenneth Merz has been selected as the recipient of the 2010 ACS Award for Computers in Chemical & Pharmaceutical Research that recognizes the advances he has made in the use of quantum mechanics to solve biological and drug discovery problems.

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