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78 results in Molecular biology, biochemistry, and structural biology

Page 1 of 4

Physicochemical Mechanics
  • With Applications in Physics, Chemistry, Membranology and Biology
  • Nikolai Kocherginsky
  • Published online:
    30 November 2023
    Print publication:
    14 December 2023
  • Physicochemical mechanics is a self-contained theoretical framework that can be used to study and model physicochemical processes, based on well-known concepts taken from classical mechanics. This intuitive approach exploits the principles of Newtonian mechanics alongside Einstein's theory of Brownian motion in order to accurately describe complex biochemical systems, and can be used to model a broad range of phenomena including thermodiffusion, transmembrane transport and protein folding. The book begins by presenting the basic principles of classical mechanics and thermodynamics, before introducing the two new postulates of physicochemical mechanics. It is shown that these foundational concepts can be applied to systematically describe all major mass transport and equilibrium equations, and many practical applications of the theory are discussed. This text will be of interest to advanced undergraduate and graduate students in biological physics, biochemistry and chemical engineering, and a useful resource for researchers seeking an introduction to this modern theoretical approach.

The History of the Brain and Mind Sciences
  • Technique, Technology, Therapy
  • Edited by Stephen T. Casper, Delia Gavrus
  • Published by:
    Boydell & Brewer
    Published online:
    26 May 2021
    Print publication:
    01 June 2017
  • How did epidemics, zoos, German exiles, methamphetamine, disgruntled technicians, modern bureaucracy, museums, and whipping cream shape the emergence of modern neuroscience?

Perfusion Cell Culture Processes for Biopharmaceuticals
  • Process Development, Design, and Scale-up
  • Moritz Wolf, Jean-Marc Bielser, Massimo Morbidelli
  • Published online:
    17 July 2020
    Print publication:
    06 August 2020
  • Master the design and operation of perfusion cell cultures with this authoritative reference. Discover the current state-of-the-art in the design and operation of continuous bioreactors, with emphasis on mammalian cell cultures for producing therapeutic proteins. Topics include the current market for recombinant therapeutic proteins, current industry challenges and the potential contribution of continuous manufacturing. Provides coverage of every step of process development and reactor operation, including small scale screening to lab-scale and scale-up to manufacturing scale. Illustrated through real-life case studies, this is a perfect resource for groups active in the cell culture field, as well as graduate students in areas such as chemical engineering, biotechnology, chemistry and biology, and to those in the pharmaceutical industry, particularly biopharma, biotechnology and food or agro industry.

Molecular Medicine for Clinicians
  • Edited by Barry Mendelow, Michèle Ramsay, Nanthakumarn Chetty, Wendy Stevens
  • Published by:
    Wits University Press
    Published online:
    04 June 2019
    Print publication:
    01 October 2008
  • The insights following the wake of the Human Genome project are radically influencing our understanding of the molecular basis of life, health and disease. The improved accuracy and precision of clinical diagnostics is also beginning to have an impact on therapeutics in a fundamental way. This book is suitable for undergraduate medical students, as part of their basic sciences training, but is also relevant to interested under and postgraduate science and engineering students. It serves as an introductory text for medical registrars in virtually all specialties, and is also of value to the General Practitioner wishing to keep up to date, especially in view of the growing, internet assisted public knowledge of the field. There is a special focus on the application of molecular medicine in Africa and in developing countries elsewhere.

Continuous Biopharmaceutical Processes
  • Chromatography, Bioconjugation, and Protein Stability
  • David Pfister, Lucrèce Nicoud, Massimo Morbidelli
  • Published online:
    22 September 2018
    Print publication:
    11 October 2018
  • This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.

Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology
  • 8th edition
  • Edited by Andreas Hofmann, Samuel Clokie
  • Published online:
    06 August 2018
    Print publication:
    19 April 2018
  • Bringing this best-selling textbook right up to date, the new edition uniquely integrates the theories and methods that drive the fields of biology, biotechnology and medicine, comprehensively covering both the techniques students will encounter in lab classes and those that underpin current key advances and discoveries. The contents have been updated to include both traditional and cutting-edge techniques most commonly used in current life science research. Emphasis is placed on understanding the theory behind the techniques, as well as analysis of the resulting data. New chapters cover proteomics, genomics, metabolomics, and bioinformatics, as well as data analysis and visualisation. Using accessible language to describe concepts and methods, and with a wealth of new in-text worked examples to challenge students' understanding, this textbook provides an essential guide to the key techniques used in current bioscience research.

The Physics of Cancer
  • Caterina A. M. La Porta, Stefano Zapperi
  • Published online:
    04 May 2017
    Print publication:
    20 April 2017
  • Recent years have witnessed an increasing number of theoretical and experimental contributions to cancer research from different fields of physics, from biomechanics and soft-condensed matter physics to the statistical mechanics of complex systems. Reviewing these contributions and providing a sophisticated overview of the topic, this is the first book devoted to the emerging interdisciplinary field of cancer physics. Systematically integrating approaches from physics and biology, it includes topics such as cancer initiation and progression, metastasis, angiogenesis, cancer stem cells, tumor immunology, cancer cell mechanics and migration. Biological hallmarks of cancer are presented in an intuitive yet comprehensive way, providing graduate-level students and researchers in physics with a thorough introduction to this important subject. The impact of the physical mechanisms of cancer are explained through analytical and computational models, making this an essential reference for cancer biologists interested in cutting-edge quantitative tools and approaches coming from physics.

Aaron Klug - A Long Way from Durban
  • A Biography
  • Kenneth C. Holmes
  • Published online:
    16 February 2017
    Print publication:
    09 February 2017
  • The atomic structures of macromolecules provide the key to understanding how life works. Aaron Klug led the way in the development of methods for solving such structures and is one of the pioneers of structural molecular biology. He was awarded a Nobel Prize in 1982 for his work. Illuminating both his personal life and scientific achievements, this unique biography begins with Klug's youth in Durban and his studies at Johannesburg, Cape Town and then Trinity College, Cambridge. Holmes proceeds to explore Klug's career from his work on the structure of viruses with Rosalind Franklin at Birkbeck College, London to his time as Director of the MRC Laboratory of Molecular Biology (LMB) in Cambridge and as President of the Royal Society. Drawing on their long-term collaboration, interviews and unique access to Klug's archives, Holmes provides a fascinating account of an innovative man and his place in the history of structural molecular biology.

Trace Elements in Plants
  • Walter Stiles
  • Published online:
    05 June 2016
    Print publication:
    10 October 2013
  • First published in 1961, as the third edition of a 1946 original, this book presents a comprehensive analysis of trace elements in plants, and the effects of their deficiency or excess on grazing animals where such effects arise directly from shortage or excess in the plants they eat. Illustrative figures and a comprehensive bibliography are also included. This book will be of value to anyone with an interest in trace elements and the historical development of biochemistry.

Fred Sanger - Double Nobel Laureate
  • A Biography
  • George G. Brownlee
  • Foreword by Edwin Southern
  • Published online:
    05 November 2014
    Print publication:
    06 November 2014
  • Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.

Methods of Molecular Analysis in the Life Sciences
  • Andreas Hofmann
  • With contributions by Anne Simon , Tanja Grkovic and Malcolm Jones
  • Published online:
    05 July 2014
    Print publication:
    19 June 2014
  • Delivering fundamental insights into the most popular methods of molecular analysis, this text is an invaluable resource for students and researchers. It encompasses an extensive range of spectroscopic and spectrometric techniques used for molecular analysis in the life sciences, especially in the elucidation of the structure and function of biological molecules. Covering the range of up-to-date methodologies from everyday mass spectrometry and centrifugation to the more probing X-ray crystallography and surface-sensitive techniques, the book is intended for undergraduates starting out in the laboratory and for more advanced postgraduates pursuing complex research goals. The comprehensive text provides strong emphasis on the background principles of each method, including equations where they are of integral importance to the individual techniques. With sections on all the major procedures for analysing biological molecules, this book will serve as a useful guide across a range of fields, from new drug discovery to forensics and environmental studies.

Fundamentals of Inflammation
  • Edited by Charles N. Serhan, Peter A. Ward, Derek W. Gilroy
  • With contributions by Samir S. Ayoub
  • Published online:
    05 April 2014
    Print publication:
    26 April 2010
  • The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Biogeography of Australasia
  • A Molecular Analysis
  • Michael Heads
  • Published online:
    05 December 2013
    Print publication:
    14 November 2013
  • Over the last decade, molecular studies carried out on the Australasian biota have revealed a new world of organic structure that exists from submicroscopic to continental scale. Furthermore, in studies of global biogeography and evolution, DNA sequencing has shown that many large groups, such as flowering plants, passerine birds and squamates, have their basal components in this area. Using examples ranging from kangaroos and platypuses to kiwis and birds of paradise, the book examines the patterns of distribution and evolution of Australasian biodiversity and explains them with reference to tectonic and climatic change in the region. The surprising results from molecular biogeography demonstrate that an understanding of evolution in Australasia is essential for understanding the development of modern life on Earth. A milestone in the literature on this subject, this book will be a valuable source of reference for students and researchers in biogeography, biodiversity, ecology and conservation.

Principles and Techniques of Biochemistry and Molecular Biology
  • 7th edition
  • Edited by Keith Wilson, John Walker
  • Published online:
    05 July 2013
    Print publication:
    04 March 2010
  • This best-selling undergraduate textbook provides an introduction to key experimental techniques from across the biosciences. It uniquely integrates the theories and practices that drive the fields of biology and medicine, comprehensively covering both the methods students will encounter in lab classes and those that underpin recent advances and discoveries. Its problem-solving approach continues with worked examples that set a challenge and then show students how the challenge is met. New to this edition are case studies, for example, that illustrate the relevance of the principles and techniques to the diagnosis and treatment of individual patients. Coverage is expanded to include a section on stem cells, chapters on immunochemical techniques and spectroscopy techniques, and additional chapters on drug discovery and development, and clinical biochemistry. Experimental design and the statistical analysis of data are emphasised throughout to ensure students are equipped to successfully plan their own experiments and examine the results obtained.

Introduction to Cancer Biology
  • Robin Hesketh
  • Published online:
    05 February 2013
    Print publication:
    13 December 2012
  • This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the functional effects of DNA damage are explained. Later chapters then build on this foundation to provide a comprehensive summary of the major signalling pathways that affect tumour development. Current therapeutic strategies are reviewed, along with a discussion of methods for tumour detection and biomarker identification. Finally, the impact of whole genome sequencing is discussed, bringing students up to date with key recent developments in the field. From basic principles to insights into cutting-edge research, this book will enable the reader to move into the cancer field with confidence.

The Zebrafish
  • Atlas of Macroscopic and Microscopic Anatomy
  • Joseph A. Holden, Lester L. Layfield, Jennifer L. Matthews
  • Published online:
    05 February 2013
    Print publication:
    21 January 2013
  • The zebrafish (Danio rerio) is a valuable and common model for researchers working in the fields of genetics, oncology and developmental sciences. This full-color atlas will aid experimental design and interpretation in these areas by providing a fundamental understanding of zebrafish anatomy. Over 150 photomicrographs are included and can be used for direct comparison with histological slides, allowing quick and accurate identification of the anatomic structures of interest. Hematoxylin and eosin stained longitudinal and transverse sections demonstrate gross anatomic relationships and illustrate the microscopic anatomy of major organs. Unlike much of the current literature, this book is focused exclusively on the zebrafish, eliminating the need for researchers to exclude structures that are only found in other fish.

Methods in Molecular Biophysics
  • Structure, Dynamics, Function
  • Igor N. Serdyuk, Nathan R. Zaccai, Joseph Zaccai
  • Published online:
    05 November 2012
    Print publication:
    29 March 2007
  • Our knowledge of biological macromolecules and their interactions is based on the application of physical methods, ranging from classical thermodynamics to recently developed techniques for the detection and manipulation of single molecules. These methods, which include mass spectrometry, hydrodynamics, microscopy, diffraction and crystallography, electron microscopy, molecular dynamics simulations, and nuclear magnetic resonance, are complementary; each has its specific advantages and limitations. Organised by method, this textbook provides descriptions and examples of applications for the key physical methods in modern biology. It is an invaluable resource for undergraduate and graduate students of molecular biophysics in science and medical schools, as well as research scientists looking for an introduction to techniques beyond their specialty. As appropriate for this interdisciplinary field, the book includes short asides to explain physics aspects to biologists and biology aspects to physicists.

The Neutral Theory of Molecular Evolution
  • Motoo Kimura
  • Published online:
    05 August 2012
    Print publication:
    27 October 1983
  • Motoo Kimura, as founder of the neutral theory, is uniquely placed to write this book. He first proposed the theory in 1968 to explain the unexpectedly high rate of evolutionary change and very large amount of intraspecific variability at the molecular level that had been uncovered by new techniques in molecular biology. The theory - which asserts that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants - has caused controversy ever since. This book is the first comprehensive treatment of this subject and the author synthesises a wealth of material - ranging from a historical perspective, through recent molecular discoveries, to sophisticated mathematical arguments - all presented in a most lucid manner.

Membrane Structural Biology
  • With Biochemical and Biophysical Foundations
  • Mary Luckey
  • Published online:
    05 June 2012
    Print publication:
    17 March 2008
  • Membrane Structural Biology brings together a physicochemical analysis of the membrane with the latest structural biology on membrane lipids and proteins to offer an exciting portrayal of biomembranes. Written with remarkable clarity, this text appears at a time when membranes have moved back into the scientific spotlight and will provide a unique foundation for advanced students and working scientists. The structure, function, and biogenesis of membrane lipids and proteins are examined, bioinformatics and computational approaches to membrane components are introduced, and the high-resolution structures that are giving new insights into the vital roles membranes play are discussed. The many correlations between membrane research and human health are discussed and key themes for future work in this area are identified. Membrane structural biology is poised to answer many basic and applied questions and this cutting-edge text will provide a solid grounding for all those working in this field.

Biological Thermodynamics
  • 2nd edition
  • Donald T. Haynie
  • Published online:
    05 June 2012
    Print publication:
    14 February 2008
  • This inter-disciplinary guide to the thermodynamics of living organisms has been thoroughly revised and updated to provide a uniquely integrated overview of the subject. Retaining its highly readable style, it will serve as an introduction to the study of energy transformation in the life sciences and particularly as an accessible means for biology, biochemistry and bioengineering undergraduate students to acquaint themselves with the physical dimension of their subject. The emphasis throughout the text is on understanding basic concepts and developing problem-solving skills. The mathematical difficulty increases gradually by chapter, but no calculus is required. Topics covered include energy and its transformation, the First Law of Thermodynamics, Gibbs free energy, statistical thermodynamics, binding equilibria and reaction kinetics. Each chapter comprises numerous illustrative examples taken from different areas of biochemistry, as well as a broad range of exercises and references for further study.

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