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13 results in Bioengineering

Introduction to Biomaterials

Molecular Communication
  • 2nd edition
  • Tadashi Nakano, Andrew Eckford, Tokuko Haraguchi
  • Published online:
    12 December 2024
    Print publication:
    19 December 2024
  • Fully revised and updated, this second edition is a comprehensive introduction to molecular communication including the theory, applications, and latest developments. Written with accessibility in mind, it requires little background knowledge, and carefully introduces the relevant aspects of biology and information theory, as well as practical systems. Capturing the significant changes and developments in the past decade, this edition includes seven new chapters covering: the architecture of molecular communication; modelling of biological molecular communication; mobile molecular communication; macroscale systems; design of components and bio-nanomachine formations. The authors present the biological foundations followed by analyses of biological systems in terms of communication theory, and go on to discuss the practical aspects of designing molecular communication systems such as drug delivery, lab-on-a-chip, and tissue engineering. Including case studies and experimental techniques, this remains a definitive guide to molecular communication for graduate students and researchers in electrical engineering, computer science, and molecular biology.

Quantum Chemistry Simulation of Biological Molecules
  • Eudenilson L. Albuquerque, Umberto L. Fulco, Ewerton W. S. Caetano, Valder N. Freire
  • Published online:
    21 January 2021
    Print publication:
    11 February 2021
  • Nano-biotechnology crosses the boundaries between physics, biochemistry and bioengineering, and has profound implications for the biomedical engineering industry. This book describes the quantum chemical simulation of a wide variety of molecular systems, with detailed analysis of their quantum chemical properties, individual molecular configurations, and cutting-edge biomedical applications. Topics covered include the basic properties of quantum chemistry and its conceptual foundations, the nanoelectronics and thermodynamics of DNA, the optoelectronic properties of the five DNA/RNA nucleobase anhydrous crystals, and key examples of molecular diode prototypes. A wide range of important applications are described, including protein binding of drugs such as cholesterol-lowering, anti-Parkinson and anti-migraine drugs, and recent developments in cancer biology are also discussed. This modern and comprehensive text is essential reading for graduate students and researchers in multidisciplinary areas of biological physics, chemical physics, chemical engineering, biochemistry and bioengineering.

Introduction to Biomaterials
  • Basic Theory with Engineering Applications
  • C. Mauli Agrawal, Joo L. Ong, Mark R. Appleford, Gopinath Mani
  • Published online:
    01 February 2019
    Print publication:
    07 November 2013
  • This succinct textbook gives students the perfect introduction to the world of biomaterials, linking the fundamental properties of metals, polymers, ceramics and natural biomaterials to the unique advantages and limitations surrounding their biomedical applications. Clinical concerns such as sterilization, surface modification, cell-biomaterial interactions, drug delivery systems and tissue engineering are discussed in detail, giving students practical insight into the real-world challenges associated with biomaterials engineering; key definitions, equations and concepts are concisely summarised alongside the text, allowing students to quickly and easily identify the most important information; and bringing together elements from across the book, the final chapter discusses modern commercial implants, challenging students to consider future industrial possibilities. Concise enough to be taught in a single semester, and requiring only a basic understanding of biology, this balanced and accessible textbook is the ideal introduction to biomaterials for students of engineering and materials science.

The Soft–Hard Tissue Junction
  • Structure, Mechanics and Function
  • Neil D. Broom, Ashvin Thambyah
  • Published online:
    13 November 2018
    Print publication:
    29 November 2018
  • Richly illustrated throughout with actual tissue images, this innovative book shows that the soft-hard tissue junction is best understood in a biomechanical context. The authors describe their pioneering experimental methods, providing an essential structure-function framework for computational modelling, and thereby encouraging the development of more realistic, predictive models of this important tissue junction. Covering the three main musculoskeletal junctions of cartilage-bone, disc-vertebra, and ligament/tendon-bone, the relevant soft tissues are examined with respect to both their own inherent structure and their mode of integration with the hard tissue. The soft-hard tissue interface is explored with a focus on structural damage resulting from overloading, and its associated pathologies. Adopting a multiscale approach, ranging in structural resolution from the macro to fibril levels, this is a must-have guide to the field and an ideal resource for researchers seeking new and creative approaches for studying the joint and spine tissues.

Cybernetic Modeling for Bioreaction Engineering
  • Doraiswami Ramkrishna, Hyun-Seob Song
  • Published online:
    29 September 2018
    Print publication:
    18 October 2018
  • Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.

Biomechanics
  • Concepts and Computation
  • 2nd edition
  • Cees Oomens, Marcel Brekelmans, Sandra Loerakker, Frank Baaijens
  • Published online:
    02 February 2018
    Print publication:
    08 February 2018
  • Thoroughly revised and updated for the second edition, this comprehensive textbook integrates basic and advanced concepts of mechanics with numerical methods and biomedical applications. Coverage is expanded to include a complete introduction to vector and tensor calculus, and new or fully updated chapters on biological materials and continuum mechanics, motion, deformation and rotation, and constitutive modelling of solids and fluids. Topics such as kinematics, equilibrium, and stresses and strains are also included, as well as the mechanical behaviour of fibres and the analysis of one-dimensional continuous elastic media. Numerical solution procedures based on the Finite Element Method are presented, with accompanying MATLAB-based software and dozens of new biomedical engineering examples and exercises allowing readers to practise and improve their skills. Solutions for instructors are also available online. This is the definitive guide for both undergraduate and graduate students taking courses in biomechanics.

Biological Thermodynamics
  • 2nd edition
  • Donald T. Haynie
  • Published online:
    05 June 2012
    Print publication:
    14 February 2008
  • This inter-disciplinary guide to the thermodynamics of living organisms has been thoroughly revised and updated to provide a uniquely integrated overview of the subject. Retaining its highly readable style, it will serve as an introduction to the study of energy transformation in the life sciences and particularly as an accessible means for biology, biochemistry and bioengineering undergraduate students to acquaint themselves with the physical dimension of their subject. The emphasis throughout the text is on understanding basic concepts and developing problem-solving skills. The mathematical difficulty increases gradually by chapter, but no calculus is required. Topics covered include energy and its transformation, the First Law of Thermodynamics, Gibbs free energy, statistical thermodynamics, binding equilibria and reaction kinetics. Each chapter comprises numerous illustrative examples taken from different areas of biochemistry, as well as a broad range of exercises and references for further study.

Introductory Biomechanics
  • From Cells to Organisms
  • C. Ross Ethier, Craig A. Simmons
  • Published online:
    05 June 2012
    Print publication:
    12 March 2007
  • Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.

Skeletal Function and Form
  • Mechanobiology of Skeletal Development, Aging, and Regeneration
  • Dennis R. Carter, Gary S. Beaupré
  • Published online:
    11 January 2010
    Print publication:
    18 December 2000
  • The intimate relationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. In the bones, cartilage, tendons, ligaments, and muscles of all vertebrates there is a graceful and efficient physical order. This book is about how function determines form. It addresses the role of mechanical factors in the development, adaptation, maintenance, ageing and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how the normal development of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age. They also show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence development and growth. Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for understanding, and will appeal to a wide audience of bioengineers, zoologists, anthropologists, palaeontologists and orthopaedists.

Microbial Biofilms
  • Edited by Hilary M. Lappin-Scott, J. William Costerton
  • Published online:
    24 November 2009
    Print publication:
    06 July 1995
  • The formation of microcolonies on surfaces is an important bacterial survival strategy. These biofilms occur on both inert and living systems, making them important to a wide range of scientific disciplines. This book first provides an analysis of the chemical, ecological and physical processes involved with the development of biofilms and their interactions with surfaces. The next section deals with biofilms on non-living surfaces. Biofilms have important engineering implications, such as in mining industries, the corrosion of pipelines and pure and waste water industries. Biofilms have medical significance when associated with the mouth, urinary tract and urinogenital tract. In addition, they form in plant root systems and in animals, such as the ruminant digestive tract, and so are agriculturally important. The final section examines these interactions with living surfaces.

Sulphate-Reducing Bacteria
  • Environmental and Engineered Systems
  • Edited by Larry L. Barton, W. Allan Hamilton
  • Published online:
    22 August 2009
    Print publication:
    31 May 2007
  • The sulphate-reducing bacteria (SRB) are a large group of anaerobic organisms that play an important role in many biogeochemical processes. Not only are they of early origins in the development of the biosphere, but their mechanisms of energy metabolism shed light on the limits of life processes in the absence of oxygen. They are widely distributed in nature, and are regular components of engineered systems including, for example, petroleum reservoirs and oil production facilities. SRB are currently subject to extensive genomic studies, which are yielding fresh understanding of their basic biochemical mechanisms, and aiding in the development of novel techniques for the analyses of their environmental roles. This volume provides a timely update on these important microorganisms, from basic science to applications, and will therefore serve as a valuable resource for researchers and graduate students in the fields of microbial ecology, microbial physiology, bioengineering, biogeochemistry and related areas of environmental science.

Pathway Analysis and Optimization in Metabolic Engineering
  • Néstor V. Torres, Eberhard O. Voit
  • Published online:
    28 July 2009
    Print publication:
    19 December 2002
  • Facility in the targeted manipulation of the genetic and metabolic composition of organisms, combined with unprecedented computational power, is forging a niche for a new subspecialty of biotechnology called metabolic engineering. First published in 2002, this book introduces researchers and advanced students in biology and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. The authors propose power-law models and methods of biochemical systems theory toward these ends. All concepts are derived from first principles, and the text is richly illustrated with numerous graphs and examples throughout. Special features include: nontechnical and technical introductions to models of biochemical systems; a review of basic methods of model design and analysis; concepts of optimization; and detailed case studies.