Principles of Pharmacogenetics and Pharmacogenomics

doi:10.1017/CBO9781139051194

The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Contributors
pp vii-x
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Introduction
pp xi-xii
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I - Critical Concepts
pp 1-2
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1 - Introduction to Population Diversity and Genetic Testing
pp 3-11
- By Michael D. Caldwell, Ingrid Glurich, Kimberly Pillsbury, James K. Burmester
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2 - Genotyping Technologies
pp 12-20
- By Cristi R. King, Sharon Marsh
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3 - Pharmacokinetics: Absorption, Distribution, Metabolism, Excretion Overview Chapter
pp 21-26
- By Terrence Blaschke
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4 - Overview: Adverse Drug Reactions
pp 27-37
- By Matthew R. Nelson
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5 - PharmGKB, a Centralized Resource for Pharmacogenomic Knowledge and Discovery
pp 38-54
- By Li Gong, Teri E Klein
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6 - DrugBank
pp 55-65
- By David S. Wishart
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7 - Ethical Considerations for Pharmacogenomics: Privacy and Confidentiality
pp 66-73
- By Sandra Soo-Jin Lee
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8 - Informed Consent in Pharmacogenomic Research and Treatment
pp 74-80
- By Mark A. Rothstein
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9 - Legal Trends Driving the Clinical Translation of Pharmacogenomics
pp 81-94
- By Barbara J. Evans
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II - Therapeutic Areas
pp 95-96
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10 - Oncologic Drugs
pp 97-114
- By Uchenna O. Njiaju, M. Eileen Dolan
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11 - Pharmacogenetics and Pharmacogenomics of Cardiovascular Disease
pp 115-124
- By Daniel Kurnik, C. Michael Stein
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12 - Statin-Induced Muscle Toxicity
pp 125-135
- By Russell A. Wilke, Melissa Antonik, Elenita I. Kanin, QiPing Feng, Ronald M. Krauss
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13 - Genomics of the Drug-Induced Long-QT Syndrome
pp 136-144
- By Dan M. Roden, Prince J. Kannankeril, Stefan Kääb, Dawood Darbar
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14 - Pharmacogenetics of Diabetes
pp 145-153
- By Mark C. H. de Groot, Olaf H. Klungel
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15 - Pharmacogenetics – Therapeutic Area – Respiratory
pp 154-174
- By Kelan Tantisira, Scott Weiss
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16 - Pharmacogenomics Associated with Therapy for Acid-Related Disorders
pp 175-187
- By Takahisa Furuta
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17 - Pharmacogenetics of Rheumatology: Focus on Rheumatoid Arthritis
pp 188-201
- By Robert M. Plenge, Yvonne C Lee, Soumya Raychaudhuri, Daniel H. Solomon
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18 - Pharmacogenetics of Obstetric Therapeutics
pp 202-216
- By David Haas, Jamie Renbarger
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19 - Pharmacogenomics of Psychiatric Drugs
pp 217-223
- By David Mrazek
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20 - Pain and Anesthesia
pp 224-237
- By Konrad Meissner, Evan D. Kharasch
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21 - HIV and Antiretroviral Therapy
pp 238-248
- By Amalio Telenti
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22 - Application of Pharmacogenetics and Pharmacogenomics in Pediatrics: What Makes Children Different?
pp 249-262
- By Jennifer A. Lowry, J. Steven Leeder
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23 - Fetal and Neonatal Pharmacogenomics
pp 263-269
- By Yair Blumenfeld
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