Contents

pp vii-viii

List of contributors

pp ix-xiv

Preface

pp xv-xvi

Acknowledgements

pp xvii-xviii

Abbreviations

pp xix-xxiv

I - The neurochemistry of the states of sleep and wakefulness

pp 1-2

1 - Neurochemistry of the preoptic hypothalamic hypnogenic mechanism

pp 3-22

2 - Neuroanatomical and neurochemical basis of wakefulness and REM sleep systems

pp 23-58

3 - Rapid eye movement sleep regulation by modulation of the noradrenergic system

pp 59-82

II - The influence of neurotransmitters on sleep and wakefulness

pp 83-84

4 - Gamma-aminobutyric acid and the regulation of paradoxical, or rapid eye movement, sleep

pp 85-108

5 - Acetylcholine modulates sleep and wakefulness: a synaptic perspective

pp 109-143

6 - Histamine in the control of sleep–wakefulness

pp 144-178

7 - Dopamine in behavioral state control

pp 179-223

8 - Glutamate neurotransmission and sleep

pp 224-243

9 - Serotonin and sleep–wake regulation

pp 244-280

III - Changing perspectives

pp 281-282

10 - Melatonin and its receptors: biological function in circadian sleep–wake regulation

pp 283-314

11 - Sleep regulatory factors

pp 315-336

12 - Adenosine and sleep–wake regulation

pp 337-362

13 - Prostaglandins and the regulation of sleep and wakefulness

pp 363-386

14 - Neuropeptides and sleep–wake regulation

pp 387-401

15 - Orexins in sleep and wakefulness: rodent models of narcolepsy–cataplexy

pp 402-432

16 - The relevance of experimental pharmacology to currently available sleep–wake therapeutics

pp 433-461

Index

pp 462-482

Plate section