Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies

doi:10.1017/CBO9780511635700

A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.

'… an excellent book for understanding where the field stands today regarding sex hormones for the treatment of brain aging and dementia.'

Source: Doody's

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Contents

Hormones, Cognition and Dementia - Half title page
pp i-ii
State of the Art and Emergent Therapeutic Strategies
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Hormones, Cognition and Dementia - Title page
pp iii-iii
State of the Art and Emergent Therapeutic Strategies
- By Eef Hogervorst, Victor W. Henderson, Robert B. Gibbs, Roberta Diaz Brinton
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Copyright page
pp iv-iv
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Contents
pp v-vi
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Contributors
pp vii-x
- By Farook Al-Azzawi, Wita Angrianni, Sanjay Asthana, Stephan Bandelow, Kathryn J. Bryan, Cynthia M. Carlsson, Jenna C. Carroll, Gemma Casadesus, Monique M. Cherrier, Laura H. Coker, María M. Corrada, Vita Priantina Dewi, Roberta Diaz Brinton, Mark A. Espeland, Mirjam I. Geerlings, Robert B. Gibbs, Carey E. Gleason, Victor W. Henderson, Patricia E. Hogan, Eef Hogervorst, Claudia H. Kawas, Anna Khaylis, Philip Kreager, Linda Kushandy, Donald Lehmann, Jin Li, Mary E. McAsey, Pauline M. Maki, Ralph N. Martins, Scott D. Moffat, Majon Muller, Theresia Ninuk, Annlia Paganini-Hill, George Perry, Christian J. Pike, Bevin N. Powers, Tri Budi W. Rahardjo, Natalie L. Rasgon, Susan M. Resnick, Emily R. Rosario, Sabarinah, Tony Sadjimim, Barbara B. Sherwin, Sally A. Shumaker, Mark A. Smith, Robert G. Struble, Chris Talbot, Wulf H. Utian, Giuseppe Verdile, Robert B. Wallace, Whitney Wharton, Katherine E. Williams, Oliver T. Wolf, Tonita E. Wroolie, Amina Yesufu, Yudarini, Liqin Zhao
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Preface
pp xi-xii
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Section 1 - Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
pp 1-64
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Chapter 1 - Women's Health Initiative Memory Study (WHIMS) program: emerging findings
pp 1-10
- By Mark A. Espeland, Sally A. Shumaker, Patricia E. Hogan, Susan M. Resnick
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Chapter 2 - Identifying risk factors for cognitive change in the Women's Health Initiative: a neural networks approach
pp 11-24
- By Stephan Bandelow, Mark A. Espeland, Victor W. Henderson, Susan M. Resnick, Robert B. Wallace, Laura H. Coker, Eef Hogervorst
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Chapter 3 - Estrogen therapy – relationship to longevity and prevalent dementia in the oldest-old: the Leisure World Cohort Study and the 90+ Study
pp 25-31
- By Claudia H. Kawas, María M. Corrada, Annlia Paganini-Hill
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Chapter 4 - The critical window hypothesis: hormone exposures and cognitive outcomes after menopause
pp 32-44
- By Victor W. Henderson
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Chapter 5 - Animal studies that support estrogen effects on cognitive performance and the cholinergic basis of the critical period hypothesis
pp 45-54
- By Robert B. Gibbs
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Chapter 6 - The healthy cell bias of estrogen action through regulating glucose metabolism and mitochondrial function: implications for prevention of Alzheimer's disease
pp 55-64
- By Roberta Diaz Brinton
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Section 2 - Varieties of estrogenic therapy
pp 65-100
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Chapter 7 - Alternative estrogenic treatment regimens and the Kronos Early Estrogen Prevention Study – Cognitive and Affective substudy (KEEPS-CA)
pp 65-79
- By Carey E. Gleason, Whitney Wharton, Cynthia M. Carlsson, Sanjay Asthana
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Chapter 8 - The use of transdermal 17β-estradiol in the treatment of Alzheimer's disease
pp 80-86
- By Whitney Wharton, Sanjay Asthana, Carey E. Gleason
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Chapter 9 - Alternative modes of treatment: pulsatile estradiol treatment
pp 87-92
- By Jin Li, Farook Al-Azzawi
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Chapter 10 - In search of estrogen alternatives for the brain
pp 93-100
- By Liqin Zhao, Roberta Diaz Brinton
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Section 3 - Potential modulators and modifiers of estrogenic effects
pp 101-142
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Chapter 11 - Progesterone regulation of neuroprotective estrogen actions
pp 101-109
- By Christian J. Pike, Jenna C. Carroll
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Chapter 12 - Clinical data of estrogen's effects in the central nervous system: estrogen and mood
pp 110-120
- By Bevin N. Powers, Katherine E. Williams, Tonita E. Wroolie, Anna Khaylis, Natalie L. Rasgon
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Chapter 13 - Different forms of soy processing may determine the positive or negative impact on cognitive function of Indonesian elderly
pp 121-132
- By Eef Hogervorst, Linda Kushandy, Wita Angrianni, Yudarini, Sabarinah, Theresia Ninuk, Vita Priantina Dewi, Amina Yesufu, Tony Sadjimim, Philip Kreager, Tri Budi W. Rahardjo
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Chapter 14 - Hypothalamus-pituitary-adrenal axis activity in aging women: its impact on the brain and the potential influence of estradiol
pp 133-142
- By Oliver T. Wolf
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Section 4 - Possible genetic factors related to hormone treatment effects
pp 143-178
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Chapter 15 - Possible genetic polymorphisms related to sex steroid metabolism and dementia in women
pp 143-152
- By Eef Hogervorst, Stephan Bandelow, Chris Talbot
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Chapter 16 - Genetics related to sex steroids: implications for Alzheimer's disease
pp 153-161
- By Chris Talbot
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Chapter 17 - Apolipoprotein E, hormone therapy, and neuroprotection
pp 162-170
- By Robert G. Struble, Mary E. McAsey
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Chapter 18 - Testosterone, gonadotropins, and genetic polymorphisms in men with Alzheimer's disease
pp 171-178
- By Eef Hogervorst, Stephan Bandelow, Donald Lehmann
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Section 5 - Testosterone, estradiol and men, and sex hormone binding globulin
pp 179-250
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Chapter 19 - Androgens and cognitive functioning in women
pp 179-186
- By Barbara B. Sherwin
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Hormones, Cognition and Dementia

State of the Art and Emergent Therapeutic Strategies

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