Chemical Genomics

doi:10.1017/CBO9781139021500

Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.

'Author Haian Fu has effectively assembled his textbook, Chemical Genomics, in a manner that is easy to comprehend and builds a basic understanding of chemical genomics.'

Danielle Gerhard Source: Yale Journal of Biology and Medicine

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Contributors
pp vii-x
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Preface
pp xi-xii
- By Haian Fu
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Section one - Overviews
pp 1-2
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Chapter 1 - Harnessing the Power of Chemistry for Biology and Medicine
pp 3-9
- By Cheryl L. Meyerkord, Haian Fu
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Chapter 2 - Exploring Biology with Small Organic Molecules
pp 10-25
- By Nicholas Aberle, Craig M. Crews
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Chapter 3 - Chemical Proteomics: A Global Study of Protein–Small Molecule Interactions
pp 26-36
- By Akihisa Matsuyama, Yoko Yashiroda, Minoru Yoshida
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Section two - Molecules for Chemical Genomics
pp 37-38
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Chapter 4 - Diversity-Oriented Synthesis
pp 39-59
- By Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O’Connell, David R. Spring
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Chapter 5 - Targeted Chemical Libraries
pp 60-73
- By Gregory P. Tochtrop, Ryan E. Looper
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Chapter 6 - Fragment-Based Ligand Discovery
pp 74-86
- By Sandra Bartoli, Antonella Squarcia, Daniela Fattori
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Chapter 7 - Basics and Principles for Building Natural Product–based Libraries for HTS
pp 87-98
- By Ronald J. Quinn
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Section Three - Basics of High-Throughput Screening
pp 99-100
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Chapter 8 - Essentials for High-Throughput Screening Operations
pp 101-107
- By Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday, Caroline E. Shamu
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Chapter 9 - High-Content Analysis and Screening: Basics, Instrumentation, and Applications
pp 108-120
- By Paul A. Johnston
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Chapter 10 - Phenotypic Screens with Model Organisms
pp 121-136
- By Grant N. Wheeler, Robert A. Field, Matthew L. Tomlinson
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Chapter 11 - Screening Informatics and Cheminformatics
pp 137-156
- By Melinda I. Sosa, Clinton Maddox, Iestyn Lewis, Cheryl L. Meyerkord, Pahk Thepchatri
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Section Four - Chemical Genomics Assays and Screens
pp 157-158
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Chapter 12 - Basics of HTS Assay Design and Optimization
pp 159-172
- By Eduard A. Sergienko
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Chapter 13 - Molecular Sensors for Transcriptional and Post-Transcriptional Assays
pp 173-197
- By Douglas S. Auld, Natasha Thorne
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Chapter 14 - Time-Resolved Fluorescence Resonance Energy Transfer Technologies in HTS
pp 198-214
- By Yuhong Du, Jonathan J. Havel
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Chapter 15 - Compound Profiling with High-Content Screening Methodology
pp 215-224
- By Thomas Mayer, Stephan Schürer
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Chapter 16 - Use of Transgenic Zebrafish in a Phenotypic Screen for Angiogenesis Inhibitors
pp 225-231
- By Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon, Ray Dingledine
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Chapter 17 - Flow Cytometry Multiplexed Screening Methodologies
pp 232-244
- By Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena Ivnitski-Steele, Bruce S. Edwards, Larry A. Sklar
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Chapter 18 - Label-Free Biosensor Technologies in Small Molecule Modulator Discovery
pp 245-258
- By Yuhong Du, Jie Xu, Haian Fu, Arron S. Xu
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Chapter 19 - Basic Principles and Practices of Computer-Aided Drug Design
pp 259-278
- By Chao-Yie Yang, Denzil Bernard, Shaomeng Wang
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Chapter 20 - Computational Approach for Drug Target Identification
pp 279-290
- By Honglin Li, Mingyue Zheng, Xiaofeng Liu, Hualiang Jiang
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Section five - Chemical Genomics and Medicine
pp 291-292
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Chapter 21 - Pharmacogenomics to Link Genetic Background with Therapeutic Efficacy and Safety
pp 293-300
- By Mark M. Bouzyk, Weining Tang, Brian Leyland-Jones
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